External Ids for TRDN Gene
Previous GeneCards Identifiers for TRDN Gene
This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]
GeneCards Summary for TRDN Gene
TRDN (Triadin) is a Protein Coding gene. Diseases associated with TRDN include ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness and catecholaminergic polymorphic ventricular tachycardia. Among its related pathways are Cardiac conduction and Ion channel transport. GO annotations related to this gene include protein homodimerization activity and ion channel binding.
UniProtKB/Swiss-Prot for TRDN Gene
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.