Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRDV3 Gene

Aliases for TRDV3 Gene

  • T Cell Receptor Delta Variable 3 2 3 5
  • HDV103S1 3

External Ids for TRDV3 Gene

Previous GeneCards Identifiers for TRDV3 Gene

  • GC14U990266
  • GC14M020928
  • GC14M022007
  • GC14M022939

Summaries for TRDV3 Gene

Entrez Gene Summary for TRDV3 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRDV3 Gene

TRDV3 (T Cell Receptor Delta Variable 3) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDV3 Gene

Genomics for TRDV3 Gene

Regulatory Elements for TRDV3 Gene

Enhancers for TRDV3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022468 1.2 Ensembl ENCODE 0.8 -0.1 -72 2.6 PKNOX1 ZGPAT REST PRDM1 ABHD4 TRDV3 TRAJ61
GH14F022463 1 ENCODE 0.8 +3.8 3773 4.6 PKNOX1 TBL1XR1 WRNIP1 BMI1 ZNF23 ETV6 FOS CREM JUNB SP1 TRDV3 TRDJ3
GH14F022456 0.9 Ensembl ENCODE 0.4 +10.4 10375 6.2 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 METTL3 PRMT5-AS1 BCL2L2 HOMEZ EFS MMP14 TRDJ3 TRDV3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRDV3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRDV3 Gene

Chromosome:
14
Start:
22,469,041 bp from pter
End:
22,469,698 bp from pter
Size:
658 bases
Orientation:
Minus strand

Genomic View for TRDV3 Gene

Genes around TRDV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDV3 Gene

Proteins for TRDV3 Gene

  • Protein details for TRDV3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0JD37
    Recommended name:
    HDV103S1
    Protein Accession:
    A0JD37

    Protein attributes for TRDV3 Gene

    Size:
    113 amino acids
    Molecular mass:
    12981 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRDV3 Gene

neXtProt entry for TRDV3 Gene

Post-translational modifications for TRDV3 Gene

No Post-translational modifications

Other Protein References for TRDV3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRDV3 Gene

Domains & Families for TRDV3 Gene

Gene Families for TRDV3 Gene

Protein Domains for TRDV3 Gene

Suggested Antigen Peptide Sequences for TRDV3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDV3: view

No data available for UniProtKB/Swiss-Prot for TRDV3 Gene

Function for TRDV3 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRDV3 Gene

Localization for TRDV3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRDV3 Gene

Pathways & Interactions for TRDV3 Gene

SuperPathways for TRDV3 Gene

No Data Available

Interacting Proteins for TRDV3 Gene

Gene Ontology (GO) - Biological Process for TRDV3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRDV3 Gene

Transcripts for TRDV3 Gene

mRNA/cDNA for TRDV3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRDV3 Gene

No ASD Table

Relevant External Links for TRDV3 Gene

GeneLoc Exon Structure for
TRDV3
ECgene alternative splicing isoforms for
TRDV3

Expression for TRDV3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRDV3 Gene

mRNA differential expression in normal tissues according to GTEx for TRDV3 Gene

This gene is overexpressed in Whole Blood (x16.7).

NURSA nuclear receptor signaling pathways regulating expression of TRDV3 Gene:

TRDV3
genes like me logo Genes that share expression patterns with TRDV3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRDV3 Gene

Orthologs for TRDV3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRDV3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TRDV3 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRDV3 35
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRDV3 35
  • 44 (a)
OneToOne
Species where no ortholog for TRDV3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRDV3 Gene

ENSEMBL:
Gene Tree for TRDV3 (if available)
TreeFam:
Gene Tree for TRDV3 (if available)

Paralogs for TRDV3 Gene

No data available for Paralogs for TRDV3 Gene

Variants for TRDV3 Gene

Relevant External Links for TRDV3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRDV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRDV3 Gene

Disorders for TRDV3 Gene

Relevant External Links for TRDV3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRDV3

No disorders were found for TRDV3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRDV3 Gene

Publications for TRDV3 Gene

  1. Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells. (PMID: 2974163) Loh E.Y. … Lanier L.L. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 64
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 64
  3. Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (PMID: 9110172) Boysen C. … Hood L. (Genome Res. 1997) 3 64
  4. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 3 64

Products for TRDV3 Gene

Sources for TRDV3 Gene

Content
Loading form....