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TREH Gene

protein-coding   GIFtS: 64
GCID: GC11M118528

Trehalase (Brush-Border Membrane Glycoprotein)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Trehalase (Brush-Border Membrane Glycoprotein)1 2     alpha-trehalase1
Alpha,Alpha-Trehalose Glucohydrolase2 3     Alpha-Trehalose Glucohydrolase1
TREA2 3     TRE2
EC 3.2.1.283 8     trehalase2
alpha1     Alpha,alpha-trehalase3

External Ids:    HGNC: 122661   Entrez Gene: 111812   Ensembl: ENSG000001180947   OMIM: 2753605   UniProtKB: O432803   
ORGUL members:         

Export aliases for TREH gene to outside databases

Previous GC identifers: GC11M120885 GC11M120040 GC11M118562 GC11M118066 GC11M118034 GC11M114466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TREH Gene:
This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found
mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on
chromosome 11. (provided by RefSeq, Jul 2008)

GeneCards Summary for TREH Gene:
TREH (trehalase (brush-border membrane glycoprotein)) is a protein-coding gene. Diseases associated with TREH include metagonimiasis, and intestinal disaccharidase deficiency. GO annotations related to this gene include alpha,alpha-trehalase activity.

UniProtKB/Swiss-Prot: TREA_HUMAN, O43280
Function: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TREH gene promoter:
         Bach1   AML1a   Olf-1   Tal-1beta   Arnt   E47   Evi-1   AREB6   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTREH promoter sequence
   Search Chromatin IP Primers for TREH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TREH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

TREH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TREH gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118528:  view genomic region     (about GC identifiers)

Start:
118,528,026 bp from pter      End:
118,550,399 bp from pter
Size:
22,374 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TREA_HUMAN, O43280 (See protein sequence)
Recommended Name: Trehalase precursor  
Size: 583 amino acids; 66568 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Secondary accessions: Q32MB9 Q53FY8
Alternative splicing: 2 isoforms:  O43280-1   O43280-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TREH: NX_O43280

Explore proteomics data for TREH at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn78, Asn239, Asn261, Asn369
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for TREH (O43280)
     GFGWTNG  SGWDFSSRW  EFYYWDSYW  RSQPPLLTLM 


    See TREH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009111.2  
    ENSEMBL proteins: 
     ENSP00000435095   ENSP00000432640   ENSP00000432853   ENSP00000264029   ENSP00000381020  
    Reactome Protein details: O43280

    TREH Human Recombinant Protein Products:

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    Novus Biologicals TREH Protein
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    Cloud-Clone Corp. Proteins for TREH

    TREH Antibody Products:

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    TREH Assay Products:

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    Cloud-Clone Corp. ELISAs for TREH
    Cloud-Clone Corp. CLIAs for TREH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018232 Glyco_hydro_37_CS
     IPR001661 Glyco_hydro_37
     IPR008928 6-hairpin_glycosidase-like

    Graphical View of Domain Structure for InterPro Entry O43280

    ProtoNet protein and cluster: O43280

    1 Blocks protein domain: IPB001661 Glycoside hydrolase

    UniProtKB/Swiss-Prot: TREA_HUMAN, O43280
    Similarity: Belongs to the glycosyl hydrolase 37 family


    TREH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TREA_HUMAN, O43280
    Function: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose
    Catalytic activity: Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose

         Enzyme Number (IUBMB): EC 3.2.1.281 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004555alpha,alpha-trehalase activity IDA8773341
         
    TREH for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Treh):
     digestive/alimentary  homeostasis/metabolism  renal/urinary system 

    TREH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trehtm1Tkam for TREH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TREH
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TREH

    miRNA
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    miRTarBase miRNAs that target TREH:
    hsa-mir-335-5p (MIRT017846)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TREA_HUMAN, O43280: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    endoplasmic reticulum2
    cytosol1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9427547
    GO:0046658anchored component of plasma membrane TAS8773341
    GO:0070062extracellular vesicular exosome IDA19056867

    TREH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TREH About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    3Glucuronidation
    Starch and sucrose metabolism0.41
    4GDP-glucose biosynthesis
    trehalose degradation II (trehalase)0.40
    5Digestion of dietary carbohydrate
    Digestion of dietary carbohydrate

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TREH
        trehalose degradation II (trehalase)

    1 Reactome Pathway for TREH
        Digestion of dietary carbohydrate


    2 Kegg Pathways  (Kegg details for TREH):
        Starch and sucrose metabolism
    Metabolic pathways


    TREH for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TREH
    Interactions:

        Search GeneGlobe Interaction Network for TREH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TREH (O432803 ENSP000002640294) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=3 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=3 STRING: ENSP00000291295
    YWHAEP622583, ENSP000002643354I2D: score=5 STRING: ENSP00000264335
    ATP6V1B2P212813, ENSP000002763904I2D: score=3 STRING: ENSP00000276390
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005991trehalose metabolic process NAS8773341
    GO:0005993trehalose catabolic process TAS9427547
    GO:0009887organ morphogenesis IEA--
    GO:0044245polysaccharide digestion TAS--

    TREH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TREH (TREA)

    4 HMDB Compounds for TREH    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    Trehalosealpha,alpha-trehalose (see all 3)99-20-7--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for TREH gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trehazolin 94.2 4 12014441 (1), 15532066 (1), 1955399 (1), 8770385 (1)
    validoxylamine a 90.4 3 11191809 (1), 1778792 (1), 10806243 (1)
    trehalose 84.5 44 11083487 (6), 2113908 (6), 19126402 (4), 11191809 (3) (see all 12)
    trehalose 6-phosphate 62.4 2 2146959 (1), 16946258 (1)
    sucrose 34 3 8506656 (1), 1364961 (1)
    glucose 30.2 8 11083487 (2), 12604583 (2), 2146959 (1), 20392097 (1)
    lead 14.3 6 11761669 (4), 11764857 (1)
    cadmium 6.64 3 11764857 (1), 11761669 (1)
    leucine 4.78 1 1674421 (1)
    carbon 4.34 3 16946258 (1), 19126402 (1)



    TREH for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TREH gene: 
    NM_007180.2  

    Unigene Cluster for TREH:

    Trehalase (brush-border membrane glycoprotein)
    Hs.129712  [show with all ESTs]
    Unigene Representative Sequence: AK223140
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529101(uc009zaj.1) ENST00000530256(uc001ptz.1) ENST00000525958
    ENST00000531295(uc009zak.3) ENST00000527558 ENST00000264029(uc001pty.1)
    ENST00000397925
    miRNA
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    GenScript: all cDNA clones in your preferred vector: TREH (NM_007180)
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      QuantiFast Probe-based Assays in human, mouse, rat TREH

    Additional mRNA sequence: 

    AB000824.1 AK091981.1 AK223140.1 AK223143.1 AK309565.1 BC109206.2 

    6 DOTS entries:

    DT.100734919  DT.101001  DT.120684566  DT.120684556  DT.91973679  DT.95328929 

    16 AceView cDNA sequences:

    BX281595 AI139831 BI039683 AK091981 CB047068 AX747289 AI793190 AI793022 
    CB047069 AI253189 AI000475 AB000824 NM_007180 AW418834 AI763260 AA894903 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TREH    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                                            -     -                             -                                                               
    SP2:                                            -     -           -                 -                                                               
    SP3:                          -                       -     -                       -                                                               
    SP4:                                                                                                                                                
    SP5:                          -                                                                                                                     


    ECgene alternative splicing isoforms for TREH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TREH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACAGCCC
    TREH Expression
    About this image


    TREH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Eye (Sensory Organs)
             Lens
     
     Kidney (Urinary System)
    TREH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TREH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129712
        Custom PCR Arrays for TREH
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TREH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TREH gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Treh1 , 5 trehalase (brush-border membrane glycoprotein)1, 5 82.66(n)1
    82.54(a)1
      9 (24.84 cM)5
    588661  NM_021481.31  NP_067456.11 
     446732335 
    lizard
    (Anolis carolinensis)
    Reptilia TREH6
    trehalase (brush-border membrane glycoprotein)
    56(a)
    1 ↔ 1
    GL344088.1(42986-50843)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia treh1 trehalase (brush-border membrane glycoprotein) 59.5(n)
    55.89(a)
      100489256  XM_002935014.2  XP_002935060.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147092 Transcribed sequence with weak similarity to protein more 76.6(n)    BM082431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Treh1 , 3 alpha,alpha-trehalase3
    Trehalase1
    43(a)3
    54.47(n)1
    44.73(a)1
      453681  NM_166424.21  NP_726026.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tre-31 tre-3 48.69(n)
    42.26(a)
      179604  NM_001269432.1  NP_001256361.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTH2(YBR001C)4 Putative neutral trehalase, required for thermotolerance more   --   2(241283-238941) 852286  NP_009555.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TRE11 TRE1 47.12(n)
    37.35(a)
      828504  NM_118536.3  NP_194135.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05210001 Os10g0521000 48.18(n)
    40.2(a)
      4349141  NM_001071622.1  NP_001065087.1 


    ENSEMBL Gene Tree for TREH (if available)
    TreeFam Gene Tree for TREH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TREH gene

    TREH for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TREH
    PGOHUM00000242501


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TREH (see all 577)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437699651,2
    C--114466277(+) CGACAG/TGGAAA 1 -- ds50010--------
    rs1511140831,2
    C--114466296(+) CTCCAA/GTGCTC 1 -- ds50010--------
    rs73891,2
    C,F,A,H--114466300(-) CTAGGA/CGCATT 1 -- ds500131Minor allele frequency- C:0.35MN NA NS EA WA CSA 3249
    rs1411232991,2
    --114466586(+) AAGGCC/TGGTGT 1 -- ds50010--------
    rs7459301,2
    C,F--114466587(+) AGGCCG/TGTGTG 1 -- ds50015Minor allele frequency- T:0.10MN WA CSA 308
    rs757302731,2
    C,F--114466588(+) GGCCGG/ATGTGG 1 -- ds50012Minor allele frequency- A:0.10WA 120
    rs74793621,2
    A,H--114466721(+) ACTTCG/CCTCTG 1 -- ds50014Minor allele frequency- C:0.00NS EA 396
    rs1500824141,2
    --114466748(+) TAGGAA/GGGCAT 1 -- ds50010--------
    rs6425231,2
    H--114466810(+) CTGGGG/TCCAGG 1 -- ut315Minor allele frequency- T:0.01MN NS EA 602
    rs724880141,2
    C--114466878(+) GTGGCC/GCCAGG 2 A syn10--------

    HapMap Linkage Disequilibrium report for TREH (118528026 - 118550399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TREH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745124CNV Deletion23290073
    esv2674547CNV Deletion23128226
    nsv832283CNV Loss17160897
    dgv1319n71CNV Loss21882294
    nsv898415CNV Loss21882294

    Human Gene Mutation Database (HGMD): TREH
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TREH
    DNA2.0 Custom Variant and Variant Library Synthesis for TREH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 275360   
    OMIM disorders: 612119  
    UniProtKB/Swiss-Prot: TREA_HUMAN, O43280
  • Note=Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms
    after ingestion of edible mushrooms

  • Selected diseases for TREH (see all 24):    
    About MalaCards
    metagonimiasis    intestinal disaccharidase deficiency    trehalase deficiency    swine influenza
    intestinal volvulus    intestinal atresia    giardiasis    oligohydramnios
    onchocerciasis    nephrotic syndrome    cystic fibrosis    influenza
    glomerulonephritis    duodenitis    vitiligo    celiac disease
    diabetes mellitus    systemic lupus erythematosus    lupus erythematosus    malaria

    3 diseases from the University of Copenhagen DISEASES database for TREH:
    Intestinal disaccharidase deficiency     Metagonimiasis     Multiple intestinal atresia

    TREH for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for TREH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic glomerulonephritis 46 5 8096331 (3), 10794745 (1)
    cystic fibrosis 22.6 3 2130675 (1), 1867893 (1), 2205827 (1)
    nephrotic syndrome 17.8 4 8096331 (3)
    metaplasia 15 1 8506656 (1)
    renal disease 0 2 1980862 (1), 10794745 (1)

    Genetic Association Database (GAD): TREH
    Human Genome Epidemiology (HuGE) Navigator: TREH (1 document)

    Export disorders for TREH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TREH gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with TREH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, sequencing and expression of cDNA encoding human trehalase. (PubMed id 9427547)1, 2, 3, 9 Ishihara R....Kobayashi Y. (Gene 1997)
    2. Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage. (PubMed id 8773341)1, 2, 9 Sasai-Takedatsu M.... Kobayashi Y. (Nephron 1996)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Human trehalase is a stress responsive protein in Saccharomyces cerevisiae. (PubMed id 19126402)1, 9 Ouyang Y....Xu Z. (Biochem. Biophys. Res. Commun. 2009)
    5. Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. (PubMed id 22951725)1 Tang X.F....Zhang X.J. (J. Invest. Dermatol. 2013)
    6. Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes. (PubMed id 23468175)1 Muller Y.L....Baier L.J. (Hum. Genet. 2013)
    7. Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma. (PubMed id 22369735)1 Li S....Zhang Y. (Cancer Epidemiol 2012)
    8. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PubMed id 21383967)4 Zhernakova A....Plenge R.M. (PLoS Genet. 2011)
    9. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11181 HGNC: 12266 AceView: TREH Ensembl:ENSG00000118094 euGenes: HUgn11181
    ECgene: TREH Kegg: 11181 H-InvDB: TREH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TREH Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Trehalase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TREH gene:
    Search GeneIP for patents involving TREH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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