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Aliases for TREM1 Gene

Aliases for TREM1 Gene

  • Triggering Receptor Expressed On Myeloid Cells 1 2 3 5
  • Triggering Receptor Expressed On Monocytes 1 3 4
  • TREM-1 3 4
  • CD354 Antigen 4
  • CD354 3

External Ids for TREM1 Gene

Previous GeneCards Identifiers for TREM1 Gene

  • GC06M041245
  • GC06M041290
  • GC06M041351
  • GC06M040962

Summaries for TREM1 Gene

Entrez Gene Summary for TREM1 Gene

  • This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for TREM1 Gene

TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) is a Protein Coding gene. Diseases associated with TREM1 include pneumonia and diffuse cutaneous systemic sclerosis. Among its related pathways are IL-2 Pathway and Immune System. GO annotations related to this gene include receptor activity and scaffold protein binding.

UniProtKB/Swiss-Prot for TREM1 Gene

  • Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

Gene Wiki entry for TREM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREM1 Gene

Genomics for TREM1 Gene

Regulatory Elements for TREM1 Gene

Enhancers for TREM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TREM1 on UCSC Golden Path with GeneCards custom track

Promoters for TREM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TREM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TREM1 Gene

Chromosome:
6
Start:
41,267,385 bp from pter
End:
41,286,719 bp from pter
Size:
19,335 bases
Orientation:
Minus strand

Genomic View for TREM1 Gene

Genes around TREM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREM1 Gene

Proteins for TREM1 Gene

  • Protein details for TREM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP99-TREM1_HUMAN
    Recommended name:
    Triggering receptor expressed on myeloid cells 1
    Protein Accession:
    Q9NP99
    Secondary Accessions:
    • B4DWG2
    • K7EJW1
    • Q53FL8
    • Q5T2C9
    • Q86YU1

    Protein attributes for TREM1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26387 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12.

    Three dimensional structures from OCA and Proteopedia for TREM1 Gene

    Alternative splice isoforms for TREM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREM1 Gene

Proteomics data for TREM1 Gene at MOPED

Post-translational modifications for TREM1 Gene

Other Protein References for TREM1 Gene

Antibody Products

No data available for DME Specific Peptides for TREM1 Gene

Domains & Families for TREM1 Gene

Gene Families for TREM1 Gene

Protein Domains for TREM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP99

UniProtKB/Swiss-Prot:

TREM1_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREM1: view

Function for TREM1 Gene

Molecular function for TREM1 Gene

UniProtKB/Swiss-Prot Function:
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).
genes like me logo Genes that share phenotypes with TREM1: view

Animal Models for TREM1 Gene

MGI Knock Outs for TREM1:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TREM1 Gene

Localization for TREM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREM1 Gene COMPARTMENTS Subcellular localization image for TREM1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 2
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10799849
genes like me logo Genes that share ontologies with TREM1: view

Pathways & Interactions for TREM1 Gene

genes like me logo Genes that share pathways with TREM1: view

Pathways by source for TREM1 Gene

Interacting Proteins for TREM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244709%0d%0a9606.ENSP00000262629%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9NP99-TREM1_HUMAN ENSP00000244709 for TREM1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002374 cytokine secretion involved in immune response IEA --
GO:0016477 cell migration IEA --
GO:0030593 neutrophil chemotaxis IEA --
GO:0042107 cytokine metabolic process IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with TREM1: view

No data available for SIGNOR curated interactions for TREM1 Gene

Drugs & Compounds for TREM1 Gene

(3) Drugs for TREM1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-tartaric acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with TREM1: view

Transcripts for TREM1 Gene

Unigene Clusters for TREM1 Gene

Triggering receptor expressed on myeloid cells 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for TREM1 Gene

GeneLoc Exon Structure for
TREM1
ECgene alternative splicing isoforms for
TREM1

Expression for TREM1 Gene

mRNA expression in normal human tissues for TREM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREM1 Gene

This gene is overexpressed in Whole Blood (x44.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREM1 Gene



SOURCE GeneReport for Unigene cluster for TREM1 Gene Hs.283022

mRNA Expression by UniProt/SwissProt for TREM1 Gene

Q9NP99-TREM1_HUMAN
Tissue specificity: Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
genes like me logo Genes that share expression patterns with TREM1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for TREM1 Gene

Orthologs for TREM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TREM1 35
  • 67.4 (n)
  • 49.78 (a)
TREM1 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TREM1 35
  • 73.88 (n)
  • 59.74 (a)
TREM1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trem1 35
  • 62.88 (n)
  • 46.29 (a)
Trem1 16
Trem1 36
  • 45 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TREM1 35
  • 99.29 (n)
  • 98.72 (a)
TREM1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trem1 35
  • 64.22 (n)
  • 49.15 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
Species with no ortholog for TREM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREM1 Gene

ENSEMBL:
Gene Tree for TREM1 (if available)
TreeFam:
Gene Tree for TREM1 (if available)

Paralogs for TREM1 Gene

Pseudogenes.org Pseudogenes for TREM1 Gene

genes like me logo Genes that share paralogs with TREM1: view

No data available for Paralogs for TREM1 Gene

Variants for TREM1 Gene

Sequence variations from dbSNP and Humsavar for TREM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2234237 - 41,282,728(-) AATTA(A/T)CTGAG reference, missense
rs2234245 - 41,276,188(-) GGATT(C/G)CTGAG intron-variant, reference, missense
VAR_035525 A breast cancer sample
rs34727391 - 41,282,397(+) CACCC(C/G/T)TGGTC reference, missense
rs1351835 -- 41,276,761(-) CTTGC(A/T)TGTCT intron-variant

Variation tolerance for TREM1 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREM1 Gene

HapMap Linkage Disequilibrium report
TREM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TREM1 Gene

Disorders for TREM1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TREM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pneumonia
  • acute pneumonia
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
behcet's disease
  • adamantiades-behcet disease
adenoiditis
  • chronic adenoiditis
- elite association - COSMIC cancer census association via MalaCards
Search TREM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TREM1

Genetic Association Database (GAD)
TREM1
Human Genome Epidemiology (HuGE) Navigator
TREM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREM1
genes like me logo Genes that share disorders with TREM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TREM1 Gene

Publications for TREM1 Gene

  1. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PMID: 10799849) Bouchon A. … Colonna M. (J. Immunol. 2000) 2 3 4 23 67
  2. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. (PMID: 11922939) Gingras M.-C. … Margolin J.F. (Mol. Immunol. 2002) 2 3 23
  3. Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes. (PMID: 19109693) Dimopoulou I. … Giamarellos-Bourboulis E.J. (Inflamm. Res. 2009) 3 23
  4. Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. (PMID: 19479878) Murakami Y. … Kohsaka H. (Arthritis Rheum. 2009) 3 23
  5. TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. (PMID: 19596984) Lagler H. … Knapp S. (J. Immunol. 2009) 3 23

Products for TREM1 Gene

Sources for TREM1 Gene

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