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Aliases for TREML1 Gene

Aliases for TREML1 Gene

  • Triggering Receptor Expressed On Myeloid Cells-Like 1 2 3
  • TLT1 3 4 6
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 1 3 4
  • TLT-1 3 4
  • Trem-Like Transcript 1 Protein 3
  • TREM-Like Transcript 1 2
  • DJ238O23.3 3
  • GLTL1825 3
  • PRO3438 3

External Ids for TREML1 Gene

Summaries for TREML1 Gene

Entrez Gene Summary for TREML1 Gene

  • This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

GeneCards Summary for TREML1 Gene

TREML1 (Triggering Receptor Expressed On Myeloid Cells-Like 1) is a Protein Coding gene. Diseases associated with TREML1 include gray platelet syndrome.

UniProtKB/Swiss-Prot for TREML1 Gene

  • Cell surface receptor that may play a role in the innate and adaptive immune response.

Gene Wiki entry for TREML1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML1 Gene

Genomics for TREML1 Gene

Genomic Location for TREML1 Gene

Start:
41,149,260 bp from pter
End:
41,154,349 bp from pter
Size:
5,090 bases
Orientation:
Minus strand

Genomic View for TREML1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TREML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML1 Gene

Regulatory Elements for TREML1 Gene

Proteins for TREML1 Gene

  • Protein details for TREML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YW5-TRML1_HUMAN
    Recommended name:
    Trem-like transcript 1 protein
    Protein Accession:
    Q86YW5
    Secondary Accessions:
    • Q496B3
    • Q8IWY1
    • Q8IWY2

    Protein attributes for TREML1 Gene

    Size:
    311 amino acids
    Molecular mass:
    32679 Da
    Quaternary structure:
    • When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.

    Three dimensional structures from OCA and Proteopedia for TREML1 Gene

    Alternative splice isoforms for TREML1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREML1 Gene

Proteomics data for TREML1 Gene at MOPED

Post-translational modifications for TREML1 Gene

Other Protein References for TREML1 Gene

No data available for DME Specific Peptides for TREML1 Gene

Domains for TREML1 Gene

Gene Families for TREML1 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for TREML1 Gene

Suggested Antigen Peptide Sequences for TREML1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YW5

UniProtKB/Swiss-Prot:

TRML1_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q86YW5
genes like me logo Genes that share domains with TREML1: view

Function for TREML1 Gene

Molecular function for TREML1 Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor that may play a role in the innate and adaptive immune response.

Gene Ontology (GO) - Molecular Function for TREML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15128762
genes like me logo Genes that share ontologies with TREML1: view
genes like me logo Genes that share phenotypes with TREML1: view

Animal Models for TREML1 Gene

MGI Knock Outs for TREML1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TREML1 Gene

Localization for TREML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML1 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREML1 Gene COMPARTMENTS Subcellular localization image for TREML1 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for TREML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane NAS 12645956
GO:0031091 platelet alpha granule IEA --
genes like me logo Genes that share ontologies with TREML1: view

Pathways for TREML1 Gene

SuperPathways for TREML1 Gene

No Data Available

Interacting Proteins for TREML1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000402855%0d%0a9606.ENSP00000340944%0d%0a9606.ENSP00000391592%0d%0a
Selected Interacting proteins: ENSP00000402855 Q86YW5-TRML1_HUMAN for TREML1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TREML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019722 calcium-mediated signaling IDA 15128762
GO:0030168 platelet activation IEP 15128762
GO:0045087 innate immune response NAS 12645956
genes like me logo Genes that share ontologies with TREML1: view

No data available for Pathways by source for TREML1 Gene

Transcripts for TREML1 Gene

mRNA/cDNA for TREML1 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TREML1 Gene

Triggering receptor expressed on myeloid cells-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREML1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TREML1 Gene

GeneLoc Exon Structure for
TREML1
ECgene alternative splicing isoforms for
TREML1

Expression for TREML1 Gene

mRNA expression in normal human tissues for TREML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREML1 Gene

This gene is overexpressed in Whole Blood (39.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TREML1 Gene

SOURCE GeneReport for Unigene cluster for TREML1 Gene Hs.117331

mRNA Expression by UniProt/SwissProt for TREML1 Gene

Q86YW5-TRML1_HUMAN
Tissue specificity: Detected in platelets, monocytic leukemia and in T-cell leukemia.
genes like me logo Genes that share expressions with TREML1: view

Orthologs for TREML1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREML1 35
  • 99.57 (n)
  • 99.04 (a)
TREML1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TREML1 35
  • 78.04 (n)
  • 66.22 (a)
TREML1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TREML1 35
  • 81.36 (n)
  • 72.88 (a)
TREML1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Treml1 35
  • 75.89 (n)
  • 70.24 (a)
Treml1 16
Treml1 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TREML1 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TREML1 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Treml1 35
  • 75.66 (n)
  • 68.86 (a)
Species with no ortholog for TREML1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML1 Gene

ENSEMBL:
Gene Tree for TREML1 (if available)
TreeFam:
Gene Tree for TREML1 (if available)

Paralogs for TREML1 Gene

No data available for Paralogs for TREML1 Gene

Variants for TREML1 Gene

Sequence variations from dbSNP and Humsavar for TREML1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3049085 -- 41,155,375(-) agaga(-/GA/GAGA/GAGAGAGA/GAGAGAGAGA)aACGT upstream-variant-2KB
rs11755923 -- 41,153,747(+) GCCTA(A/G)GATAA intron-variant
rs11965371 -- 41,152,533(+) AGAAG(A/G)ATTCT intron-variant
rs12194477 -- 41,149,036(+) ATATG(C/T)TTTCG downstream-variant-500B
rs12197617 -- 41,156,010(+) GCTTT(C/T)TTTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TREML1 Gene

Variant ID Type Subtype PubMed ID
nsv482095 CNV Loss 20164927

Relevant External Links for TREML1 Gene

HapMap Linkage Disequilibrium report
TREML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML1 Gene

Disorders for TREML1 Gene

(1) MalaCards Diseases for TREML1 Gene

Search for TREML1 Gene in MalaCards »
genes like me logo Genes that share disorders with TREML1: view

No data available for UniProtKB/Swiss-Prot for TREML1 Gene

Publications for TREML1 Gene

  1. Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. (PMID: 12393607) Washington A.V. … McVicar D.W. (Blood 2002) 2 3 4
  2. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock R.J.N. … Trowsdale J. (Eur. J. Immunol. 2003) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. A TREM family member, TLT-1, is found exclusively in the alpha- granules of megakaryocytes and platelets. (PMID: 15100151) Washington A.V. … McVicar D.W. (Blood 2004) 3 4

Products for TREML1 Gene

Sources for TREML1 Gene

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