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Aliases for TRERF1 Gene

Aliases for TRERF1 Gene

  • Transcriptional Regulating Factor 1 2 3
  • Breast Cancer Anti-Estrogen Resistance 2 2 3 4
  • TREP132 3 4 6
  • Zinc Finger Transcription Factor TReP-132 3 4
  • Transcriptional-Regulating Protein 132 3 4
  • Zinc Finger Protein Rapa 3 4
  • BCAR2 3 4
  • RAPA 3 4
  • Transcriptional Regulating Protein 132 3
  • Transcriptional-Regulating Factor 1 3
  • HSA277276 3
  • DJ139D8.5 3
  • TReP-132 3
  • Rapa-1 3
  • Rapa-2 3

External Ids for TRERF1 Gene

Previous Symbols for TRERF1 Gene

  • BCAR2

Summaries for TRERF1 Gene

Entrez Gene Summary for TRERF1 Gene

  • This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for TRERF1 Gene

TRERF1 (Transcriptional Regulating Factor 1) is a Protein Coding gene. Diseases associated with TRERF1 include estrogen resistance and breast cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is ZNF541.

UniProtKB/Swiss-Prot for TRERF1 Gene

  • Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.

Gene Wiki entry for TRERF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRERF1 Gene

Genomics for TRERF1 Gene

Genomic Location for TRERF1 Gene

Start:
42,224,931 bp from pter
End:
42,452,205 bp from pter
Size:
227,275 bases
Orientation:
Minus strand

Genomic View for TRERF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRERF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRERF1 Gene

Regulatory Elements for TRERF1 Gene

Transcription factor binding sites by QIAGEN in the TRERF1 gene promoter:

Proteins for TRERF1 Gene

  • Protein details for TRERF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PN7-TREF1_HUMAN
    Recommended name:
    Transcriptional-regulating factor 1
    Protein Accession:
    Q96PN7
    Secondary Accessions:
    • Q05GC6
    • Q7Z6T2
    • Q7Z6T3
    • Q9NQ72
    • Q9NQ73
    • Q9NUN9

    Protein attributes for TRERF1 Gene

    Size:
    1200 amino acids
    Molecular mass:
    132256 Da
    Quaternary structure:
    • Interacts with CREBBP and EP300 (PubMed:11349124). Interacts with DNTTIP1 and DNTT (PubMed:16371131).
    SequenceCaution:
    • Sequence=BAA92082.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRERF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRERF1 Gene

Proteomics data for TRERF1 Gene at MOPED

Post-translational modifications for TRERF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys72 and Lys812

Other Protein References for TRERF1 Gene

No data available for DME Specific Peptides for TRERF1 Gene

Domains for TRERF1 Gene

Protein Domains for TRERF1 Gene

UniProtKB/Swiss-Prot:

TREF1_HUMAN
Domain:
  • Contains 1 ELM2 domain.:
    • Q96PN7
  • Contains 1 SANT domain.:
    • Q96PN7
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q96PN7
genes like me logo Genes that share domains with TRERF1: view

No data available for Gene Families for TRERF1 Gene

Function for TRERF1 Gene

Molecular function for TRERF1 Gene

UniProtKB/Swiss-Prot Function: Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.

Gene Ontology (GO) - Molecular Function for TRERF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity NAS 11349124
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 11349124
GO:0008134 transcription factor binding IPI 11349124
genes like me logo Genes that share ontologies with TRERF1: view
genes like me logo Genes that share phenotypes with TRERF1: view

miRNA for TRERF1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRERF1 Gene

Localization for TRERF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRERF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRERF1 Gene COMPARTMENTS Subcellular localization image for TRERF1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TRERF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11349124
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TRERF1: view

Pathways for TRERF1 Gene

SuperPathways for TRERF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRERF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter NAS 11349124
GO:0006366 transcription from RNA polymerase II promoter NAS 11349124
GO:0006694 steroid biosynthetic process NAS 11349124
GO:0006707 cholesterol catabolic process NAS 11349124
GO:0007275 multicellular organismal development NAS 11349124
genes like me logo Genes that share ontologies with TRERF1: view

No data available for Pathways by source for TRERF1 Gene

Compounds for TRERF1 Gene

(1) Novoseek inferred chemical compound relationships for TRERF1 Gene

Compound -log(P) Hits PubMed IDs
steroid 48.4 1
genes like me logo Genes that share compounds with TRERF1: view

Transcripts for TRERF1 Gene

Unigene Clusters for TRERF1 Gene

Transcriptional regulating factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRERF1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b
SP1:
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for TRERF1 Gene

GeneLoc Exon Structure for
TRERF1
ECgene alternative splicing isoforms for
TRERF1

Expression for TRERF1 Gene

mRNA expression in normal human tissues for TRERF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRERF1 Gene

SOURCE GeneReport for Unigene cluster for TRERF1 Gene Hs.485392

mRNA Expression by UniProt/SwissProt for TRERF1 Gene

Q96PN7-TREF1_HUMAN
Tissue specificity: Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells.
genes like me logo Genes that share expressions with TRERF1: view

Orthologs for TRERF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRERF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRERF1 36
  • 97.33 (n)
  • 96.16 (a)
TRERF1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRERF1 36
  • 89.59 (n)
  • 90.07 (a)
TRERF1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRERF1 36
  • 90 (n)
  • 91.11 (a)
TRERF1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trerf1 36
  • 87.41 (n)
  • 89.03 (a)
Trerf1 16
Trerf1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRERF1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRERF1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trerf1 36
  • 87.32 (n)
  • 89.42 (a)
chicken
(Gallus gallus)
Aves TRERF1 36
  • 68.41 (n)
  • 68.09 (a)
TRERF1 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRERF1 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trerf1 36
  • 60.16 (n)
  • 54.62 (a)
zebrafish
(Danio rerio)
Actinopterygii BX000363.2 37
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16779 37
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea saeg-1 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for TRERF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRERF1 Gene

ENSEMBL:
Gene Tree for TRERF1 (if available)
TreeFam:
Gene Tree for TRERF1 (if available)

Paralogs for TRERF1 Gene

Paralogs for TRERF1 Gene

Selected SIMAP similar genes for TRERF1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRERF1: view

Variants for TRERF1 Gene

Sequence variations from dbSNP and Humsavar for TRERF1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs77522 -- 42,316,359(-) GTGAC(C/G)AGGAA intron-variant
rs94776 -- 42,375,177(+) TGGGG(C/T)GCCAA intron-variant
rs166338 -- 42,444,597(-) ccatc(A/G)tgaca intron-variant
rs166339 -- 42,400,019(+) GTGAG(A/G)CTGTG intron-variant
rs171849 -- 42,378,400(+) AAAAA(A/C)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRERF1 Gene

Variant ID Type Subtype PubMed ID
nsv830649 CNV Loss 17160897
esv2731985 CNV Deletion 23290073
esv2662164 CNV Deletion 23128226
esv2226832 CNV Deletion 18987734
esv2731986 CNV Deletion 23290073
esv2731987 CNV Deletion 23290073
nsv5279 CNV Loss 18451855

Relevant External Links for TRERF1 Gene

HapMap Linkage Disequilibrium report
TRERF1
Human Gene Mutation Database (HGMD)
TRERF1

Disorders for TRERF1 Gene

(1) University of Copenhagen DISEASES for TRERF1 Gene

Relevant External Links for TRERF1

Genetic Association Database (GAD)
TRERF1
Human Genome Epidemiology (HuGE) Navigator
TRERF1
genes like me logo Genes that share disorders with TRERF1: view

No data available for UniProtKB/Swiss-Prot for TRERF1 Gene

Publications for TRERF1 Gene

  1. A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression. (PMID: 11349124) Gizard F. … Hum D.W. (J. Biol. Chem. 2001) 2 3 4 23
  2. The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells. (PMID: 12101186) Gizard F. … Hum D.W. (J. Biol. Chem. 2002) 3 23
  3. Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression. (PMID: 12530663) Gizard F. … Hum D.W. (Endocr. Res. 2002) 3 23
  4. The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells. (PMID: 15072559) Gizard F. … Hum D.W. (J. Mol. Endocrinol. 2004) 3 23
  5. TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1. (PMID: 15899840) Gizard F. … Hum D.W. (Mol. Cell. Biol. 2005) 3 23

Products for TRERF1 Gene

Sources for TRERF1 Gene

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