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Aliases for TREML4 Gene

Aliases for TREML4 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 4 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 4 3 4
  • TREM Like Transcript 4 2 3
  • TLT-4 3 4
  • TLT4 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 4 2
  • Trem-Like Transcript 4 Protein 3

External Ids for TREML4 Gene

Previous GeneCards Identifiers for TREML4 Gene

  • GC06P041304
  • GC06P041196
  • GC06P040914

Summaries for TREML4 Gene

GeneCards Summary for TREML4 Gene

TREML4 (Triggering Receptor Expressed On Myeloid Cells Like 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is NCR2.

Additional gene information for TREML4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML4 Gene

Genomics for TREML4 Gene

Regulatory Elements for TREML4 Gene

Enhancers for TREML4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H041227 0.9 Ensembl ENCODE 79.2 +0.2 198 1 CTCF ZNF654 CEBPB MAFG CEBPG DPF2 CTBP1 ZNF316 NFE2 TRIM24 TREML4 TREML3P RNA5SP207
GH06H041198 1.5 Ensembl ENCODE dbSUPER 42.4 -26.9 -26894 6 HDGF ATF1 ARNT TCF12 GATA2 RUNX3 NCOA1 ZNF592 MBD2 SMARCA4 TREML4 TREML3P TREM2 USP49 ADCY10P1 NFYA TREML5P TREML1 ENSG00000218809 TREML2
GH06H041271 1.5 FANTOM5 Ensembl ENCODE dbSUPER 26 +43.8 43835 2 CTCF ZFP64 MAX ZKSCAN1 GABPA POLR2A CREB1 MYC TREM1 TREML4 NFYA TREML3P TFEB TREML2 TREML1 ENSG00000218809 GC06M041280
GH06H041181 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -45.7 -45692 1 CTCF MAX RAD21 TCF12 GATA2 SMC3 ZNF143 ZNF654 L3MBTL2 USF2 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 TREM2
GH06H041185 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -42.3 -42326 1 PKNOX1 SPI1 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 TREM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TREML4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREML4 Gene

Chromosome:
6
Start:
41,228,324 bp from pter
End:
41,238,882 bp from pter
Size:
10,559 bases
Orientation:
Plus strand

Genomic View for TREML4 Gene

Genes around TREML4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML4 Gene

Proteins for TREML4 Gene

  • Protein details for TREML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN2-TRML4_HUMAN
    Recommended name:
    Trem-like transcript 4 protein
    Protein Accession:
    Q6UXN2
    Secondary Accessions:
    • B7ZL92

    Protein attributes for TREML4 Gene

    Size:
    200 amino acids
    Molecular mass:
    21924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TREML4 Gene

Post-translational modifications for TREML4 Gene

  • Glycosylation at Asn93
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TREML4 Gene

Domains & Families for TREML4 Gene

Gene Families for TREML4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TREML4 Gene

Suggested Antigen Peptide Sequences for TREML4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TREML4: view

No data available for UniProtKB/Swiss-Prot for TREML4 Gene

Function for TREML4 Gene

Phenotypes From GWAS Catalog for TREML4 Gene

genes like me logo Genes that share phenotypes with TREML4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TREML4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TREML4 Gene

Localization for TREML4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREML4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TREML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TREML4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TREML4 Gene

Pathways & Interactions for TREML4 Gene

genes like me logo Genes that share pathways with TREML4: view

Pathways by source for TREML4 Gene

Gene Ontology (GO) - Biological Process for TREML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway IMP 25848864
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML4: view

No data available for SIGNOR curated interactions for TREML4 Gene

Drugs & Compounds for TREML4 Gene

No Compound Related Data Available

Transcripts for TREML4 Gene

mRNA/cDNA for TREML4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TREML4 Gene

Triggering receptor expressed on myeloid cells-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TREML4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TREML4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for TREML4 Gene

GeneLoc Exon Structure for
TREML4
ECgene alternative splicing isoforms for
TREML4

Expression for TREML4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TREML4 Gene

mRNA differential expression in normal tissues according to GTEx for TREML4 Gene

This gene is overexpressed in Whole Blood (x40.5).

NURSA nuclear receptor signaling pathways regulating expression of TREML4 Gene:

TREML4

SOURCE GeneReport for Unigene cluster for TREML4 Gene:

Hs.434181

Evidence on tissue expression from TISSUES for TREML4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TREML4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TREML4 Gene

Orthologs for TREML4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREML4 33 34
  • 99.49 (n)
rat
(Rattus norvegicus)
Mammalia Treml4 33
  • 68.15 (n)
mouse
(Mus musculus)
Mammalia Treml4 34
  • 38 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 17 (a)
ManyToMany
Species where no ortholog for TREML4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML4 Gene

ENSEMBL:
Gene Tree for TREML4 (if available)
TreeFam:
Gene Tree for TREML4 (if available)

Paralogs for TREML4 Gene

Paralogs for TREML4 Gene

(1) SIMAP similar genes for TREML4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TREML4 Gene

genes like me logo Genes that share paralogs with TREML4: view

Variants for TREML4 Gene

Sequence variations from dbSNP and Humsavar for TREML4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000926736 -- 41,235,169(+) ATGTT(A/G)TCTGA intron-variant
rs1001152977 -- 41,236,046(+) AGGTC(C/T)GTGCT intron-variant
rs1001201250 -- 41,227,484(+) TTGAA(C/T)ATATG upstream-variant-2KB
rs1001255266 -- 41,227,311(+) AACCT(A/C)AGTTG upstream-variant-2KB
rs1001267993 -- 41,230,613(+) GGGAC(A/C)ATGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TREML4 Gene

Variant ID Type Subtype PubMed ID
nsv602970 CNV gain 21841781
nsv823679 CNV loss 20364138

Variation tolerance for TREML4 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREML4 Gene

Human Gene Mutation Database (HGMD)
TREML4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREML4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML4 Gene

Disorders for TREML4 Gene

Relevant External Links for TREML4

Human Genome Epidemiology (HuGE) Navigator
TREML4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREML4

No disorders were found for TREML4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREML4 Gene

Publications for TREML4 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock RJ … Trowsdale J (European journal of immunology 2003) 2 3 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. (PMID: 25848864) Ramirez-Ortiz ZG … Means TK (Nature immunology 2015) 3 60
  4. Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification. (PMID: 24975946) Sen SK … Biesecker LG (American journal of human genetics 2014) 3 60
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 60

Products for TREML4 Gene

Sources for TREML4 Gene

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