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Aliases for TREH Gene

Aliases for TREH Gene

  • Trehalase (Brush-Border Membrane Glycoprotein) 2 3
  • Alpha,Alpha-Trehalose Glucohydrolase 2 3 4
  • Alpha,Alpha-Trehalase 2 4
  • EC 4 63
  • TREA 3 4
  • Trehalase 3
  • TRE 3

External Ids for TREH Gene

Previous GeneCards Identifiers for TREH Gene

  • GC11M120885
  • GC11M120040
  • GC11M118066
  • GC11M118034
  • GC11M118528
  • GC11M114466

Summaries for TREH Gene

Entrez Gene Summary for TREH Gene

  • This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TREH Gene

TREH (Trehalase (Brush-Border Membrane Glycoprotein)) is a Protein Coding gene. Diseases associated with TREH include trehalase deficiency and diarrhea-vomiting due to trehalase deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include alpha,alpha-trehalase activity.

UniProtKB/Swiss-Prot for TREH Gene

  • Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREH Gene

Genomics for TREH Gene

Regulatory Elements for TREH Gene

Genomic Location for TREH Gene

118,657,316 bp from pter
118,679,690 bp from pter
22,375 bases
Minus strand

Genomic View for TREH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TREH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREH Gene

Proteins for TREH Gene

  • Protein details for TREH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q32MB9
    • Q53FY8

    Protein attributes for TREH Gene

    583 amino acids
    Molecular mass:
    66568 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for TREH Gene


neXtProt entry for TREH Gene

Proteomics data for TREH Gene at MOPED

Selected DME Specific Peptides for TREH Gene

Post-translational modifications for TREH Gene

  • Glycosylation at Asn78, Asn239, Asn261, and Asn369
  • Modification sites at PhosphoSitePlus

Other Protein References for TREH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TREH Gene

Protein Domains for TREH Gene

Suggested Antigen Peptide Sequences for TREH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43280
  • Belongs to the glycosyl hydrolase 37 family.
genes like me logo Genes that share domains with TREH: view

No data available for Gene Families for TREH Gene

Function for TREH Gene

Molecular function for TREH Gene

UniProtKB/Swiss-Prot CatalyticActivity: Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose
UniProtKB/Swiss-Prot Function: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose

Enzyme Numbers (IUBMB) for TREH Gene

Gene Ontology (GO) - Molecular Function for TREH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004555 alpha,alpha-trehalase activity IDA 8773341
genes like me logo Genes that share ontologies with TREH: view
genes like me logo Genes that share phenotypes with TREH: view

Animal Models for TREH Gene

MGI Knock Outs for TREH:

miRNA for TREH Gene

miRTarBase miRNAs that target TREH

No data available for Transcription Factor Targeting and HOMER Transcription for TREH Gene

Localization for TREH Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREH Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for TREH Gene COMPARTMENTS Subcellular localization image for TREH gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 2
cytosol 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TREH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9427547
GO:0046658 anchored component of plasma membrane TAS 8773341
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TREH: view

Pathways for TREH Gene

genes like me logo Genes that share pathways with TREH: view

Pathways by source for TREH Gene

1 BioSystems pathway for TREH Gene
2 KEGG pathways for TREH Gene

Gene Ontology (GO) - Biological Process for TREH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005991 trehalose metabolic process NAS 8773341
GO:0005993 trehalose catabolic process TAS 9427547
GO:0009887 organ morphogenesis IEA --
GO:0044245 polysaccharide digestion TAS --
genes like me logo Genes that share ontologies with TREH: view

Compounds for TREH Gene

(4) HMDB Compounds for TREH Gene

Compound Synonyms Cas Number PubMed IDs
  • (+)-Glucose
  • alpha,alpha-trehalose
Uridine diphosphate glucose
  • (UPD)-glucose
  • Dihydrogen oxide

(13) Novoseek inferred chemical compound relationships for TREH Gene

Compound -log(P) Hits PubMed IDs
trehazolin 94.2 4
validoxylamine a 90.4 3
trehalose 84.5 30
trehalose 6-phosphate 62.4 2
sucrose 34 2
genes like me logo Genes that share compounds with TREH: view

Transcripts for TREH Gene

mRNA/cDNA for TREH Gene

Unigene Clusters for TREH Gene

Trehalase (brush-border membrane glycoprotein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TREH Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: - - - -
SP3: - - - -
SP5: -

Relevant External Links for TREH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TREH Gene

mRNA expression in normal human tissues for TREH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREH Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (19.4) and Kidney - Cortex (8.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TREH Gene

SOURCE GeneReport for Unigene cluster for TREH Gene Hs.129712

genes like me logo Genes that share expressions with TREH: view

No data available for mRNA Expression by UniProt/SwissProt for TREH Gene

Orthologs for TREH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TREH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TREH 35
  • 99.31 (n)
  • 99.14 (a)
  • 98 (a)
(Bos Taurus)
Mammalia TREH 35
  • 84.62 (n)
  • 83.9 (a)
  • 83 (a)
(Canis familiaris)
Mammalia TREH 35
  • 84.79 (n)
  • 82.48 (a)
  • 82 (a)
(Mus musculus)
Mammalia Treh 35
  • 82.66 (n)
  • 82.54 (a)
Treh 16
Treh 36
  • 82 (a)
(Monodelphis domestica)
Mammalia TREH 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TREH 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Treh 35
  • 83.01 (n)
  • 82.54 (a)
(Anolis carolinensis)
Reptilia TREH 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia treh 35
  • 59.5 (n)
  • 55.89 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2295 35
(Danio rerio)
Actinopterygii Dr.14709 35
treh 35
  • 60.51 (n)
  • 54.48 (a)
treh 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012053 35
  • 54.81 (n)
  • 46.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6262 36
  • 19 (a)
Treh 35
  • 54.47 (n)
  • 44.73 (a)
Treh 36
  • 40 (a)
Treh 37
  • 43 (a)
(Caenorhabditis elegans)
Secernentea tre-1 36
  • 39 (a)
tre-2 36
  • 31 (a)
tre-3 35
  • 48.69 (n)
  • 42.26 (a)
tre-3 36
  • 37 (a)
tre-4 36
  • 32 (a)
tre-5 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTH1 36
  • 18 (a)
NTH2 36
  • 17 (a)
NTH2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TRE1 35
  • 47.12 (n)
  • 37.35 (a)
(Oryza sativa)
Liliopsida Os10g0521000 35
  • 48.18 (n)
  • 40.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00943 35
  • 50 (n)
  • 41.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for TREH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TREH Gene

Gene Tree for TREH (if available)
Gene Tree for TREH (if available)

Paralogs for TREH Gene Pseudogenes for TREH Gene

genes like me logo Genes that share paralogs with TREH: view

No data available for Paralogs for TREH Gene

Variants for TREH Gene

Sequence variations from dbSNP and Humsavar for TREH Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs484246 -- 118,665,050(+) gttgc(A/C)atgaa intron-variant
rs494610 -- 118,665,147(-) CTCCT(C/T)TCAAG intron-variant
rs499156 -- 118,664,679(-) CCATT(G/T)GCTGT intron-variant
rs506234 -- 118,669,395(-) AACAT(C/G)GGAGT intron-variant
rs520543 -- 118,667,448(-) caagc(C/T)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TREH Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294
nsv832283 CNV Loss 17160897
nsv898415 CNV Loss 21882294
esv2745124 CNV Deletion 23290073
esv2674547 CNV Deletion 23128226

Relevant External Links for TREH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREH Gene

Disorders for TREH Gene

(1) OMIM Diseases for TREH Gene (275360)


  • Note=Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms.

(5) Novoseek inferred disease relationships for TREH Gene

Disease -log(P) Hits PubMed IDs
chronic glomerulonephritis 46 4
cystic fibrosis 22.6 3
nephrotic syndrome 17.8 3
metaplasia 15 1
renal disease 0 2

Relevant External Links for TREH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TREH: view

Publications for TREH Gene

  1. Molecular cloning, sequencing and expression of cDNA encoding human trehalase. (PMID: 9427547) Ishihara R. … Kobayashi Y. (Gene 1997) 2 3 4 23
  2. Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage. (PMID: 8773341) Sasai-Takedatsu M. … Kobayashi Y. (Nephron 1996) 3 4 23
  3. Human trehalase is a stress responsive protein in Saccharomyces cerevisiae. (PMID: 19126402) Ouyang Y. … Xu Z. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3

Products for TREH Gene

Sources for TREH Gene

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