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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRDMT1 Gene

protein-coding   GIFtS: 60
GCID: GC10M017098

tRNA aspartic acid methyltransferase 1

(Previous name: DNA (cytosine-5-)-methyltransferase 2 )
(Previous symbol: DNMT2)
 Explore 15 diseases affiliated with
TRDMT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRDMT1    

Aliases
for TRDMT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TRNA Aspartic Acid Methyltransferase 11 2     TRNA (Cytosine(38)-C(5))-Methyltransferase2
DNMT21 2 3     TRNA (Cytosine-5-)-Methyltransferase2
RNMT11 2     Dnmt23
DNA (Cytosine-5)-Methyltransferase-Like Protein 22 3     EC 2.1.1.2043
DNA MTase Homolog HsaIIP2 3     M.HsaIIP3
DMNT22 5     PuMet3
DNA (Cytosine-5-)-Methyltransferase 21     DNA Methyltransferase Homolog HsaIIP3
MHSAIIP2     EC 2.1.18
PUMET2     EC 2.1.1.298
DNA Methyltransferase-22     

External Ids:    HGNC: 29771   Entrez Gene: 17872   Ensembl: ENSG000001076147   OMIM: 6024785   UniProtKB: O147173   

Export aliases for TRDMT1 gene to outside databases

Previous GC identifer: GC10M017225


Summaries
for TRDMT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRDMT1:
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the
cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase
activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly
conserved in its function among taxa. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)

Gene Wiki entry for TRDMT1


Genomic Views
for TRDMT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRDMT1 gene promoter:
         Nkx3-1   ISGF-3   p53   MyoD   Nkx3-1 v1   Tal-1beta   E47   AREB6   Nkx3-1 v2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRDMT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRDMT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRDMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p15.1

TRDMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRDMT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M017098:  view genomic region     (about GC identifiers)

Start:
 17,184,253 bp from pter      End:
 17,244,070 bp from pter
Size:
 59,818 bases      Orientation:
 minus strand

Proteins
for TRDMT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717 (See protein sequence)
Recommended Name: tRNA (cytosine(38)-C(5))-methyltransferase  
Size: 391 amino acids; 44597 Da
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for TRDMT1:
1G55 (3D)    
Secondary accessions: B0YJ02 B0YJ03 B0YJ07 B0YJ08 O43669 Q86WW6
Alternative splicing: 6 isoforms:  O14717-1   O14717-2   O14717-3   O14717-4   O14717-5   O14717-6   

Explore the universe of human proteins at neXtProt for TRDMT1: NX_O14717

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14717

    • 3 DME Specific Peptides for TRDMT1 (O14717)
     QQDSDLSV  LMSPPCQPFTR  MILMSPPCQPFTRIG 

    TRDMT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004403.1  
    ENSEMBL proteins: 
     ENSP00000346652   ENSP00000367030   ENSP00000417594   ENSP00000419625   ENSP00000324263  
     ENSP00000390611   ENSP00000431476   ENSP00000389497   ENSP00000409354   ENSP00000324328  
     ENSP00000412256   ENSP00000366996   ENSP00000351027  

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    Uscn Proteins for TRDMT1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TRDMT1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRDMT1

    Protein Domains /
    Families
    for TRDMT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRDMT1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018117 C5_DNA_meth_AS
     IPR025813 tRNA_MeTrfase_TRDMT1
     IPR001525 C5_MeTfrase

    Graphical View of Domain Structure for InterPro Entry O14717

    ProtoNet protein and cluster: O14717

    1 Blocks protein family: IPB001525 C-5 cytosine-specific DNA methylase

    UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
    Similarity: Belongs to the C5-methyltransferase family


    Function
    for TRDMT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
    Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)
    Catalytic activity: S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38)
    in tRNA

    Enzyme Numbers (IUBMB): EC 2.1.12 EC 2.1.1.292 EC 2.1.1.2041

    miRNA
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    hsa-miR-4291 hsa-miR-146a hsa-miR-578 hsa-miR-183* hsa-miR-29a* hsa-miR-23a hsa-miR-520g hsa-miR-556-3p
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0003886DNA (cytosine-5-)-methyltransferase activity TAS9425235
    GO:0008168methyltransferase activity ----


    TRDMT1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TRDMT1:
     Decreased viability  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Trdmt1tm1Bes for TRDMT1
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trdmt1):
     hematopoietic system  immune system  normal 

    TRDMT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRDMT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolic pathways0.38
    2Sulfur amino acid metabolism
    		Cysteine and methionine metabolism0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for TRDMT1):
        Cysteine and methionine metabolism
    Metabolic pathways


    TRDMT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRDMT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/27 Interacting proteins for TRDMT1 (O147173 ENSP000003670304) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPA1P096613, ENSP000002541934I2D: score=1 STRING: ENSP00000254193
    STX1AQ166233, ENSP000002228124I2D: score=4 STRING: ENSP00000222812
    COPS6Q7L5N13I2D: score=4 
    DDX24Q9GZR73I2D: score=4 
    EEF1A1P681043I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006306DNA methylation ----
    GO:0008033tRNA processing IEA--
    GO:0090116C-5 methylation of cytosine TAS9425235


    TRDMT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRDMT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRDMT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for TRDMT1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TRDMT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RG 108Non-nucleoside DNA methyltransferase inhibitor[48208-26-0]
    ZebularineDNA methyltransferase and cytidine deaminase inhibitor[3690-10-6]
    DecitabineDNA methyltransferase inhibitor[2353-33-5]
    5-AzacytidineDNA methyltransferase inhibitor[320-67-2]

    3 HMDB Compounds for TRDMT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Methylcytosine4-Amino-5-methyl-2-pyrimidinol (see all 5)554-01-8--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    3 DrugBank Compounds for TRDMT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentamidine1,3-bis(4-amidinophenoxy)pentane (see all 5)100-33-4targetother18263620
    Glycerol-- --target----
    S-Adenosyl-L-Homocysteine-- 979-92-0target----

    3 Novoseek chemical compound relationships for TRDMT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-methylcytosine 74.5 2 9425235 (2)
    cytosine 54.4 2 16424344 (1)
    azathioprine 40.5 1 15188362 (1)

    Search CenterWatch for drugs/clinical trials and news about TRDMT1 / TRDMT 

    Transcripts
    for TRDMT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRDMT1 gene (6 alternative transcripts): 
    NM_004412.5  NM_176081.2  NM_176083.2  NM_176084.1  NM_176085.1  NM_176086.1  

    Unigene Cluster for TRDMT1:

    TRNA aspartic acid methyltransferase 1
    Hs.351665  [show with all ESTs]
    Unigene Representative Sequence: BX537961
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354631(uc001iop.3 uc001ios.3 uc009xjt.3) ENST00000377799
    ENST00000495022 ENST00000452380(uc010qcc.1) ENST00000488990(uc010qcd.2)
    ENST00000313936(uc021pno.1) ENST00000436968 ENST00000525762 ENST00000424636
    ENST00000486947 ENST00000451253 ENST00000479046 ENST00000412821(uc021pnn.1)
    ENST00000351358 ENST00000457442 ENST00000377766(uc009xju.1) ENST00000358282(uc009xjs.1)


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    hsa-miR-4291 hsa-miR-146a hsa-miR-578 hsa-miR-183* hsa-miR-29a* hsa-miR-23a hsa-miR-520g hsa-miR-556-3p
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    Additional cDNA sequence: 

    AF012128.1 AF045888.1 AF329940.1 AF329941.1 AF329944.1 AJ223333.1 AK021659.1 AK123512.1 
    AK291417.1 AK294100.1 AK299027.1 AK303428.1 BC047733.1 BX537961.1 CR450316.1 

    7 DOTS entries:

    DT.456091  DT.100707639  DT.97836581  DT.97836582  DT.75169900  DT.91690081  DT.428106 

    24/70 AceView cDNA sequences (see all 70):

    NM_004412 CA391362 CR450316 AA399001 AI056280 NM_176084 NM_176083 AK123512 
    BX117729 AF329943 NM_176085 AL120264 AF045888 AW665188 AF329940 NM_176086 
    CR604140 AI005167 AI384115 NM_176081 CD673710 AA668760 AF329941 AW772430 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRDMT1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -                                                                 -               
    SP2:              -           -                                                     -               
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for TRDMT1

    Expression
    for TRDMT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRDMT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TRDMT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRDMT1

    SOURCE GeneReport for Unigene cluster: Hs.351665

    UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
    Tissue specificity: Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen,
    prostate, colon, small intestine, and peripheral blood leukocytes

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    In Situ
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    Orthologs
    for TRDMT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRDMT1 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trdmt11 , 5 tRNA aspartic acid methyltransferase 11, 5 83.25(n)1
    81.54(a)1    		   2 (10.00 cM)5
    134341  NM_010067.41  NP_034197.31 
     135090145 
    chicken
    (Gallus gallus)    		 Aves TRDMT11 tRNA aspartic acid methyltransferase 1 72.92(n)
    68.91(a)    		   420520  NM_001024831.1  NP_001020002.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TRDMT16
    		 --
    		 62(a)
    		 1 ↔ 1
    		 6(18340223-18366889)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC532072 similar to DNA (cytosine-5-)-methyltransferase 2 73.39(n)    BC046854.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii trdmt11 tRNA aspartic acid methyltransferase 1 60.05(n)
    62.2(a)    		   449878  NM_001018143.1  NP_001018153.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mt21 Methyltransferase 2 50.15(n)
    44.04(a)    		   34632  NM_001042890.1  NP_001036355.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DNMT21 DNA methyltransferase-2 48.95(n)
    39.45(a)    		   832623  NM_122459.2  NP_568474.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    		 C-5 cytosine-specific DNA methylase, putative, exp...
    		 33(a)
    		 1 ↔ 1
    		 1(24244687-24248335)


    ENSEMBL Gene Tree for TRDMT1 (if available)
    TreeFam Gene Tree for TRDMT1 (if available) 

    Paralogs
    for TRDMT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TRDMT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1177 NCBI SNPs in TRDMT1 are shown (see all 1177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38339851,2
    		C--17116768(-) TCTTT-/ACTTT 
                TTCTT     		1 -- int1 trp30--------
    rs741177221,2
    		C,--17184694(+) AGGAAC/TGAGCC 1 -- ds50012Minor allele frequency- T:0.13WA 120
    rs1420042041,2
    		--17184826(+) CCTCCA/GCAGTG 1 -- ds50010--------
    rs122543341,2
    		C,F,H,--17184945(+) AGAAAT/GAAATC 1 -- ds500111Minor allele frequency- G:0.07NS EA NA WA 1208
    rs70817901,2
    		C,F,A,H,--17184971(+) AGACCG/AGAAGT 1 -- ds5001 ese324Minor allele frequency- A:0.17NS EA NA WA CSA 2071
    rs1877971191,2
    		--17184979(+) AGTCAG/TAATAC 1 -- ds50010--------
    rs2021604581,2
    		C--17185114(+) GGCAGG/TANNNN 1 -- ut310--------
    rs1926240341,2
    		--17185158(+) AGACAC/TTGTTT 1 -- ut310--------
    rs122482561,2
    		C,F,H,--17185313(+) TCTCTG/ACCCTT 1 -- ut31 ese311Minor allele frequency- A:0.07NS EA NA WA 1210
    rs618417631,2
    		C,--17185374(+) NNNNTC/TGTAAC 1 -- ut312Minor allele frequency- T:0.04NA 122

    HapMap Linkage Disequilibrium report for TRDMT1 (17184253 - 17244070 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRDMT1: --

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    Disorders / Diseases
    for TRDMT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRDMT1 for disorders           About GeneDecksing

    OMIM gene information: 602478    OMIM disorders: --

    15 diseases for TRDMT1:    About MalaCards
    spina bifida    acute lymphoblastic leukemia    lymphoblastic leukemia    progeria
    epithelial ovarian cancer    ovarian cancer    hepatitis b    endometrial cancer
    homocysteine    leukemia    lung cancer    prostate cancer
    hepatitis    prostatitis    malaria

    1 Novoseek disease relationship for TRDMT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 15721400 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRDMT1 (8 documents)

    Export disorders for TRDMT1 gene to outside databases

    Publications
    for TRDMT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRDMT1 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with TRDMT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. (PubMed id 9425235)1, 2, 3, 9 Yoder J.A. and Bestor T.H. (1998)
    2. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. (PubMed id 16424344)1, 2, 3, 9 Goll M.G.... Bestor T.H. (2006)
    3. Cloning and analysis of a novel human putative DNA methyltransferase. (PubMed id 9599025)1, 2, 9 Van den Wyngaert I.... Luyten W.H.M.L. (1998)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Five novel alternatively spliced transcripts of DNA (cytosine-5) methyltransferase 2 in human peripheral blood leukocytes. (PubMed id 11551826)1, 2 Franchina M.... Kay P.H. (2001)
    6. Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. (PubMed id 11139614)1, 2 Dong A.... Cheng X. (2001)
    7. Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization. (PubMed id 9763678)1, 3 Vilain A....Malfoy B. (1998)
    8. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. (PubMed id 9592134)1, 2 Okano M.... Li E. (1998)
    9. Endogenous assays of DNA methyltransferases: Evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo. (PubMed id 12665573)1, 9 Liu K....Muller M.T. (2003)
    10. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. (PubMed id 18567810)1, 9 Jurkowski T.P....Jeltsch A. (2008)

    External Searches for TRDMT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRDMT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1787 HGNC: 2977 AceView: DNMT2 Ensembl:ENSG00000107614 euGenes: HUgn1787
    ECgene: TRDMT1 Kegg: 1787 H-InvDB: TRDMT1

    Other Databases showing TRDMT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRDMT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRDMT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRDMT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRDMT1 gene:
    Search GeneIP for patents involving TRDMT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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