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Aliases for TREX2 Gene

Aliases for TREX2 Gene

  • Three Prime Repair Exonuclease 2 2 3
  • 3-5 Exonuclease TREX2 4
  • EC 3.1.11.2 4

External Ids for TREX2 Gene

Previous GeneCards Identifiers for TREX2 Gene

  • GC0XM146847
  • GC0XM149165
  • GC0XM150295
  • GC0XM151178
  • GC0XM152231
  • GC0XM152363
  • GC0XM152710
  • GC0XM141369

Summaries for TREX2 Gene

Entrez Gene Summary for TREX2 Gene

  • This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

GeneCards Summary for TREX2 Gene

TREX2 (Three Prime Repair Exonuclease 2) is a Protein Coding gene. Among its related pathways are Chks in Checkpoint Regulation. GO annotations related to this gene include protein homodimerization activity and magnesium ion binding.

UniProtKB/Swiss-Prot for TREX2 Gene

  • Exonuclease with a preference for double-stranded DNA with mismatched 3 termini. May play a role in DNA repair.

Gene Wiki entry for TREX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREX2 Gene

Genomics for TREX2 Gene

Regulatory Elements for TREX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TREX2 Gene

Start:
153,444,720 bp from pter
End:
153,470,587 bp from pter
Size:
25,868 bases
Orientation:
Minus strand

Genomic View for TREX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TREX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREX2 Gene

Proteins for TREX2 Gene

  • Protein details for TREX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ50-TREX2_HUMAN
    Recommended name:
    Three prime repair exonuclease 2
    Protein Accession:
    Q9BQ50
    Secondary Accessions:
    • Q45F08
    • Q9UN77

    Protein attributes for TREX2 Gene

    Size:
    279 amino acids
    Molecular mass:
    30621 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 Mg(2+) per subunit. The second magnesium ion interacts with only one residue. Substitution with Mn(2+) results in partial activity.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TREX2 Gene

    Alternative splice isoforms for TREX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREX2 Gene

Proteomics data for TREX2 Gene at MOPED

Post-translational modifications for TREX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TREX2 Gene

No data available for DME Specific Peptides for TREX2 Gene

Domains for TREX2 Gene

Suggested Antigen Peptide Sequences for TREX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ50

UniProtKB/Swiss-Prot:

TREX2_HUMAN :
  • Q9BQ50
Family:
  • Belongs to the exonuclease superfamily. TREX family.
genes like me logo Genes that share domains with TREX2: view

No data available for Gene Families for TREX2 Gene

Function for TREX2 Gene

Molecular function for TREX2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 7.5-8.0.;
UniProtKB/Swiss-Prot CatalyticActivity: Exonucleolytic cleavage in the 3- to 5-direction to yield nucleoside 5-phosphates
UniProtKB/Swiss-Prot Function: Exonuclease with a preference for double-stranded DNA with mismatched 3 termini. May play a role in DNA repair.

Enzyme Numbers (IUBMB) for TREX2 Gene

Gene Ontology (GO) - Molecular Function for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11279105
GO:0003676 nucleic acid binding IEA --
GO:0004527 exonuclease activity --
GO:0008296 3-5-exodeoxyribonuclease activity IDA 11279105
GO:0008853 exodeoxyribonuclease III activity IEA --
genes like me logo Genes that share ontologies with TREX2: view
genes like me logo Genes that share phenotypes with TREX2: view

Animal Models for TREX2 Gene

MGI Knock Outs for TREX2:

Animal Model Products

CRISPR Products

miRNA for TREX2 Gene

miRTarBase miRNAs that target TREX2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TREX2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TREX2 Gene

Localization for TREX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREX2 Gene COMPARTMENTS Subcellular localization image for TREX2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TREX2: view

Pathways for TREX2 Gene

SuperPathways for TREX2 Gene

Superpath Contained pathways
1 Chks in Checkpoint Regulation
genes like me logo Genes that share pathways with TREX2: view

Pathways by source for TREX2 Gene

1 Qiagen pathway for TREX2 Gene

Interacting Proteins for TREX2 Gene

Gene Ontology (GO) - Biological Process for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000738 DNA catabolic process, exonucleolytic --
GO:0006259 DNA metabolic process IDA 11279105
GO:0006281 DNA repair IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis TAS 10391904
genes like me logo Genes that share ontologies with TREX2: view

Compounds for TREX2 Gene

(1) HMDB Compounds for TREX2 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with TREX2: view

Transcripts for TREX2 Gene

Unigene Clusters for TREX2 Gene

Three prime repair exonuclease 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TREX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11:
SP12:

ExUns: 13b · 13c ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TREX2 Gene

GeneLoc Exon Structure for
TREX2
ECgene alternative splicing isoforms for
TREX2

Expression for TREX2 Gene

mRNA expression in normal human tissues for TREX2 Gene

mRNA differential expression in normal tissues according to GTEx for TREX2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (9.7), Skin - Sun Exposed (Lower leg) (8.8), and Artery - Aorta (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TREX2 Gene

SOURCE GeneReport for Unigene cluster for TREX2 Gene Hs.644635

mRNA Expression by UniProt/SwissProt for TREX2 Gene

Q9BQ50-TREX2_HUMAN
Tissue specificity: Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus.
genes like me logo Genes that share expressions with TREX2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TREX2 Gene

Orthologs for TREX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TREX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREX2 35
  • 99.15 (n)
  • 100 (a)
TREX2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TREX2 35
  • 87.01 (n)
  • 86.44 (a)
TREX2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trex2 35
  • 83.19 (n)
  • 88.14 (a)
Trex2 16
Trex2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TREX2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trex2 35
  • 81.5 (n)
  • 87.29 (a)
lizard
(Anolis carolinensis)
Reptilia TREX2 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488944 35
  • 56.74 (n)
  • 52.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3165 36
  • 22 (a)
OneToMany
Species with no ortholog for TREX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREX2 Gene

ENSEMBL:
Gene Tree for TREX2 (if available)
TreeFam:
Gene Tree for TREX2 (if available)

Paralogs for TREX2 Gene

Selected SIMAP similar genes for TREX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TREX2: view

No data available for Paralogs for TREX2 Gene

Variants for TREX2 Gene

Sequence variations from dbSNP and Humsavar for TREX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs916046 -- 153,444,780(+) CACCC(A/G)CGGGC synonymous-codon, reference
rs3020962 -- 153,447,002(+) AGGCC(G/T)GCCCG upstream-variant-2KB
rs4898459 -- 153,447,100(+) TTGCC(G/T)TGTGT upstream-variant-2KB
rs34136705 -- 153,444,930(-) GGCCG(C/T)CAGGG reference, synonymous-codon
rs34137672 -- 153,445,789(+) GGAAC(-/C)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TREX2 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407

Relevant External Links for TREX2 Gene

HapMap Linkage Disequilibrium report
TREX2
Human Gene Mutation Database (HGMD)
TREX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREX2 Gene

Disorders for TREX2 Gene

Relevant External Links for TREX2

Genetic Association Database (GAD)
TREX2
Human Genome Epidemiology (HuGE) Navigator
TREX2
genes like me logo Genes that share disorders with TREX2: view

No data available for UniProtKB/Swiss-Prot for TREX2 Gene

Publications for TREX2 Gene

  1. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. (PMID: 10391904) Mazur D.J. … Perrino F.W. (J. Biol. Chem. 1999) 2 3 4
  2. Structure and expression of the TREX1 and TREX2 3'-->5' exonuclease genes. (PMID: 11278605) Mazur D.J. … Perrino F.W. (J. Biol. Chem. 2001) 3 4 23
  3. Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. (PMID: 11279105) Mazur D.J. … Perrino F.W. (J. Biol. Chem. 2001) 3 4 23
  4. DNA binding induces active site conformational change in the human TREX2 3'-exonuclease. (PMID: 19321497) de Silva U. … Hollis T. (Nucleic Acids Res. 2009) 3 23
  5. The human TREX2 3' ->5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis. (PMID: 15661738) Perrino F.W. … Hollis T. (J. Biol. Chem. 2005) 3 4

Products for TREX2 Gene

Sources for TREX2 Gene

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