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Aliases for TREML4 Gene

Aliases for TREML4 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 4 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 4 3 4
  • TREM Like Transcript 4 2 3
  • TLT-4 3 4
  • TLT4 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 4 2
  • Trem-Like Transcript 4 Protein 3

External Ids for TREML4 Gene

Previous GeneCards Identifiers for TREML4 Gene

  • GC06P041304
  • GC06P041196
  • GC06P040914

Summaries for TREML4 Gene

GeneCards Summary for TREML4 Gene

TREML4 (Triggering Receptor Expressed On Myeloid Cells Like 4) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. An important paralog of this gene is NCR2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML4 Gene

Genomics for TREML4 Gene

Regulatory Elements for TREML4 Gene

Enhancers for TREML4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F041227 0.8 Ensembl ENCODE 79.2 +0.2 214 1.3 CTCF ZNF654 HLF MAFG CEBPB ZNF316 PBX2 TRIM24 NFE2 MAFK TREML4 TREML3P RNA5SP207
GH06F041222 0.5 Ensembl 72.5 -5.6 -5624 0.6 CBX1 CBX3 CBX5 TRIM24 TREML4 TREML2 TREML1 NCR2 LOC105375055
GH06F041198 1.2 Ensembl ENCODE 42.4 -27.0 -26951 6.3 HDGF ATF1 WRNIP1 SIN3A ZNF766 GATA2 ELK1 ZNF263 NCOA1 MIER2 TREML4 TREML3P TREM2 ADCY10P1 TREML5P TREML1 ENSG00000218809 TREML2
GH06F041270 1.1 FANTOM5 Ensembl ENCODE 26 +43.7 43735 2.5 CTCF ZFP64 MAX MYC EZH2 TREM1 TREML4 NFYA TREML3P TFEB TREML2 TREML1 ENSG00000218809 GC06M041280
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TREML4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREML4 Gene

41,228,324 bp from pter
41,238,882 bp from pter
10,559 bases
Plus strand

Genomic View for TREML4 Gene

Genes around TREML4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML4 Gene

Proteins for TREML4 Gene

  • Protein details for TREML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trem-like transcript 4 protein
    Protein Accession:
    Secondary Accessions:
    • B7ZL92

    Protein attributes for TREML4 Gene

    200 amino acids
    Molecular mass:
    21924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TREML4 Gene

Post-translational modifications for TREML4 Gene

  • Glycosylation at Asn 93
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TREML4 Gene

Domains & Families for TREML4 Gene

Gene Families for TREML4 Gene

Protein Domains for TREML4 Gene

Suggested Antigen Peptide Sequences for TREML4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREML4: view

Function for TREML4 Gene

genes like me logo Genes that share phenotypes with TREML4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TREML4 Gene

Localization for TREML4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML4 Gene


Subcellular locations from

Jensen Localization Image for TREML4 Gene COMPARTMENTS Subcellular localization image for TREML4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TREML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TREML4: view

Pathways & Interactions for TREML4 Gene

genes like me logo Genes that share pathways with TREML4: view

Pathways by source for TREML4 Gene

Gene Ontology (GO) - Biological Process for TREML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML4: view

No data available for SIGNOR curated interactions for TREML4 Gene

Transcripts for TREML4 Gene

mRNA/cDNA for TREML4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TREML4 Gene

Triggering receptor expressed on myeloid cells-like 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREML4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -

Relevant External Links for TREML4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TREML4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TREML4 Gene

mRNA differential expression in normal tissues according to GTEx for TREML4 Gene

This gene is overexpressed in Whole Blood (x40.5).

NURSA nuclear receptor signaling pathways regulating expression of TREML4 Gene:


SOURCE GeneReport for Unigene cluster for TREML4 Gene:

genes like me logo Genes that share expression patterns with TREML4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TREML4 Gene

Orthologs for TREML4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TREML4 34 35
  • 99.49 (n)
(Rattus norvegicus)
Mammalia Treml4 34
  • 68.15 (n)
(Mus musculus)
Mammalia Treml4 35
  • 38 (a)
(Canis familiaris)
Mammalia -- 35
  • 17 (a)
Species where no ortholog for TREML4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML4 Gene

Gene Tree for TREML4 (if available)
Gene Tree for TREML4 (if available)

Paralogs for TREML4 Gene

Paralogs for TREML4 Gene

(1) SIMAP similar genes for TREML4 Gene using alignment to 2 proteins: Pseudogenes for TREML4 Gene

genes like me logo Genes that share paralogs with TREML4: view

Variants for TREML4 Gene

Sequence variations from dbSNP and Humsavar for TREML4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10223843 -- 41,229,898(+) CTTGA(A/C)TTCAG intron-variant
rs10616534 -- 41,235,996(+) TACAC(-/AG)AGGGG intron-variant
rs10700462 -- 41,228,366(+) GACTC(-/CTT)CTCCT nc-transcript-variant, utr-variant-5-prime
rs10807255 -- 41,226,677(+) tccag(A/G)atccc upstream-variant-2KB
rs10807256 -- 41,226,744(+) tagca(A/G)tttct upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TREML4 Gene

Variant ID Type Subtype PubMed ID
nsv602970 CNV gain 21841781
nsv823679 CNV loss 20364138

Variation tolerance for TREML4 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREML4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML4 Gene

Disorders for TREML4 Gene

Relevant External Links for TREML4

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TREML4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREML4 Gene

Publications for TREML4 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock R.J.N. … Trowsdale J. (Eur. J. Immunol. 2003) 2 3 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification. (PMID: 24975946) Sen S.K. … Biesecker L.G. (Am. J. Hum. Genet. 2014) 3 64
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64
  5. A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. (PMID: 19155473) Hemmi H. … Steinman R.M. (J. Immunol. 2009) 22 64

Products for TREML4 Gene

Sources for TREML4 Gene

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