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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRDMT1 Gene

protein-coding   GIFtS: 61
GCID: GC10M017098

TRNA Aspartic Acid Methyltransferase 1

(Previous name: DNA (cytosine-5-)-methyltransferase 2)
(Previous symbol: DNMT2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TRNA Aspartic Acid Methyltransferase 11 2     TRNA (Cytosine(38)-C(5))-Methyltransferase2
DNMT21 2 3     TRNA (Cytosine-5-)-Methyltransferase2
DNA (Cytosine-5)-Methyltransferase-Like Protein 22 3     Dnmt23
DNA MTase Homolog HsaIIP2 3     EC 2.1.1.2043
DMNT22 5     M.HsaIIP3
DNA (Cytosine-5-)-Methyltransferase 21     PuMet3
MHSAIIP2     DNA Methyltransferase Homolog HsaIIP3
PUMET2     EC 2.1.18
RNMT12     EC 2.1.1.298
DNA Methyltransferase-22     

External Ids:    HGNC: 29771   Entrez Gene: 17872   Ensembl: ENSG000001076147   OMIM: 6024785   UniProtKB: O147173   

Export aliases for TRDMT1 gene to outside databases

Previous GC identifer: GC10M017225


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRDMT1 Gene:
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the
cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5)
methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene
is distinct and highly conserved in its function among taxa. (provided by RefSeq, Jun 2010)

GeneCards Summary for TRDMT1 Gene: 
TRDMT1 (tRNA aspartic acid methyltransferase 1) is a protein-coding gene. Diseases associated with TRDMT1 include progeria, and spina bifida. GO annotations related to this gene include RNA binding and DNA (cytosine-5-)-methyltransferase activity.

UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)

Gene Wiki entry for TRDMT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRDMT1 gene promoter:
         Nkx3-1   ISGF-3   p53   MyoD   Nkx3-1 v1   Tal-1beta   E47   AREB6   Nkx3-1 v2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRDMT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRDMT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRDMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p15.1

TRDMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRDMT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M017098:  view genomic region     (about GC identifiers)

Start:
17,184,253 bp from pter      End:
17,244,070 bp from pter
Size:
59,818 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717 (See protein sequence)
Recommended Name: tRNA (cytosine(38)-C(5))-methyltransferase  
Size: 391 amino acids; 44597 Da
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for TRDMT1:
1G55 (3D)    
Secondary accessions: B0YJ02 B0YJ03 B0YJ07 B0YJ08 O43669 Q86WW6
Alternative splicing: 6 isoforms:  O14717-1   O14717-2   O14717-3   O14717-4   O14717-5   O14717-6   

Explore the universe of human proteins at neXtProt for TRDMT1: NX_O14717

Explore proteomics data for TRDMT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14717

  • 3 DME Specific Peptides for TRDMT1 (O14717)
     QQDSDLSV  LMSPPCQPFTR  MILMSPPCQPFTRIG 

    TRDMT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRDMT1 Protein Expression
    REFSEQ proteins: NP_004403.1  
    ENSEMBL proteins: 
     ENSP00000346652   ENSP00000367030   ENSP00000417594   ENSP00000419625   ENSP00000324263  
     ENSP00000390611   ENSP00000431476   ENSP00000389497   ENSP00000409354   ENSP00000324328  
     ENSP00000412256   ENSP00000366996   ENSP00000351027  

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    Cloud-Clone Corp. Proteins for TRDMT1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TRDMT1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR018117 C5_DNA_meth_AS
     IPR025813 DNA/tRNA_C5-MeTrfase
     IPR001525 C5_MeTfrase

    Graphical View of Domain Structure for InterPro Entry O14717

    ProtoNet protein and cluster: O14717

    1 Blocks protein domain: IPB001525 C-5 cytosine-specific DNA methylase

    UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
    Similarity: Belongs to the C5-methyltransferase family


    TRDMT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRDMT_HUMAN, O14717
    Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)
    Catalytic activity: S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine +
    5-methylcytosine(38) in tRNA

         Enzyme Numbers (IUBMB): EC 2.1.12 EC 2.1.1.292 EC 2.1.1.2041

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0003886DNA (cytosine-5-)-methyltransferase activity TAS9425235
    GO:0008168methyltransferase activity ----
         
    TRDMT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRDMT1:
     Decreased viability  Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trdmt1):
     hematopoietic system  immune system  normal 

    TRDMT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trdmt1tm1Bes for TRDMT1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRDMT1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRDMT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/27 Interacting proteins for TRDMT1 (O147173 ENSP000003670304) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPA1P096613, ENSP000002541934I2D: score=1 STRING: ENSP00000254193
    STX1AQ166233, ENSP000002228124I2D: score=4 STRING: ENSP00000222812
    COPS6Q7L5N13I2D: score=4 
    DDX24Q9GZR73I2D: score=4 
    EEF1A1P681043I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006306DNA methylation ----
    GO:0008033tRNA processing IEA--
    GO:0090116C-5 methylation of cytosine TAS9425235

    TRDMT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRDMT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for TRDMT1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TRDMT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    UNC 0638Selective G9a and GLP histone lysine methyltransferase inhibitor[1255517-77-1]
    BIX 01294G9a-like protein and G9a histone lysine methyltransferase inhibitor[935693-62-2]
    SGC 0946Highly potent and selective DOT1L inhibitor; cell permeable--
    3-Deazaneplanocin A hydrochlorideHistone methyltransferase inhibitor[120964-45-6]
    UNC 0646Potent and selective G9a/GLP inhibitor[1320288-17-2]

    3 HMDB Compounds for TRDMT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Methylcytosine4-Amino-5-methyl-2-pyrimidinol (see all 5)554-01-8--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    3 DrugBank Compounds for TRDMT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentamidine1,3-bis(4-amidinophenoxy)pentane (see all 5)100-33-4targetother18263620
    Glycerol-- --target----
    S-Adenosyl-L-Homocysteine-- 979-92-0target----

    3 Novoseek inferred chemical compound relationships for TRDMT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-methylcytosine 74.5 2 9425235 (2)
    cytosine 54.4 2 16424344 (1)
    azathioprine 40.5 1 15188362 (1)

    Search CenterWatch for drugs/clinical trials and news about TRDMT1 / TRDMT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRDMT1 gene (6 alternative transcripts): 
    NM_004412.5  NM_176081.2  NM_176083.2  NM_176084.1  NM_176085.1  NM_176086.1  

    Unigene Cluster for TRDMT1:

    TRNA aspartic acid methyltransferase 1
    Hs.351665  [show with all ESTs]
    Unigene Representative Sequence: BX537961
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354631(uc001iop.3 uc001ios.3 uc009xjt.3) ENST00000377799
    ENST00000495022 ENST00000452380(uc010qcc.1) ENST00000488990(uc010qcd.2)
    ENST00000313936(uc021pno.1) ENST00000436968 ENST00000525762 ENST00000424636
    ENST00000486947 ENST00000451253 ENST00000479046 ENST00000412821(uc021pnn.1)
    ENST00000351358 ENST00000457442 ENST00000377766(uc009xju.1) ENST00000358282(uc009xjs.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-4291 hsa-miR-146a hsa-miR-578 hsa-miR-183* hsa-miR-29a* hsa-miR-23a hsa-miR-520g hsa-miR-556-3p
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    Additional mRNA sequence: 

    AF012128.1 AF045888.1 AF329940.1 AF329941.1 AF329944.1 AJ223333.1 AK021659.1 AK123512.1 
    AK291417.1 AK294100.1 AK299027.1 AK303428.1 BC047733.1 BX537961.1 CR450316.1 

    7 DOTS entries:

    DT.456091  DT.100707639  DT.97836581  DT.97836582  DT.75169900  DT.91690081  DT.428106 

    24/70 AceView cDNA sequences (see all 70):

    AA399001 AW665188 CA391362 AI056280 AK123512 AF045888 NM_176083 AF329943 
    NM_176084 NM_176085 BX117729 AF012128 AW772430 AF329941 AA668760 NM_004412 
    CR604140 NM_176086 AI005167 AF329940 CR450316 CD673710 AI384115 NM_176081 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRDMT1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -                                                                 -               
    SP2:              -           -                                                     -               
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for TRDMT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRDMT1 expression in normal human tissues (normalized intensities)      TRDMT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRDMT1 Expression
    About this image


    TRDMT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             cervix, uterine ; squamous epithelial cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             skeletal muscle ; myocytes   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   

    See TRDMT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRDMT1

    SOURCE GeneReport for Unigene cluster: Hs.351665

    UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
    Tissue specificity: Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen,
    prostate, colon, small intestine, and peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRDMT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRDMT1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trdmt11 , 5 tRNA aspartic acid methyltransferase 11, 5 83.25(n)1
    81.54(a)1
      2 (10.00 cM)5
    134341  NM_010067.41  NP_034197.31 
     135090145 
    chicken
    (Gallus gallus)
    Aves TRDMT11 tRNA aspartic acid methyltransferase 1 72.92(n)
    68.91(a)
      420520  NM_001024831.1  NP_001020002.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRDMT16
    Uncharacterized protein
    61(a)
    1 ↔ 1
    6(18339897-18366889)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC532072 similar to DNA (cytosine-5-)-methyltransferase 2 73.39(n)    BC046854.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trdmt11 tRNA aspartic acid methyltransferase 1 60.05(n)
    62.2(a)
      449878  NM_001018143.1  NP_001018153.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mt21 Methyltransferase 2 50.15(n)
    44.04(a)
      34632  NM_001042890.1  NP_001036355.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DNMT21 DNA methyltransferase-2 48.95(n)
    39.45(a)
      832623  NM_122459.2  NP_568474.1 


    ENSEMBL Gene Tree for TRDMT1 (if available)
    TreeFam Gene Tree for TRDMT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRDMT1 gene
    2 SIMAP similar genes for TRDMT1 using alignment to 6 protein entries:     TRDMT_HUMAN (see all proteins):
    DKFZp686N1286    DNMT2

    TRDMT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1408 SNPs in TRDMT1 are shown (see all 1408)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741177221,2
    C,F--17184694(+) AGGAAC/TGAGCC 1 -- ds50012Minor allele frequency- T:0.13WA 120
    rs1420042041,2
    C--17184826(+) CCTCCA/GCAGTG 1 -- ds50010--------
    rs122543341,2
    C,F,H--17184945(+) agaaaT/Gaaatc 1 -- ds500111Minor allele frequency- G:0.07NS EA NA WA 1208
    rs70817901,2
    C,F,A,H--17184971(+) AGACCG/AGAAGT 1 -- ds5001 ese324Minor allele frequency- A:0.17NS EA NA WA CSA 2071
    rs1877971191,2
    --17184979(+) AGTCAG/TAATAC 1 -- ds50010--------
    rs2021604581,2
    C--17185114(+) GGCAGG/TANNNN 1 -- ut310--------
    rs1926240341,2
    --17185158(+) AGACAC/TTGTTT 1 -- ut310--------
    rs122482561,2
    C,F,H--17185313(+) tctctG/Accctt 1 -- ut31 ese311Minor allele frequency- A:0.07NS EA NA WA 1210
    rs618417631,2
    C--17185374(+) CAGATC/TGTAAC 1 -- ut312Minor allele frequency- T:0.04NA 122
    rs112543961,2
    H--17185402(+) TCTACT/CCATTC 1 -- ut31 ese34Minor allele frequency- C:0.00NS EA 418

    HapMap Linkage Disequilibrium report for TRDMT1 (17184253 - 17244070 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TRDMT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733606CNV Deletion23290073
    nsv508571CNV Loss20534489
    nsv831801CNV Gain17160897
    nsv894908CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602478    OMIM disorders: --

    11 diseases for TRDMT1:    About MalaCards
    progeria    spina bifida    acute lymphoblastic leukemia    lymphoblastic leukemia
    ovarian cancer    hepatitis b    lung cancer    hepatitis
    prostate cancer    prostatitis    leukemia


    TRDMT1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TRDMT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 15721400 (1)

    Genetic Association Database (GAD): TRDMT1
    Human Genome Epidemiology (HuGE) Navigator: TRDMT1 (8 documents)

    Export disorders for TRDMT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRDMT1 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with TRDMT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. (PubMed id 9425235)1, 2, 3, 9 Yoder J.A. and Bestor T.H. (1998)
    2. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. (PubMed id 16424344)1, 2, 3, 9 Goll M.G.... Bestor T.H. (2006)
    3. A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. (PubMed id 19246518)1, 4, 9 El-Maarri O....ChAcdin F. (2009)
    4. Cloning and analysis of a novel human putative DNA methyltransferase. (PubMed id 9599025)1, 2, 9 Van den Wyngaert I.... Luyten W.H.M.L. (1998)
    5. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    6. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    7. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (2009)
    8. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4 Halaschek-Wiener J....Brooks-Wilson A.R. (2009)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    10. Prognostic significance of folate metabolism polymorphisms for lung cancer. (PubMed id 17533396)1, 4 Matakidou A....Houlston R.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1787 HGNC: 2977 AceView: DNMT2 Ensembl:ENSG00000107614 euGenes: HUgn1787
    ECgene: TRDMT1 H-InvDB: TRDMT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRDMT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRDMT1 gene:
    Search GeneIP for patents involving TRDMT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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