Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TREM2 Gene

protein-coding GIFtS: 59
GCID: GC06M041126

triggering receptor expressed on myeloid cells 2

(Previous name: triggering receptor expressed on myeloid cells 2a )

Explore 6 diseases affiliated with
TREM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Triggering Receptor Expressed On Myeloid Cells 2¹ ²		Trem2c¹ ²
TREM-2¹ ² ³		Triggering Receptor Expressed On Myeloid Cells 2a¹ ²
Trem2a¹ ²		Triggering Receptor Expressed On Monocytes 2² ³
Trem2b¹ ²

External Ids:	HGNC: 17761¹	Entrez Gene: 54209²	Ensembl: ENSG00000095970⁷	OMIM: 605086⁵	UniProtKB: Q9NZC2³

Export aliases for TREM2 gene to outside databases

Previous GC identifers: GC06M041128 GC06M041173 GC06M041234 GC06M040844

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TREM2:

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase

binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by

triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic

lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple

transcript variants encoding different isoforms. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2

Function: May have a role in chronic inflammations and may stimulate production of constitutive rather than

inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the

immune responses in macrophages and dendritic cells

Gene Wiki entry for TREM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TREM2 gene promoter:
AML1a p53 NRSF form 1 LCR-F1 NRSF form 2 Arnt Evi-1 CREB HOXA5 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TREM2 promoter sequence

Search SABiosciences Chromatin IP Primers for TREM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

TREM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREM2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M041126: view genomic region (about GC identifiers)

Start:	41,126,244 bp from pter	End:	41,130,924 bp from pter
Size:	4,681 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2 (See protein sequence)

Recommended Name: Triggering receptor expressed on myeloid cells 2 precursor

Size: 230 amino acids; 25447 Da

Subunit: Interacts with TYROBP/DAP12 (By similarity)

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)

Subcellular location: Isoform 2: Secreted (Potential)

Subcellular location: Isoform 3: Secreted (Potential)

Sequence caution: Sequence=BAB78736.1; Type=Erroneous initiation;

Secondary accessions: Q8N5H8 Q8WYN6

Alternative splicing: 3 isoforms: Q9NZC2-1 Q9NZC2-2 Q9NZC2-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TREM2: NX_Q9NZC2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NZC2

TREM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001258750.1 NP_061838.1

ENSEMBL proteins:

ENSP00000362214 ENSP00000362205 ENSP00000342651

Reactome Protein details: Q9NZC2
Human Recombinant Protein Products for TREM2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TREM2 (TREM-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TREM2 OriGene Custom Protein Services for TREM2
	GenScript Custom Purified and Recombinant Proteins Services for TREM2
	Novus Biologicals TREM2 Protein Novus Biologicals TREM2 Lysates
	Sino Biological Recombinant Protein for TREM2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TREM2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

TREM2 for ontologies About GeneDecksing

TREM2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TREM2 (TREM-2)
	OriGene Antibodies: TREM2 OriGene Custom Antibody Services for TREM2
	GenScript Custom Superior Antibodies Services for TREM2
	Novus Biologicals TREM2 Antibodies
	Abcam antibodies for TREM2
	Uscn Antibodies for TREM2
	ThermoFisher Antibodies for TREM2

Assay Products for TREM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for TREM2 (TREM-2)
	GenScript Custom Assay Services for TREM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TREM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TREM2 for domains About GeneDecksing

3 InterPro domains/families:

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q9NZC2

ProtoNet protein and cluster: Q9NZC2

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TREM2_HUMAN, Q9NZC2

Function: May have a role in chronic inflammations and may stimulate production of constitutive rather than

inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the

immune responses in macrophages and dendritic cells

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	10799849

TREM2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TREM2:

Increased circadian rhythm amp

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trem2):

homeostasis/metabolism

immune system

TREM2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Trem2^tm1Cln for TREM2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TREM2

miRNA Products:		OriGene 3'-UTR Clone: TREM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TREM2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TREM2
		SwitchGear 3'UTR luciferase reporter plasmid: TREM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TREM2 (see all 7) OriGene shRNA RFP: TREM2 OriGene siRNA: TREM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TREM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against TREM2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TREM2
			Sirion Biotech Customized adenovirus for overexpression of TREM2 Sirion Biotech Customized adenovirus for potent knockdown of TREM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREM2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TREM2 (NM_018965)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TREM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TREM2
		Search LifeMap BioReagents cell lines for TREM2
		Sirion Biotech Customized stable knockdown cell line services for TREM2 Sirion Biotech Customized inducible knockdown cell line services for TREM2 Sirion Biotech Customized stable overexpressing cell line services for TREM2 Sirion Biotech Customized inducible overexpressing cell line services for TREM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREM2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Innate Immune System

0.46

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Signaling by FGFR

DAP12 signaling

0.83

DAP12 interactions

0.76

Other semaphorin interactions

Other semaphorin interactions

1.00

Osteoclast differentiation

Osteoclast differentiation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for TREM2 (see all 8)

	Developmental Biology
	Other semaphorin interactions
	Semaphorin interactions
	DAP12 interactions
	DAP12 signaling

1 Kegg Pathway (Kegg details for TREM2):

Osteoclast differentiation

TREM2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TREM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/18 Interacting proteins for TREM2 (Q9NZC2³ ENSP00000362205⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TYROBP	O43914³, ENSP00000262629⁴	I2D: score=2 STRING: ENSP00000262629
BTK	ENSP00000308176⁴	STRING: ENSP00000308176
PLXNA1	ENSP00000251772⁴	STRING: ENSP00000251772
SEMA6D	ENSP00000324857⁴	STRING: ENSP00000324857
SYK	ENSP00000364898⁴	STRING: ENSP00000364898

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006959	humoral immune response	TAS	10799849
GO:0007411	axon guidance	TAS	--

TREM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TREM2
Search CenterWatch for drugs/clinical trials and news about TREM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TREM2 gene (2 alternative transcripts):

NM_001271821.1 NM_018965.3

Unigene Cluster for TREM2:

Triggering receptor expressed on myeloid cells 2

Hs.435295 [show with all ESTs]

Unigene Representative Sequence: BM548441

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373122 ENST00000373113(uc003opy.2 uc003opz.2) ENST00000338469(uc010jxl.1)

miRNA Products:		OriGene 3'-UTR Clone: TREM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TREM2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TREM2
		SwitchGear 3'UTR luciferase reporter plasmid: TREM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TREM2 (see all 7) OriGene shRNA RFP: TREM2 OriGene siRNA: TREM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TREM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against TREM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREM2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TREM2 (NM_018965)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TREM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TREM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TREM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREM2

Additional cDNA sequence:

AB062787.1 AF213457.1 AK312215.1 BC018284.1 BC032362.1

5 DOTS entries:

DT.311466 DT.100777353 DT.92418240 DT.97838360 DT.100021722

24/47 AceView cDNA sequences (see all 47):

AA133297 CD368189 CD367707 BM713926 BC032362 AI198313 AB062787 CA306968

AW304912 AA115735 BM710072 BE044046 AW072019 CD368600 BC018284 BM974675

AI648557 CD369539 BX106100 CB269854 AI991673 CF529053 AA133244 AW517119

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TREM2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5
SP1:											-
SP2:
SP3:											-		-

ECgene alternative splicing isoforms for TREM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TREM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCAGGGTA

About this image

TREM2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Autopod

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TREM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TREM2

SOURCE GeneReport for Unigene cluster: Hs.435295

UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2

Tissue specificity: Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS

strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord

SABiosciences Custom PCR Arrays for TREM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TREM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TREM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TREM2 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trem2^{1 , 5}	triggering receptor expressed on myeloid cells 2^{1, 5}	77.28(n)¹ 69.96(a)¹		17 (23.99 cM)⁵ 83433¹ NM_031254.2¹ NP_112544.1¹ 48346401⁵
chicken (Gallus gallus)	Aves	TREM2¹	triggering receptor expressed on myeloid cells 2	59.09(n) 43.18(a)		419920 NM_001037832.1 NP_001032921.1
lizard (Anolis carolinensis)	Reptilia	TREM2⁶	--	33(a)	1 ↔ 1	4(120403900-120411555)

ENSEMBL Gene Tree for TREM2 (if available)
TreeFam Gene Tree for TREM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104894002^1,2	C	pathogenic	73688699(-)	`CCCTGC/TAGGTG`	2	Q *	stg¹		0	--	--	--	--
rs104894001^1,2	C	pathogenic	73688734(-)	`CACTGA/GGGGAG`	2	* W	stg¹		0	--	--	--	--
rs104893998^1,2	C	pathogenic	73688835(-)	`GAGGTA/GGAATG`	2	* W	stg¹		0	--	--	--	--
rs28937876^1,2	C	pathogenic	73691265(-)	`ATCAAG/TATTCT`	2	K N	mis¹ ese³		1		NA	2
rs2234258^1,2	C,F,H	--	40844229(-)	`CACTTG/AGCCAC`	1	--	ut3¹ ese³		9		NS NA WA	1164
rs58443802^1,2	C	--	40844756(+)	`TGGGAG/ACCCAT`	1	--	int¹		2		WA	120
rs2234254^1,2	H	--	40845493(-)	`ATAAAG/AGTTCT`	1	--	int¹		4		NS EA	420
rs115121185^1,2	C,F	--	40845697(+)	`CCTTCC/TGCACA`	1	--	int¹		1		WA	118
rs112455001^1,2		--	40845706(+)	`CAGGGG/TCTAAG`	1	--	int¹		1		CSA	2
rs7748513^1,2	C,F,A,H	--	40845772(+)	`TCTACA/GCAAGC`	1	--	int¹		28		NA EA NS WA CSA	2968

HapMap Linkage Disequilibrium report for TREM2 (41126244 - 41130924 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TREM2: --
Human Gene Mutation Database (HGMD): TREM2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TREM2

DNA2.0 Custom Variant and Variant Library Synthesis for TREM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TREM2 for disorders           About GeneDecksing

OMIM gene information: 605086
OMIM disorders: 221770
UniProtKB/Swiss-Prot: TREM2_HUMAN, Q9NZC2

Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy

(PLOSL) [MIM:221770]; also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a

recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile

dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the

patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns

6 diseases for TREM2: About MalaCards

nasu-hakola disease basal ganglia calcification corpus callosum dementia

encephalomyelitis alzheimer's disease

4 Novoseek disease relationships for TREM2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nasu-hakola disease	98.8	9	15883308 (3), 17530208 (2), 16418779 (1), 15049507 (1) (see all 6)
lipomembranous polycystic osteodysplasia	97.7	1	17530208 (1)
bone cysts	85.8	1	15883308 (1)
dementia	42.8	2	15883308 (1), 17530208 (1)

GeneTests: TREM2

Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy

Human Genome Epidemiology (HuGE) Navigator: TREM2 (4 documents)

Export disorders for TREM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TREM2 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with TREM2)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. (PubMed id 12080485)^{1, 2, 3} Paloneva J.... Peltonen L. (2002)
Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PubMed id 10799849)^{1, 2, 3} Bouchon A.... Colonna M. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The surface-exposed chaperone, Hsp60, is an agonist o f the microglial TREM2 receptor. (PubMed id 19457124)^{1, 9} Stefano L....Meldolesi J. (2009)
Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes. (PubMed id 15966270)^{1, 9} Montalbetti L....Soragna D. (2005)
Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response. (PubMed id 17530208)^{1, 9} Kiialainen A....Peltonen L. (2007)
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. (PubMed id 12925681)^{1, 9} Paloneva J....Peltonen L. (2003)
Variant of TREM2 associated with the risk of Alzheimer 's disease. (PubMed id 23150908)¹ Jonsson T....Stefansson K. (2013)
TREM2 variants in Alzheimer's disease. (PubMed id 23150934)¹ Guerreiro R....Hardy J. (2013)
Genome-wide association and population genetic analysi s of C-reactive protein in African American and Hispanic American women. (PubMed id 22939635)¹ Reiner A.P....Tang H. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54209	HGNC: 17761	AceView: TREM2	Ensembl:ENSG00000095970	euGenes: HUgn54209
ECgene: TREM2	Kegg: 54209	H-InvDB: TREM2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TREM2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TREM2

Intellectual Property for TREM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TREM2 gene:
Search GeneIP for patents involving TREM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for TREM2 (TREM-2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for TREM2 (TREM-2)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for TREM2 (TREM-2)

	OriGene Antibodies for TREM2		OriGene shRNA RFP for TREM2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TREM2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TREM2
	OriGene Protein Over-expression Lysate for TREM2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TREM2		OriGene 3'-UTR Clone for TREM2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TREM2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TREM2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TREM2		OriGene Custom Protein Services for TREM2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TREM2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TREM2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREM2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TREM2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TREM2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREM2

	GenScript Custom Purified and Recombinant Proteins Services for TREM2		GenScript cDNA clones with any tag delivered in your preferred vector for TREM2
	GenScript Custom Assay Services for TREM2		GenScript Custom Superior Antibodies Services for TREM2
	GenScript Custom overexpressing Cell Line Services for TREM2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TREM2 promoter
	Search Chromatin IP Primers for TREM2
	RT² qPCR Primer Assay in human, mouse, rat TREM2
	GNC Network for TREM2
	SABiosciences Custom PCR Arrays for TREM2

Search Tocris compounds for TREM2

	Proteins and Antibodies for TREM2
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TREM2 antibodies
	TREM2 proteins
	TREM2 lysates

	Antibodies for TREM2
	See all of Abcam's Antibodies, Kits and Proteins for TREM2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TREM2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TREM2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREM2

	SwitchGear 3'UTR luciferase reporter plasmids for TREM2
	SwitchGear Promoter luciferase reporter plasmids for TREM2

ThermoFisher Antibodies for TREM2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREM2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TREM2

Sirion Biotech Customized:

	stable knockdown cell line services for TREM2
	inducible knockdown cell line services for TREM2
	design and validation of potent shRNA sequences against TREM2
	adenovirus for potent knockdown of TREM2
	adenovirus for overexpression of TREM2
	stable overexpressing cell line services for TREM2
	inducible overexpressing cell line services for TREM2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TREM2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TREM2 Gene

triggering receptor expressed on myeloid cells 2

Aliases
for TREM2 gene

Summaries
for TREM2 gene

Genomic Views
for TREM2 gene

Proteins
for TREM2 gene

Protein Domains /
Families
for TREM2 gene

Function
for TREM2 gene

Pathways & Interactions
for TREM2 gene

Drugs & Compounds
for TREM2 gene

Transcripts
for TREM2 gene

Expression
for TREM2 gene

Orthologs
for TREM2 gene

Paralogs
for TREM2 gene

Genomic Variants
for TREM2 gene

Disorders / Diseases
for TREM2 gene

Publications
for TREM2 gene

External Searches for TREM2 gene

Genome Databases showing TREM2 gene

Other Databases showing TREM2 gene

Specialized Databases showing TREM2 gene

Intellectual Property
for TREM2 gene

Products
for TREM2 gene

View Random Gene

Advanced Search

Export list of displayed genes

TREM2 Gene

triggering receptor expressed on myeloid cells 2

Aliasesfor TREM2 gene

Summariesfor TREM2 gene

Genomic Viewsfor TREM2 gene

Proteinsfor TREM2 gene

Protein Domains /Familiesfor TREM2 gene

Functionfor TREM2 gene

Pathways & Interactionsfor TREM2 gene

Drugs & Compoundsfor TREM2 gene

Transcriptsfor TREM2 gene

Expression for TREM2 gene

Orthologsfor TREM2 gene

Paralogsfor TREM2 gene

Genomic Variantsfor TREM2 gene

Disorders / Diseasesfor TREM2 gene

Publicationsfor TREM2 gene

External Searches for TREM2 gene

Genome Databases showing TREM2 gene

Other Databases showing TREM2 gene

Specialized Databases showing TREM2 gene

Intellectual Propertyfor TREM2 gene

Productsfor TREM2 gene

View Random Gene

Aliases
for TREM2 gene

Summaries
for TREM2 gene

Genomic Views
for TREM2 gene

Proteins
for TREM2 gene

Protein Domains /
Families
for TREM2 gene

Function
for TREM2 gene

Pathways & Interactions
for TREM2 gene

Drugs & Compounds
for TREM2 gene

Transcripts
for TREM2 gene

Expression
for TREM2 gene

Orthologs
for TREM2 gene

Paralogs
for TREM2 gene

Genomic Variants
for TREM2 gene

Disorders / Diseases
for TREM2 gene

Publications
for TREM2 gene

Intellectual Property
for TREM2 gene

Products
for TREM2 gene