TRDN Gene

Aliases
for TRDN gene

Previous GC identifers: GC06M123198 GC06M123386 GC06M123519 GC06M121115

Summaries
for TRDN gene

Genomic Views
for TRDN gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_025741.15  

SwitchGear Promoter luciferase reporter plasmid: TRDN promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRDN

TRDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M123580:  view genomic region     (about GC identifiers)

Proteins
for TRDN gene

Explore the universe of human proteins at neXtProt for TRDN: NX_Q13061

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TRDN
	GenScript Custom Purified and Recombinant Proteins Services for TRDN
	Novus Biologicals TRDN Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRDN

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TRDN
	GenScript Custom Superior Antibodies Services for TRDN
	Novus Biologicals TRDN Antibodies
	Search for Antibodies for TRDN at Abcam
	Uscn Antibodies for TRDN
	Search ThermoFisher Antibodies for TRDN

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRDN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRDN

Protein Domains /
Families
for TRDN gene

ProtoNet protein and cluster: Q13061

Function
for TRDN gene

miRNA Products:		OriGene 3'-UTR Clone: TRDN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRDN
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TRDN (see all 10):
		hsa-miR-30c hsa-miR-125a-3p hsa-miR-30d hsa-miR-3617 hsa-miR-3133 hsa-miR-4282 hsa-miR-30a hsa-miR-641
		SwitchGear 3'UTR luciferase reporter plasmid: TRDN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRDN (see all 4) OriGene shRNA RFP: TRDN OriGene siRNA: TRDN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRDN

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TRDN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRDN (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRDN OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRDN (NM_006073)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRDN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRDN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRDN
		Search LifeMap BioReagents cell lines for TRDN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRDN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Trdn)

Pathways & Interactions
for TRDN gene

	Super-pathway	contained gene-specific pathways
1	Ion channel transport	Ion channel transport 1.00 Stimuli-sensing channels 0.49
2	SLC-mediated transmembrane transport	Transmembrane transport of small molecules 0.50

3        Reactome Pathways for TRDN

	Transmembrane transport of small molecules
	Stimuli-sensing channels
	Ion channel transport

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for TRDN gene

Transcripts
for TRDN gene

Expression
for TRDN gene

TRDN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACAAATA

6 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeVisceral White AdiposeVisceral White Adipocytes			Adipose
	HeartAtrioventricular CanalAtrioventricular Canal Cells			Myocardium
	TestisSeminiferous TubulesSpermatid			Germ Cells, Male Gametocytes
	AdiposeInterscapular Brown Adipose Depot			Adipose
	BoneMaxillary Process			Bone
	HeartOutflow Tract			Heart
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Definitive endoderm-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRDN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRDN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRDN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRDN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRDN

Orthologs
for TRDN gene

Paralogs
for TRDN gene

Genomic Variants
for TRDN gene

10/7539 NCBI SNPs in TRDN are shown (see all 7539)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1887132171,2	C,	unknown	189092997(+)	AAACTG/TGGCAT	1	--	int1		0	--	--	--	--
rs737715281,2	C,	--	121114998(+)	GGGGAT/CGAAGG	1	--	ds5001		2		WA	120
rs119642921,2	C,F,H,	--	121116751(+)	TTTCCA/GCTGGA	1	--	ut31 ese3		4		NS EA	414
rs770493161,2	F,	--	121117225(+)	CCACCG/ACAGCA	1	--	ut31		1		WA	118
rs735431271,2	C,	--	121117323(+)	AGGCCA/TAAGAG	1	--	ut31		2		WA	120
rs729726221,2		--	121117760(+)	AACAAC/TGAAAA	1	--	int1		0	--	--	--	--
rs784560991,2		--	121118084(+)	GGTGGC/TTTGGT	1	--	int1		1		WA	118
rs792904101,2	F,	--	121118535(+)	AGAATC/ATTGAA	1	--	int1		1		EA	120
rs737715291,2	C,	--	121118624(+)	CTTCCG/ATCTCT	1	--	int1		2		WA	120
rs77597481,2	C,F,A,H,	--	121118695(+)	AAAGCC/TGGCCC	1	--	int1		8		EA NS NA CSA WA	560

HapMap Linkage Disequilibrium report for TRDN (123537483 - 123787483 bp, first 250kb of TRDN)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TRDN
     1 CNV: 69599
     5 Indels: 99692 59290 28082 12860 81574
Human Gene Mutation Database (HGMD): TRDN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRDN

DNA2.0 Custom Variant and Variant Library Synthesis for TRDN

Disorders / Diseases
for TRDN gene

8 diseases for TRDN

1 Novoseek disease relationship for TRDN gene    About this table

Publications
for TRDN gene

PubMed articles for TRDN gene, integrated from 9 sources (see all 87): (articles sorted by number of sources associating them with TRDN)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23. (PubMed id 7588753)^{1, 2, 3, 9} Taske N.L....Foster P.S. (1995)
2. Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. (PubMed id 22422768)^{1, 2} Roux-Buisson N.... Marty I. (2012)
3. Interaction of triadin with histidine-rich Ca(2+)-binding protein at the triadic junction in skeletal muscle fibers. (PubMed id 10531621)^{1, 9} Sacchetto R....Margreth A. (1999)
4. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. (PubMed id 10212196)^{1, 9} Groh S....Ronjat M. (1999)
5. Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. (PubMed id 14638677)^{1, 9} Lee J.M....Kim D.H. (2004)
6. Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum. (PubMed id 11504710)^{1, 9} Lee H.G....Park W.J. (2001)
7. Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. (PubMed id 9287354)^{1, 9} Zhang L....Jones L.R. (1997)
8. Association of triadin with the ryanodine receptor and calsequestrin in the lumen of the sarcoplasmic reticulum. (PubMed id 7721813)^{1, 9} Guo W. and Campbell K.P. (1995)
9. Localization and characterization of the calsequestrin-binding domain of triadin 1. Evidence for a charged beta-strand in mediating the protein-protein interaction. (PubMed id 10748065)^{1, 9} Kobayashi Y.M....Jones L.R. (2000)
10. Location of ryanodine receptor binding site on skeletal muscle triadin. (PubMed id 9890886)^{1, 9} Caswell A.H....Brandt N.R. (1999)

External Searches for TRDN gene

Genome Databases showing TRDN gene

Other Databases showing TRDN gene

Specialized Databases showing TRDN gene

Products
for TRDN gene