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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TREX2 Gene

protein-coding   GIFtS: 58
GCID: GC0XM152710

Three Prime Repair Exonuclease 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Three Prime Repair Exonuclease 21 2
3'-5' Exonuclease TREX2 Long Form2
3'-5' Exonuclease TREX23
EC 3.1.11.23

External Ids:    HGNC: 122701   Entrez Gene: 112192   Ensembl: ENSG000001834797   OMIM: 3003705   UniProtKB: Q9BQ503   

Export aliases for TREX2 gene to outside databases

Previous GC identifers: GC0XM146847 GC0XM149165 GC0XM150295 GC0XM151178 GC0XM152231 GC0XM152363 GC0XM141369


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TREX2 Gene:
This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in
double-stranded DNA break repair, and may interact with DNA polymerase delta. (provided by RefSeq, Nov 2012)

GeneCards Summary for TREX2 Gene: 
TREX2 (three prime repair exonuclease 2) is a protein-coding gene. Diseases associated with TREX2 include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Chks in Checkpoint Regulation. GO annotations related to this gene include 3'-5'-exodeoxyribonuclease activity and nucleic acid binding. An important paralog of this gene is TREX1.

UniProtKB/Swiss-Prot: TREX2_HUMAN, Q9BQ50
Function: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA
repair

Gene Wiki entry for TREX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TREX2 gene promoter:
         GR   Pax-5   NRSF form 1   NRSF form 2   FOXL1   E47   AREB6   POU2F1a   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTREX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TREX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

TREX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREX2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM152710:  view genomic region     (about GC identifiers)

Start:
152,710,178 bp from pter      End:
152,736,045 bp from pter
Size:
25,868 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TREX2_HUMAN, Q9BQ50 (See protein sequence)
Recommended Name: Three prime repair exonuclease 2  
Size: 279 amino acids; 30621 Da
Cofactor: Binds 2 Mg(2+) per subunit. The second magnesium ion interacts with only one residue. Substitution with
Mn(2+) results in partial activity (By similarity)
Subunit: Homodimer
Subcellular location: Nucleus (Probable)
Caution: The gene for this protein is either identical to or adjacent to that of UCHL5IP. Most mRNAs that encode
UCHL5IP also include the N-terminal part of TREX2
1 PDB 3D structure from and Proteopedia for TREX2:
1Y97 (3D)    
Secondary accessions: Q45F08 Q9UN77
Alternative splicing: 2 isoforms:  Q9BQ50-1   Q9BQ50-2   

Explore the universe of human proteins at neXtProt for TREX2: NX_Q9BQ50

Explore proteomics data for TREX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BQ50

  • TREX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TREX2 Protein Expression
    REFSEQ proteins: NP_542432.2  
    ENSEMBL proteins: 
     ENSP00000377442   ENSP00000333441   ENSP00000345218   ENSP00000334993   ENSP00000359252  
     ENSP00000386078   ENSP00000401692   ENSP00000359251  

    Human Recombinant Protein Products for TREX2: 
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    Novus Biologicals TREX2 Proteins
    Novus Biologicals TREX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TREX2
    Cloud-Clone Corp. Proteins for TREX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    TREX2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TREX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQ50

    ProtoNet protein and cluster: Q9BQ50

    2 Blocks protein domains:
    IPB006055 Exonuclease
    IPB013520 Exonuclease


    UniProtKB/Swiss-Prot: TREX2_HUMAN, Q9BQ50
    Similarity: Belongs to the exonuclease superfamily. TREX family


    TREX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TREX2_HUMAN, Q9BQ50
    Function: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA
    repair
    Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
    Biophysicochemical properties: pH dependence: Optimum pH is 7.5-8.0;

         Enzyme Number (IUBMB): EC 3.1.11.21

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA11279105
    GO:0003676nucleic acid binding IEA--
    GO:0004527exonuclease activity ----
    GO:00082963'-5'-exodeoxyribonuclease activity IDA11279105
    GO:0008853exodeoxyribonuclease III activity IEA--
         
    TREX2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TREX2:
     Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trex2):
     cellular  homeostasis/metabolism  integument  no phenotypic analysis  tumorigenesis 

    TREX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trex2tm1.2Coso for TREX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TREX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TREX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TREX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TREX2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TREX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TREX2
        DNA Repair Mechanisms


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TREX2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for TREX2 (Q9BQ502, 3 ENSP000003334414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF4P188483, ENSP000003367904I2D: score=1 STRING: ENSP00000336790
    HAUS7ENSP000003592394STRING: ENSP00000359239
    --Q96AQ33, 2MINT-66904 I2D: score=1 
    --Q96AQ33, 2MINT-66904 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process IDA11279105
    GO:0006281DNA repair IEA--

    TREX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TREX2

    1 HMDB Compound for TREX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about TREX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TREX2 gene (3 alternative transcripts): 
    NM_080701.3  NM_080699.2  NM_080700.2  

    Unigene Cluster for TREX2:

    Three prime repair exonuclease 2
    Hs.644635  [show with all ESTs]
    Unigene Representative Sequence: NM_080701
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393862 ENST00000330912 ENST00000338525 ENST00000334497(uc004fhl.3)
    ENST00000370232(uc004fhm.3) ENST00000402951 ENST00000414588(uc010nue.2)
    ENST00000370231(uc010nud.2 uc011myp.2)
    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: TREX2 (NM_080701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TREX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREX2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREX2

    Additional mRNA sequence: AF151107.1 

    2 DOTS entries:

    DT.97855554  DT.121287253 

    24/189 AceView cDNA sequences (see all 189):

    BQ007469 AL122036 BF437715 AI522209 BX331754 BC008141 BE326764 AI682308 
    BQ772751 BE047013 BM823979 NM_080699 BU957340 CR614042 BM827152 AI474940 
    AI810865 NM_007205 NM_207107 AF319570 AI095730 BQ424904 BG575157 CA441020 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TREX2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a ·
    SP1:                                                        -     -     -           -                                               -     -                     
    SP2:                                            -           -                       -                             -     -           -     -                     
    SP3:                                                        -     -     -           -                                               -     -     -               
    SP4:                                                        -     -     -           -                                               -     -     -               
    SP5:                                                        -     -     -           -                             -     -           -     -     -               

    ExUns: 13b · 13c ^ 14 ^ 15a · 15b
    SP1:        -           -         
    SP2:                              
    SP3:        -                     
    SP4:        -     -     -         
    SP5:        -     -     -         


    ECgene alternative splicing isoforms for TREX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TREX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTGCCGC
    TREX2 Expression
    About this image


    See TREX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TREX2

    SOURCE GeneReport for Unigene cluster: Hs.644635

    UniProtKB/Swiss-Prot: TREX2_HUMAN, Q9BQ50
    Tissue specificity: Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon,
    small intestine, stomach and thymus

        SABiosciences Custom PCR Arrays for TREX2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TREX2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trex21 , 5 three prime repair exonuclease 21, 5 83.19(n)1
    88.14(a)1
      X (37.31 cM)5
    241021  NM_011907.41  NP_036037.11 
     734337055 
    lizard
    (Anolis carolinensis)
    Reptilia TREX26
    Uncharacterized protein
    51(a)
    1 ↔ 1
    2(88891870-88893237)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31656
    --
    23(a)
    1 → many
    2L(2977132-2978500)


    ENSEMBL Gene Tree for TREX2 (if available)
    TreeFam Gene Tree for TREX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TREX2 gene
    TREX12  
    1 SIMAP similar gene for TREX2 using alignment to 2 protein entries:     TREX2_HUMAN (see all proteins):
    TREX1

    TREX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 SNPs in TREX2 are shown (see all 90)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870680121,2
    --152577514(+) TCTCCC/TTACCC 1 -- ds50010--------
    rs1902506511,2
    --152577540(+) TCACCA/GCGAGG 1 -- ds50010--------
    rs1819911951,2
    --152577776(+) GGGCCA/GTATGG 1 -- ds50010--------
    rs1453514951,2
    F--152577950(+) GGCAAG/ATACAT 2 /Y syn11Minor allele frequency- A:0.00NA 2886
    rs9160461,2
    C,F,A,H--152577977(+) CACCCA/GCGGGC 2 R syn1 ese320Minor allele frequency- G:0.16NS EA NA CSA 4573
    rs2015559621,2
    C--152578000(+) CCAGGC/TGAGCA 2 T A mis10--------
    rs356394161,2
    C,F--152578004(-) GAGCTT/GCTCGC 2 /L syn16Minor allele frequency- G:0.95NS NA 3256
    rs1407053851,2
    F--152578016(+) GCGGCG/ACGGTG 2 /R syn11Minor allele frequency- A:0.00NA 3176
    rs1412055091,2
    C,F--152578087(+) TGCCCG/AGAAGT 2 /R /W mis11Minor allele frequency- A:0.00NA 3402
    rs1503165451,2
    C,F--152578112(+) CTGCCG/AAGGCT 2 /L syn11Minor allele frequency- A:0.01NA 2650

    HapMap Linkage Disequilibrium report for TREX2 (152710178 - 152736045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TREX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300370    OMIM disorders: --

    3 diseases for TREX2:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    prostatitis


    TREX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TREX2
    Human Genome Epidemiology (HuGE) Navigator: TREX2 (1 document)

    Export disorders for TREX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TREX2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with TREX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. (PubMed id 10391904)1, 2, 3 Mazur D.J. and Perrino F.W. (1999)
    2. Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. (PubMed id 11279105)1, 2, 9 Mazur D.J. and Perrino F.W. (2001)
    3. Structure and expression of the TREX1 and TREX2 3'-->5' exonuclease genes. (PubMed id 11278605)1, 2, 9 Mazur D.J. and Perrino F.W. (2001)
    4. TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus. (PubMed id 18092167)1, 4 Hur J.W....Bae S.C. (2008)
    5. The human TREX2 3' ->5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis. (PubMed id 15661738)1, 2 Perrino F.W.... Hollis T. (2005)
    6. DNA binding induces active site conformational change in the human TREX2 3'-exonuclease. (PubMed id 19321497)1, 9 de Silva U....Hollis T. (2009)
    7. Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. (PubMed id 21546543)1 Dumitrache L.C....Hasty P. (2011)
    8. Correct end use during end joining of multiple chromos omal double strand breaks is influenced by repair protein RAD50, DNA-dependent p rotein kinase DNA-PKcs, and transcription context. (PubMed id 22027841)1 Gunn A....Stark J.M. (2011)
    9. ATM limits incorrect end utilization during non-homolo gous end joining of multiple chromosome breaks. (PubMed id 21079684)1 Bennardo N. and Stark J.M. (2010)
    10. TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations. (PubMed id 19094998)1 Dumitrache L.C....Hasty P. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11219 HGNC: 12270 AceView: TREX2 Ensembl:ENSG00000183479 euGenes: HUgn11219
    ECgene: TREX2 H-InvDB: TREX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TREX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TREX2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/trex2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TREX2 gene:
    Search GeneIP for patents involving TREX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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