Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TREH Gene

Aliases for TREH Gene

  • Trehalase (Brush-Border Membrane Glycoprotein) 2 3
  • Alpha,Alpha-Trehalose Glucohydrolase 2 3 4
  • Alpha,Alpha-Trehalase 2 4
  • EC 3.2.1.28 4 63
  • TREA 3 4
  • TRE 3

External Ids for TREH Gene

Previous GeneCards Identifiers for TREH Gene

  • GC11M120885
  • GC11M120040
  • GC11M118066
  • GC11M118034
  • GC11M118528
  • GC11M114466

Summaries for TREH Gene

Entrez Gene Summary for TREH Gene

  • This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TREH Gene

TREH (Trehalase (Brush-Border Membrane Glycoprotein)) is a Protein Coding gene. Diseases associated with TREH include diarrhea-vomiting due to trehalase deficiency and trehalase deficiency. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include alpha,alpha-trehalase activity.

UniProtKB/Swiss-Prot for TREH Gene

  • Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREH Gene

Genomics for TREH Gene

Regulatory Elements for TREH Gene

Genomic Location for TREH Gene

Chromosome:
11
Start:
118,657,316 bp from pter
End:
118,679,690 bp from pter
Size:
22,375 bases
Orientation:
Minus strand

Genomic View for TREH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TREH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREH Gene

Proteins for TREH Gene

  • Protein details for TREH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43280-TREA_HUMAN
    Recommended name:
    Trehalase
    Protein Accession:
    O43280
    Secondary Accessions:
    • Q32MB9
    • Q53FY8

    Protein attributes for TREH Gene

    Size:
    583 amino acids
    Molecular mass:
    66568 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for TREH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREH Gene

Proteomics data for TREH Gene at MOPED

Selected DME Specific Peptides for TREH Gene

Post-translational modifications for TREH Gene

  • Glycosylation at Asn 78, Asn 239, Asn 261, and Asn 369
  • Modification sites at PhosphoSitePlus

Other Protein References for TREH Gene

Antibody Products

Domains & Families for TREH Gene

Protein Domains for TREH Gene

Suggested Antigen Peptide Sequences for TREH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43280

UniProtKB/Swiss-Prot:

TREA_HUMAN :
  • Belongs to the glycosyl hydrolase 37 family.
Family:
  • Belongs to the glycosyl hydrolase 37 family.
genes like me logo Genes that share domains with TREH: view

No data available for Gene Families for TREH Gene

Function for TREH Gene

Molecular function for TREH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose
UniProtKB/Swiss-Prot Function:
Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose

Enzyme Numbers (IUBMB) for TREH Gene

Gene Ontology (GO) - Molecular Function for TREH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004555 alpha,alpha-trehalase activity IDA 8773341
genes like me logo Genes that share ontologies with TREH: view
genes like me logo Genes that share phenotypes with TREH: view

Animal Models for TREH Gene

MGI Knock Outs for TREH:

miRNA for TREH Gene

miRTarBase miRNAs that target TREH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TREH

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TREH Gene

Localization for TREH Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREH Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TREH Gene COMPARTMENTS Subcellular localization image for TREH gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TREH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9427547
GO:0046658 anchored component of plasma membrane TAS 8773341
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TREH: view

Pathways & Interactions for TREH Gene

genes like me logo Genes that share pathways with TREH: view

Pathways by source for TREH Gene

1 BioSystems pathway for TREH Gene
2 KEGG pathways for TREH Gene

Gene Ontology (GO) - Biological Process for TREH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005991 trehalose metabolic process NAS 8773341
GO:0005993 trehalose catabolic process TAS 9427547
GO:0009887 organ morphogenesis IEA --
GO:0044245 polysaccharide digestion TAS --
genes like me logo Genes that share ontologies with TREH: view

No data available for SIGNOR curated interactions for TREH Gene

Drugs & Compounds for TREH Gene

(5) Drugs for TREH Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma 0
Sucrose Experimental Pharma 0
trehalose 6-phosphate Experimental Pharma 0
alanine Nutra 97
leucine Nutra 93

(13) Additional Compounds for TREH Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
trehalose
  • alpha,alpha-Trehalose
  • D-Trehalose-anhydrous
  • delta-Trehalose-anhydrous
99-20-7
Alpha-D-Glucose
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
492-62-6
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7
Uridine diphosphate glucose
  • (UDP)glucose
  • (UPD)-glucose
  • UDP Glucose
  • UDP-a-D-Glucose
  • UDP-alpha-D-Glucose
133-89-1
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with TREH: view

Transcripts for TREH Gene

mRNA/cDNA for TREH Gene

Unigene Clusters for TREH Gene

Trehalase (brush-border membrane glycoprotein):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TREH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREH Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for TREH Gene

GeneLoc Exon Structure for
TREH
ECgene alternative splicing isoforms for
TREH

Expression for TREH Gene

mRNA expression in normal human tissues for TREH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREH Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.4) and Kidney - Cortex (x8.6).

Protein differential expression in normal tissues from HIPED for TREH Gene

This gene is overexpressed in Urine (44.3) and Serum (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREH Gene



SOURCE GeneReport for Unigene cluster for TREH Gene Hs.129712

genes like me logo Genes that share expression patterns with TREH: view

Protein tissue co-expression partners for TREH Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TREH Gene

Orthologs for TREH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TREH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TREH 35
  • 84.62 (n)
  • 83.9 (a)
TREH 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TREH 35
  • 84.79 (n)
  • 82.48 (a)
TREH 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Treh 35
  • 82.66 (n)
  • 82.54 (a)
Treh 16
Treh 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TREH 35
  • 99.31 (n)
  • 99.14 (a)
TREH 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Treh 35
  • 83.01 (n)
  • 82.54 (a)
oppossum
(Monodelphis domestica)
Mammalia TREH 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TREH 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TREH 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia treh 35
  • 59.5 (n)
  • 55.89 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14709 35
treh 35
  • 60.51 (n)
  • 54.48 (a)
treh 36
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2295 35
fruit fly
(Drosophila melanogaster)
Insecta Treh 37
  • 43 (a)
Treh 35
  • 54.47 (n)
  • 44.73 (a)
CG6262 36
  • 19 (a)
OneToMany
Treh 36
  • 40 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012053 35
  • 54.81 (n)
  • 46.46 (a)
worm
(Caenorhabditis elegans)
Secernentea tre-3 35
  • 48.69 (n)
  • 42.26 (a)
tre-1 36
  • 39 (a)
OneToMany
tre-2 36
  • 31 (a)
OneToMany
tre-3 36
  • 37 (a)
OneToMany
tre-4 36
  • 32 (a)
OneToMany
tre-5 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTH1 36
  • 18 (a)
OneToMany
NTH2 36
  • 17 (a)
OneToMany
NTH2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TRE1 35
  • 47.12 (n)
  • 37.35 (a)
rice
(Oryza sativa)
Liliopsida Os10g0521000 35
  • 48.18 (n)
  • 40.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00943 35
  • 50 (n)
  • 41.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for TREH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TREH Gene

ENSEMBL:
Gene Tree for TREH (if available)
TreeFam:
Gene Tree for TREH (if available)

Paralogs for TREH Gene

Pseudogenes.org Pseudogenes for TREH Gene

genes like me logo Genes that share paralogs with TREH: view

No data available for Paralogs for TREH Gene

Variants for TREH Gene

Sequence variations from dbSNP and Humsavar for TREH Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs504206 -- 118,678,544(+) TTTTC(A/G)TAGAG intron-variant
rs506234 -- 118,669,395(-) AACAT(C/G)GGAGT intron-variant
rs507080 -- 118,678,873(+) GTCAG(A/G)GCTCA intron-variant
rs526597 -- 118,675,892(+) GAGAC(A/C/G)GGGTT intron-variant
rs537369 -- 118,675,796(+) cctcc(C/T)aggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TREH Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294
nsv832283 CNV Loss 17160897
nsv898415 CNV Loss 21882294
esv2745124 CNV Deletion 23290073
esv2674547 CNV Deletion 23128226

Variation tolerance for TREH Gene

Gene Damage Index Score: 6.88; 79.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TREH Gene

HapMap Linkage Disequilibrium report
TREH
Human Gene Mutation Database (HGMD)
TREH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREH Gene

Disorders for TREH Gene

MalaCards: The human disease database

(8) MalaCards diseases for TREH Gene - From: OMIM, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
diarrhea-vomiting due to trehalase deficiency
  • isolated trehalose intolerance
trehalase deficiency
  • trehalase
metagonimiasis
  • infection by metagonimus yokogawai
intestinal disaccharidase deficiency
  • disaccharidase deficiency
gastrointestinal defects and immunodeficiency syndrome
  • multiple intestinal atresia
- elite association
Search TREH in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TREA_HUMAN
  • Note=Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms.

Relevant External Links for TREH

Genetic Association Database (GAD)
TREH
Human Genome Epidemiology (HuGE) Navigator
TREH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TREH
genes like me logo Genes that share disorders with TREH: view

No data available for Genatlas for TREH Gene

Publications for TREH Gene

  1. Molecular cloning, sequencing and expression of cDNA encoding human trehalase. (PMID: 9427547) Ishihara R. … Kobayashi Y. (Gene 1997) 2 23 67
  2. Conidial surface proteins of Metarhizium anisopliae: Source of activities related with toxic effects, host penetration and pathogenesis. (PMID: 20034509) Santi L. … Vainstein M.H. (Toxicon 2010) 23 67
  3. An alternative synthesis of 1,1'-bis-valienamine from D-glucose. (PMID: 20392097) Shing T.K. … Cheng H.M. (J. Org. Chem. 2010) 23 67
  4. Effects of extrusion and supplementation of exogenous enzymes to diets containing Chinese storage brown rice on the carbohydrase activity in the digestive tract of piglets. (PMID: 20465715) He J. … Li J. (J Anim Physiol Anim Nutr (Berl) 2010) 23 67
  5. Mapping of HNF4alpha target genes in intestinal epithelial cells. (PMID: 19761587) Boyd M. … Troelsen J.T. (BMC Gastroenterol 2009) 23 67

Products for TREH Gene

Sources for TREH Gene

Back to Top

Content