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Aliases for TRDN Gene

Aliases for TRDN Gene

  • Triadin 2 3 5
  • CPVT5 3
  • TRISK 3
  • TDN 3

External Ids for TRDN Gene

Previous GeneCards Identifiers for TRDN Gene

  • GC06M123386
  • GC06M123519
  • GC06M123580
  • GC06M121115

Summaries for TRDN Gene

Entrez Gene Summary for TRDN Gene

  • This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]

GeneCards Summary for TRDN Gene

TRDN (Triadin) is a Protein Coding gene. Diseases associated with TRDN include ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness and catecholaminergic polymorphic ventricular tachycardia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cardiac conduction. GO annotations related to this gene include protein homodimerization activity and ion channel binding.

UniProtKB/Swiss-Prot for TRDN Gene

  • Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

Gene Wiki entry for TRDN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDN Gene

Genomics for TRDN Gene

Genomic Location for TRDN Gene

Chromosome:
6
Start:
123,216,339 bp from pter
End:
123,637,283 bp from pter
Size:
420,945 bases
Orientation:
Minus strand

Genomic View for TRDN Gene

Genes around TRDN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDN Gene

Proteins for TRDN Gene

  • Protein details for TRDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13061-TRDN_HUMAN
    Recommended name:
    Triadin
    Protein Accession:
    Q13061
    Secondary Accessions:
    • A5D6W5
    • F5H2W7
    • Q6NSB8

    Protein attributes for TRDN Gene

    Size:
    729 amino acids
    Molecular mass:
    81595 Da
    Quaternary structure:
    • Homooligomer of variable subunit number; disulfide-linked (By similarity). Interacts with CASQ1 and RYR1 in skeletal muscle. Interacts with CASQ2.

    Alternative splice isoforms for TRDN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRDN Gene

Proteomics data for TRDN Gene at MOPED

Post-translational modifications for TRDN Gene

No data available for DME Specific Peptides for TRDN Gene

Domains & Families for TRDN Gene

Protein Domains for TRDN Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRDN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TRDN Gene

Function for TRDN Gene

Molecular function for TRDN Gene

GENATLAS Biochemistry:
triadin,94/95 kDa,junctional terminal cisternae protein from skeletal muscle,putatively involved in excitation/contraction coupling
UniProtKB/Swiss-Prot Function:
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
genes like me logo Genes that share phenotypes with TRDN: view

Human Phenotype Ontology for TRDN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRDN Gene

MGI Knock Outs for TRDN:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TRDN Gene

Localization for TRDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRDN Gene

Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRDN Gene COMPARTMENTS Subcellular localization image for TRDN gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 3
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11026130
GO:0014701 junctional sarcoplasmic reticulum membrane TAS 17569730
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TRDN: view

Pathways & Interactions for TRDN Gene

genes like me logo Genes that share pathways with TRDN: view

Interacting Proteins for TRDN Gene

Selected Interacting proteins: Q13061-TRDN_HUMAN for TRDN Gene via I2D

Gene Ontology (GO) - Biological Process for TRDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 7588753
GO:0010649 regulation of cell communication by electrical coupling TAS 19567751
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS --
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS --
GO:0031122 cytoplasmic microtubule organization ISS --
genes like me logo Genes that share ontologies with TRDN: view

No data available for SIGNOR curated interactions for TRDN Gene

Drugs & Compounds for TRDN Gene

(4) Drugs for TRDN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TRDN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRDN: view

Transcripts for TRDN Gene

Unigene Clusters for TRDN Gene

Triadin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRDN Gene

No ASD Table

Relevant External Links for TRDN Gene

GeneLoc Exon Structure for
TRDN
ECgene alternative splicing isoforms for
TRDN

Expression for TRDN Gene

mRNA expression in normal human tissues for TRDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRDN Gene

This gene is overexpressed in Muscle - Skeletal (x40.4), Heart - Left Ventricle (x5.2), and Heart - Atrial Appendage (x5.0).

Protein differential expression in normal tissues from HIPED for TRDN Gene

This gene is overexpressed in Bone (27.4), Heart (19.7), and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRDN Gene



SOURCE GeneReport for Unigene cluster for TRDN Gene Hs.144744

genes like me logo Genes that share expression patterns with TRDN: view

Protein tissue co-expression partners for TRDN Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRDN Gene

Orthologs for TRDN Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRDN 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRDN 36
  • 87 (a)
OneToOne
TRDN 35
  • 89.73 (n)
  • 85.17 (a)
dog
(Canis familiaris)
Mammalia TRDN 35
  • 90.44 (n)
  • 85.59 (a)
TRDN 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trdn 16
Trdn 36
  • 69 (a)
OneToOne
Trdn 35
  • 80.9 (n)
  • 71.28 (a)
oppossum
(Monodelphis domestica)
Mammalia TRDN 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRDN 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trdn 35
  • 81.17 (n)
  • 72.58 (a)
chicken
(Gallus gallus)
Aves TRDN 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRDN 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trdn 36
  • 18 (a)
OneToOne
Species with no ortholog for TRDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRDN Gene

ENSEMBL:
Gene Tree for TRDN (if available)
TreeFam:
Gene Tree for TRDN (if available)

Paralogs for TRDN Gene

(1) SIMAP similar genes for TRDN Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TRDN: view

No data available for Paralogs for TRDN Gene

Variants for TRDN Gene

Sequence variations from dbSNP and Humsavar for TRDN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_057008 -
VAR_057009 -
rs28494009 - 123,377,874(+) GTTCC(A/C)CATGT reference, missense
rs17737379 - 123,375,621(+) TGTTT(C/G/T)TCACT reference, missense
rs6569336 - 123,337,631(+) TTTCA(G/T)AATTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRDN Gene

Variant ID Type Subtype PubMed ID
nsv524559 CNV Gain 19592680
esv2732659 CNV Deletion 23290073
esv1699630 CNV Deletion 17803354
esv274430 CNV Insertion 20981092
esv1205067 CNV Insertion 17803354
esv29144 CNV Loss 19812545
dgv6986n71 CNV Loss 21882294
nsv470856 CNV Gain 18288195
nsv886604 CNV Loss 21882294
nsv526420 CNV Gain 19592680
esv2576909 CNV Insertion 19546169
esv274102 CNV Insertion 20981092
esv270771 CNV Insertion 20981092
nsv886605 CNV Loss 21882294
nsv830792 CNV Gain 17160897
esv2663350 CNV Deletion 23128226
nsv349422 CNV Loss 16902084
esv2732660 CNV Deletion 23290073
esv1326854 CNV Deletion 17803354
nsv520198 CNV Loss 19592680
nsv886606 CNV Loss 21882294
nsv886607 CNV Loss 21882294
nsv886608 CNV Loss 21882294
nsv5461 CNV Insertion 18451855
nsv509152 CNV Insertion 20534489
esv2676890 CNV Deletion 23128226
nsv820113 CNV Loss 19587683
esv1000992 CNV Insertion 20482838
esv273371 CNV Insertion 20981092
esv269332 CNV Insertion 20981092
nsv886609 CNV Loss 21882294
nsv520332 CNV Loss 19592680
nsv349674 CNV Insertion 16902084
esv1007052 CNV Insertion 20482838

Variation tolerance for TRDN Gene

Gene Damage Index Score: 13.28; 95.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRDN Gene

HapMap Linkage Disequilibrium report
TRDN
Human Gene Mutation Database (HGMD)
TRDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRDN Gene

Disorders for TRDN Gene

MalaCards: The human disease database

(22) MalaCards diseases for TRDN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TRDN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRDN_HUMAN
  • Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5) [MIM:615441]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, or sudden death after physical activity or emotional stress. Some patients have muscle weakness. {ECO:0000269 PubMed:22422768}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRDN

Genetic Association Database (GAD)
TRDN
Human Genome Epidemiology (HuGE) Navigator
TRDN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRDN
genes like me logo Genes that share disorders with TRDN: view

No data available for Genatlas for TRDN Gene

Publications for TRDN Gene

  1. Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23. (PMID: 7588753) Taske N.L. … Foster P.S. (Eur. J. Biochem. 1995) 2 3 4 23 67
  2. Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. (PMID: 19890582) Woo K.T. … Chan C.M. (Ann. Acad. Med. Singap. 2009) 3 23
  3. Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis. (PMID: 19403607) Pritchard T.J. … Kranias E.G. (J. Physiol. (Lond.) 2009) 3 23
  4. Inefficient glycosylation leads to high steady-state levels of actively degrading cardiac triadin-1. (PMID: 18025088) Milstein M.L. … Cala S.E. (J. Biol. Chem. 2008) 3 23
  5. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. (PMID: 17526652) Arvanitis D.A. … Kranias E.G. (Am. J. Physiol. Heart Circ. Physiol. 2007) 3 23

Products for TRDN Gene

Sources for TRDN Gene

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