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Aliases for TREM2 Gene

Aliases for TREM2 Gene

  • Triggering Receptor Expressed On Myeloid Cells 2 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells 2a 2 3
  • Triggering Receptor Expressed On Monocytes 2 3 4
  • TREM-2 3 4
  • Trem2a 3
  • Trem2b 3
  • Trem2c 3

External Ids for TREM2 Gene

Previous GeneCards Identifiers for TREM2 Gene

  • GC06M041128
  • GC06M041173
  • GC06M041234
  • GC06M040844

Summaries for TREM2 Gene

Entrez Gene Summary for TREM2 Gene

  • This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

GeneCards Summary for TREM2 Gene

TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) is a Protein Coding gene. Diseases associated with TREM2 include nasu-hakola disease and trem2-related polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy. Among its related pathways are Immune System and Developmental Biology. GO annotations related to this gene include receptor activity and lipopolysaccharide binding.

UniProtKB/Swiss-Prot for TREM2 Gene

  • May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

Gene Wiki entry for TREM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREM2 Gene

Genomics for TREM2 Gene

Regulatory Elements for TREM2 Gene

Promoters for TREM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TREM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREM2 Gene

Chromosome:
6
Start:
41,158,506 bp from pter
End:
41,163,198 bp from pter
Size:
4,693 bases
Orientation:
Minus strand

Genomic View for TREM2 Gene

Genes around TREM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREM2 Gene

Proteins for TREM2 Gene

  • Protein details for TREM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZC2-TREM2_HUMAN
    Recommended name:
    Triggering receptor expressed on myeloid cells 2
    Protein Accession:
    Q9NZC2
    Secondary Accessions:
    • Q8N5H8
    • Q8WYN6

    Protein attributes for TREM2 Gene

    Size:
    230 amino acids
    Molecular mass:
    25447 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12.
    SequenceCaution:
    • Sequence=BAB78736.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TREM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREM2 Gene

Proteomics data for TREM2 Gene at MOPED

Post-translational modifications for TREM2 Gene

  • Glycosylation at Asn 20 and Asn 79
  • Modification sites at PhosphoSitePlus

Other Protein References for TREM2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TREM2 (TREM2)

No data available for DME Specific Peptides for TREM2 Gene

Domains & Families for TREM2 Gene

Gene Families for TREM2 Gene

Protein Domains for TREM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZC2

UniProtKB/Swiss-Prot:

TREM2_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREM2: view

Function for TREM2 Gene

Molecular function for TREM2 Gene

UniProtKB/Swiss-Prot Function:
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
genes like me logo Genes that share phenotypes with TREM2: view

Human Phenotype Ontology for TREM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TREM2 Gene

MGI Knock Outs for TREM2:

Animal Model Products

miRNA for TREM2 Gene

miRTarBase miRNAs that target TREM2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TREM2 Gene

Localization for TREM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREM2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREM2 Gene COMPARTMENTS Subcellular localization image for TREM2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TREM2: view

Pathways & Interactions for TREM2 Gene

genes like me logo Genes that share pathways with TREM2: view

Pathways by source for TREM2 Gene

1 KEGG pathway for TREM2 Gene

Gene Ontology (GO) - Biological Process for TREM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0032499 detection of peptidoglycan IEA --
GO:0045087 innate immune response TAS --
GO:0050850 positive regulation of calcium-mediated signaling IDA 11602640
GO:0071224 cellular response to peptidoglycan IEA --
genes like me logo Genes that share ontologies with TREM2: view

No data available for SIGNOR curated interactions for TREM2 Gene

Drugs & Compounds for TREM2 Gene

No Compound Related Data Available

Transcripts for TREM2 Gene

Unigene Clusters for TREM2 Gene

Triggering receptor expressed on myeloid cells 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for TREM2 Gene

GeneLoc Exon Structure for
TREM2
ECgene alternative splicing isoforms for
TREM2

Expression for TREM2 Gene

mRNA expression in normal human tissues for TREM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.9) and Brain - Substantia nigra (x6.2).

Protein differential expression in normal tissues from HIPED for TREM2 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TREM2 Gene



SOURCE GeneReport for Unigene cluster for TREM2 Gene Hs.435295

mRNA Expression by UniProt/SwissProt for TREM2 Gene

Q9NZC2-TREM2_HUMAN
Tissue specificity: Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.
genes like me logo Genes that share expression patterns with TREM2: view

Protein tissue co-expression partners for TREM2 Gene

Primer Products

In Situ Assay Products

Orthologs for TREM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TREM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREM2 35
  • 99.42 (n)
  • 98.7 (a)
TREM2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TREM2 36
  • 80 (a)
OneToOne
TREM2 35
  • 85.94 (n)
  • 80 (a)
dog
(Canis familiaris)
Mammalia TREM2 35
  • 84.28 (n)
  • 82.1 (a)
TREM2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trem2 16
Trem2 36
  • 68 (a)
OneToOne
Trem2 35
  • 77.28 (n)
  • 69.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TREM2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TREM2 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TREM2 35
  • 59.09 (n)
  • 43.18 (a)
TREM-A1 36
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TREM2 36
  • 26 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trem2 35
  • 49.9 (n)
  • 37.13 (a)
Species with no ortholog for TREM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREM2 Gene

ENSEMBL:
Gene Tree for TREM2 (if available)
TreeFam:
Gene Tree for TREM2 (if available)

Paralogs for TREM2 Gene

No data available for Paralogs for TREM2 Gene

Variants for TREM2 Gene

Sequence variations from dbSNP and Humsavar for TREM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_019334 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)
VAR_019335 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)
VAR_033625 -
VAR_033626 -
VAR_061329 -, -

Variation tolerance for TREM2 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREM2 Gene

HapMap Linkage Disequilibrium report
TREM2
Human Gene Mutation Database (HGMD)
TREM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TREM2 Gene

Disorders for TREM2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for TREM2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nasu-hakola disease
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
trem2-related polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
  • trem2-related plosl
cole disease
  • guttate hypopigmentation
amyotrophic lateral sclerosis 20
  • amyotrophic lateral sclerosis type 20
progressive non-fluent aphasia
  • non-fluent primary progressive aphasia
- elite association - COSMIC cancer census association via MalaCards
Search TREM2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TREM2_HUMAN
  • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. {ECO:0000269 PubMed:12080485}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TREM2

Genetic Association Database (GAD)
TREM2
Human Genome Epidemiology (HuGE) Navigator
TREM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREM2
genes like me logo Genes that share disorders with TREM2: view

No data available for Genatlas for TREM2 Gene

Publications for TREM2 Gene

  1. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. (PMID: 12080485) Paloneva J. … Peltonen L. (Am. J. Hum. Genet. 2002) 2 3 4 67
  2. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. (PMID: 19457124) Stefano L. … Meldolesi J. (J. Neurochem. 2009) 3 23
  3. Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response. (PMID: 17530208) Kiialainen A. … Peltonen L. (J. Mol. Med. 2007) 3 23
  4. Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes. (PMID: 15966270) Montalbetti L. … Soragna D. (Funct. Neurol. 2005) 3 23
  5. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. (PMID: 12925681) Paloneva J. … Peltonen L. (J. Exp. Med. 2003) 3 23

Products for TREM2 Gene

Sources for TREM2 Gene

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