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Aliases for TRG Gene

Aliases for TRG Gene

  • T Cell Receptor Gamma Locus 2 3
  • T-Cell Antigen Receptor, Gamma Polypeptide 3
  • T-Cell Rearranging Gene, Gamma 3
  • T-Cell Receptor, Gamma Cluster 3
  • T-Cell Antigen Receptor 2
  • T-Cell Rearranging Gene 2
  • Gamma Polypeptide 2
  • T-Cell Receptor 2
  • Gamma Cluster 2
  • SAP30BP 6
  • Gamma 2
  • HCNGP 6
  • TCRG 3
  • TRG@ 3
  • HTRP 6
  • H 6

External Ids for TRG Gene

Previous HGNC Symbols for TRG Gene

  • TCRG
  • TRG@

Previous GeneCards Identifiers for TRG Gene

  • GC07M038284

Summaries for TRG Gene

Entrez Gene Summary for TRG Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRG Gene

TRG (T Cell Receptor Gamma Locus) is a Protein Coding gene. Diseases associated with TRG include angioimmunoblastic lymphadenopathy with dysproteinemia and subcutaneous panniculitis-like t-cell lymphoma.

Gene Wiki entry for TRG Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRG Gene

Genomics for TRG Gene

Genomic Location for TRG Gene

38,240,024 bp from pter
38,368,055 bp from pter
128,032 bases
Minus strand

Genomic View for TRG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRG Gene

No data available for Regulatory Elements for TRG Gene

Proteins for TRG Gene

Post-translational modifications for TRG Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRG Gene

Domains for TRG Gene

Gene Families for TRG Gene

  • TRG :T cell receptors / TRG locus

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRG: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRG Gene

Function for TRG Gene

genes like me logo Genes that share phenotypes with TRG: view

Animal Models for TRG Gene

MGI Knock Outs for TRG:

miRNA for TRG Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for TRG Gene

Localization for TRG Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRG Gene

Pathways for TRG Gene

SuperPathways for TRG Gene

No Data Available

Interacting Proteins for TRG Gene

Gene Ontology (GO) - Biological Process for TRG Gene


No data available for Pathways by source for TRG Gene

Compounds for TRG Gene

(2) Novoseek inferred chemical compound relationships for TRG Gene

Compound -log(P) Hits PubMed IDs
polyacrylamide 39.1 2
testosterone 0 1
genes like me logo Genes that share compounds with TRG: view

Transcripts for TRG Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRG Gene

No ASD Table

Relevant External Links for TRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for TRG Gene

Expression for TRG Gene

mRNA expression in normal human tissues for TRG Gene

genes like me logo Genes that share expressions with TRG: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TRG Gene

Orthologs for TRG Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TRG Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tcrg 16
Species with no ortholog for TRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for TRG Gene

Paralogs for TRG Gene

No data available for Paralogs for TRG Gene

Variants for TRG Gene

Relevant External Links for TRG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TRG Gene

Disorders for TRG Gene

(17) Novoseek inferred disease relationships for TRG Gene

Disease -log(P) Hits PubMed IDs
minimal residual disease 80.1 9
t-all 77.4 21
lymphoma t-cell peripheral 74.2 1
lymphoma t-cell 70.3 1
lymphoblastic leukemia acute 67.8 3
genes like me logo Genes that share disorders with TRG: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for TRG Gene

Publications for TRG Gene

  1. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (PMID: 12865322) Cheng W.S. … Essand M. (Endocrinology 2003) 3 23
  2. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. (PMID: 3102973) Littman D.R. … Weiss A. (Nature 1987) 2 3
  3. Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions. (PMID: 2526744) Lefranc M.P. … Lefranc G. (Eur. J. Immunol. 1989) 2 3
  4. The human T-cell receptor gamma (TRG) genes. (PMID: 2527426) Lefranc M.P. … Rabbitts T.H. (Trends Biochem. Sci. 1989) 3
  5. Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma. (PMID: 2879283) Lefranc M.P. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3

Products for TRG Gene

Sources for TRG Gene

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