Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TREM1 Gene

Aliases for TREM1 Gene

  • Triggering Receptor Expressed On Myeloid Cells 1 2 3
  • Triggering Receptor Expressed On Monocytes 1 3 4
  • TREM-1 3 4
  • Triggering-Receptor TREM1 3
  • CD354 Antigen 4
  • CD354 3

External Ids for TREM1 Gene

Previous GeneCards Identifiers for TREM1 Gene

  • GC06M041245
  • GC06M041290
  • GC06M041351
  • GC06M040962

Summaries for TREM1 Gene

Entrez Gene Summary for TREM1 Gene

  • This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for TREM1 Gene

TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) is a Protein Coding gene. Diseases associated with TREM1 include acute cholangitis and suppurative cholangitis. Among its related pathways are Signaling by FGFR and Hemostasis. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TREM1 Gene

  • Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

Gene Wiki entry for TREM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREM1 Gene

Genomics for TREM1 Gene

Regulatory Elements for TREM1 Gene

Genomic Location for TREM1 Gene

Start:
41,267,386 bp from pter
End:
41,286,719 bp from pter
Size:
19,334 bases
Orientation:
Minus strand

Genomic View for TREM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TREM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREM1 Gene

Proteins for TREM1 Gene

  • Protein details for TREM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP99-TREM1_HUMAN
    Recommended name:
    Triggering receptor expressed on myeloid cells 1
    Protein Accession:
    Q9NP99
    Secondary Accessions:
    • B4DWG2
    • K7EJW1
    • Q53FL8
    • Q5T2C9
    • Q86YU1

    Protein attributes for TREM1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26387 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12.

    Three dimensional structures from OCA and Proteopedia for TREM1 Gene

    Alternative splice isoforms for TREM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREM1 Gene

Proteomics data for TREM1 Gene at MOPED

Post-translational modifications for TREM1 Gene

Other Protein References for TREM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TREM1 Gene

Domains for TREM1 Gene

Gene Families for TREM1 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for TREM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP99

UniProtKB/Swiss-Prot:

TREM1_HUMAN :
  • Q9NP99
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TREM1: view

Function for TREM1 Gene

Molecular function for TREM1 Gene

UniProtKB/Swiss-Prot Function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
UniProtKB/Swiss-Prot Induction: Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10799849
GO:0097110 scaffold protein binding IPI 11602640
genes like me logo Genes that share ontologies with TREM1: view
genes like me logo Genes that share phenotypes with TREM1: view

Animal Models for TREM1 Gene

MGI Knock Outs for TREM1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TREM1 Gene

Localization for TREM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREM1 Gene COMPARTMENTS Subcellular localization image for TREM1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 2
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TREM1: view

Pathways for TREM1 Gene

genes like me logo Genes that share pathways with TREM1: view

Pathways by source for TREM1 Gene

1 Qiagen pathway for TREM1 Gene

Interacting Proteins for TREM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244709%0d%0a9606.ENSP00000262629%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000244709 Q9NP99-TREM1_HUMAN for TREM1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0002374 cytokine secretion involved in immune response IEA --
GO:0006959 humoral immune response TAS 10799849
GO:0007596 blood coagulation TAS --
GO:0016477 cell migration --
genes like me logo Genes that share ontologies with TREM1: view

Compounds for TREM1 Gene

(1) Drugbank Compounds for TREM1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
D-tartaric acid
  • (-)-Tartaric acid
147-71-7 target

(2) Novoseek inferred chemical compound relationships for TREM1 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
tyrosine 0 2
genes like me logo Genes that share compounds with TREM1: view

Transcripts for TREM1 Gene

Unigene Clusters for TREM1 Gene

Triggering receptor expressed on myeloid cells 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for TREM1 Gene

GeneLoc Exon Structure for
TREM1
ECgene alternative splicing isoforms for
TREM1

Expression for TREM1 Gene

mRNA expression in normal human tissues for TREM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREM1 Gene

This gene is overexpressed in Whole Blood (44.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TREM1 Gene

SOURCE GeneReport for Unigene cluster for TREM1 Gene Hs.283022

mRNA Expression by UniProt/SwissProt for TREM1 Gene

Q9NP99-TREM1_HUMAN
Tissue specificity: Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.
genes like me logo Genes that share expressions with TREM1: view

Orthologs for TREM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREM1 35
  • 99.29 (n)
  • 98.72 (a)
TREM1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TREM1 35
  • 67.4 (n)
  • 49.78 (a)
TREM1 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TREM1 35
  • 73.88 (n)
  • 59.74 (a)
TREM1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trem1 35
  • 62.88 (n)
  • 46.29 (a)
Trem1 16
Trem1 36
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trem1 35
  • 64.22 (n)
  • 49.15 (a)
Species with no ortholog for TREM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREM1 Gene

ENSEMBL:
Gene Tree for TREM1 (if available)
TreeFam:
Gene Tree for TREM1 (if available)

Paralogs for TREM1 Gene

Pseudogenes.org Pseudogenes for TREM1 Gene

genes like me logo Genes that share paralogs with TREM1: view

No data available for Paralogs for TREM1 Gene

Variants for TREM1 Gene

Sequence variations from dbSNP and Humsavar for TREM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs715862 -- 41,272,934(+) GGGGG(C/G)ACAGG intron-variant
rs1351835 -- 41,276,761(-) CTTGC(A/T)TGTCT intron-variant
rs1471742 -- 41,268,181(-) TGTTG(C/G)AGAGG intron-variant
rs1471743 -- 41,268,141(-) TTGCC(C/T)ATCTC intron-variant
rs1817537 -- 41,276,829(-) CCTTT(C/G)TGTTC intron-variant

Relevant External Links for TREM1 Gene

HapMap Linkage Disequilibrium report
TREM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TREM1 Gene

Disorders for TREM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TREM1 Gene including...

Search for TREM1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TREM1 Gene

(11) Novoseek inferred disease relationships for TREM1 Gene

Disease -log(P) Hits PubMed IDs
sepsis 65.2 30
shock septic 63 8
systemic inflammatory response syndrome 56.9 1
inflammation 52.8 17
bacterial infections 43.4 5

Relevant External Links for TREM1

Genetic Association Database (GAD)
TREM1
Human Genome Epidemiology (HuGE) Navigator
TREM1
genes like me logo Genes that share disorders with TREM1: view

No data available for UniProtKB/Swiss-Prot for TREM1 Gene

Publications for TREM1 Gene

  1. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PMID: 10799849) Bouchon A. … Colonna M. (J. Immunol. 2000) 2 3 4 23
  2. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. (PMID: 11922939) Gingras M.-C. … Margolin J.F. (Mol. Immunol. 2002) 2 3 4 23
  3. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. (PMID: 11323674) Bouchon A. … Colonna M. (Nature 2001) 3 4 23
  4. Crystal structure of the human myeloid cell activating receptor TREM- 1. (PMID: 14656437) Radaev S. … Sun P.D. (Structure 2003) 3 4 23
  5. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. (PMID: 15351648) Kelker M.S. … Wilson I.A. (J. Mol. Biol. 2004) 3 4 23

Products for TREM1 Gene

Sources for TREM1 Gene

Back to Top

Content