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TREML1 Gene

protein-coding   GIFtS: 50
GCID: GC06M041120

Triggering Receptor Expressed On Myeloid Cells-Like 1

  See TREML1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Triggering Receptor Expressed On Myeloid Cells-Like 11 2     GLTL18252
TLT12 3 5     PRO34382
Triggering Receptor Expressed On Myeloid Cells-Like Protein 12 3     dJ238O23.32
TLT-12 3     Trem-Like Transcript 1 Protein2
TREM-Like Transcript 11     

External Ids:    HGNC: 204341   Entrez Gene: 3402052   Ensembl: ENSG000001619117   OMIM: 6097145   UniProtKB: Q86YW53   

Export aliases for TREML1 gene to outside databases

Previous GC identifers: GC06M041118 GC06M041164 GC06M041225 GC06M040835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TREML1 Gene:
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded
protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The
encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to
Gray platelet syndrome. Alternative splicing results in multiple transcript variants (provided by RefSeq, Nov
2012)

GeneCards Summary for TREML1 Gene:
TREML1 (triggering receptor expressed on myeloid cells-like 1) is a protein-coding gene. Diseases associated with TREML1 include gray platelet syndrome.

UniProtKB/Swiss-Prot: TRML1_HUMAN, Q86YW5
Function: Cell surface receptor that may play a role in the innate and adaptive immune response

Gene Wiki entry for TREML1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TREML1 gene promoter:
         AML1a   p53   Bach2   NRSF form 1   NRSF form 2   CREB   FOXJ2 (long isoform)   HOXA5   FOXJ2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTREML1 promoter sequence
   Search Chromatin IP Primers for TREML1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TREML1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TREML1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREML1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041120:  view genomic region     (about GC identifiers)

Start:
41,117,080 bp from pter      End:
41,122,075 bp from pter
Size:
4,996 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRML1_HUMAN, Q86YW5 (See protein sequence)
Recommended Name: Trem-like transcript 1 protein precursor  
Size: 311 amino acids; 32679 Da
Subunit: When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11
1 PDB 3D structure from and Proteopedia for TREML1:
2FRG (3D)    
Secondary accessions: Q496B3 Q8IWY1 Q8IWY2
Alternative splicing: 3 isoforms:  Q86YW5-1   Q86YW5-2   Q86YW5-3   

Explore the universe of human proteins at neXtProt for TREML1: NX_Q86YW5

Explore proteomics data for TREML1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TREML1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258736.1  NP_001258737.1  NP_835468.1  

    ENSEMBL proteins: 
     ENSP00000362219   ENSP00000402855   ENSP00000400405  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q86YW5

    ProtoNet protein and cluster: Q86YW5

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: TRML1_HUMAN, Q86YW5
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with TREML1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRML1_HUMAN, Q86YW5
    Function: Cell surface receptor that may play a role in the innate and adaptive immune response

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15128762
         
    Find genes that share ontologies with TREML1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Treml1):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  integument 

    Find genes that share phenotypes with TREML1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TREML1: Treml1tm1Mcvic Treml1tm1Lex

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRML1_HUMAN, Q86YW5: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in
    cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble
    fragments can be released into the serum by proteolysis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane NAS12645956
    GO:0031091platelet alpha granule IEA--

    Find genes that share ontologies with TREML1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TREML1
    Interactions:

        GeneGlobe Interaction Network for TREML1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for TREML1 (Q86YW53 ENSP000003622194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061243, ENSP000003409444I2D: score=2 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=2 STRING: ENSP00000391592
    SIRPAP783243I2D: score=1 
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019722calcium-mediated signaling IDA15128762
    GO:0030168platelet activation IEP15128762
    GO:0045087innate immune response NAS12645956

    Find genes that share ontologies with TREML1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TREML1 (TRML1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TREML1 gene (3 alternative transcripts): 
    NM_001271807.1  NM_001271808.1  NM_178174.3  

    Unigene Cluster for TREML1:

    Triggering receptor expressed on myeloid cells-like 1
    Hs.117331  [show with all ESTs]
    Unigene Representative Sequence: NM_178174
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373127(uc011duc.2) ENST00000426005(uc003opx.3) ENST00000437044(uc011dud.2)
    ENST00000590581
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    Additional mRNA sequence: 

    AF508193.1 AF534822.1 AF534823.1 AY358357.1 BC100944.1 BC100945.1 BC100946.1 

    3 DOTS entries:

    DT.100746791  DT.100746790  DT.40122972 

    13 AceView cDNA sequences:

    BQ023322 BX091632 AY358357 AF534822 AF534823 NM_178174 AF508193 CK002305 
    BF439604 AA699715 BU753776 AI052571 R02728 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TREML1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:              -                                       
    SP2:              -                 -                     
    SP3:        -     -                                       
    SP4:                                                      


    ECgene alternative splicing isoforms for TREML1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TREML1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAGATGT
    TREML1 Expression
    About this image


    TREML1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
    TREML1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TREML1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.117331

    UniProtKB/Swiss-Prot: TRML1_HUMAN, Q86YW5
    Tissue specificity: Detected in platelets, monocytic leukemia and in T-cell leukemia

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TREML1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Treml11 , 5 triggering receptor expressed on myeloid cells-like more1, 5 75.89(n)1
    70.24(a)1
      17 (23.99 cM)5
    713261  NM_027763.11  NP_082039.11 
     483599165 


    ENSEMBL Gene Tree for TREML1 (if available)
    TreeFam Gene Tree for TREML1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TREML1 (see all 185)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355264
    A breast cancer sample4--see VAR_0355262 L V mis40--------
    rs755761241,2
    C--41116542(+) GAAACA/GGTGCT 3 -- ds50010--------
    rs1894035021,2
    --41116562(+) CCACCA/TAGTTA 3 -- ds50010--------
    rs1128608651,2
    F--41116683(+) TTCCTG/ATTTCT 3 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1819544541,2
    --41116687(+) TATTTC/TTTTCC 3 -- ds50010--------
    rs1468512861,2
    C--41116722(+) GTCCTG/TGGTCT 3 -- ds50010--------
    rs121944771,2
    C,F,H--41116774(+) ATATGC/TTTTCG 3 -- ds500117Minor allele frequency- T:0.16NS EA NA WA CSA 2240
    rs1869892181,2
    --41116861(+) TGGAGG/TCATCA 3 -- ds50010--------
    rs1392516541,2
    --41116889(+) ACTTCC/TGAAGA 3 -- ds50010--------
    rs1899847631,2
    --41116919(+) GAATCA/CAACTG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for TREML1 (41117080 - 41122075 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TREML1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482095CNV Loss20164927

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609714    OMIM disorders: --

    1 disease for TREML1:    
    About MalaCards
    gray platelet syndrome


    Find genes that share disorders with TREML1           About GenesLikeMe


    Export disorders for TREML1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TREML1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TREML1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PubMed id 12645956)1, 2, 3 Allcock R.J.N.... Trowsdale J. (Eur. J. Immunol. 2003)
    2. Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. (PubMed id 12393607)1, 2, 3 Washington A.V.... McVicar D.W. (Blood 2002)
    3. The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. (PubMed id 16505478)1, 2 Gattis J.L.... Lubkowski J. (J. Biol. Chem. 2006)
    4. A TREM family member, TLT-1, is found exclusively in the alpha- granules of megakaryocytes and platelets. (PubMed id 15100151)1, 2 Washington A.V.... McVicar D.W. (Blood 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. (PubMed id 15128762)1, 2 Barrow A.D.... Trowsdale J. (J. Immunol. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis. (PubMed id 22551551)1 Derive M....Gibot S. (J. Immunol. 2012)
    10. Proteomic analysis of palmitoylated platelet proteins. (PubMed id 21813449)2 Dowal L.... Flaumenhaft R. (Blood 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340205 HGNC: 20434 AceView: TREML1 Ensembl:ENSG00000161911 euGenes: HUgn340205
    ECgene: TREML1 H-InvDB: TREML1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TREML1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TREML1 gene:
    Search GeneIP for patents involving TREML1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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