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TREM1 Gene

protein-coding   GIFtS: 59
GCID: GC06M041243

Triggering Receptor Expressed On Myeloid Cells 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Triggering Receptor Expressed On Myeloid Cells 11 2
Triggering Receptor Expressed On Monocytes 12 3
TREM-12 3
CD3542
Triggering-Receptor TREM12
CD354 Antigen3

External Ids:    HGNC: 177601   Entrez Gene: 542102   Ensembl: ENSG000001247317   OMIM: 6050855   UniProtKB: Q9NP993   

Export aliases for TREM1 gene to outside databases

Previous GC identifers: GC06M041245 GC06M041290 GC06M041351 GC06M040962


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TREM1 Gene:
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein
amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by
stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell
activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for
this gene.(provided by RefSeq, Jun 2011)

GeneCards Summary for TREM1 Gene:
TREM1 (triggering receptor expressed on myeloid cells 1) is a protein-coding gene. Diseases associated with TREM1 include acute cholangitis, and suppurative cholangitis. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99
Function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory
chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of
inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic
shock

Gene Wiki entry for TREM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TREM1 gene promoter:
         ISGF-3   AP-1   Brachyury   Bach2   STAT5A   Nkx2-5   Roaz   AREB6   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTREM1 promoter sequence
   Search Chromatin IP Primers for TREM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TREM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TREM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREM1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041243:  view genomic region     (about GC identifiers)

Start:
41,235,664 bp from pter      End:
41,254,457 bp from pter
Size:
18,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99 (See protein sequence)
Recommended Name: Triggering receptor expressed on myeloid cells 1 precursor  
Size: 234 amino acids; 26387 Da
Subunit: Interacts with TYROBP/DAP12
2 PDB 3D structures from and Proteopedia for TREM1:
1Q8M (3D)        1SMO (3D)    
Secondary accessions: B4DWG2 Q53FL8 Q5T2C9 Q86YU1
Alternative splicing: 2 isoforms:  Q9NP99-1   Q9NP99-2   

Explore the universe of human proteins at neXtProt for TREM1: NX_Q9NP99

Explore proteomics data for TREM1 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn146, Asn191, Asn194
  • Modification sites at PhosphoSitePlus

  • See TREM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229518.1  NP_001229519.1  NP_061113.1  

    ENSEMBL proteins: 
     ENSP00000465688   ENSP00000244709   ENSP00000334284   ENSP00000465345  
    Reactome Protein details: Q9NP99

    TREM1 Human Recombinant Protein Products:

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    TREM1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9NP99

    ProtoNet protein and cluster: Q9NP99

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    TREM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TREM1_HUMAN, Q9NP99
    Function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory
    chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of
    inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic
    shock
    Induction: Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10799849
         
    TREM1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trem1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     tumorigenesis 

    TREM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trem1/Trem3Trem1/tm1.1Jkt for TREM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TREM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TREM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TREM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TREM1

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    hsa-miR-224 hsa-miR-642a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidTREM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TREM1

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    GenScript: all cDNA clones in your preferred vector: TREM1 (NM_018643)
    Sino Biological Human cDNA Clone for TREM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TREM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREM1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TREM1_HUMAN, Q9NP99: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
    TREM1_HUMAN, Q9NP99: Isoform 2: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    mitochondrion2
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    TREM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TREM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    DAP12 interactions0.89
    2Hemostasis
    Hemostasis0.43
    3ErbB4 Pathway
    TREM1 Pathway0.43
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TREM1
        TREM1 Pathway


    2 Reactome Pathways for TREM1
        DAP12 interactions
    Cell surface interactions at the vascular wall



    TREM1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TREM1
    Interactions:

        GeneGlobe Interaction Network for TREM1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for TREM1 (Q9NP993 ENSP000002447094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPO439143, ENSP000002626294I2D: score=3 STRING: ENSP00000262629
    TLR4O002063I2D: score=1 
    CD8BENSP000003311724STRING: ENSP00000331172
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000003935494STRING: ENSP00000393549
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006959humoral immune response TAS10799849
    GO:0007596blood coagulation TAS--
    GO:0035556intracellular signal transduction TAS10799849
    GO:0045087innate immune response TAS--
    GO:0050900leukocyte migration TAS--

    TREM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TREM1

    1 DrugBank Compound for TREM1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-tartaric acid(-)-Tartaric acid (see all 7)147-71-7target--17139284 17016423

    2 Novoseek inferred chemical compound relationships for TREM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 10799849 (1), 16809329 (1)
    tyrosine 0 3 17277102 (1), 10799849 (1)



    TREM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TREM1 gene (3 alternative transcripts): 
    NM_001242589.1  NM_001242590.1  NM_018643.3  

    Unigene Cluster for TREM1:

    Triggering receptor expressed on myeloid cells 1
    Hs.283022  [show with all ESTs]
    Unigene Representative Sequence: NM_001242589
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589614 ENST00000244709(uc003oqf.2 uc021yzj.1) ENST00000334475(uc003oqg.2)
    ENST00000589695 ENST00000591620 ENST00000589882 ENST00000586287
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TREM1:
    hsa-miR-224 hsa-miR-642a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidTREM1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TREM1 (NM_018643)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TREM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TREM1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TREM1
      QuantiTect SYBR Green Assays in human, mouse, rat TREM1
      QuantiFast Probe-based Assays in human, mouse, rat TREM1

    Additional mRNA sequence: 

    AF196329.1 AF287008.1 AK130673.1 AK223264.1 AK292162.1 AK301519.1 AK313104.1 AY074783.1 
    BC017773.1 

    7 DOTS entries:

    DT.100812081  DT.97841251  DT.121384918  DT.97841252  DT.86848518  DT.91817433  DT.92418867 

    Selected AceView cDNA sequences (see all 87):

    AK130673 BQ011675 BQ011708 BQ011079 BQ011159 BQ012111 BG235928 CF530027 
    AW467992 BQ012042 AW630450 BQ011659 CF529059 BQ013123 C01665 AI621023 
    BQ018212 BX098268 CF529924 AI186456 AA101983 BU754028 BQ011087 CA307479 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TREM1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:                          -           -               
    SP2:                          -                           
    SP3:                          -     -     -               
    SP4:                                                      


    ECgene alternative splicing isoforms for TREM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TREM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTAAATCT
    TREM1 Expression
    About this image


    TREM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lung (Respiratory System)
     
     Placenta (Extraembryonic Tissues)
    TREM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TREM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283022

    UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99
    Tissue specificity: Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also
    expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral
    blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the
    early development of the hematopoietic system and in the promonocytic stage and at high levels in mature
    monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected
    in the lung, liver and mature monocytes

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    QuantiFast Probe-based Assays in human, mouse, rat TREM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TREM1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trem11 , 5 triggering receptor expressed on myeloid cells 11, 5 62.88(n)1
    46.29(a)1
      17 (23.99 cM)5
    582171  NM_021406.51  NP_067381.11 
     482327685 


    ENSEMBL Gene Tree for TREM1 (if available)
    TreeFam Gene Tree for TREM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TREM1 gene

    TREM1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TREM1
    PGOHUM00000243621


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TREM1 (see all 336)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355254
    A breast cancer sample4--see VAR_0355252 R S mis40--------
    rs1468905371,2
    C--41153297(+) TCCCCA/GTGCAG 2 -- ds50010--------
    rs1397628941,2
    --41153323(+) GAAGTA/GGTGCT 2 -- ds50010--------
    rs1444569141,2
    --41153412(+) AATATC/TTGCCC 2 -- ds50010--------
    rs1465526881,2
    --41153453(+) CACCAA/TCCTTT 2 -- ds50010--------
    rs1840767251,2
    --41153654(+) ACTGAC/GAGAAG 2 -- ds50010--------
    rs1491287211,2
    C--41153670(+) GAGGGA/CAGAGT 2 -- ds50010--------
    rs69140901,2
    C,F,A,H--41153737(+) TTTACT/CCCACC 2 -- ds500110Minor allele frequency- C:0.37NA WA CSA EA 372
    rs1433068551,2
    --41153775(+) AAGAGA/GCATTT 2 -- ut310--------
    rs1112741871,2
    F--41153791(+) CAGGCG/AGAACT 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TREM1 (41235664 - 41254457 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TREM1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TREM1
    DNA2.0 Custom Variant and Variant Library Synthesis for TREM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605085    OMIM disorders: --

    Selected diseases for TREM1 (see all 39):    
    About MalaCards
    acute cholangitis    suppurative cholangitis    septic arthritis    melioidosis
    septic shock    sepsis    chorioamnionitis    cholangitis
    peptic ulcer    allergic asthma    pneumonia    acute pancreatitis
    burns    behcet's disease    ankylosing spondylitis    spondylitis
    neutropenia    peritonitis    pulmonary fibrosis    inflammatory bowel disease

    1 disease from the University of Copenhagen DISEASES database for TREM1:
    Pneumonia

    TREM1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TREM1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sepsis 65.2 35 18396215 (6), 17343659 (3), 16622220 (3), 16437719 (3) (see all 17)
    shock septic 63 11 11323674 (2), 15557347 (1), 19109693 (1), 15754199 (1) (see all 7)
    systemic inflammatory response syndrome 56.9 2 15238365 (1)
    inflammation 52.8 17 18321350 (2), 19596984 (2), 19149696 (1), 17853946 (1) (see all 15)
    bacterial infections 43.4 8 19596984 (2), 19149696 (1), 19479878 (1), 12792857 (1)
    necrosis 32.3 10 18321350 (1), 19054829 (1), 18096709 (1), 16809329 (1) (see all 5)
    pneumonia 24.3 5 16960786 (2), 15332392 (2), 17659879 (1), 19596984 (1)
    critically ill 24.2 3 17343659 (1), 15238365 (1)
    shock 5.46 1 11323674 (1)
    tumors 0 7 18096709 (1), 16809329 (1), 19403498 (1)

    Genetic Association Database (GAD): TREM1
    Human Genome Epidemiology (HuGE) Navigator: TREM1 (9 documents)

    Export disorders for TREM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TREM1 gene, integrated from 10 sources (see all 134):
    (articles sorted by number of sources associating them with TREM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PubMed id 10799849)1, 2, 3, 9 Bouchon A.... Colonna M. (J. Immunol. 2000)
    2. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. (PubMed id 11922939)1, 2, 3, 9 Gingras M.-C.... Margolin J.F. (Mol. Immunol. 2002)
    3. Lack of association between TREM-1 gene polymorphisms and severe sepsis in a Chinese Han population. (PubMed id 18396215)1, 4, 9 Chen Q....Fang X. (Hum. Immunol. 2008)
    4. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. (PubMed id 15351648)1, 2, 9 Kelker M.S....Wilson I.A. (J. Mol. Biol. 2004)
    5. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. (PubMed id 11323674)1, 2, 9 Bouchon A.... Colonna M. (Nature 2001)
    6. Crystal structure of the human myeloid cell activating receptor TREM- 1. (PubMed id 14656437)1, 2, 9 Radaev S.... Sun P.D. (Structure 2003)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    9. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    10. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54210 HGNC: 17760 AceView: TREM1 Ensembl:ENSG00000124731 euGenes: HUgn54210
    ECgene: TREM1 H-InvDB: TREM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TREM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TREM1 gene:
    Search GeneIP for patents involving TREM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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