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TREM2 Gene

protein-coding   GIFtS: 59
GCID: GC06M041126

Triggering Receptor Expressed On Myeloid Cells 2

(Previous name: triggering receptor expressed on myeloid cells 2a)
  See TREM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Triggering Receptor Expressed On Myeloid Cells 21 2     Trem2a2
Triggering Receptor Expressed On Myeloid Cells 2a1 2     Trem2b2
Triggering Receptor Expressed On Monocytes 22 3     Trem2c2
TREM-22 3     

External Ids:    HGNC: 177611   Entrez Gene: 542092   Ensembl: ENSG000000959707   OMIM: 6050865   UniProtKB: Q9NZC23   

Export aliases for TREM2 gene to outside databases

Previous GC identifers: GC06M041128 GC06M041173 GC06M041234 GC06M040844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TREM2 Gene:
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase
binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by
triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic
lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Nov 2012)

GeneCards Summary for TREM2 Gene:
TREM2 (triggering receptor expressed on myeloid cells 2) is a protein-coding gene. Diseases associated with TREM2 include polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, and trem2-related polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy. GO annotations related to this gene include lipopolysaccharide binding and receptor activity.

UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2
Function: May have a role in chronic inflammations and may stimulate production of constitutive rather than
inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of
the immune responses in macrophages and dendritic cells

Gene Wiki entry for TREM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TREM2 gene promoter:
         AML1a   p53   NRSF form 1   LCR-F1   NRSF form 2   Arnt   Evi-1   CREB   HOXA5   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTREM2 promoter sequence
   Search Chromatin IP Primers for TREM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TREM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TREM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREM2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041126:  view genomic region     (about GC identifiers)

Start:
41,126,244 bp from pter      End:
41,130,924 bp from pter
Size:
4,681 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2 (See protein sequence)
Recommended Name: Triggering receptor expressed on myeloid cells 2 precursor  
Size: 230 amino acids; 25447 Da
Subunit: Interacts with TYROBP/DAP12 (By similarity)
Sequence caution: Sequence=BAB78736.1; Type=Erroneous initiation;
Secondary accessions: Q8N5H8 Q8WYN6
Alternative splicing: 3 isoforms:  Q9NZC2-1   Q9NZC2-2   Q9NZC2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TREM2: NX_Q9NZC2

Explore proteomics data for TREM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn20, Asn79

  • See TREM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258750.1  NP_061838.1  

    ENSEMBL proteins: 
     ENSP00000362214   ENSP00000362205   ENSP00000342651  
    Reactome Protein details: Q9NZC2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9NZC2

    ProtoNet protein and cluster: Q9NZC2

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with TREM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TREM2_HUMAN, Q9NZC2
    Function: May have a role in chronic inflammations and may stimulate production of constitutive rather than
    inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of
    the immune responses in macrophages and dendritic cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001530lipopolysaccharide binding IEA--
    GO:0004872receptor activity TAS10799849
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TREM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TREM2:
     Increased circadian rhythm amp 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trem2):
     homeostasis/metabolism  immune system 

    Find genes that share phenotypes with TREM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trem2tm1Cln for TREM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TREM2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TREM2_HUMAN, Q9NZC2: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
    TREM2_HUMAN, Q9NZC2: Isoform 2: Secreted (Potential)
    TREM2_HUMAN, Q9NZC2: Isoform 3: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TREM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TREM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    DAP12 signaling0.89
    DAP12 interactions0.89
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Semaphorin interactions
    Semaphorin interactions0.43
    Other semaphorin interactions0.00
    4Osteoclast differentiation
    Osteoclast differentiation


    Find genes that share SuperPaths with TREM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for TREM2
        DAP12 interactions
    DAP12 signaling
    Other semaphorin interactions


    1 Kegg Pathway  (Kegg details for TREM2):
        Osteoclast differentiation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TREM2
    Interactions:

        GeneGlobe Interaction Network for TREM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for TREM2 (Q9NZC23 ENSP000003622054) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPO439143, ENSP000002626294I2D: score=2 STRING: ENSP00000262629
    BTKENSP000003081764STRING: ENSP00000308176
    PLXNA1ENSP000002517724STRING: ENSP00000251772
    RAC1ENSP000003484614STRING: ENSP00000348461
    SEMA6DENSP000003248574STRING: ENSP00000324857
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006959humoral immune response TAS10799849
    GO:0007411axon guidance TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with TREM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TREM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TREM2 gene (2 alternative transcripts): 
    NM_001271821.1  NM_018965.3  

    Unigene Cluster for TREM2:

    Triggering receptor expressed on myeloid cells 2
    Hs.435295  [show with all ESTs]
    Unigene Representative Sequence: BM548441
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373122 ENST00000373113(uc003opy.2 uc003opz.2) ENST00000338469(uc010jxl.1)

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    Additional mRNA sequence: 

    AB062787.1 AF213457.1 AK312215.1 BC018284.1 BC032362.1 

    5 DOTS entries:

    DT.311466  DT.100777353  DT.92418240  DT.97838360  DT.100021722 

    Selected AceView cDNA sequences (see all 47):

    BC032362 AI198313 CD367707 AA133297 CD368600 CA306968 BM713926 BE044046 
    AA115735 BM710072 AB062787 CD368189 AW072019 AW304912 AA133244 BF438499 
    CA306797 BM974675 CB269854 AF213457 BC018284 CD369539 AI648557 BG570278 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TREM2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                -               
    SP2:                                                
    SP3:                                -     -         


    ECgene alternative splicing isoforms for TREM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TREM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCAGGGTA
    TREM2 Expression
    About this image


    TREM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Limb (Muscoskeletal System)
             Autopod
    TREM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TREM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435295

    UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2
    Tissue specificity: Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS
    strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TREM2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trem21 , 5 triggering receptor expressed on myeloid cells 21, 5 77.28(n)1
    69.96(a)1
      17 (23.99 cM)5
    834331  NM_031254.31  NP_112544.11 
     483464015 
    chicken
    (Gallus gallus)
    Aves TREM21 triggering receptor expressed on myeloid cells 2 59.09(n)
    43.18(a)
      419920  NM_001037832.1  NP_001032921.1 
    lizard
    (Anolis carolinensis)
    Reptilia TREM26
    triggering receptor expressed on myeloid cells 2
    26(a)
    1 ↔ 1
    4(120403804-120413732)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trem21 triggering receptor expressed on myeloid cells 2 49.9(n)
    37.13(a)
      100126214  NM_001110052.1  NP_001103522.1 


    ENSEMBL Gene Tree for TREM2 (if available)
    TreeFam Gene Tree for TREM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TREM2 (see all 201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0193344
    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)4--see VAR_0193342 D G mis40--------
    VAR_0193354
    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)4--see VAR_0193352 K N mis40--------
    rs289378761,2
    Cpathogenic141037028(-) ATCAAG/TATTCT 3 K N int1 mis1 ese30--------
    rs289390791,2
    Cpathogenic141037910(-) CCTGGA/GTCACC 4 D G mis1 ese30--------
    rs1048939981,2
    Cpathogenic141039458(-) GAGGTA/GGAATG 4 * W stg10--------
    rs1048940011,2
    Cpathogenic141039559(-) CACTGA/GGGGAG 4 * W stg10--------
    rs1048940021,2
    Cpathogenic141039594(-) CCCTGC/TAGGTG 4 Q * stg10--------
    rs1845749531,2
    --41036047(+) TGAGCC/TTCAGT 2 -- ds50010--------
    rs1888803021,2
    --41036063(+) TTCTAA/TATGAT 2 -- ds50010--------
    rs1412258891,2
    --41036073(+) TGAGGA/GGCTTG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TREM2 (41126244 - 41130924 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TREM2: --
    Human Gene Mutation Database (HGMD): TREM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TREM2
    DNA2.0 Custom Variant and Variant Library Synthesis for TREM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605086   
    OMIM disorders: 221770  
    UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2
  • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]:
    Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to
    presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most
    of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in
    the Finns. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for TREM2:    
    About MalaCards
    polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy    trem2-related polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy    frontotemporal lobar degeneration with ubiquitin-positive inclusions    dementia, familial, nonspecific
    semantic dementia    amyotrophic lateral sclerosis    alzheimer's disease


    Find genes that share disorders with TREM2           About GenesLikeMe

    4 Novoseek inferred disease relationships for TREM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasu-hakola disease 98.8 9 15883308 (3), 17530208 (2), 16418779 (1), 15049507 (1) (see all 6)
    lipomembranous polycystic osteodysplasia 97.7 1 17530208 (1)
    bone cysts 85.8 1 15883308 (1)
    dementia 42.8 2 15883308 (1), 17530208 (1)

    GeneTests: TREM2
    GeneReviews: TREM2
    Genetic Association Database (GAD): TREM2
    Human Genome Epidemiology (HuGE) Navigator: TREM2 (4 documents)

    Export disorders for TREM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TREM2 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with TREM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. (PubMed id 12080485)1, 2, 3 Paloneva J.... Peltonen L. (Am. J. Hum. Genet. 2002)
    2. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PubMed id 10799849)1, 2, 3 Bouchon A.... Colonna M. (J. Immunol. 2000)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. No evidence for shared etiology in two demyelinative disorders, MS and PLOSL. (PubMed id 19019460)1, 4 Sulonen A.M....Saarela J. (J. Neuroimmunol. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. (PubMed id 19457124)1, 9 Stefano L....Meldolesi J. (J. Neurochem. 2009)
    7. Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes. (PubMed id 15966270)1, 9 Montalbetti L....Soragna D. (Funct. Neurol. 2005)
    8. Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response. (PubMed id 17530208)1, 9 Kiialainen A....Peltonen L. (J. Mol. Med. 2007)
    9. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. (PubMed id 12925681)1, 9 Paloneva J....Peltonen L. (J. Exp. Med. 2003)
    10. TREM2 in Alzheimer's disease. (PubMed id 23407992)1 Jiang T....Tan L. (Mol. Neurobiol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54209 HGNC: 17761 AceView: TREM2 Ensembl:ENSG00000095970 euGenes: HUgn54209
    ECgene: TREM2 Kegg: 54209 H-InvDB: TREM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TREM2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TREM2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TREM2 gene:
    Search GeneIP for patents involving TREM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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