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Aliases for TRG Gene

Aliases for TRG Gene

  • T Cell Receptor Gamma Locus 2 3
  • T-Cell Antigen Receptor, Gamma Polypeptide 3
  • T-Cell Rearranging Gene, Gamma 3
  • T-Cell Receptor, Gamma Cluster 3
  • T-Cell Antigen Receptor 2
  • T-Cell Rearranging Gene 2
  • Gamma Polypeptide 2
  • T-Cell Receptor 2
  • Gamma Cluster 2
  • Gamma 2
  • TCRG 3
  • TRG@ 3

External Ids for TRG Gene

Previous HGNC Symbols for TRG Gene

  • TCRG
  • TRG@

Previous GeneCards Identifiers for TRG Gene

  • GC07M038284

Summaries for TRG Gene

Entrez Gene Summary for TRG Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRG Gene

TRG (T Cell Receptor Gamma Locus) is a Protein Coding gene. Diseases associated with TRG include Cytophagic Histiocytic Panniculitis and Precursor T-Cell Acute Lymphoblastic Leukemia.

Gene Wiki entry for TRG Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRG Gene

Genomics for TRG Gene

Regulatory Elements for TRG Gene

Enhancers for TRG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRG on UCSC Golden Path with GeneCards custom track

Genomic Location for TRG Gene

38,240,024 bp from pter
38,368,055 bp from pter
128,032 bases
Minus strand

Genomic View for TRG Gene

Genes around TRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRG Gene

Proteins for TRG Gene

Post-translational modifications for TRG Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRG Gene

Domains & Families for TRG Gene

Gene Families for TRG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRG: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRG Gene

Function for TRG Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRG Gene

Localization for TRG Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRG Gene

Pathways & Interactions for TRG Gene

SuperPathways for TRG Gene

No Data Available

Interacting Proteins for TRG Gene

Gene Ontology (GO) - Biological Process for TRG Gene


No data available for Pathways by source and SIGNOR curated interactions for TRG Gene

Drugs & Compounds for TRG Gene

(1) Drugs for TRG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TRG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRG: view

Transcripts for TRG Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRG Gene

No ASD Table

Relevant External Links for TRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for TRG Gene

Expression for TRG Gene

mRNA expression in normal human tissues for TRG Gene

genes like me logo Genes that share expression patterns with TRG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRG Gene

Orthologs for TRG Gene

No data available for Orthologs and Evolution for TRG Gene

Paralogs for TRG Gene

No data available for Paralogs for TRG Gene

Variants for TRG Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for TRG Gene

Disorders for TRG Gene

MalaCards: The human disease database

(10) MalaCards diseases for TRG Gene - From: Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cytophagic histiocytic panniculitis
  • chp
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
angioimmunoblastic lymphadenopathy with dysproteinemia
  • angioimmunoblastic with dysproteinemia lymphadenopathy
subcutaneous panniculitis-like t-cell lymphoma
  • sptcl
primary cutaneous anaplastic large cell lymphoma
  • primary c-alcl
- elite association - COSMIC cancer census association via MalaCards
Search TRG in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRG Gene

Publications for TRG Gene

  1. Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions. (PMID: 2526744) Lefranc M.P. … Lefranc G. (Eur. J. Immunol. 1989) 2 3 67
  2. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (PMID: 12865322) Cheng W.S. … Essand M. (Endocrinology 2003) 3 23
  3. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. (PMID: 3102973) Littman D.R. … Weiss A. (Nature 1987) 2 3
  4. Small intestinal intraepithelial TCRI^I'+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis. (PMID: 24905458) Weitkamp J.H. … Denning P.W. (PLoS ONE 2014) 3
  5. Combined TCRG and TCRA TREC analysis reveals increased peripheral T-lymphocyte but constant intra-thymic proliferative history upon ageing. (PMID: 23000520) van der Weerd K. … Staal F.J. (Mol. Immunol. 2013) 3

Products for TRG Gene

Sources for TRG Gene