TREML2 Gene
protein-coding GIFtS: 44
GCID: GC06M041157
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triggering receptor expressed on myeloid cells-like 2(Previous name: chromosome 6 open reading frame 76 )
(Previous symbol: C6orf76)
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Aliases
for TREML2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Triggering Receptor Expressed On Myeloid Cells-Like 21 2 | | TLT-22 3 | | TLT21 2 3 5 | | FLJ136931 | | C6orf761 2 3 | | Chromosome 6 Open Reading Frame 761 | | DJ238O23.11 | | Trem-Like Transcript 2 Protein2 | | Triggering Receptor Expressed On Myeloid Cells-Like Protein 22 3 | | |
Export aliases for TREML2 gene to outside databasesPrevious GC identifers: GC06M041206 GC06M041266 GC06M040875 |
Summaries
for TREML2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TREML2:
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1(MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003(PubMed 12645956)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2Function: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as acounter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation
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Genomic Views
for TREML2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TREML2 gene promoter:
c-Ets-1 Arnt PPAR-alpha NRF-2 POU2F1 POU2F1a POU2F1b ARP-1 POU2F1c LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TREML2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREML2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1TREML2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M041157: view genomic region
(about GC identifiers)
Start:
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41,157,552 bp from pter |
End:
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41,168,932 bp from pter |
Size:
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11,381 bases |
Orientation:
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minus strand |
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Proteins
for TREML2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2 (See
protein sequence)Recommended Name: Trem-like transcript 2 protein precursor Size: 321 amino acids; 35127 Da
Subunit: Interacts with CD276 and this interaction enhances T-cell activation
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=AAI25079.1; Type=Erroneous initiation; Sequence=AAI25080.1; Type=Erroneous initiation;Sequence=BAB14668.1; Type=Erroneous initiation; Sequence=CAI19858.1; Type=Erroneous initiation; Sequence=CAI19909.1;Type=Erroneous initiation;
Secondary accessions: Q08AP8 Q08AP9 Q8IWY0 Q9H8E9Explore the universe of human proteins at neXtProt for TREML2: NX_Q5T2D2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T2D2
TREML2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079083.2
ENSEMBL proteins: ENSP00000418767
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TREML2 for ontologies About GeneDecksing
TREML2 Antibody Products:
Assay Products for TREML2: |
Protein
Domains /
Families
for TREML2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TREML2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T2D2ProtoNet protein and cluster: Q5T2D2 1 Blocks protein family: IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for TREML2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2Function: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as acounter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activationInduction: Induced in CD4 T-cells by concanavalin-A
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREML2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREML2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREML2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TREML2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Treml2tm1Lex for TREML2
1 MGI phenotypic allele  for Treml2 (no phenotypes)
TREML2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TREML2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TREML2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
TREML2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TREML2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TREML2
Search CenterWatch for drugs/clinical trials and news about TREML2 / TRML2
|
Transcripts
for TREML2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TREML2 gene: NM_024807.2 Unigene Cluster for TREML2: Triggering receptor expressed on myeloid cells-like 2 Hs.164797 [show with all ESTs]Unigene Representative Sequence: NM_0248071 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000483722(uc010jxm.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREML2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREML2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TREML2 (NM_024807) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TREML2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREML2 |
Additional cDNA sequence: AF534824.1 AJ420509.1 AK023755.1 AY358171.1 BC125078.1 BC125079.1 2 DOTS entries: DT.86843336 DT.100672597 24/46 AceView cDNA sequences (see all 46): BG236416 AF534824 CB997592 AU140201 BX494974 BI052447 NM_024807 AI361759 BF976263 BF975321 AI223427 AJ420509 BU752698 BX338019 CB961633 AK023755 BF109560 BQ883836 BX103485 BI827715 BV175324 AI189960 CB992941 BU754021
GeneLoc Exon Structure
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Expression
for TREML2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TREML2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTATGCAG
About this image
See TREML2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TREML2
SOURCE GeneReport for Unigene cluster: Hs.164797
UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively onCD8 T-cells and induced on CD4 T-cells after activation
SABiosciences Custom PCR Arrays for TREML2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TREML2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TREML2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREML2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREML2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREML2 |
Orthologs
for TREML2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for TREML2 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for TREML2 (if available)
TreeFam Gene Tree for TREML2 (if available) |
Paralogs
for TREML2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TREML2 gene
TREML2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TREML2
PGOHUM00000243619
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Genomic Variants
for TREML2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TREML2 (41157552 - 41168932 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TREML2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TREML2 |
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Disorders
/ Diseases
for TREML2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TREML2 for disorders About GeneDecksing
OMIM gene information: 609715
OMIM disorders: --
3  diseases for TREML2: About MalaCardsmonocytic leukemia t-cell leukemia leukemia
Human Genome Epidemiology (HuGE) Navigator: TREML2 (1 document)
Export disorders for TREML2 gene to outside databases
|
Publications
for TREML2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TREML2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TREML2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PubMed id 12645956)1, 2, 3 Allcock R.J.N.... Trowsdale J. (2003)
- Triggering receptor expressed on myeloid cell-like transcript 2 (TLT- 2) is a counter-receptor for B7-H3 and enhances T cell responses. (PubMed id 18650384)1, 2 Hashiguchi M....Azuma M. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- B7-H3 is a potent inhibitor of human T-cell activatio n: No evidence for B7-H3 and TREML2 interaction. (PubMed id 19544488)1 Leitner J....Steinberger P. (2009)
- Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
- Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. (PubMed id 16670310)1 King R.G....Justement L.B. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for TREML2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TREML2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TREML2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TREML2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TREML2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TREML2 gene:
Search GeneIP for patents involving TREML2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TREML2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TREML2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TREML2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TREML2 | | | OriGene Protein Over-expression Lysate for TREML2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TREML2 | | OriGene 3'-UTR Clone for TREML2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREML2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREML2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TREML2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TREML2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREML2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TREML2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREML2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREML2 |
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 | | | TREML2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREML2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TREML2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREML2 |
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