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Aliases for TRDV2 Gene

Aliases for TRDV2 Gene

  • T Cell Receptor Delta Variable 2 2 3
  • T-Cell Receptor Delta Variable 2 5
  • HDV102S1 3

External Ids for TRDV2 Gene

Previous GeneCards Identifiers for TRDV2 Gene

  • GC14U990267
  • GC14P020881
  • GC14P021962
  • GC14P021182
  • GC14P022892
  • GC14P023684

Summaries for TRDV2 Gene

Entrez Gene Summary for TRDV2 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRDV2 Gene

TRDV2 (T Cell Receptor Delta Variable 2) is a Protein Coding gene.

Additional gene information for TRDV2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDV2 Gene

Genomics for TRDV2 Gene

GeneHancer (GH) Regulatory Elements for TRDV2 Gene

Promoters and enhancers for TRDV2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022421 Enhancer 0.6 ENCODE dbSUPER 550.8 +0.1 52 1.2 POLR2A EBF1 TRD TRDV2 MMP14 METTL3 ENSG00000251002 TRA
GH14I022417 Enhancer 0.8 ENCODE dbSUPER 0.8 -3.8 -3798 3.1 BCOR FOXA2 ZMYM3 EBF1 GLIS1 IKZF1 HMBOX1 ZNF24 RUNX3 ENSG00000259042 MMP14 METTL3 TRDV2 ENSG00000251002 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRDV2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRDV2 Gene

Genomic Locations for TRDV2 Gene
chr14:22,422,371-22,423,042
(GRCh38/hg38)
Size:
672 bases
Orientation:
Plus strand
chr14:22,891,362-22,892,033
(GRCh37/hg19)

Genomic View for TRDV2 Gene

Genes around TRDV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDV2 Gene

Proteins for TRDV2 Gene

  • Protein details for TRDV2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0JD36
    Recommended name:
    HDV102S1
    Protein Accession:
    A0JD36

    Protein attributes for TRDV2 Gene

    Size:
    115 amino acids
    Molecular mass:
    12944 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRDV2 Gene

Post-translational modifications for TRDV2 Gene

No Post-translational modifications

Other Protein References for TRDV2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRDV2 Gene

Domains & Families for TRDV2 Gene

Gene Families for TRDV2 Gene

Protein Domains for TRDV2 Gene

Suggested Antigen Peptide Sequences for TRDV2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDV2: view

No data available for UniProtKB/Swiss-Prot for TRDV2 Gene

Function for TRDV2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRDV2 Gene

Localization for TRDV2 Gene

Gene Ontology (GO) - Cellular Components for TRDV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with TRDV2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRDV2 Gene

Pathways & Interactions for TRDV2 Gene

SuperPathways for TRDV2 Gene

No Data Available

Interacting Proteins for TRDV2 Gene

Gene Ontology (GO) - Biological Process for TRDV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with TRDV2: view

No data available for Pathways by source and SIGNOR curated interactions for TRDV2 Gene

Drugs & Compounds for TRDV2 Gene

No Compound Related Data Available

Transcripts for TRDV2 Gene

mRNA/cDNA for TRDV2 Gene

(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRDV2 Gene

No ASD Table

Relevant External Links for TRDV2 Gene

GeneLoc Exon Structure for
TRDV2
ECgene alternative splicing isoforms for
TRDV2

Expression for TRDV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRDV2 Gene

mRNA differential expression in normal tissues according to GTEx for TRDV2 Gene

This gene is overexpressed in Whole Blood (x40.6) and Spleen (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of TRDV2 Gene:

TRDV2
genes like me logo Genes that share expression patterns with TRDV2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRDV2 Gene

Orthologs for TRDV2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRDV2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia TRDV2 34
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
-- 34
  • 16 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRDV2 34
  • 37 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRDV2 34
  • 23 (a)
OneToOne
Species where no ortholog for TRDV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRDV2 Gene

ENSEMBL:
Gene Tree for TRDV2 (if available)
TreeFam:
Gene Tree for TRDV2 (if available)

Paralogs for TRDV2 Gene

No data available for Paralogs for TRDV2 Gene

Variants for TRDV2 Gene

Additional Variant Information for TRDV2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRDV2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRDV2 Gene

Disorders for TRDV2 Gene

Additional Disease Information for TRDV2

No disorders were found for TRDV2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRDV2 Gene

Publications for TRDV2 Gene

  1. First genomic sequence of the human T-cell receptor delta 2 gene (TRDV2). (PMID: 2526321) Dariavach P … Lefranc MP (Nucleic acids research 1989) 2 3 58
  2. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. (PMID: 19494338) Li J … Herrmann T (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 58
  3. Large scale expansion of Vgamma9Vdelta2 T lymphocytes from human peripheral blood mononuclear cells after a positive selection using MACS "TCR gamma/delta+ T cell isolation kit". (PMID: 19465023) Salot S … Sicard H (Journal of immunological methods 2009) 3 58
  4. V gamma 9V delta 2 T cell response to colon carcinoma cells. (PMID: 16210656) Corvaisier M … Jotereau F (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TRDV2 Gene

Sources for TRDV2 Gene

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