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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRDN Gene

protein-coding   GIFtS: 53
GCID: GC06M123580

Triadin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
triadin1 2
TDN2 5
TRISK2

External Ids:    HGNC: 122611   Entrez Gene: 103452   Ensembl: ENSG000001864397   OMIM: 6032835   UniProtKB: Q130613   

Export aliases for TRDN gene to outside databases

Previous GC identifers: GC06M123198 GC06M123386 GC06M123519 GC06M121115


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRDN Gene:
This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in
rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in
association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms
have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA
nephritis. (provided by RefSeq, Oct 2011)

GeneCards Summary for TRDN Gene: 
TRDN (triadin) is a protein-coding gene. Diseases associated with TRDN include trdn-related catecholaminergic polymorphic ventricular tachycardia, and nephritis, and among its related super-pathways are Stimuli-sensing channels and SLC-mediated transmembrane transport. GO annotations related to this gene include ion channel binding and receptor binding.

UniProtKB/Swiss-Prot: TRDN_HUMAN, Q13061
Function: May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its
functional coupling with the ryanodine receptor (By similarity)

Gene Wiki entry for TRDN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRDN gene promoter:
         C/EBPbeta   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Nkx6-1   POU2F1   HSF2   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRDN promoter sequence
   Search SABiosciences Chromatin IP Primers for TRDN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.31

TRDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRDN gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M123580:  view genomic region     (about GC identifiers)

Start:
123,537,483 bp from pter      End:
123,958,238 bp from pter
Size:
420,756 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRDN_HUMAN, Q13061 (See protein sequence)
Recommended Name: Triadin  
Size: 729 amino acids; 81595 Da
Subunit: Homooligomer of variable subunit number; disulfide-linked. Interacts with RYR1 (By similarity)
Subcellular location: Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein
Secondary accessions: A5D6W5 F5H2W7 Q6NSB8
Alternative splicing: 3 isoforms:  Q13061-1   Q13061-2   Q13061-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRDN: NX_Q13061

Explore proteomics data for TRDN at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CaMK2 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13061

  • TRDN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRDN Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001238916.1  NP_001242949.1  NP_001242950.1  NP_001242951.1  NP_006064.2  

    ENSEMBL proteins: 
     ENSP00000333984   ENSP00000354307   ENSP00000352728   ENSP00000406768   ENSP00000381240  
     ENSP00000439281   ENSP00000437684  
    Reactome Protein details: Q13061
    Human Recombinant Protein Products for TRDN: 
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals TRDN Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRDN 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11026130
    GO:0005783endoplasmic reticulum ISS--
    GO:0005886plasma membrane IDA11026130
    GO:0005891colocalizes with voltage-gated calcium channel complex ISS--
    GO:0014701junctional sarcoplasmic reticulum membrane TAS17569730

    TRDN for ontologies           About GeneDecksing



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    Assay Products for TRDN: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007943 Asp-B-hydro/Triadin_dom
     IPR010798 Triadin

    Graphical View of Domain Structure for InterPro Entry Q13061

    ProtoNet protein and cluster: Q13061

    1 Blocks protein domain: IPB010798 Triadin


    TRDN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRDN_HUMAN, Q13061
    Function: May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its
    functional coupling with the ryanodine receptor (By similarity)

         Genatlas biochemistry entry for TRDN:
    triadin,94/95 kDa,junctional terminal cisternae protein from skeletal muscle,putatively involved in
    excitation/contraction coupling

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI17526652
    GO:0030674protein binding, bridging ISS--
    GO:0042803protein homodimerization activity ISS--
    GO:0044325ion channel binding ISS--
         
    TRDN for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trdn):
     behavior/neurological  growth/size  muscle  no phenotypic analysis 

    TRDN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRDN: Trdntm1.1Cfp Trdntm1.2Isma

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRDN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRDN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRDN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRDN 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRDN
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TRDN (see all 10):
    hsa-miR-30c hsa-miR-125a-3p hsa-miR-30d hsa-miR-3617 hsa-miR-3133 hsa-miR-4282 hsa-miR-30a hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidTRDN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRDN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRDN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for TRDN
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    TRDN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRDN

    5/7 Interacting proteins for TRDN (Q130613) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    CASQ2O149583I2D: score=2 
    HRCP233273I2D: score=2 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis ISS--
    GO:0006936muscle contraction TAS7588753
    GO:0010649regulation of cell communication by electrical coupling TAS19567751
    GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS--
    GO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS--

    TRDN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRDN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRDN

    8 Novoseek inferred chemical compound relationships for TRDN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 89.4 73 10212196 (6), 19398037 (6), 9287354 (6), 19230141 (4) (see all 30)
    dihydropyridine 71.5 5 15269663 (1), 11206130 (1), 17204937 (1), 19403623 (1)
    calcium 57.1 61 18620751 (5), 19230141 (5), 7806531 (3), 10212196 (3) (see all 20)
    naphthoquinone 53.9 3 10220560 (1), 8114670 (1)
    caffeine 46.7 2 18620751 (1)
    ruthenium 39 1 7806531 (1)
    2-mercaptoethanol 31.2 2 7806531 (1), 7578102 (1)
    dithiothreitol 21.2 2 9304407 (1), 7806531 (1)

    Search CenterWatch for drugs/clinical trials and news about TRDN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRDN gene (5 alternative transcripts): 
    NM_001251987.1  NM_001256020.1  NM_001256021.1  NM_001256022.1  NM_006073.3  

    Unigene Cluster for TRDN:

    Triadin
    Hs.144744  [show with all ESTs]
    Unigene Representative Sequence: NM_006073
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334268(uc003pzj.2 uc003pzk.2 uc021zem.1) ENST00000361029
    ENST00000359698 ENST00000422596 ENST00000398178(uc010kem.2) ENST00000546248(uc010ken.3)
    ENST00000542443(uc010keo.2)
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TRDN (see all 10):
    hsa-miR-30c hsa-miR-125a-3p hsa-miR-30d hsa-miR-3617 hsa-miR-3133 hsa-miR-4282 hsa-miR-30a hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidTRDN 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TRDN (NM_006073)
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    Additional mRNA sequence: 

    AJ489257.2 AK291867.1 AK307619.1 BC012590.1 BC029393.1 BC054863.1 BC057222.1 BC070290.1 
    BC139910.1 CR749591.1 JN900469.1 U18985.1 

    10 DOTS entries:

    DT.91713164  DT.91668393  DT.40131865  DT.407642  DT.314724  DT.91640981  DT.97827213  DT.407643 
    DT.100744945  DT.121407444 

    24/202 AceView cDNA sequences (see all 202):

    BE646013 F28591 F22203 AA112792 F28818 AA111843 F26667 F28240 
    BX499870 BM720361 BM717545 F30254 BE646014 F29625 BM678702 F32534 
    AA086288 BM727507 BM684280 BC029393 F25824 BU740737 AA483648 BC070290 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRDN expression in normal human tissues (normalized intensities)      TRDN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACAAATA
    TRDN Expression
    About this image


    TRDN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             vastus lateralis   
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Primitive Streak (Early Embryonic Tissues)
             Definitive endoderm-like cells ( Generation and expansion of endodermal progenitor...
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See TRDN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRDN

    SOURCE GeneReport for Unigene cluster: Hs.144744
        SABiosciences Custom PCR Arrays for TRDN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRDN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRDN gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trdn1 , 5 triadin1, 5 82.48(n)1
    74.25(a)1
      10 (18.37 cM)5
    767571  NM_029726.21  NP_084002.21 
     330834835 
    chicken
    (Gallus gallus)
    Aves TRDN1 triadin 63.53(n)
    50.52(a)
      421721  XM_419757.3  XP_419757.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRDN6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    1(181799207-181799404)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ030455.12   -- 71.19(n)    BJ030455.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trdn1 triadin 47.88(n)
    29.26(a)
      100038781  XM_003200741.1  XP_003200789.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C32E12.16
    Protein C32E12.1
    16(a)
    1 ↔ 1
    I(5232576-5235276)


    ENSEMBL Gene Tree for TRDN (if available)
    TreeFam Gene Tree for TRDN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRDN gene
    1 SIMAP similar gene for TRDN using alignment to 9 protein entries:     TRDN_HUMAN (see all proteins):
    DKFZp779I2253

    TRDN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8865 SNPs in TRDN are shown (see all 8865)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887132171,2
    Cuntested1123576791(+) AAACTG/TGGCAT 1 -- int10--------
    VAR_0673504
    ----see VAR_0673502 T R mis40--------
    rs1837106641,2
    C--121164986(+) AATATA/GTATTA 1 -- int10--------
    rs1884786331,2
    --121165008(+) AATATA/GTATTA 1 -- int10--------
    rs1819058061,2
    --121165015(+) TATATA/GTAATA 1 -- int10--------
    rs1920248851,2
    --121165021(+) TATTAG/TATATA 1 -- int10--------
    rs1816497611,2
    C--121165129(+) ATATAG/TATTAT 1 -- int10--------
    rs1869065421,2
    --121165196(+) ATTATA/GATATG 1 -- int10--------
    rs1913322601,2
    C--121165285(+) ATTATA/GATATG 1 -- int10--------
    rs1832103131,2
    --121165290(+) AATATA/GTATTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRDN (123537483 - 123787483 bp, first 250kb of TRDN)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for TRDN (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1699630CNV Deletion17803354
    esv2676890CNV Deletion23128226
    esv2732660CNV Deletion23290073
    esv1326854CNV Deletion17803354
    esv2732659CNV Deletion23290073
    esv2663350CNV Deletion23128226
    esv270771CNV Insertion20981092
    esv269332CNV Insertion20981092
    esv273371CNV Insertion20981092
    esv1007052CNV Insertion20482838


    Human Gene Mutation Database (HGMD): TRDN
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603283    OMIM disorders: --

    UniProtKB/Swiss-Prot: TRDN_HUMAN, Q13061
  • Note=TRDN mutations have been found in catecholaminergic polymorphic ventricular tachycardia (CPVT)
    (PubMed:22422768). CPVT is an arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular
    tachycardia that may degenerate into cardiac arrest and cause sudden death

  • 6 diseases for TRDN:    About MalaCards
    trdn-related catecholaminergic polymorphic ventricular tachycardia    nephritis    familial dilated cardiomyopathy    dilated cardiomyopathy
    muscular dystrophy    myopathy


    TRDN for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TRDN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 28.1 1 17400717 (1)

    Genetic Association Database (GAD): TRDN
    Human Genome Epidemiology (HuGE) Navigator: TRDN (4 documents)

    Export disorders for TRDN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRDN gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with TRDN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23. (PubMed id 7588753)1, 2, 3, 9 Taske N.L....Foster P.S. (1995)
    2. Parallel genotyping of 10,204 single nucleotide polym orphisms to screen for susceptible genes for IgA nephropathy. (PubMed id 19890582)1, 4, 9 Woo K.T....Chan C.M. (2009)
    3. Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. (PubMed id 22422768)1, 2 Roux-Buisson N.... Marty I. (2012)
    4. Family-based association study for bipolar affective disorder. (PubMed id 20414141)1, 4 Secolin R....Lopes-Cendes I. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Interaction of triadin with histidine-rich Ca(2+)-binding protein at the triadic junction in skeletal muscle fibers. (PubMed id 10531621)1, 9 Sacchetto R....Margreth A. (1999)
    7. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. (PubMed id 10212196)1, 9 Groh S....Ronjat M. (1999)
    8. Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. (PubMed id 14638677)1, 9 Lee J.M....Kim D.H. (2004)
    9. Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum. (PubMed id 11504710)1, 9 Lee H.G....Park W.J. (2001)
    10. Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. (PubMed id 9287354)1, 9 Zhang L....Jones L.R. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10345 HGNC: 12261 AceView: TRDN Ensembl:ENSG00000186439 euGenes: HUgn10345
    ECgene: TRDN H-InvDB: TRDN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRDN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRDN gene:
    Search GeneIP for patents involving TRDN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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