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TRDMT1 Gene

protein-coding   GIFtS: 59
GCID: GC10M017098

TRNA Aspartic Acid Methyltransferase 1

(Previous name: DNA (cytosine-5-)-methyltransferase 2)
(Previous symbol: DNMT2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Aspartic Acid Methyltransferase 11 2     TRNA (Cytosine(38)-C(5))-Methyltransferase2
DNMT21 2 3     TRNA (Cytosine-5-)-Methyltransferase2
DNA (Cytosine-5)-Methyltransferase-Like Protein 22 3     Dnmt23
DNA MTase Homolog HsaIIP2 3     EC 2.1.1.2043
DMNT22 5     M.HsaIIP3
DNA (Cytosine-5-)-Methyltransferase 21     PuMet3
MHSAIIP2     DNA Methyltransferase Homolog HsaIIP3
PUMET2     EC 2.1.18
RNMT12     EC 2.1.1.298
DNA Methyltransferase-22     

External Ids:    HGNC: 29771   Entrez Gene: 17872   Ensembl: ENSG000001076147   OMIM: 6024785   UniProtKB: O147173   

Export aliases for TRDMT1 gene to outside databases

Previous GC identifer: GC10M017225


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRDMT1 Gene:
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the
cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5)
methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene
is distinct and highly conserved in its function among taxa. (provided by RefSeq, Jun 2010)

GeneCards Summary for TRDMT1 Gene:
TRDMT1 (tRNA aspartic acid methyltransferase 1) is a protein-coding gene. GO annotations related to this gene include RNA binding and DNA (cytosine-5-)-methyltransferase activity.

UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)

Gene Wiki entry for TRDMT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRDMT1 gene promoter:
         Nkx3-1   ISGF-3   p53   MyoD   Nkx3-1 v1   Tal-1beta   E47   AREB6   Nkx3-1 v2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRDMT1 promoter sequence
   Search Chromatin IP Primers for TRDMT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRDMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p15.1

TRDMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRDMT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M017098:  view genomic region     (about GC identifiers)

Start:
17,184,253 bp from pter      End:
17,244,070 bp from pter
Size:
59,818 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717 (See protein sequence)
Recommended Name: tRNA (cytosine(38)-C(5))-methyltransferase  
Size: 391 amino acids; 44597 Da
1 PDB 3D structure from and Proteopedia for TRDMT1:
1G55 (3D)    
Secondary accessions: B0YJ02 B0YJ03 B0YJ07 B0YJ08 O43669 Q86WW6
Alternative splicing: 6 isoforms:  O14717-1   O14717-2   O14717-3   O14717-4   O14717-5   O14717-6   

Explore the universe of human proteins at neXtProt for TRDMT1: NX_O14717

Explore proteomics data for TRDMT1 at MOPED

3 DME Specific Peptides for TRDMT1 (O14717)
 QQDSDLSV  LMSPPCQPFTR  MILMSPPCQPFTRIG 


See TRDMT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004403.1  
ENSEMBL proteins: 
 ENSP00000346652   ENSP00000367030   ENSP00000417594   ENSP00000419625   ENSP00000324263  
 ENSP00000390611   ENSP00000431476   ENSP00000389497   ENSP00000409354   ENSP00000324328  
 ENSP00000412256   ENSP00000366996   ENSP00000351027  

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Cloud-Clone Corp. Proteins for TRDMT1

 
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antibodies-online proteins for TRDMT1 (7 products) 

 
antibodies-online peptides for TRDMT1

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antibodies-online kits for TRDMT1 (5 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR018117 C5_DNA_meth_AS
 IPR025813 DNA/tRNA_C5-MeTrfase
 IPR001525 C5_MeTfrase

Graphical View of Domain Structure for InterPro Entry O14717

ProtoNet protein and cluster: O14717

1 Blocks protein domain: IPB001525 C-5 cytosine-specific DNA methylase

UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
Similarity: Contains 1 SAM-dependent MTase C5-type domain


Find genes that share domains with TRDMT1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TRDMT_HUMAN, O14717
Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)
Catalytic activity: S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine +
5-methylcytosine(38) in tRNA

     Enzyme Numbers (IUBMB): EC 2.1.12 EC 2.1.1.292 EC 2.1.1.2041

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003723RNA binding IEA--
GO:0003886DNA (cytosine-5-)-methyltransferase activity TAS9425235
GO:0008168methyltransferase activity ----
GO:0008175tRNA methyltransferase activity IDA16424344
     
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Phenotypes:
     2 GenomeRNAi human phenotypes for TRDMT1:
 Decreased viability  Increased G1 DNA content 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trdmt1):
 hematopoietic system  immune system  normal 

Find genes that share phenotypes with TRDMT1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Trdmt1tm1Bes for TRDMT1

   genOway: Develop your customized and physiologically relevant rodent model for TRDMT1

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TRDMT_HUMAN, O14717: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytoskeleton2
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm IDA16424344

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRDMT1
    DNA Methylation and Transcriptional Repression



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRDMT1
Interactions:

    Search GeneGlobe Interaction Network for TRDMT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

Selected Interacting proteins for TRDMT1 (O147173 ENSP000003670304) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
InteractantInteraction Details
GeneCardExternal ID(s)
SETDB1Q150473, ENSP000003579654I2D: score=4 STRING: ENSP00000357965
SNRPA1P096613, ENSP000002541934I2D: score=1 STRING: ENSP00000254193
STX1AQ166233, ENSP000002228124I2D: score=4 STRING: ENSP00000222812
COPS6Q7L5N13I2D: score=4 
DDX24Q9GZR73I2D: score=4 
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001975response to amphetamine IEA--
GO:0006306DNA methylation ----
GO:0008033tRNA processing ----
GO:0030488tRNA methylation IDA16424344
GO:0090116C-5 methylation of cytosine TAS9425235

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for TRDMT1 available from Tocris Bioscience    About this table
CompoundAction CAS #
UNC 0638Selective G9a and GLP histone lysine methyltransferase inhibitor[1255517-77-1]
BIX 01294G9a-like protein and G9a histone lysine methyltransferase inhibitor[935693-62-2]
SGC 0946Highly potent and selective DOT1L inhibitor; cell permeable--
3-Deazaneplanocin A hydrochlorideHistone methyltransferase inhibitor[120964-45-6]
UNC 0646Potent and selective G9a/GLP inhibitor[1320288-17-2]

3 HMDB Compounds for TRDMT1    About this table
CompoundSynonyms CAS #PubMed Ids
5-Methylcytosine4-Amino-5-methyl-2-pyrimidinol (see all 5)554-01-8--
S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

3 DrugBank Compounds for TRDMT1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Pentamidine1,3-bis(4-amidinophenoxy)pentane (see all 5)100-33-4targetother18263620
Glycerol-- --target----
S-Adenosyl-L-Homocysteine-- 979-92-0target----

3 Novoseek inferred chemical compound relationships for TRDMT1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
5-methylcytosine 74.5 2 9425235 (2)
cytosine 54.4 2 16424344 (1)
azathioprine 40.5 1 15188362 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TRDMT1 gene (6 alternative transcripts): 
NM_004412.5  NM_176081.2  NM_176083.2  NM_176084.1  NM_176085.1  NM_176086.1  

Unigene Cluster for TRDMT1:

TRNA aspartic acid methyltransferase 1
Hs.351665  [show with all ESTs]
Unigene Representative Sequence: BX537961
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000354631(uc001iop.3 uc001ios.3 uc009xjt.3) ENST00000377799
ENST00000495022 ENST00000452380(uc010qcc.1) ENST00000488990(uc010qcd.2)
ENST00000313936(uc021pno.1) ENST00000436968 ENST00000525762 ENST00000424636
ENST00000486947 ENST00000451253 ENST00000479046 ENST00000412821(uc021pnn.1)
ENST00000351358 ENST00000457442 ENST00000377766(uc009xju.1) ENST00000358282(uc009xjs.1)

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hsa-miR-4291 hsa-miR-146a hsa-miR-578 hsa-miR-183* hsa-miR-29a* hsa-miR-23a hsa-miR-520g hsa-miR-556-3p
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Additional mRNA sequence: 

AF012128.1 AF045888.1 AF329940.1 AF329941.1 AF329944.1 AJ223333.1 AK021659.1 AK123512.1 
AK291417.1 AK294100.1 AK299027.1 AK303428.1 BC047733.1 BX537961.1 CR450316.1 

7 DOTS entries:

DT.456091  DT.100707639  DT.97836581  DT.97836582  DT.75169900  DT.91690081  DT.428106 

Selected AceView cDNA sequences (see all 70):

AA399001 AI056280 AW665188 CA391362 CR450316 CD673710 AI384115 NM_176081 
AL120264 AK123512 AF045888 NM_176083 AF329943 NM_176084 NM_176085 BX117729 
AF012128 AW772430 AF329941 AA668760 NM_004412 CR604140 NM_176086 AI005167 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TRDMT1    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:              -                                                                 -               
SP2:              -           -                                                     -               
SP3:                                                                                                
SP4:                                                                                                


ECgene alternative splicing isoforms for TRDMT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRDMT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRDMT1 Expression
About this image


TRDMT1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
TRDMT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TRDMT1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.351665

UniProtKB/Swiss-Prot: TRDMT_HUMAN, O14717
Tissue specificity: Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen,
prostate, colon, small intestine, and peripheral blood leukocytes

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TRDMT1 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Trdmt11 , 5 tRNA aspartic acid methyltransferase 11, 5 83.25(n)1
81.54(a)1
  2 (10.00 cM)5
134341  NM_010067.41  NP_034197.31 
 135090145 
chicken
(Gallus gallus)
Aves TRDMT11 tRNA aspartic acid methyltransferase 1 72.92(n)
68.91(a)
  420520  NM_001024831.2  NP_001020002.1 
lizard
(Anolis carolinensis)
Reptilia TRDMT16
tRNA aspartic acid methyltransferase 1
62(a)
1 ↔ 1
6(18339897-18366889)
African clawed frog
(Xenopus laevis)
Amphibia MGC532072 similar to DNA (cytosine-5-)-methyltransferase 2 73.39(n)    BC046854.1 
zebrafish
(Danio rerio)
Actinopterygii trdmt11 tRNA aspartic acid methyltransferase 1 61.74(n)
64.11(a)
  449878  NM_001018143.1  NP_001018153.1 
fruit fly
(Drosophila melanogaster)
Insecta Mt21 Methyltransferase 2 50.2(n)
44.82(a)
  34632  NM_001042890.2  NP_001036355.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons DNMT21 DNMT2 48.65(n)
40.95(a)
  832623  NM_122459.2  NP_568474.1 


ENSEMBL Gene Tree for TRDMT1 (if available)
TreeFam Gene Tree for TRDMT1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TRDMT1 gene
2 SIMAP similar genes for TRDMT1 using alignment to 6 protein entries:     TRDMT_HUMAN (see all proteins):
DKFZp686N1286    DNMT2

Find genes that share paralogs with TRDMT1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRDMT1 (see all 1408)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs741177221,2
C,F--17184694(+) AGGAAC/TGAGCC 1 -- ds50012Minor allele frequency- T:0.13WA 120
rs1420042041,2
C--17184826(+) CCTCCA/GCAGTG 1 -- ds50010--------
rs122543341,2
C,F,H--17184945(+) agaaaT/Gaaatc 1 -- ds500111Minor allele frequency- G:0.07NS EA NA WA 1208
rs70817901,2
C,F,A,H--17184971(+) AGACCG/AGAAGT 1 -- ds5001 ese324Minor allele frequency- A:0.17NS EA NA WA CSA 2071
rs1877971191,2
--17184979(+) AGTCAG/TAATAC 1 -- ds50010--------
rs2021604581,2
C--17185114(+) GGCAGG/TANNNN 1 -- ut310--------
rs1926240341,2
--17185158(+) AGACAC/TTGTTT 1 -- ut310--------
rs122482561,2
C,F,H--17185313(+) tctctG/Accctt 1 -- ut31 ese311Minor allele frequency- A:0.07NS EA NA WA 1210
rs618417631,2
C--17185374(+) CAGATC/TGTAAC 1 -- ut312Minor allele frequency- T:0.04NA 122
rs112543961,2
H--17185402(+) TCTACT/CCATTC 1 -- ut31 ese34Minor allele frequency- C:0.00NS EA 418

HapMap Linkage Disequilibrium report for TRDMT1 (17184253 - 17244070 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TRDMT1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2733606CNV Deletion23290073
nsv508571CNV Loss20534489
nsv831801CNV Gain17160897
nsv894908CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602478    OMIM disorders: --


Find genes that share disorders with TRDMT1           About GenesLikeMe

1 Novoseek inferred disease relationship for TRDMT1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cancer 0 1 15721400 (1)

Genetic Association Database (GAD): TRDMT1
Human Genome Epidemiology (HuGE) Navigator: TRDMT1 (8 documents)

Export disorders for TRDMT1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TRDMT1 gene, integrated from 10 sources (see all 49):
(articles sorted by number of sources associating them with TRDMT1)
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  1. A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. (PubMed id 9425235)1, 2, 3, 9 Yoder J.A. and Bestor T.H. (Hum. Mol. Genet. 1998)
  2. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. (PubMed id 16424344)1, 2, 3, 9 Goll M.G.... Bestor T.H. (Science 2006)
  3. A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. (PubMed id 19246518)1, 4, 9 El-Maarri O....ChAcdin F. (Hum. Mol. Genet. 2009)
  4. Cloning and analysis of a novel human putative DNA methyltransferase. (PubMed id 9599025)1, 2, 9 Van den Wyngaert I.... Luyten W.H.M.L. (FEBS Lett. 1998)
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
  6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
  7. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
  8. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4 Halaschek-Wiener J....Brooks-Wilson A.R. (PLoS ONE 2009)
  9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
  10. Prognostic significance of folate metabolism polymorphisms for lung cancer. (PubMed id 17533396)1, 4 Matakidou A....Houlston R.S. (Br. J. Cancer 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1787 HGNC: 2977 AceView: DNMT2 Ensembl:ENSG00000107614 euGenes: HUgn1787
ECgene: TRDMT1 H-InvDB: TRDMT1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TRDMT1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TRDMT1 gene:
Search GeneIP for patents involving TRDMT1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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