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Aliases for TREX2 Gene

Aliases for TREX2 Gene

  • Three Prime Repair Exonuclease 2 2 3 5
  • 3-5 Exonuclease TREX2 4
  • EC 3.1.11.2 4

External Ids for TREX2 Gene

Previous GeneCards Identifiers for TREX2 Gene

  • GC0XM146847
  • GC0XM149165
  • GC0XM150295
  • GC0XM151178
  • GC0XM152231
  • GC0XM152363
  • GC0XM152710
  • GC0XM141369

Summaries for TREX2 Gene

Entrez Gene Summary for TREX2 Gene

  • This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

GeneCards Summary for TREX2 Gene

TREX2 (Three Prime Repair Exonuclease 2) is a Protein Coding gene. Among its related pathways are Chks in Checkpoint Regulation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and magnesium ion binding. An important paralog of this gene is TREX1.

UniProtKB/Swiss-Prot for TREX2 Gene

  • Exonuclease with a preference for double-stranded DNA with mismatched 3 termini. May play a role in DNA repair.

Gene Wiki entry for TREX2 Gene

Additional gene information for TREX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREX2 Gene

Genomics for TREX2 Gene

GeneHancer (GH) Regulatory Elements for TREX2 Gene

Promoters and enhancers for TREX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI153469 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 558.3 -0.4 -387 2.8 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 YY1 GLIS2 ZNF143 TREX2 HAUS7 LOC105373381
GH0XI153493 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 4.4 -24.6 -24559 3 CTCF NFIB NRF1 ARID4B REST ZIC2 RAD21 ZNF335 GLIS2 POLR2A HAUS7 BGN TREX2
GH0XI153459 Enhancer 0.8 Ensembl ENCODE 6.3 +10.4 10378 1.6 CTCF MAZ ZNF654 JUN RAD21 SCRT2 ZNF143 SMC3 ZBTB33 TREX2 GC0XP153425 HAUS7
GH0XI153474 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -5.9 -5906 4.4 ZIC2 RAD21 ZKSCAN1 ZFHX2 POLR2A VEZF1 RCOR1 FOS CHD2 EGR2 KRT18P48 LOC105373381 TREX2 HAUS7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TREX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TREX2 gene promoter:

Genomic Locations for TREX2 Gene

Genomic Locations for TREX2 Gene
chrX:153,444,720-153,470,587
(GRCh38/hg38)
Size:
25,868 bases
Orientation:
Minus strand
chrX:152,710,178-152,736,045
(GRCh37/hg19)

Genomic View for TREX2 Gene

Genes around TREX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREX2 Gene

Proteins for TREX2 Gene

  • Protein details for TREX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ50-TREX2_HUMAN
    Recommended name:
    Three prime repair exonuclease 2
    Protein Accession:
    Q9BQ50
    Secondary Accessions:
    • Q45F08
    • Q9UN77

    Protein attributes for TREX2 Gene

    Size:
    279 amino acids
    Molecular mass:
    30621 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TREX2 Gene

    Alternative splice isoforms for TREX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREX2 Gene

Post-translational modifications for TREX2 Gene

No Post-translational modifications

Other Protein References for TREX2 Gene

No data available for DME Specific Peptides for TREX2 Gene

Domains & Families for TREX2 Gene

Gene Families for TREX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TREX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ50

UniProtKB/Swiss-Prot:

TREX2_HUMAN :
  • Belongs to the exonuclease superfamily. TREX family.
Family:
  • Belongs to the exonuclease superfamily. TREX family.
genes like me logo Genes that share domains with TREX2: view

Function for TREX2 Gene

Molecular function for TREX2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.5-8.0.;
UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage in the 3- to 5-direction to yield nucleoside 5-phosphates.
UniProtKB/Swiss-Prot Function:
Exonuclease with a preference for double-stranded DNA with mismatched 3 termini. May play a role in DNA repair.

Enzyme Numbers (IUBMB) for TREX2 Gene

Gene Ontology (GO) - Molecular Function for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11279105
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0008296 3-5-exodeoxyribonuclease activity IDA 11279105
genes like me logo Genes that share ontologies with TREX2: view
genes like me logo Genes that share phenotypes with TREX2: view

Animal Models for TREX2 Gene

MGI Knock Outs for TREX2:

Animal Model Products

CRISPR Products

miRNA for TREX2 Gene

miRTarBase miRNAs that target TREX2

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TREX2 Gene

Localization for TREX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREX2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TREX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TREX2 Gene

Pathways & Interactions for TREX2 Gene

SuperPathways for TREX2 Gene

SuperPathway Contained pathways
1 Chks in Checkpoint Regulation
genes like me logo Genes that share pathways with TREX2: view

Pathways by source for TREX2 Gene

1 Qiagen pathway for TREX2 Gene

Gene Ontology (GO) - Biological Process for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IDA 11279105
GO:0006281 DNA repair IEA,TAS --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TREX2: view

No data available for SIGNOR curated interactions for TREX2 Gene

Drugs & Compounds for TREX2 Gene

(1) Drugs for TREX2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
genes like me logo Genes that share compounds with TREX2: view

Transcripts for TREX2 Gene

Unigene Clusters for TREX2 Gene

Three prime repair exonuclease 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11:
SP12:

ExUns: 13b · 13c ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TREX2 Gene

GeneLoc Exon Structure for
TREX2
ECgene alternative splicing isoforms for
TREX2

Expression for TREX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TREX2 Gene

mRNA differential expression in normal tissues according to GTEx for TREX2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.7), Skin - Sun Exposed (Lower leg) (x8.8), and Artery - Aorta (x4.6).

Protein differential expression in normal tissues from HIPED for TREX2 Gene

This gene is overexpressed in Monocytes (58.2) and Plasma (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TREX2 Gene



Protein tissue co-expression partners for TREX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TREX2 Gene:

TREX2

SOURCE GeneReport for Unigene cluster for TREX2 Gene:

Hs.644635

mRNA Expression by UniProt/SwissProt for TREX2 Gene:

Q9BQ50-TREX2_HUMAN
Tissue specificity: Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus.
genes like me logo Genes that share expression patterns with TREX2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TREX2 Gene

Orthologs for TREX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TREX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREX2 33 34
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia TREX2 33 34
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Trex2 33 16 34
  • 83.19 (n)
rat
(Rattus norvegicus)
Mammalia Trex2 33
  • 81.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TREX2 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TREX2 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488944 33
  • 56.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3165 34
  • 22 (a)
OneToMany
Species where no ortholog for TREX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREX2 Gene

ENSEMBL:
Gene Tree for TREX2 (if available)
TreeFam:
Gene Tree for TREX2 (if available)

Paralogs for TREX2 Gene

Paralogs for TREX2 Gene

(1) SIMAP similar genes for TREX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TREX2: view

Variants for TREX2 Gene

Sequence variations from dbSNP and Humsavar for TREX2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs141078733 benign, Abnormality of neuronal migration 153,445,172(-) G/A coding_sequence_variant, stop_gained
rs1000359306 -- 153,448,287(-) C/T upstream_transcript_variant
rs1001795778 -- 153,444,234(-) G/A downstream_transcript_variant
rs1004497678 -- 153,448,008(-) A/G upstream_transcript_variant
rs1004551448 -- 153,448,222(-) A/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TREX2 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv3577532 CNV gain 25503493

Variation tolerance for TREX2 Gene

Gene Damage Index Score: 1.29; 25.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TREX2 Gene

Human Gene Mutation Database (HGMD)
TREX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREX2 Gene

Disorders for TREX2 Gene

Additional Disease Information for TREX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TREX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREX2 Gene

Publications for TREX2 Gene

  1. Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. (PMID: 11278605) Mazur DJ … Perrino FW (The Journal of biological chemistry 2001) 3 4 22 58
  2. Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. (PMID: 11279105) Mazur DJ … Perrino FW (The Journal of biological chemistry 2001) 3 4 22 58
  3. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. (PMID: 10391904) Mazur DJ … Perrino FW (The Journal of biological chemistry 1999) 2 3 4 58
  4. DNA binding induces active site conformational change in the human TREX2 3'-exonuclease. (PMID: 19321497) de Silva U … Hollis T (Nucleic acids research 2009) 3 22 58
  5. TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus. (PMID: 18092167) Hur JW … Bae SC (Rheumatology international 2008) 3 44 58

Products for TREX2 Gene

Sources for TREX2 Gene

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