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TREML2 Gene

protein-coding   GIFtS: 48
GCID: GC06M041157

Triggering Receptor Expressed On Myeloid Cells-Like 2

(Previous name: chromosome 6 open reading frame 76)
(Previous symbol: C6orf76)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Triggering Receptor Expressed On Myeloid Cells-Like 21 2     Chromosome 6 Open Reading Frame 761
C6orf761 2 3     TREM-Like Transcript 21
TLT22 3 5     dJ238O23.12
Triggering Receptor Expressed On Myeloid Cells-Like Protein 22 3     Trem-Like Transcript 2 Protein2
TLT-22 3     

External Ids:    HGNC: 210921   Entrez Gene: 798652   Ensembl: ENSG000001121957   OMIM: 6097155   UniProtKB: Q5T2D23   

Export aliases for TREML2 gene to outside databases

Previous GC identifers: GC06M041206 GC06M041266 GC06M040875


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TREML2 Gene:
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors
TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et
al., 2003 (PubMed 12645956)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TREML2 Gene:
TREML2 (triggering receptor expressed on myeloid cells-like 2) is a protein-coding gene. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2
Function: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a
counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TREML2 gene promoter:
         c-Ets-1   Arnt   PPAR-alpha   NRF-2   POU2F1   POU2F1a   POU2F1b   ARP-1   POU2F1c   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTREML2 promoter sequence
   Search Chromatin IP Primers for TREML2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TREML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TREML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREML2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041157:  view genomic region     (about GC identifiers)

Start:
41,157,552 bp from pter      End:
41,168,932 bp from pter
Size:
11,381 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2 (See protein sequence)
Recommended Name: Trem-like transcript 2 protein precursor  
Size: 321 amino acids; 35127 Da
Subunit: Interacts with CD276 and this interaction enhances T-cell activation
Sequence caution: Sequence=AAI25079.1; Type=Erroneous initiation; Sequence=AAI25080.1; Type=Erroneous initiation;
Sequence=BAB14668.1; Type=Erroneous initiation; Sequence=CAI19858.1; Type=Erroneous initiation;
Sequence=CAI19909.1; Type=Erroneous initiation;
Secondary accessions: Q08AP8 Q08AP9 Q8IWY0 Q9H8E9

Explore the universe of human proteins at neXtProt for TREML2: NX_Q5T2D2

Explore proteomics data for TREML2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn89
  • Modification sites at PhosphoSitePlus

  • See TREML2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079083.2  
    ENSEMBL proteins: 
     ENSP00000418767  

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    antibodies-online antibodies for TREML2 (28 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q5T2D2

    ProtoNet protein and cluster: Q5T2D2

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with TREML2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRML2_HUMAN, Q5T2D2
    Function: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a
    counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation
    Induction: Induced in CD4 T-cells by concanavalin-A

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA18650384
    GO:0005515protein binding IPI18650384
         
    Find genes that share ontologies with TREML2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Treml2 (no phenotypes)

    Find genes that share phenotypes with TREML2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Treml2tm1Lex for TREML2

       genOway: Develop your customized and physiologically relevant rodent model for TREML2

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    hsa-miR-3164 hsa-miR-3690 hsa-miR-4303 hsa-miR-642a hsa-miR-1197 hsa-miR-330-5p hsa-miR-766 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidTREML2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRML2_HUMAN, Q5T2D2: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IDA18650384
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TREML2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TREML2
    Interactions:

        Search GeneGlobe Interaction Network for TREML2

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042110T cell activation IDA18650384

    Find genes that share ontologies with TREML2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TREML2 (TRML2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TREML2 gene: 
    NM_024807.3  

    Unigene Cluster for TREML2:

    Triggering receptor expressed on myeloid cells-like 2
    Hs.164797  [show with all ESTs]
    Unigene Representative Sequence: NM_024807
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000483722(uc010jxm.1)
    miRNA
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    hsa-miR-3164 hsa-miR-3690 hsa-miR-4303 hsa-miR-642a hsa-miR-1197 hsa-miR-330-5p hsa-miR-766 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidTREML2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat TREML2

    Additional mRNA sequence: 

    AF534824.1 AJ420509.1 AK023755.1 AY358171.1 BC125078.1 BC125079.1 

    2 DOTS entries:

    DT.86843336  DT.100672597 

    Selected AceView cDNA sequences (see all 46):

    BG236416 AF534824 BF109560 BI052447 BX494974 AI189960 AI361759 AI093606 
    BX338019 AV661459 BQ883836 CB997592 NM_024807 BF975321 BF976263 AK023755 
    AI223427 AY358171 BU752698 BI827715 AJ420509 BU754021 CB961633 BV175324 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TREML2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTATGCAG
    TREML2 Expression
    About this image


    TREML2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Placenta (Extraembryonic Tissues)
    TREML2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TREML2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164797

    UniProtKB/Swiss-Prot: TRML2_HUMAN, Q5T2D2
    Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively
    on CD8 T-cells and induced on CD4 T-cells after activation

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TREML2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Treml21 , 5 triggering receptor expressed on myeloid cells-like more1, 5 69.06(n)1
    55.48(a)1
      17 (23.99 cM)5
    3288331  NM_001033405.21  NP_001028577.21 
     483000385 


    ENSEMBL Gene Tree for TREML2 (if available)
    TreeFam Gene Tree for TREML2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TREML2 gene

    Find genes that share paralogs with TREML2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TREML2
    PGOHUM00000243619


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TREML2 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47144301,2
    C,F--41157054(+) tcttaT/Gcatgc 1 -- ds50019Minor allele frequency- G:0.37NA WA CSA EA 252
    rs1825146131,2
    --41157116(+) TCTCAC/TTGCCA 1 -- ds50010--------
    rs1867987561,2
    --41157201(+) TCTTGG/TGTCAA 1 -- ds50010--------
    rs1912149201,2
    C--41157255(+) CAACCC/TGGTAG 1 -- ds50010--------
    rs623963541,2
    C--41157256(+) AACCCG/AGTAGG 1 -- ds50013Minor allele frequency- A:0.11NA WA 240
    rs608592921,2
    F--41157302(+) GGAGTC/TCATCT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1500104761,2
    --41157337(+) ACCCAA/TGGAAG 1 -- ds50010--------
    rs94714941,2
    C,F,A,H--41157344(+) GAagtC/Gagaag 1 -- ds500114Minor allele frequency- G:0.17NS EA NA WA 1698
    rs94714951,2
    C,F,H--41157372(+) tccacC/Actcct 1 -- ds500114Minor allele frequency- A:0.20NS EA NA WA 1880
    rs568846821,2
    C--41157439(+) CTGGA-/GTTCTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TREML2 (41157552 - 41168932 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TREML2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv994929CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609715    OMIM disorders: --


    Find genes that share disorders with TREML2           About GenesLikeMe

    Genetic Association Database (GAD): TREML2
    Human Genome Epidemiology (HuGE) Navigator: TREML2 (1 document)

    Export disorders for TREML2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TREML2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TREML2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PubMed id 12645956)1, 2, 3 Allcock R.J.N.... Trowsdale J. (Eur. J. Immunol. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT- 2) is a counter-receptor for B7-H3 and enhances T cell responses. (PubMed id 18650384)1, 2 Hashiguchi M....Azuma M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction. (PubMed id 19544488)1 Leitner J....Steinberger P. (Eur. J. Immunol. 2009)
    8. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (Blood 2007)
    9. Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. (PubMed id 16670310)1 King R.G....Justement L.B. (J. Immunol. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79865 HGNC: 21092 AceView: TREML2 Ensembl:ENSG00000112195 euGenes: HUgn79865
    ECgene: TREML2 H-InvDB: TREML2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TREML2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TREML2 gene:
    Search GeneIP for patents involving TREML2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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