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Aliases for TREML2 Gene

Aliases for TREML2 Gene

  • Triggering Receptor Expressed On Myeloid Cells-Like 2 2 3
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 2 3 4
  • C6orf76 3 4
  • TLT-2 3 4
  • TLT2 3 4
  • Chromosome 6 Open Reading Frame 76 2
  • TREM-Like Transcript 2 2
  • DJ238O23.1 3

External Ids for TREML2 Gene

Previous HGNC Symbols for TREML2 Gene

  • C6orf76

Previous GeneCards Identifiers for TREML2 Gene

  • GC06M041206
  • GC06M041266
  • GC06M040875

Summaries for TREML2 Gene

Entrez Gene Summary for TREML2 Gene

  • TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TREML2 Gene

TREML2 (Triggering Receptor Expressed On Myeloid Cells-Like 2) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TREML2 Gene

  • Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML2 Gene

Genomics for TREML2 Gene

Regulatory Elements for TREML2 Gene

Genomic Location for TREML2 Gene

Chromosome:
6
Start:
41,189,749 bp from pter
End:
41,201,194 bp from pter
Size:
11,446 bases
Orientation:
Minus strand

Genomic View for TREML2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TREML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML2 Gene

Proteins for TREML2 Gene

  • Protein details for TREML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2D2-TRML2_HUMAN
    Recommended name:
    Trem-like transcript 2 protein
    Protein Accession:
    Q5T2D2
    Secondary Accessions:
    • Q08AP8
    • Q08AP9
    • Q8IWY0
    • Q9H8E9

    Protein attributes for TREML2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35127 Da
    Quaternary structure:
    • Interacts with CD276 and this interaction enhances T-cell activation.
    SequenceCaution:
    • Sequence=AAI25079.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25080.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14668.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19858.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TREML2 Gene

Proteomics data for TREML2 Gene at MOPED

Post-translational modifications for TREML2 Gene

  • Glycosylation at Asn 89
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TREML2 (TREML2/TLT-2)

No data available for DME Specific Peptides for TREML2 Gene

Domains & Families for TREML2 Gene

Gene Families for TREML2 Gene

Protein Domains for TREML2 Gene

Suggested Antigen Peptide Sequences for TREML2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T2D2

UniProtKB/Swiss-Prot:

TRML2_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREML2: view

Function for TREML2 Gene

Molecular function for TREML2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
UniProtKB/Swiss-Prot Induction:
Induced in CD4 T-cells by concanavalin-A.

Gene Ontology (GO) - Molecular Function for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 18650384
GO:0005515 protein binding IPI 18650384
genes like me logo Genes that share ontologies with TREML2: view

Phenotypes for TREML2 Gene

GenomeRNAi human phenotypes for TREML2:
genes like me logo Genes that share phenotypes with TREML2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TREML2 Gene

Localization for TREML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREML2 Gene COMPARTMENTS Subcellular localization image for TREML2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 18650384
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TREML2: view

Pathways & Interactions for TREML2 Gene

genes like me logo Genes that share pathways with TREML2: view

Pathways by source for TREML2 Gene

Interacting Proteins for TREML2 Gene

Gene Ontology (GO) - Biological Process for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042110 T cell activation IDA 18650384
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML2: view

No data available for SIGNOR curated interactions for TREML2 Gene

Drugs & Compounds for TREML2 Gene

No Compound Related Data Available

Transcripts for TREML2 Gene

mRNA/cDNA for TREML2 Gene

Unigene Clusters for TREML2 Gene

Triggering receptor expressed on myeloid cells-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREML2 Gene

No ASD Table

Relevant External Links for TREML2 Gene

GeneLoc Exon Structure for
TREML2
ECgene alternative splicing isoforms for
TREML2

Expression for TREML2 Gene

mRNA expression in normal human tissues for TREML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREML2 Gene

This gene is overexpressed in Whole Blood (x43.0).

Protein differential expression in normal tissues from HIPED for TREML2 Gene

This gene is overexpressed in Serum (30.4), Lung (23.2), and Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREML2 Gene



SOURCE GeneReport for Unigene cluster for TREML2 Gene Hs.164797

mRNA Expression by UniProt/SwissProt for TREML2 Gene

Q5T2D2-TRML2_HUMAN
Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
genes like me logo Genes that share expression patterns with TREML2: view

Protein tissue co-expression partners for TREML2 Gene

Primer Products

In Situ Assay Products

Orthologs for TREML2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TREML2 35
  • 74.83 (n)
  • 63.76 (a)
TREML2 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481791 35
  • 79.53 (n)
  • 68.46 (a)
TREML2 36
  • 44 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Treml2 35
  • 69.06 (n)
  • 55.48 (a)
Treml2 16
Treml2 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TREML2 35
  • 99.38 (n)
  • 98.44 (a)
TREML2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Treml2 35
  • 68.35 (n)
  • 52.52 (a)
oppossum
(Monodelphis domestica)
Mammalia TREML2 36
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TREML2 36
  • 38 (a)
OneToOne
Species with no ortholog for TREML2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML2 Gene

ENSEMBL:
Gene Tree for TREML2 (if available)
TreeFam:
Gene Tree for TREML2 (if available)

Paralogs for TREML2 Gene

Pseudogenes.org Pseudogenes for TREML2 Gene

genes like me logo Genes that share paralogs with TREML2: view

No data available for Paralogs for TREML2 Gene

Variants for TREML2 Gene

Sequence variations from dbSNP and Humsavar for TREML2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1135521 -- 41,189,849(-) TAAAA(C/G)CCTTT utr-variant-3-prime
rs2006080 -- 41,199,030(-) AAAAA(A/G)TTAGC intron-variant
rs2038566 -- 41,190,982(-) CTGGG(A/G)GACAG utr-variant-3-prime
rs2038567 -- 41,190,851(-) agaca(C/G)gcaca utr-variant-3-prime
rs2038568 -- 41,190,394(-) TCTTG(C/G)TTTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TREML2 Gene

Variant ID Type Subtype PubMed ID
esv994929 CNV Deletion 20482838

Variation tolerance for TREML2 Gene

Residual Variation Intolerance Score: 90.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREML2 Gene

HapMap Linkage Disequilibrium report
TREML2
Human Gene Mutation Database (HGMD)
TREML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML2 Gene

Disorders for TREML2 Gene

Relevant External Links for TREML2

Genetic Association Database (GAD)
TREML2
Human Genome Epidemiology (HuGE) Navigator
TREML2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREML2
genes like me logo Genes that share disorders with TREML2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREML2 Gene

Publications for TREML2 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock R.J.N. … Trowsdale J. (Eur. J. Immunol. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Missense variant in TREML2 protects against Alzheimer's disease. (PMID: 24439484) Benitez B.A. … Cruchaga C. (Neurobiol. Aging 2014) 67
  4. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. (PMID: 24162737) Lambert J.C. … Amouyel P. (Nat. Genet. 2013) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for TREML2 Gene

Sources for TREML2 Gene

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