TREX1 Gene
protein-coding GIFtS: 59
GCID: GC03P048506
|
|
three prime repair exonuclease 1(Previous name: Aicardi-Goutieres syndrome 1 )
(Previous symbol: AGS1)
| |
Aliases
for TREX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Three Prime Repair Exonuclease 11 2 | | HERNS2 5 | | AGS11 2 5 | | Aicardi-Goutieres Syndrome 11 | | DRN31 2 | | 3' Repair Exonuclease 12 | | 3'-5' Exonuclease TREX12 3 | | Deoxyribonuclease III2 | | DNase III2 3 | | EC 3.1.11.23 | | CRV2 5 | | |
Export aliases for TREX1 gene to outside databasesPrevious GC identifers: GC03P048289 GC03P047770 GC03P048448 GC03P048463 GC03P048482 |
Summaries
for TREX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TREX1:
This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair andserve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome,chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Sep 2012)
UniProtKB/Swiss-Prot: TREX1_HUMAN, Q9NSU2Function: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNArepair
Gene Wiki entry for TREX1
|
Genomic Views
for TREX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TREX1 gene promoter:
GR AML1a p53 GR-beta GR-alpha ATF Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for TREX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31TREX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P048506: view genomic region
(about GC identifiers)
Start:
|
48,506,445 bp from pter |
End:
|
48,509,044 bp from pter |
Size:
|
2,600 bases |
Orientation:
|
plus strand |
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Proteins
for TREX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TREX1_HUMAN, Q9NSU2 (See
protein sequence)Recommended Name: Three prime repair exonuclease 1 Size: 369 amino acids; 38923 Da
Cofactor: Magnesium. Required for activity. Substitution with Mn(2+) results in partial activity (By similarity)
Subunit: Homodimer
Subcellular location: Nucleus (By similarity)
Caution: The gene for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encodeATRIP also encode TREX1 in another reading frame
Sequence caution: Sequence=AAD48774.2; Type=Erroneous initiation;
Secondary accessions: B2RCN9 Q8TEU2 Q9BPW1 Q9Y4X2Alternative splicing: 3 isoforms: Q9NSU2-1 Q9NSU2-2 Q9NSU2-3 Explore the universe of human proteins at neXtProt for TREX1: NX_Q9NSU2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NSU2
TREX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_009179.2 NP_057465.1 NP_338599.1
ENSEMBL proteins: ENSP00000296443 ENSP00000412404 ENSP00000415972 ENSP00000411331 ENSP00000390478 ENSP00000392569
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TREX1 for ontologies About GeneDecksing
TREX1 Antibody Products:
Assay Products for TREX1: |
Protein
Domains /
Families
for TREX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TREX1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NSU2ProtoNet protein and cluster: Q9NSU2 1 Blocks protein family: IPB006055 Exonuclease
UniProtKB/Swiss-Prot: TREX1_HUMAN, Q9NSU2Similarity: Belongs to the exonuclease superfamily. TREX family |
Function
for TREX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TREX1_HUMAN, Q9NSU2Function: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNArepairCatalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphatesEnzyme Number (IUBMB): EC 3.1.11.21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREX1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TREX1 (NM_033629) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TREX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREX1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREX1 |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
TREX1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for TREX1: Trex1tm1Tld Trex1tm1(KOMP)Wtsi
13 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Trex1):
TREX1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TREX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytosolic DNA-sensing pathway | | | 2 | Chks in Checkpoint Regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TREX1
1 
Kegg Pathway (Kegg details for TREX1):
TREX1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TREX1
5/10 Interacting proteins for TREX1 (Q9NSU22, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
TREX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TREX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TREX1 for compounds About GeneDecksing
 Browse Tocris compounds for TREX1
1 HMDB Compound for TREX1 About this table
4 Novoseek chemical compound relationships for TREX1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphoglycolate |
80.8 |
1 |
11839093 (1) |
| phosphonate |
54.8 |
1 |
11839093 (1) |
| phosphoinositide |
32.3 |
1 |
15527801 (1) |
| oligonucleotide |
13.1 |
2 |
17224176 (1), 11279105 (1) |
Search CenterWatch for drugs/clinical trials and news about TREX1
|
Transcripts
for TREX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TREX1 gene (5 alternative transcripts): NM_007248.2 NM_016381.4 NM_033629.3 NM_033627.3 NM_033628.2 Unigene Clusters for TREX1: Three prime repair exonuclease 1 Hs.707026 [show with all ESTs], Hs.713742 [show with all ESTs], Hs.744646 Unigene Representative Sequences: AL137745, BC023630, BC0198638 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395677(uc003ctj.3) ENST00000296443(uc010hjy.3 uc010hjz.3)
ENST00000433541(uc003ctk.3) ENST00000444177 ENST00000456089 ENST00000492235
ENST00000422277(uc010hka.3) ENST00000436480
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREX1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREX1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TREX1 (NM_033629) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TREX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREX1 |
Additional cDNA sequence: BC019863.1 9 DOTS entries: DT.403585 DT.92427781 DT.100788182 DT.92427779 DT.112143 DT.120906357 DT.100788185 DT.120906024 DT.95239570 24/185 AceView cDNA sequences (see all 185): CR622505 AF319569 BF588494 AU147975 AF319568 AK022405 BC020563 BC023630 AF451323 AI080144 BM919749 BM832282 BC030597 AU122387 CD673015 AI285342 BC014153 BM830640 NM_033627 NM_130384 BF914851 AL137745 AI422509 AL832917
GeneLoc Exon Structure
|
Expression
for TREX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TREX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGGGGTCA
About this image
See TREX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TREX1
SOURCE GeneReport for Unigene clusters: Hs.707026 Hs.713742 Hs.744646
UniProtKB/Swiss-Prot: TREX1_HUMAN, Q9NSU2Tissue specificity: Detected in thymus, spleen, liver, brain, heart, small intestine and colon
SABiosciences Expression via Pathway-Focused PCR Array including TREX1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TREX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TREX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREX1 |
Orthologs
for TREX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TREX1 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Trex11 , 5 |
three prime repair exonuclease 11, 5 |
80.19(n)1
73.8(a)1 |
|
9 (59.63 cM)5
220401 NM_001012236.11 NP_001012236.11
1090579335 |
lizard
(Anolis carolinensis) |
Reptilia |
TREX16 |
-- |
45(a) |
1 ↔ 1 |
2(155923062-155923799) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.11852 |
Transcribed sequence with weak similarity to protein more |
79.53(n) |
|
142016464 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG31656 |
-- |
21(a) |
1 → many |
2L(2977132-2978500) |
ENSEMBL Gene Tree for TREX1 (if available)
TreeFam Gene Tree for TREX1 (if available) |
Paralogs
for TREX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TREX1 gene
- TREX22
1 SIMAP similar gene for TREX1 using alignment to 5 protein entries: TREX1_HUMAN (see all proteins):TREX2
TREX1 for paralogs About GeneDecksing
|
Genomic Variants
for TREX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TREX1 (48506445 - 48509044 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TREX1: --
Human Gene Mutation Database (HGMD): TREX1
Locus Specific Mutation Databases (LSDB): TREX1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TREX1 |
|
Disorders
/ Diseases
for TREX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TREX1 for disorders About GeneDecksing
OMIM gene information: 606609
OMIM disorders: 225750 610448 192315 152700
UniProtKB/Swiss-Prot: TREX1_HUMAN, Q9NSU2
Defects in TREX1 are the cause of Aicardi-Goutieres syndrome type 1 (AGS1) [MIM:225750]. A form ofAicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy,leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSFalpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features asthrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneouslysuggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly,spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. AGS1inheritance can be autosomal recessive or dominant Defects in TREX1 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is achronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin,joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of theautoimmune system Defects in TREX1 are the cause of chilblain lupus type 1 (CHBL1) [MIM:610448]. A cutaneous form of lupuserythematosus. Affected individuals present with painful bluish-red papular or nodular lesions of the skin in acrallocations precipitated by cold and wet exposure at temperatures less than 10 degrees centigrade Defects in TREX1 are the cause of vasculopathy, retinal, with cerebral leukodystrophy (RVCL) [MIM:192315]. Amicrovascular endotheliopathy with middle-age onset. This retinal vasculopathy is characterized by telangiectasias,microaneurysms and retinal capillary obliteration starting in the macula. Diseased cerebral white matter has prominentsmall infarcts that often coalesce to pseudotumors
20/26  diseases for TREX1 (see all 26): About MalaCardsaicardi-goutieres syndrome chilblain lupus aicardi-goutieres syndrome 1, dominant and recessive aicardi-goutieres syndrome type 1
vasculopathy, retinal, with cerebral leukodystrophy encephalitis systemic lupus erythematosus lupus erythematosus
fibromuscular dysplasia leukodystrophy werner syndrome cadasil
moyamoya disease breast-ovarian cancer cerebral atrophy ovarian cancer
cerebritis rheumatoid arthritis myositis microcephaly
2 diseases from the University of Copenhagen DISEASES database for TREX1:Aicardi-Goutieres syndrome Systemic lupus erythematosus 2 Novoseek disease relationships for TREX1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| werner syndrome |
61.3 |
1 |
16822725 (1) |
| cancer |
0 |
1 |
17616665 (1) |
GeneTests: TREX1
Aicardi-Goutieres Syndrome
Human Genome Epidemiology (HuGE) Navigator: TREX1 (5 documents)
Export disorders for TREX1 gene to outside databases
|
Publications
for TREX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TREX1 gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with TREX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. (PubMed id 16845398)1, 2, 3 Crow Y.J....Lindahl T. (2006)
- Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. (PubMed id 10391904)1, 2, 3 Mazur D.J. and Perrino F.W. (1999)
- A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. (PubMed id 10393201)1, 2, 3 Hoess M....Lindahl T. (1999)
- Structure and expression of the TREX1 and TREX2 3'-->5' exonuclease genes. (PubMed id 11278605)1, 2, 9 Mazur D.J. and Perrino F.W. (2001)
- A de novo p.Asp18Asn mutation in TREX1 in a patient w ith Aicardi-GoutiA"res syndrome. (PubMed id 20799324)1, 2 Haaxma C.A....Willemsen M.A. (2010)
- Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. (PubMed id 17660818)1, 2 Lee-Kirsch M.A.... Huebner N. (2007)
- C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. (PubMed id 17660820)1, 2 Richards A....Atkinson J.P. (2007)
- Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. (PubMed id 17357087)1, 2 Rice G.... Crow Y.J. (2007)
- A mutation in TREX1 that impairs susceptibility to granzyme A- mediated cell death underlies familial chilblain lupus. (PubMed id 17440703)1, 2 Lee-Kirsch M.A....Hubner N. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for TREX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TREX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TREX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TREX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TREX1 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for TREX1 | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TREX1 | | NIEHS-SNPs | http://egp.gs.washington.edu/data/trex1/ |
|
| | |
About This Section
| Patent Information for TREX1 gene:
Search GeneIP for patents involving TREX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TREX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for TREX1 | | OriGene shRNA RFP for TREX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TREX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TREX1 | | | OriGene Protein Over-expression Lysate for TREX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TREX1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TREX1 | | OriGene Custom Protein Services for TREX1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TREX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TREX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TREX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREX1 |
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| | Antibodies & Assays for TREX1 |
| | | | Search Tocris compounds for TREX1 |
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 | | | TREX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREX1 |
|  |  |  | | | | ThermoFisher Antibodies for TREX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREX1 |
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