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Aliases for TREML2 Gene

Aliases for TREML2 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 2 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 2 3 4
  • C6orf76 3 4
  • TLT-2 3 4
  • TLT2 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 2 2
  • Chromosome 6 Open Reading Frame 76 2
  • Trem-Like Transcript 2 Protein 3
  • TREM-Like Transcript 2 2
  • DJ238O23.1 3

External Ids for TREML2 Gene

Previous HGNC Symbols for TREML2 Gene

  • C6orf76

Previous GeneCards Identifiers for TREML2 Gene

  • GC06M041206
  • GC06M041266
  • GC06M040875

Summaries for TREML2 Gene

Entrez Gene Summary for TREML2 Gene

  • TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TREML2 Gene

TREML2 (Triggering Receptor Expressed On Myeloid Cells Like 2) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TREML2 Gene

  • Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML2 Gene

Genomics for TREML2 Gene

Regulatory Elements for TREML2 Gene

Enhancers for TREML2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F041171 0.6 ENCODE 12.2 +29.4 29364 0.8 HDAC1 TAL1 MAX ZEB2 MNT ZKSCAN1 ARID1B HDAC2 NCOR1 KLF16 TREML2 TSPO2 UNC5CL TREM2
GH06F040714 0.5 ENCODE 12.1 +486.0 486017 1.7 PKNOX1 ARNT MLX ARID4B CBX5 FOS SP5 MXD4 REST KAT8 TREML2 LOC101929535 GC06M040695
GH06F042038 1.2 FANTOM5 Ensembl ENCODE 12 -843.7 -843745 13.7 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D PRICKLE4 TREML2 RNU6-761P ENSG00000207371 MED20 BYSL FRS3 CCND3 USP49 RRP36
GH06F041746 0.6 ENCODE 12 -546.4 -546410 2.9 HDGF ATF1 ARID4B DMAP1 SLC30A9 GATA2 FOS ZNF263 SP5 JUNB TREML2 PGC TFEB
GH06F041779 0.2 ENCODE 12 -579.4 -579396 2.9 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 PRICKLE4 GLTSCR1L TREML2 UBR2 USP49 MED20 PIR31477
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TREML2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREML2 Gene

Chromosome:
6
Start:
41,189,749 bp from pter
End:
41,201,194 bp from pter
Size:
11,446 bases
Orientation:
Minus strand

Genomic View for TREML2 Gene

Genes around TREML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML2 Gene

Proteins for TREML2 Gene

  • Protein details for TREML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2D2-TRML2_HUMAN
    Recommended name:
    Trem-like transcript 2 protein
    Protein Accession:
    Q5T2D2
    Secondary Accessions:
    • Q08AP8
    • Q08AP9
    • Q8IWY0
    • Q9H8E9

    Protein attributes for TREML2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35127 Da
    Quaternary structure:
    • Interacts with CD276 and this interaction enhances T-cell activation.
    SequenceCaution:
    • Sequence=AAI25079.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25080.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14668.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19858.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TREML2 Gene

Post-translational modifications for TREML2 Gene

  • Glycosylation at Asn 89
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TREML2 Gene

Domains & Families for TREML2 Gene

Gene Families for TREML2 Gene

Protein Domains for TREML2 Gene

Suggested Antigen Peptide Sequences for TREML2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T2D2

UniProtKB/Swiss-Prot:

TRML2_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREML2: view

Function for TREML2 Gene

Molecular function for TREML2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
UniProtKB/Swiss-Prot Induction:
Induced in CD4 T-cells by concanavalin-A.

Gene Ontology (GO) - Molecular Function for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 18650384
GO:0005515 protein binding IPI 18650384
genes like me logo Genes that share ontologies with TREML2: view
genes like me logo Genes that share phenotypes with TREML2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TREML2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TREML2 Gene

Localization for TREML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREML2 Gene COMPARTMENTS Subcellular localization image for TREML2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 18650384
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TREML2: view

Pathways & Interactions for TREML2 Gene

genes like me logo Genes that share pathways with TREML2: view

Pathways by source for TREML2 Gene

Interacting Proteins for TREML2 Gene

Selected Interacting proteins: Q5T2D2-TRML2_HUMAN for TREML2 Gene via IID

Gene Ontology (GO) - Biological Process for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042110 T cell activation IDA 18650384
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML2: view

No data available for SIGNOR curated interactions for TREML2 Gene

Transcripts for TREML2 Gene

mRNA/cDNA for TREML2 Gene

Unigene Clusters for TREML2 Gene

Triggering receptor expressed on myeloid cells-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREML2 Gene

No ASD Table

Relevant External Links for TREML2 Gene

GeneLoc Exon Structure for
TREML2
ECgene alternative splicing isoforms for
TREML2

Expression for TREML2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TREML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREML2 Gene

This gene is overexpressed in Whole Blood (x43.0).

Protein differential expression in normal tissues from HIPED for TREML2 Gene

This gene is overexpressed in Serum (30.4), Lung (23.2), and Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREML2 Gene



Protein tissue co-expression partners for TREML2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TREML2 Gene:

TREML2

SOURCE GeneReport for Unigene cluster for TREML2 Gene:

Hs.164797

mRNA Expression by UniProt/SwissProt for TREML2 Gene:

Q5T2D2-TRML2_HUMAN
Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
genes like me logo Genes that share expression patterns with TREML2: view

Primer Products

Orthologs for TREML2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREML2 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia LOC481791 34
  • 79.53 (n)
TREML2 35
  • 44 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TREML2 34 35
  • 74.83 (n)
mouse
(Mus musculus)
Mammalia Treml2 34 16 35
  • 69.06 (n)
rat
(Rattus norvegicus)
Mammalia Treml2 34
  • 68.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TREML2 35
  • 38 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TREML2 35
  • 34 (a)
OneToOne
Species where no ortholog for TREML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML2 Gene

ENSEMBL:
Gene Tree for TREML2 (if available)
TreeFam:
Gene Tree for TREML2 (if available)

Paralogs for TREML2 Gene

Pseudogenes.org Pseudogenes for TREML2 Gene

genes like me logo Genes that share paralogs with TREML2: view

No data available for Paralogs for TREML2 Gene

Variants for TREML2 Gene

Sequence variations from dbSNP and Humsavar for TREML2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10533554 -- 41,201,794(+) CACAC(-/ACAC)GCCCA upstream-variant-2KB
rs10567485 -- 41,202,845(+) CACTC(-/ATTA)ATTCA upstream-variant-2KB
rs111729024 -- 41,191,597(+) CTGGA(A/G)GCTGC utr-variant-3-prime
rs111876628 -- 41,201,963(+) CCTCC(A/G)CAGTA upstream-variant-2KB
rs111965172 -- 41,193,692(+) TGAGG(C/T)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TREML2 Gene

Variant ID Type Subtype PubMed ID
esv994929 CNV deletion 20482838
nsv602970 CNV gain 21841781

Variation tolerance for TREML2 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREML2 Gene

Human Gene Mutation Database (HGMD)
TREML2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML2 Gene

Disorders for TREML2 Gene

Relevant External Links for TREML2

Genetic Association Database (GAD)
TREML2
Human Genome Epidemiology (HuGE) Navigator
TREML2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREML2

No disorders were found for TREML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREML2 Gene

Publications for TREML2 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock R.J.N. … Trowsdale J. (Eur. J. Immunol. 2003) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT- 2) is a counter-receptor for B7-H3 and enhances T cell responses. (PMID: 18650384) Hashiguchi M. … Azuma M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for TREML2 Gene

Sources for TREML2 Gene

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