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Aliases for TREML4 Gene

Aliases for TREML4 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 4 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 4 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 4 2 3
  • TREM Like Transcript 4 2 3
  • TLT-4 3 4
  • TLT4 3 4

External Ids for TREML4 Gene

Previous GeneCards Identifiers for TREML4 Gene

  • GC06P041304
  • GC06P041196
  • GC06P040914

Summaries for TREML4 Gene

GeneCards Summary for TREML4 Gene

TREML4 (Triggering Receptor Expressed On Myeloid Cells Like 4) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is NCR2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML4 Gene

Genomics for TREML4 Gene

Regulatory Elements for TREML4 Gene

Enhancers for TREML4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TREML4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREML4 Gene

41,228,324 bp from pter
41,238,882 bp from pter
10,559 bases
Plus strand

Genomic View for TREML4 Gene

Genes around TREML4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML4 Gene

Proteins for TREML4 Gene

  • Protein details for TREML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trem-like transcript 4 protein
    Protein Accession:
    Secondary Accessions:
    • B7ZL92

    Protein attributes for TREML4 Gene

    200 amino acids
    Molecular mass:
    21924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TREML4 Gene

Proteomics data for TREML4 Gene at MOPED

Post-translational modifications for TREML4 Gene

  • Glycosylation at Asn 93
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TREML4 Gene

Domains & Families for TREML4 Gene

Gene Families for TREML4 Gene

Protein Domains for TREML4 Gene

Suggested Antigen Peptide Sequences for TREML4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREML4: view

Function for TREML4 Gene

genes like me logo Genes that share phenotypes with TREML4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TREML4 Gene

Localization for TREML4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML4 Gene


Subcellular locations from

Jensen Localization Image for TREML4 Gene COMPARTMENTS Subcellular localization image for TREML4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TREML4 Gene

Pathways & Interactions for TREML4 Gene

genes like me logo Genes that share pathways with TREML4: view

Pathways by source for TREML4 Gene

Interacting Proteins for TREML4 Gene

Gene Ontology (GO) - Biological Process for TREML4 Gene


No data available for SIGNOR curated interactions for TREML4 Gene

Drugs & Compounds for TREML4 Gene

No Compound Related Data Available

Transcripts for TREML4 Gene

mRNA/cDNA for TREML4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TREML4 Gene

Triggering receptor expressed on myeloid cells-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREML4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -

Relevant External Links for TREML4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TREML4 Gene

mRNA expression in normal human tissues for TREML4 Gene

mRNA differential expression in normal tissues according to GTEx for TREML4 Gene

This gene is overexpressed in Whole Blood (x40.5).

SOURCE GeneReport for Unigene cluster for TREML4 Gene Hs.434181

genes like me logo Genes that share expression patterns with TREML4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TREML4 Gene

Orthologs for TREML4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TREML4 35
  • 99.49 (n)
  • 98.46 (a)
  • 92 (a)
(Rattus norvegicus)
Mammalia Treml4 35
  • 68.15 (n)
  • 57.22 (a)
(Canis familiaris)
Mammalia -- 36
  • 17 (a)
(Mus musculus)
Mammalia Treml4 36
  • 38 (a)
Species with no ortholog for TREML4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML4 Gene

Gene Tree for TREML4 (if available)
Gene Tree for TREML4 (if available)

Paralogs for TREML4 Gene

Paralogs for TREML4 Gene

(1) SIMAP similar genes for TREML4 Gene using alignment to 2 proteins: Pseudogenes for TREML4 Gene

genes like me logo Genes that share paralogs with TREML4: view

Variants for TREML4 Gene

Sequence variations from dbSNP and Humsavar for TREML4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9369265 - 41,228,867(+) AGCCC(C/T)GGACA reference, missense
rs9471515 - 41,229,563(+) CCCAA(A/C/G)AAGCA reference, missense
rs7769759 - 41,230,119(+) TGAGA(C/T)CAGGT reference, missense
rs5875744 -- 41,228,368(+) CTCCT(-/TCT)CCTGA utr-variant-5-prime
rs6458200 -- 41,227,682(+) tTTCT(G/T)TTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TREML4 Gene

Variant ID Type Subtype PubMed ID
nsv823679 CNV Loss 20364138

Variation tolerance for TREML4 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TREML4 Gene

Disorders for TREML4 Gene

Relevant External Links for TREML4

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TREML4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREML4 Gene

Publications for TREML4 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock R.J.N. … Trowsdale J. (Eur. J. Immunol. 2003) 2 3 67
  2. Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification. (PMID: 24975946) Sen S.K. … Biesecker L.G. (Am. J. Hum. Genet. 2014) 3
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. (PMID: 19155473) Hemmi H. … Steinman R.M. (J. Immunol. 2009) 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TREML4 Gene

Sources for TREML4 Gene