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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TREM1 Gene

protein-coding   GIFtS: 56
GCID: GC06M041243

triggering receptor expressed on myeloid cells 1

 Explore 31 diseases affiliated with
TREM1 via our new
 Human Malady Compendium 
Biological research products
for TREM1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Triggering Receptor Expressed On Myeloid Cells 11 2
TREM-11 2 3
CD3541 2
Triggering Receptor Expressed On Monocytes 12 3
Triggering-Receptor TREM12
CD354 Antigen3

External Ids:    HGNC: 177601   Entrez Gene: 542102   Ensembl: ENSG000001247317   OMIM: 6050855   UniProtKB: Q9NP993   

Export aliases for TREM1 gene to outside databases

Previous GC identifers: GC06M041245 GC06M041290 GC06M041351 GC06M040962


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TREM1:
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies
neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating
release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation
markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.(provided
by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99
Function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory
chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of
inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock

Gene Wiki entry for TREM1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TREM1 gene promoter:
         ISGF-3   AP-1   Brachyury   Bach2   STAT5A   Nkx2-5   Roaz   AREB6   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTREM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TREM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TREM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TREM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREM1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041243:  view genomic region     (about GC identifiers)

Start:
41,235,664 bp from pter      End:
41,254,457 bp from pter
Size:
18,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99 (See protein sequence)
Recommended Name: Triggering receptor expressed on myeloid cells 1 precursor  
Size: 234 amino acids; 26387 Da
Subunit: Interacts with TYROBP/DAP12
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 2: Secreted (Potential)
2 PDB 3D structures from and Proteopedia for TREM1:
1Q8M (3D)        1SMO (3D)    
Secondary accessions: B4DWG2 Q53FL8 Q5T2C9 Q86YU1
Alternative splicing: 2 isoforms:  Q9NP99-1   Q9NP99-2   

Explore the universe of human proteins at neXtProt for TREM1: NX_Q9NP99

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NP99

  • TREM1 Protein expression data from MOPED and PaxDb:    About this image 
    TREM1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001229518.1  NP_001229519.1  NP_061113.1  

    ENSEMBL proteins: 
     ENSP00000465688   ENSP00000244709   ENSP00000334284   ENSP00000465345  
    Reactome Protein details: Q9NP99
    Human Recombinant Protein Products for TREM1: 
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    Novus Biologicals TREM1 Proteins
    Novus Biologicals TREM1 Lysates
    Sino Biological Recombinant Protein for TREM1
    ProSpec Recombinant Protein for TREM1
    Uscn Proteins for TREM1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    TREM1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TREM1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TREM1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9NP99

    ProtoNet protein and cluster: Q9NP99

    2 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TREM1_HUMAN, Q9NP99
    Function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory
    chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of
    inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock
    Induction: Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10799849
         
    TREM1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trem1):
     hematopoietic system  homeostasis/metabolism  immune system  tumorigenesis 

    TREM1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TREM1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTREM1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    Immune System1.00
    Innate Immune System0.46
    2Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall1.00
    3Signaling by FGFR
    DAP12 interactions0.76
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5ErbB4 Pathway
    TREM1 Pathway0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TREM1
        TREM1 Pathway

    5        Reactome Pathways for TREM1
        Hemostasis
    DAP12 interactions
    Cell surface interactions at the vascular wall
    Immune System
    Innate Immune System



    TREM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TREM1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for TREM1 (Q9NP993 ENSP000002447094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPO439143, ENSP000002626294I2D: score=3 STRING: ENSP00000262629
    TLR4O002063I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006959humoral immune response TAS10799849
    GO:0007596blood coagulation TAS--
    GO:0035556intracellular signal transduction TAS10799849
    GO:0050900leukocyte migration TAS--

    TREM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TREM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TREM1

    1 DrugBank Compound for TREM1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-tartaric acid(-)-Tartaric acid (see all 7)147-71-7target--17139284 17016423

    2 Novoseek chemical compound relationships for TREM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 10799849 (1), 16809329 (1)
    tyrosine 0 3 17277102 (1), 10799849 (1)

    Search CenterWatch for drugs/clinical trials and news about TREM1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TREM1 gene (3 alternative transcripts): 
    NM_001242589.1  NM_001242590.1  NM_018643.3  

    Unigene Cluster for TREM1:

    Triggering receptor expressed on myeloid cells 1
    Hs.283022  [show with all ESTs]
    Unigene Representative Sequence: NM_001242589
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589614 ENST00000244709(uc003oqf.2 uc021yzj.1) ENST00000334475(uc003oqg.2)
    ENST00000589695 ENST00000591620 ENST00000589882 ENST00000586287

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TREM1:
    hsa-miR-224 hsa-miR-642a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidTREM1 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TREM1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TREM1
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    Additional cDNA sequence: 

    AF196329.1 AF287008.1 AK130673.1 AK223264.1 AK292162.1 AK301519.1 AK313104.1 AY074783.1 
    BC017773.1 

    7 DOTS entries:

    DT.100812081  DT.97841251  DT.121384918  DT.97841252  DT.86848518  DT.91817433  DT.92418867 

    24/87 AceView cDNA sequences (see all 87):

    AA101983 AW467992 CF530027 BQ011159 BX098268 BU754028 BQ012111 AI621023 
    AW630450 BQ013123 BQ011659 BQ012042 BQ011079 CF529924 BQ011708 BQ011675 
    C01665 BQ018212 AK130673 AI186456 BG235928 CF529059 CA307479 BE348713 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TREM1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:                          -           -               
    SP2:                          -                           
    SP3:                          -     -     -               
    SP4:                                                      


    ECgene alternative splicing isoforms for TREM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TREM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTAAATCT
    TREM1 Expression
    About this image
    See TREM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TREM1

    SOURCE GeneReport for Unigene cluster: Hs.283022

    UniProtKB/Swiss-Prot: TREM1_HUMAN, Q9NP99
    Tissue specificity: Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed
    in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes
    than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of
    the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in
    acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature
    monocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TREM1 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trem11 , 5 triggering receptor expressed on myeloid cells 11, 5 62.88(n)1
    46.29(a)1
      17 (23.99 cM)5
    582171  NM_021406.51  NP_067381.11 
     482327685 


    ENSEMBL Gene Tree for TREM1 (if available)
    TreeFam Gene Tree for TREM1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TREM1 gene

    TREM1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TREM1
    PGOHUM00000243621


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/276 NCBI SNPs in TREM1 are shown (see all 276    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1112741871,2
    --40961545(+) CAGGCG/AGAACT 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1128063801,2
    F--40961649(+) GCCTCG/ATTCTA 2 -- ut313Minor allele frequency- A:0.26CSA WA 122
    rs168943901,2
    C,F,H--40961708(+) AAATGC/TACACA 2 -- ut3110Minor allele frequency- T:0.05NA NS EA WA 558
    rs1841362471,2
    C--40961923(+) AAGTGC/TCTGAT 2 -- ut310--------
    rs768337341,2
    F--40962084(+) AATTAC/TGGTGA 2 -- ut313Minor allele frequency- T:0.24CSA WA 122
    rs26275631,2
    H--40962251(-) TATTTC/TTAAAG 2 -- ut31 ese34Minor allele frequency- T:0.00NS EA 410
    rs28034901,2
    H--40962356(+) AGTCAG/AAGGAC 2 -- ut31 ese34Minor allele frequency- A:0.00NS EA 418
    rs69414351,2
    C,F--40962922(+) TTTGGC/AGAAAT 2 -- int13Minor allele frequency- A:0.22CSA WA 122
    rs1161346921,2
    C,F--40963849(+) ACTCCT/CGGGGC 2 -- int11Minor allele frequency- C:0.04WA 118
    rs117568231,2
    H--40964885(+) ccagcC/Ttgatt 2 -- int10--------

    HapMap Linkage Disequilibrium report for TREM1 (41235664 - 41254457 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TREM1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TREM1
    DNA2.0 Custom Variant and Variant Library Synthesis for TREM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TREM1 for disorders           About GeneDecksing

    OMIM gene information: 605085    OMIM disorders: --

    20/31 diseases for TREM1 (see all 31):    About MalaCards
    suppurative cholangitis    chronic obstructive pulmonary disease    ankylosing spondylitis    cholangitis
    peptic ulcer    systemic lupus erythematosus    lupus erythematosus    septic arthritis
    inflammatory bowel disease    melioidosis    acute cholangitis    spondylitis
    cystic fibrosis    behcet's disease    pulmonary disease    pulmonary fibrosis
    fibrosis    pneumonia    sepsis    hepatitis b

    1 disease from the University of Copenhagen DISEASES database for TREM1:
    Pneumonia

    10/11 Novoseek disease relationships for TREM1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sepsis 65.2 35 18396215 (6), 17343659 (3), 16622220 (3), 16437719 (3) (see all 17)
    shock septic 63 11 11323674 (2), 15557347 (1), 19109693 (1), 15754199 (1) (see all 7)
    systemic inflammatory response syndrome 56.9 2 15238365 (1)
    inflammation 52.8 17 18321350 (2), 19596984 (2), 19149696 (1), 17853946 (1) (see all 15)
    bacterial infections 43.4 8 19596984 (2), 19149696 (1), 19479878 (1), 12792857 (1)
    necrosis 32.3 10 18321350 (1), 19054829 (1), 18096709 (1), 16809329 (1) (see all 5)
    pneumonia 24.3 5 16960786 (2), 15332392 (2), 17659879 (1), 19596984 (1)
    critically ill 24.2 3 17343659 (1), 15238365 (1)
    shock 5.46 1 11323674 (1)
    tumors 0 7 18096709 (1), 16809329 (1), 19403498 (1)

    Human Genome Epidemiology (HuGE) Navigator: TREM1 (9 documents)

    Export disorders for TREM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TREM1 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with TREM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PubMed id 10799849)1, 2, 3, 9 Bouchon A.... Colonna M. (2000)
    2. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. (PubMed id 11922939)1, 2, 3, 9 Gingras M.-C.... Margolin J.F. (2002)
    3. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. (PubMed id 15351648)1, 2, 9 Kelker M.S....Wilson I.A. (2004)
    4. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. (PubMed id 11323674)1, 2, 9 Bouchon A.... Colonna M. (2001)
    5. Crystal structure of the human myeloid cell activating receptor TREM- 1. (PubMed id 14656437)1, 2, 9 Radaev S.... Sun P.D. (2003)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous prostaglandin E2. (PubMed id 17202378)1, 9 Murakami Y....Akahoshi T. (2007)
    9. Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery. (PubMed id 16437719)1, 9 Gonzalez-Roldan N....Isibasi A. (2005)
    10. Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis. (PubMed id 18008257)1, 9 Wiersinga W.J....van der Poll T. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54210 HGNC: 17760 AceView: TREM1 Ensembl:ENSG00000124731 euGenes: HUgn54210
    ECgene: TREM1 H-InvDB: TREM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TREM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TREM1 gene:
    Search GeneIP for patents involving TREM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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