Aliases for TRDMT1 Gene
- TRNA Aspartic Acid Methyltransferase 1 2 3 5
- DNA (Cytosine-5)-Methyltransferase-Like Protein 2 3 4
- TRNA (Cytosine(38)-C(5))-Methyltransferase 2 3
- DNA MTase Homolog HsaIIP 3 4
- PUMET 3 4
- DNMT2 3 4
- DNA (Cytosine-5-)-Methyltransferase 2 2
- TRNA (Cytosine-5-)-Methyltransferase 3
- DNA Methyltransferase Homolog HsaIIP 4
- DNA Cytosine-5 Methyltransferase 2 3
External Ids for TRDMT1 Gene
Previous HGNC Symbols for TRDMT1 Gene
Previous GeneCards Identifiers for TRDMT1 Gene
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]
GeneCards Summary for TRDMT1 Gene
TRDMT1 (TRNA Aspartic Acid Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Gene Expression. GO annotations related to this gene include RNA binding and DNA (cytosine-5-)-methyltransferase activity.
UniProtKB/Swiss-Prot for TRDMT1 Gene
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.