Aliases for TREM2 Gene
External Ids for TREM2 Gene
Previous GeneCards Identifiers for TREM2 Gene
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
GeneCards Summary for TREM2 Gene
TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) is a Protein Coding gene. Diseases associated with TREM2 include Nasu-Hakola Disease and Trem2-Related Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy. Among its related pathways are Semaphorin interactions and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor activity and lipopolysaccharide binding.
UniProtKB/Swiss-Prot for TREM2 Gene
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.