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Aliases for TREH Gene

Aliases for TREH Gene

  • Trehalase 2 3 5
  • Alpha,Alpha-Trehalose Glucohydrolase 2 3 4
  • Trehalase (Brush-Border Membrane Glycoprotein) 2 3
  • Alpha,Alpha-Trehalase 2 4
  • EC 4 63
  • TREA 3 4
  • TRE 3

External Ids for TREH Gene

Previous GeneCards Identifiers for TREH Gene

  • GC11M120885
  • GC11M120040
  • GC11M118066
  • GC11M118034
  • GC11M118528
  • GC11M114466

Summaries for TREH Gene

Entrez Gene Summary for TREH Gene

  • This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TREH Gene

TREH (Trehalase) is a Protein Coding gene. Diseases associated with TREH include Diarrhea-Vomiting Due To Trehalase Deficiency and Trehalase Deficiency. Among its related pathways are Glycosaminoglycan metabolism and Digestion of dietary carbohydrate. GO annotations related to this gene include alpha,alpha-trehalase activity.

UniProtKB/Swiss-Prot for TREH Gene

  • Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREH Gene

Genomics for TREH Gene

Regulatory Elements for TREH Gene

Enhancers for TREH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TREH on UCSC Golden Path with GeneCards custom track

Promoters for TREH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TREH on UCSC Golden Path with GeneCards custom track

Genomic Location for TREH Gene

118,657,316 bp from pter
118,679,690 bp from pter
22,375 bases
Minus strand

Genomic View for TREH Gene

Genes around TREH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREH Gene

Proteins for TREH Gene

  • Protein details for TREH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q32MB9
    • Q53FY8

    Protein attributes for TREH Gene

    583 amino acids
    Molecular mass:
    66568 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for TREH Gene


neXtProt entry for TREH Gene

Proteomics data for TREH Gene at MOPED

Selected DME Specific Peptides for TREH Gene

Post-translational modifications for TREH Gene

  • Glycosylation at Asn 78, Asn 239, Asn 261, and Asn 369
  • Modification sites at PhosphoSitePlus

Other Protein References for TREH Gene

Antibody Products

Domains & Families for TREH Gene

Protein Domains for TREH Gene

Suggested Antigen Peptide Sequences for TREH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 37 family.
  • Belongs to the glycosyl hydrolase 37 family.
genes like me logo Genes that share domains with TREH: view

No data available for Gene Families for TREH Gene

Function for TREH Gene

Molecular function for TREH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose.
UniProtKB/Swiss-Prot Function:
Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.

Enzyme Numbers (IUBMB) for TREH Gene

genes like me logo Genes that share phenotypes with TREH: view

Human Phenotype Ontology for TREH Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TREH Gene

MGI Knock Outs for TREH:

Animal Model Products

miRNA for TREH Gene

miRTarBase miRNAs that target TREH

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TREH Gene

Localization for TREH Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREH Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for TREH Gene COMPARTMENTS Subcellular localization image for TREH gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TREH Gene

Pathways & Interactions for TREH Gene

genes like me logo Genes that share pathways with TREH: view

Pathways by source for TREH Gene

1 BioSystems pathway for TREH Gene
2 KEGG pathways for TREH Gene

Gene Ontology (GO) - Biological Process for TREH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005993 trehalose catabolic process TAS 9427547
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with TREH: view

No data available for SIGNOR curated interactions for TREH Gene

Drugs & Compounds for TREH Gene

(5) Drugs for TREH Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma 0

(13) Additional Compounds for TREH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • alpha,alpha-Trehalose
  • D-Trehalose-anhydrous
  • delta-Trehalose-anhydrous
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
Uridine diphosphate glucose
  • (UDP)glucose
  • (UPD)-glucose
  • UDP Glucose
  • UDP-a-D-Glucose
  • UDP-alpha-D-Glucose
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with TREH: view

Transcripts for TREH Gene

Unigene Clusters for TREH Gene

Trehalase (brush-border membrane glycoprotein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREH Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP5: -

Relevant External Links for TREH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TREH Gene

mRNA expression in normal human tissues for TREH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREH Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.4) and Kidney - Cortex (x8.6).

Protein differential expression in normal tissues from HIPED for TREH Gene

This gene is overexpressed in Urine (44.3) and Serum (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TREH Gene

SOURCE GeneReport for Unigene cluster for TREH Gene Hs.129712

genes like me logo Genes that share expression patterns with TREH: view

Protein tissue co-expression partners for TREH Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TREH Gene

Orthologs for TREH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TREH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TREH 35
  • 84.62 (n)
  • 83.9 (a)
  • 83 (a)
(Canis familiaris)
Mammalia TREH 35
  • 84.79 (n)
  • 82.48 (a)
  • 82 (a)
(Mus musculus)
Mammalia Treh 35
  • 82.66 (n)
  • 82.54 (a)
Treh 16
Treh 36
  • 82 (a)
(Pan troglodytes)
Mammalia TREH 35
  • 99.31 (n)
  • 99.14 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Treh 35
  • 83.01 (n)
  • 82.54 (a)
(Monodelphis domestica)
Mammalia TREH 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TREH 36
  • 54 (a)
(Anolis carolinensis)
Reptilia TREH 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia treh 35
  • 59.5 (n)
  • 55.89 (a)
(Danio rerio)
Actinopterygii Dr.14709 35
treh 35
  • 60.51 (n)
  • 54.48 (a)
treh 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2295 35
fruit fly
(Drosophila melanogaster)
Insecta Treh 37
  • 43 (a)
Treh 35
  • 54.47 (n)
  • 44.73 (a)
CG6262 36
  • 19 (a)
Treh 36
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012053 35
  • 54.81 (n)
  • 46.46 (a)
(Caenorhabditis elegans)
Secernentea tre-3 35
  • 48.69 (n)
  • 42.26 (a)
tre-1 36
  • 39 (a)
tre-2 36
  • 31 (a)
tre-3 36
  • 37 (a)
tre-4 36
  • 32 (a)
tre-5 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTH1 36
  • 18 (a)
NTH2 36
  • 17 (a)
NTH2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TRE1 35
  • 47.12 (n)
  • 37.35 (a)
(Oryza sativa)
Liliopsida Os10g0521000 35
  • 48.18 (n)
  • 40.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00943 35
  • 50 (n)
  • 41.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for TREH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TREH Gene

Gene Tree for TREH (if available)
Gene Tree for TREH (if available)

Paralogs for TREH Gene Pseudogenes for TREH Gene

genes like me logo Genes that share paralogs with TREH: view

No data available for Paralogs for TREH Gene

Variants for TREH Gene

Sequence variations from dbSNP and Humsavar for TREH Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2276065 - 118,659,902(+) GACTG(C/T)GTTCA reference, missense
rs11827611 - 118,659,457(+) CCCAT(A/G)CTGGT reference, missense
rs2276064 - 118,658,994(+) GGCCC(A/G)ACGTA reference, missense
VAR_049208 -
VAR_061191 -

Structural Variations from Database of Genomic Variants (DGV) for TREH Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294
nsv832283 CNV Loss 17160897
nsv898415 CNV Loss 21882294
esv2745124 CNV Deletion 23290073
esv2674547 CNV Deletion 23128226

Variation tolerance for TREH Gene

Gene Damage Index Score: 6.88; 79.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREH Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREH Gene

Disorders for TREH Gene

MalaCards: The human disease database

(7) MalaCards diseases for TREH Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diarrhea-vomiting due to trehalase deficiency
  • isolated trehalose intolerance
trehalase deficiency
  • trehalase
gastrointestinal defects and immunodeficiency syndrome
  • multiple intestinal atresia
  • vulvo-vaginitis
lactose intolerance
  • lm - lactose malabsorption
- elite association - COSMIC cancer census association via MalaCards
Search TREH in MalaCards View complete list of genes associated with diseases


  • Note=Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms.

Relevant External Links for TREH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TREH: view

No data available for Genatlas for TREH Gene

Publications for TREH Gene

  1. Molecular cloning, sequencing and expression of cDNA encoding human trehalase. (PMID: 9427547) Ishihara R. … Kobayashi Y. (Gene 1997) 2 3 4 23 67
  2. Human trehalase is a stress responsive protein in Saccharomyces cerevisiae. (PMID: 19126402) Ouyang Y. … Xu Z. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage. (PMID: 8773341) Sasai-Takedatsu M. … Kobayashi Y. (Nephron 1996) 3 23
  4. Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study. (PMID: 26156397) Yang B. … Li S. (Med. Sci. Monit. 2015) 3
  5. Genetic determinants influencing human serum metabolome among African Americans. (PMID: 24625756) Yu B. … Boerwinkle E. (PLoS Genet. 2014) 3

Products for TREH Gene

Sources for TREH Gene