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Aliases for TREML2 Gene

Aliases for TREML2 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 2 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 2 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 2 2 3
  • C6orf76 3 4
  • TLT-2 3 4
  • TLT2 3 4
  • Chromosome 6 Open Reading Frame 76 2
  • TREM-Like Transcript 2 2
  • DJ238O23.1 3

External Ids for TREML2 Gene

Previous HGNC Symbols for TREML2 Gene

  • C6orf76

Previous GeneCards Identifiers for TREML2 Gene

  • GC06M041206
  • GC06M041266
  • GC06M040875

Summaries for TREML2 Gene

Entrez Gene Summary for TREML2 Gene

  • TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TREML2 Gene

TREML2 (Triggering Receptor Expressed On Myeloid Cells Like 2) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TREML2 Gene

  • Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML2 Gene

Genomics for TREML2 Gene

Regulatory Elements for TREML2 Gene

Enhancers for TREML2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TREML2 on UCSC Golden Path with GeneCards custom track

Promoters for TREML2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TREML2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREML2 Gene

Chromosome:
6
Start:
41,189,749 bp from pter
End:
41,201,194 bp from pter
Size:
11,446 bases
Orientation:
Minus strand

Genomic View for TREML2 Gene

Genes around TREML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML2 Gene

Proteins for TREML2 Gene

  • Protein details for TREML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2D2-TRML2_HUMAN
    Recommended name:
    Trem-like transcript 2 protein
    Protein Accession:
    Q5T2D2
    Secondary Accessions:
    • Q08AP8
    • Q08AP9
    • Q8IWY0
    • Q9H8E9

    Protein attributes for TREML2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35127 Da
    Quaternary structure:
    • Interacts with CD276 and this interaction enhances T-cell activation.
    SequenceCaution:
    • Sequence=AAI25079.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25080.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14668.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19858.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TREML2 Gene

Proteomics data for TREML2 Gene at MOPED

Post-translational modifications for TREML2 Gene

  • Glycosylation at Asn 89
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TREML2 (TREML2/TLT-2)

No data available for DME Specific Peptides for TREML2 Gene

Domains & Families for TREML2 Gene

Gene Families for TREML2 Gene

Protein Domains for TREML2 Gene

Suggested Antigen Peptide Sequences for TREML2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T2D2

UniProtKB/Swiss-Prot:

TRML2_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREML2: view

Function for TREML2 Gene

Molecular function for TREML2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
UniProtKB/Swiss-Prot Induction:
Induced in CD4 T-cells by concanavalin-A.
genes like me logo Genes that share phenotypes with TREML2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TREML2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TREML2 Gene

Localization for TREML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREML2 Gene COMPARTMENTS Subcellular localization image for TREML2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TREML2 Gene

Pathways & Interactions for TREML2 Gene

genes like me logo Genes that share pathways with TREML2: view

Pathways by source for TREML2 Gene

Interacting Proteins for TREML2 Gene

Gene Ontology (GO) - Biological Process for TREML2 Gene

None

No data available for SIGNOR curated interactions for TREML2 Gene

Drugs & Compounds for TREML2 Gene

No Compound Related Data Available

Transcripts for TREML2 Gene

mRNA/cDNA for TREML2 Gene

Unigene Clusters for TREML2 Gene

Triggering receptor expressed on myeloid cells-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREML2 Gene

No ASD Table

Relevant External Links for TREML2 Gene

GeneLoc Exon Structure for
TREML2
ECgene alternative splicing isoforms for
TREML2

Expression for TREML2 Gene

mRNA expression in normal human tissues for TREML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREML2 Gene

This gene is overexpressed in Whole Blood (x43.0).

Protein differential expression in normal tissues from HIPED for TREML2 Gene

This gene is overexpressed in Serum (30.4), Lung (23.2), and Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREML2 Gene



SOURCE GeneReport for Unigene cluster for TREML2 Gene Hs.164797

mRNA Expression by UniProt/SwissProt for TREML2 Gene

Q5T2D2-TRML2_HUMAN
Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
genes like me logo Genes that share expression patterns with TREML2: view

Protein tissue co-expression partners for TREML2 Gene

Primer Products

Orthologs for TREML2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TREML2 35
  • 74.83 (n)
  • 63.76 (a)
TREML2 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481791 35
  • 79.53 (n)
  • 68.46 (a)
TREML2 36
  • 44 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Treml2 35
  • 69.06 (n)
  • 55.48 (a)
Treml2 16
Treml2 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TREML2 35
  • 99.38 (n)
  • 98.44 (a)
TREML2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Treml2 35
  • 68.35 (n)
  • 52.52 (a)
oppossum
(Monodelphis domestica)
Mammalia TREML2 36
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TREML2 36
  • 38 (a)
OneToOne
Species with no ortholog for TREML2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML2 Gene

ENSEMBL:
Gene Tree for TREML2 (if available)
TreeFam:
Gene Tree for TREML2 (if available)

Paralogs for TREML2 Gene

Pseudogenes.org Pseudogenes for TREML2 Gene

genes like me logo Genes that share paralogs with TREML2: view

No data available for Paralogs for TREML2 Gene

Variants for TREML2 Gene

Sequence variations from dbSNP and Humsavar for TREML2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs35512890 - 41,198,337(+) CTCCA(C/T)GCGGT intron-variant, reference, missense
rs3747742 - 41,194,780(+) TCCAC(C/T)CTTGA reference, missense
rs35521209 - 41,192,834(+) ATAGA(C/T)CATGA reference, missense
rs4418164 - 41,200,954(+) CTCAC(A/C)TGAGA reference, missense
rs1135521 -- 41,189,849(-) TAAAA(C/G)CCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TREML2 Gene

Variant ID Type Subtype PubMed ID
esv994929 CNV Deletion 20482838

Variation tolerance for TREML2 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREML2 Gene

Human Gene Mutation Database (HGMD)
TREML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML2 Gene

Disorders for TREML2 Gene

Relevant External Links for TREML2

Genetic Association Database (GAD)
TREML2
Human Genome Epidemiology (HuGE) Navigator
TREML2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREML2

No disorders were found for TREML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREML2 Gene

Publications for TREML2 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock R.J.N. … Trowsdale J. (Eur. J. Immunol. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Missense variant in TREML2 protects against Alzheimer's disease. (PMID: 24439484) Benitez B.A. … Cruchaga C. (Neurobiol. Aging 2014) 3
  4. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. (PMID: 24162737) Lambert J.C. … Amouyel P. (Nat. Genet. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TREML2 Gene

Sources for TREML2 Gene

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