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Aliases for TRDJ1 Gene

Aliases for TRDJ1 Gene

  • T-Cell Receptor Delta Joining 1 2 5
  • T Cell Receptor Delta Joining 1 2 3
  • TCRD 3

External Ids for TRDJ1 Gene

Previous GeneCards Identifiers for TRDJ1 Gene

  • GC14U990272
  • GC14P020909
  • GC14P021988
  • GC14P022921
  • GC14P022933
  • GC14P022451
  • GC14P022463

Summaries for TRDJ1 Gene

Entrez Gene Summary for TRDJ1 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRDJ1 Gene

TRDJ1 (T-Cell Receptor Delta Joining 1) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDJ1 Gene

Genomics for TRDJ1 Gene

Regulatory Elements for TRDJ1 Gene

Enhancers for TRDJ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022451 0.6 dbSUPER 0.7 +2.1 2065 0.9 EGR1 HLF MAFG ZBTB33 NFE2 NFE2L2 TRDJ4 TRDJ1
GH14G022453 0.5 dbSUPER 0.7 +4.2 4150 1.0 ZNF589 ETV1 TRIM22 RBFOX2 TRDJ4 TRDJ1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRDJ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRDJ1 Gene

Chromosome:
14
Start:
22,450,089 bp from pter
End:
22,450,139 bp from pter
Size:
51 bases
Orientation:
Plus strand

Genomic View for TRDJ1 Gene

Genes around TRDJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDJ1 Gene

Proteins for TRDJ1 Gene

  • Protein details for TRDJ1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A075B706
    Recommended name:
    T-cell receptor delta joining 1
    Protein Accession:
    A0A075B706

    Protein attributes for TRDJ1 Gene

    Size:
    17 amino acids
    Molecular mass:
    1872 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRDJ1 Gene

Post-translational modifications for TRDJ1 Gene

No Post-translational modifications

Other Protein References for TRDJ1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRDJ1 Gene

Domains & Families for TRDJ1 Gene

Gene Families for TRDJ1 Gene

Protein Domains for TRDJ1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDJ1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRDJ1 Gene

Function for TRDJ1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRDJ1 Gene

Localization for TRDJ1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRDJ1 Gene

Pathways & Interactions for TRDJ1 Gene

SuperPathways for TRDJ1 Gene

No Data Available

Interacting Proteins for TRDJ1 Gene

Gene Ontology (GO) - Biological Process for TRDJ1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRDJ1 Gene

Drugs & Compounds for TRDJ1 Gene

No Compound Related Data Available

Transcripts for TRDJ1 Gene

mRNA/cDNA for TRDJ1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRDJ1 Gene

No ASD Table

Relevant External Links for TRDJ1 Gene

GeneLoc Exon Structure for
TRDJ1
ECgene alternative splicing isoforms for
TRDJ1

Expression for TRDJ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRDJ1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRDJ1 Gene:

TRDJ1
genes like me logo Genes that share expression patterns with TRDJ1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRDJ1 Gene

Orthologs for TRDJ1 Gene

Evolution for TRDJ1 Gene

ENSEMBL:
Gene Tree for TRDJ1 (if available)
TreeFam:
Gene Tree for TRDJ1 (if available)

No data available for Orthologs for TRDJ1 Gene

Paralogs for TRDJ1 Gene

No data available for Paralogs for TRDJ1 Gene

Variants for TRDJ1 Gene

Relevant External Links for TRDJ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRDJ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRDJ1 Gene

Disorders for TRDJ1 Gene

No disorders were found for TRDJ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRDJ1 Gene

Publications for TRDJ1 Gene

  1. Cloning of the gene encoding the delta subunit of the human T-cell receptor reveals its physical organization within the alpha-subunit locus and its involvement in chromosome translocations in T-cell malignancy. (PMID: 2836865) Isobe M. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 64

Products for TRDJ1 Gene

Sources for TRDJ1 Gene

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