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Aliases for TRDV1 Gene

Aliases for TRDV1 Gene

  • T-Cell Receptor Delta Variable 1 2 5
  • T Cell Receptor Delta Variable 1 2 3
  • HDV101S1 3

External Ids for TRDV1 Gene

Previous GeneCards Identifiers for TRDV1 Gene

  • GC14U990268
  • GC14P020554
  • GC14P021634
  • GC14P022565
  • GC14P022572
  • GC14P022604
  • GC14P022721
  • GC14P022830

Summaries for TRDV1 Gene

Entrez Gene Summary for TRDV1 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRDV1 Gene

TRDV1 (T-Cell Receptor Delta Variable 1) is a Protein Coding gene. An important paralog of this gene is TRAV14DV4.

Additional gene information for TRDV1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDV1 Gene

Genomics for TRDV1 Gene

Regulatory Elements for TRDV1 Gene

Enhancers for TRDV1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H022095 1.1 Ensembl ENCODE dbSUPER 0.7 +1.0 1043 3 ZBED1 ZFP64 MNT FOXP2 RFX5 ZNF7 TRDV1 TRAV24
GH14H022100 0.9 ENCODE 0.7 +4.4 4377 0 ELF3 ARID4B ZSCAN9 RAD21 ZNF143 MIXL1 THAP11 SMARCA5 MXD4 REST TRDV1 TRAV24
GH14H022104 0.5 ENCODE dbSUPER 0.4 +9.1 9149 1 RBM23 TRAV8-4 TRAV24 TRDV1
GH14H022085 0.2 dbSUPER 0.4 -9.6 -9551 1 TRAV23DV6 TRDV1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRDV1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRDV1 Gene

Chromosome:
14
Start:
22,096,032 bp from pter
End:
22,096,619 bp from pter
Size:
588 bases
Orientation:
Plus strand

Genomic View for TRDV1 Gene

Genes around TRDV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDV1 Gene

Proteins for TRDV1 Gene

  • Protein details for TRDV1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087X2F4
    Recommended name:
    T-cell receptor delta variable 1
    Protein Accession:
    A0A087X2F4

    Protein attributes for TRDV1 Gene

    Size:
    34 amino acids
    Molecular mass:
    3696 Da
    Quaternary structure:
    No Data Available
  • Protein details for TRDV1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GX56
    Recommended name:
    T-cell receptor delta variable 1
    Protein Accession:
    A0A1B0GX56

    Protein attributes for TRDV1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12955 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRDV1 Gene

Post-translational modifications for TRDV1 Gene

No Post-translational modifications

Other Protein References for TRDV1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRDV1 Gene

Domains & Families for TRDV1 Gene

Gene Families for TRDV1 Gene

Protein Domains for TRDV1 Gene

Suggested Antigen Peptide Sequences for TRDV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDV1: view

No data available for UniProtKB/Swiss-Prot for TRDV1 Gene

Function for TRDV1 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRDV1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRDV1 Gene

Localization for TRDV1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRDV1 Gene

Pathways & Interactions for TRDV1 Gene

SuperPathways for TRDV1 Gene

No Data Available

Interacting Proteins for TRDV1 Gene

Gene Ontology (GO) - Biological Process for TRDV1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRDV1 Gene

Drugs & Compounds for TRDV1 Gene

No Compound Related Data Available

Transcripts for TRDV1 Gene

mRNA/cDNA for TRDV1 Gene

(37) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRDV1 Gene

T cell receptor delta variable 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRDV1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRDV1 Gene

No ASD Table

Relevant External Links for TRDV1 Gene

GeneLoc Exon Structure for
TRDV1
ECgene alternative splicing isoforms for
TRDV1

Expression for TRDV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRDV1 Gene

mRNA differential expression in normal tissues according to GTEx for TRDV1 Gene

This gene is overexpressed in Whole Blood (x29.1) and Spleen (x10.3).

NURSA nuclear receptor signaling pathways regulating expression of TRDV1 Gene:

TRDV1

SOURCE GeneReport for Unigene cluster for TRDV1 Gene:

Hs.435144
genes like me logo Genes that share expression patterns with TRDV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRDV1 Gene

Orthologs for TRDV1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRDV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trav15-2-dv6-2 34
  • 54 (a)
OneToMany
Trav15d-1-dv6d-1 34
  • 51 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRDV1 34
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRDV1 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
Species where no ortholog for TRDV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRDV1 Gene

ENSEMBL:
Gene Tree for TRDV1 (if available)
TreeFam:
Gene Tree for TRDV1 (if available)

Paralogs for TRDV1 Gene

Paralogs for TRDV1 Gene

Pseudogenes.org Pseudogenes for TRDV1 Gene

genes like me logo Genes that share paralogs with TRDV1: view

Variants for TRDV1 Gene

Relevant External Links for TRDV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRDV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRDV1 Gene

Disorders for TRDV1 Gene

Relevant External Links for TRDV1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRDV1

No disorders were found for TRDV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRDV1 Gene

Publications for TRDV1 Gene

  1. Genomic organization of the human T-cell antigen-receptor alpha/delta locus. (PMID: 3186718) Satyanarayana K … Krangel MS (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 60
  2. The TCR-delta repertoire in human intestine undergoes characteristic changes during fetal to adult development. (PMID: 9190911) Holtmeier W … Kagnoff MF (Journal of immunology (Baltimore, Md. : 1950) 1997) 3 60
  3. Sequence and evolution of the human germline V lambda repertoire. (PMID: 8951372) Williams SC … Winter G (Journal of molecular biology 1996) 3 60

Products for TRDV1 Gene

Sources for TRDV1 Gene

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