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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRG Gene

protein-coding   GIFtS: 16
GCID: GC07M038284

T Cell Receptor Gamma Locus


(Previous symbols: TCRG, TRG@)
  Search for TRG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T Cell Receptor Gamma Locus1 2     T-Cell Receptor1
TCRG1 2     T-Cell Antigen Receptor, Gamma Polypeptide2
TRG@1 2     T-Cell Rearranging Gene, Gamma2
gamma1     T-Cell Receptor, Gamma Cluster2
Gamma Cluster1     H5
Gamma Polypeptide1     HCNGP5
T-Cell Antigen Receptor1     HTRP5
T-Cell Rearranging Gene1     SAP30BP5

External Ids:    HGNC: 122711   Entrez Gene: 69652   OMIM: 6102185   

Export aliases for TRG gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRG Gene:
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major
histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor
is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T
cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and
gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to
rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma
locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development,
the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment;
the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with
several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional
diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V
segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes.
Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia
and ataxia telangiectasia. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRG Gene: 
TRG (T cell receptor gamma locus) is a protein-coding gene.

Gene Wiki entry for TRG (TRG@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRG
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SwitchGear Promoter luciferase reporter plasmidTRG promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   HGNC cytogenetic band: 7p14

TRG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRG gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M038284:  view genomic region     (about GC identifiers)

Start:
38,279,625 bp from pter      End:
38,407,656 bp from pter
Size:
128,032 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 38,317,305-38,445,327     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRG: T cell receptors / TRG locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     7 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Tcrg):
 cellular  digestive/alimentary  hematopoietic system  immune system  integument 
 no phenotypic analysis  normal 

TRG for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TRG: Tcrgtm1Iku Tcrgtm1.1Dhr Tcrgtm1Ahay Tcrgtm1Scar Tcrgtm1.1Hish

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRG

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRG for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TRG

2 Novoseek inferred chemical compound relationships for TRG gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
polyacrylamide 39.1 2 16404354 (1), 11407983 (1)
testosterone 0 1 12865322 (1)

Search CenterWatch for drugs/clinical trials and news about TRG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRG Expression
About this image

    SABiosciences Custom PCR Arrays for TRG
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TRG gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcrg5 T cell receptor gamma chain   --   13 -

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRG
DNA2.0 Custom Variant and Variant Library Synthesis for TRG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRG for disorders           About MalaCards
OMIM gene information: 610218    OMIM disorders: --


TRG for disorders           About GeneDecksing

10/17 Novoseek inferred disease relationships for TRG gene (see all 17)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
minimal residual disease 80.1 10 10914544 (2), 14687622 (2), 12970784 (1), 16247752 (1) (see all 7)
t-all 77.4 26 10914544 (8), 8289500 (3), 10025894 (2), 10516765 (2) (see all 10)
lymphoma t-cell peripheral 74.2 1 17431414 (1)
lymphoma t-cell 70.3 1 16266900 (1)
lymphoblastic leukemia acute 67.8 3 10025893 (1), 8289500 (1), 14687622 (1)
mycosis fungoides 57.7 3 15660892 (1), 18644018 (1), 8409516 (1)
lymphoma t-cell cutaneous 54.6 1 7769255 (1)
lymphoma 52.8 2 10890990 (1), 8199020 (1)
leukemia 51.8 4 10613353 (2), 10865981 (1), 7992601 (1)
lymphoid neoplasm 44.6 1 16266900 (1)


Export disorders for TRG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRG gene, integrated from 9 sources (see all 153):
(articles sorted by number of sources associating them with TRG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions. (PubMed id 2526744)1, 3 Lefranc M.P....Lefranc G. (1989)
  2. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. (PubMed id 3102973)1, 3 Littman D.R....Weiss A. (1987)
  3. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (PubMed id 12865322)1, 9 Cheng W.S....Essand M. (2003)
  4. Human CD3g, but not CD3d, haploinsufficiency different ially impairs gd versus ab surface TCR expression. (PubMed id 23336327)1 Munoz-Ruiz M....Regueiro J.R. (2013)
  5. An abnormal phenotype of lung Vg9Vd2 T cells impairs t heir responsiveness in tuberculosis patients. (PubMed id 23770719)1 El Daker S....Martino A. (2013)
  6. Combined TCRG and TCRA TREC analysis reveals increased peripheral T-lymphocyte but constant intra-thymic proliferative history upon ag eing. (PubMed id 23000520)1 van der Weerd K....Staal F.J. (2013)
  7. Antibody-dependent anti-cytomegalovirus activity of hu man gd T cells expressing CD16 (FcgRIIIa). (PubMed id 22180442)1 Couzi L....Dechanet-Merville J. (2012)
  8. Activated human gd T cells induce peptide-specific CD8 + T-cell responses to tumor-associated self-antigens. (PubMed id 21928126)1 Altvater B....Rossig C. (2012)
  9. Granulocyte colony-stimulating factor affects the dist ribution and clonality of TRGV and TRDV repertoire of T cells and graft-versus-h ost disease. (PubMed id 22171570)1 Xuan L....Liu Q. (2011)
  10. Nonhepatosplenic I^I' T-cell lymphomas represent a spec trum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presenta tion. (PubMed id 21753698)1 Garcia-Herrera A....Martinez A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6965 HGNC: 12271 euGenes: HUgn6965 ECgene: TRG H-InvDB: TRG

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRG Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRG gene:
Search GeneIP for patents involving TRG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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