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Aliases for TREML1 Gene

Aliases for TREML1 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 1 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 1 3 4
  • TLT-1 3 4
  • TLT1 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 1 2
  • Trem-Like Transcript 1 Protein 3
  • TREM-Like Transcript 1 2
  • DJ238O23.3 3
  • GLTL1825 3
  • PRO3438 3

External Ids for TREML1 Gene

Previous GeneCards Identifiers for TREML1 Gene

  • GC06M041118
  • GC06M041164
  • GC06M041225
  • GC06M040835

Summaries for TREML1 Gene

Entrez Gene Summary for TREML1 Gene

  • This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

GeneCards Summary for TREML1 Gene

TREML1 (Triggering Receptor Expressed On Myeloid Cells Like 1) is a Protein Coding gene. Diseases associated with TREML1 include Gray Platelet Syndrome. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System.

UniProtKB/Swiss-Prot for TREML1 Gene

  • Cell surface receptor that may play a role in the innate and adaptive immune response.

Gene Wiki entry for TREML1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML1 Gene

Genomics for TREML1 Gene

Regulatory Elements for TREML1 Gene

Enhancers for TREML1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G041181 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -28.3 -28284 1.7 CTCF ESRRA MAX YBX1 RAD21 TCF12 GATA2 SMC3 NR2F6 TCF7L2 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 TREM2
GH06G041185 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -31.7 -31650 1.6 PKNOX1 SPI1 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 TREM2
GH06G041198 1.5 Ensembl ENCODE dbSUPER 5.4 -47.1 -47082 6.2 HDGF ATF1 ARNT WRNIP1 SIN3A TCF12 ZNF766 GATA2 ELK1 KLF13 TREML4 TREML3P TREM2 USP49 ADCY10P1 TREML5P TREML1 ENSG00000218809 TREML2
GH06G041079 0.5 dbSUPER 9.6 +74.3 74259 0.5 ZNF121 GATA3 TCF7 FOS TSPO2 UNC5CL TREML1 NFYA OARD1
GH06G041080 0.5 Ensembl dbSUPER 9.6 +73.4 73449 0.2 TSPO2 UNC5CL TREML1 NFYA OARD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TREML1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREML1 Gene

Chromosome:
6
Start:
41,149,260 bp from pter
End:
41,154,349 bp from pter
Size:
5,090 bases
Orientation:
Minus strand

Genomic View for TREML1 Gene

Genes around TREML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML1 Gene

Proteins for TREML1 Gene

  • Protein details for TREML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YW5-TRML1_HUMAN
    Recommended name:
    Trem-like transcript 1 protein
    Protein Accession:
    Q86YW5
    Secondary Accessions:
    • Q496B3
    • Q8IWY1
    • Q8IWY2

    Protein attributes for TREML1 Gene

    Size:
    311 amino acids
    Molecular mass:
    32679 Da
    Quaternary structure:
    • When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.

    Three dimensional structures from OCA and Proteopedia for TREML1 Gene

    Alternative splice isoforms for TREML1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREML1 Gene

Post-translational modifications for TREML1 Gene

No data available for DME Specific Peptides for TREML1 Gene

Domains & Families for TREML1 Gene

Gene Families for TREML1 Gene

Protein Domains for TREML1 Gene

Suggested Antigen Peptide Sequences for TREML1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TREML1: view

No data available for UniProtKB/Swiss-Prot for TREML1 Gene

Function for TREML1 Gene

Molecular function for TREML1 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that may play a role in the innate and adaptive immune response.
genes like me logo Genes that share phenotypes with TREML1: view

Animal Models for TREML1 Gene

MGI Knock Outs for TREML1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TREML1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TREML1 Gene

Localization for TREML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML1 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREML1 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for TREML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12645956
GO:0031091 platelet alpha granule IEA --
genes like me logo Genes that share ontologies with TREML1: view

Pathways & Interactions for TREML1 Gene

genes like me logo Genes that share pathways with TREML1: view

Pathways by source for TREML1 Gene

Interacting Proteins for TREML1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000402855%0d%0a9606.ENSP00000340944%0d%0a9606.ENSP00000391592%0d%0a
Selected Interacting proteins: Q86YW5-TRML1_HUMAN ENSP00000402855 for TREML1 Gene via IID STRING

Symbol External ID(s) Details
HLA-B
HLA-DRB1
HLA-A
PTPN11
PTPN6

Gene Ontology (GO) - Biological Process for TREML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030168 platelet activation IEA --
GO:0045087 innate immune response NAS 12645956
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML1: view

No data available for SIGNOR curated interactions for TREML1 Gene

Transcripts for TREML1 Gene

mRNA/cDNA for TREML1 Gene

Unigene Clusters for TREML1 Gene

Triggering receptor expressed on myeloid cells-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREML1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TREML1 Gene

GeneLoc Exon Structure for
TREML1
ECgene alternative splicing isoforms for
TREML1

Expression for TREML1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TREML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREML1 Gene

This gene is overexpressed in Whole Blood (x39.7).

Protein differential expression in normal tissues from HIPED for TREML1 Gene

This gene is overexpressed in Platelet (31.1), Serum (19.2), and Peripheral blood mononuclear cells (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TREML1 Gene



Protein tissue co-expression partners for TREML1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TREML1 Gene:

TREML1

SOURCE GeneReport for Unigene cluster for TREML1 Gene:

Hs.117331

mRNA Expression by UniProt/SwissProt for TREML1 Gene:

Q86YW5-TRML1_HUMAN
Tissue specificity: Detected in platelets, monocytic leukemia and in T-cell leukemia.

Evidence on tissue expression from TISSUES for TREML1 Gene

  • Blood(4.4)
genes like me logo Genes that share expression patterns with TREML1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TREML1 Gene

Orthologs for TREML1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREML1 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia TREML1 34 35
  • 81.36 (n)
cow
(Bos Taurus)
Mammalia TREML1 34 35
  • 78.04 (n)
mouse
(Mus musculus)
Mammalia Treml1 34 16 35
  • 75.89 (n)
rat
(Rattus norvegicus)
Mammalia Treml1 34
  • 75.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TREML1 35
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TREML1 35
  • 39 (a)
OneToOne
Species where no ortholog for TREML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML1 Gene

ENSEMBL:
Gene Tree for TREML1 (if available)
TreeFam:
Gene Tree for TREML1 (if available)

Paralogs for TREML1 Gene

No data available for Paralogs for TREML1 Gene

Variants for TREML1 Gene

Sequence variations from dbSNP and Humsavar for TREML1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_035526 A breast cancer sample
rs28937876 Pathogenic 41,158,991(-) ATCAA(G/T)ATTCT intron-variant, upstream-variant-2KB, reference, missense
rs28939079 Pathogenic 41,159,873(-) CCTGG(A/G)TCACC intron-variant, upstream-variant-2KB, reference, missense
rs386834144 Likely pathogenic 41,159,790(-) CCAGG(C/T)ACAGC intron-variant, upstream-variant-2KB, splice-donor-variant
rs2234255 Likely benign 41,159,805(-) TGGAG(C/T)ACAGC intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TREML1 Gene

Variant ID Type Subtype PubMed ID
nsv482095 CNV loss 20164927
nsv602970 CNV gain 21841781

Variation tolerance for TREML1 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML1 Gene

Disorders for TREML1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TREML1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gray platelet syndrome
  • bdplt4
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TREML1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREML1
genes like me logo Genes that share disorders with TREML1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TREML1 Gene

Publications for TREML1 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock R.J.N. … Trowsdale J. (Eur. J. Immunol. 2003) 2 3 4 64
  2. Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. (PMID: 12393607) Washington A.V. … McVicar D.W. (Blood 2002) 2 3 4 64
  3. The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. (PMID: 16505478) Gattis J.L. … Lubkowski J. (J. Biol. Chem. 2006) 3 4 64
  4. A TREM family member, TLT-1, is found exclusively in the alpha- granules of megakaryocytes and platelets. (PMID: 15100151) Washington A.V. … McVicar D.W. (Blood 2004) 3 4 64
  5. TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. (PMID: 15128762) Barrow A.D. … Trowsdale J. (J. Immunol. 2004) 3 4 64

Products for TREML1 Gene

Sources for TREML1 Gene

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