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Aliases for TRDD2 Gene

Aliases for TRDD2 Gene

  • T-Cell Receptor Delta Diversity 2 2 5
  • T Cell Receptor Delta Diversity 2 2 3

External Ids for TRDD2 Gene

Previous GeneCards Identifiers for TRDD2 Gene

  • GC14U990274
  • GC14P020898
  • GC14P021978
  • GC14P022910
  • GC14P022914
  • GC14P022440

Summaries for TRDD2 Gene

Entrez Gene Summary for TRDD2 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRDD2 Gene

TRDD2 (T-Cell Receptor Delta Diversity 2) is a Protein Coding gene.

Additional gene information for TRDD2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDD2 Gene

Genomics for TRDD2 Gene

Regulatory Elements for TRDD2 Gene

Enhancers for TRDD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H022447 1.2 Ensembl ENCODE dbSUPER 0.4 +9.5 9476 1 ZNF687 TBL1XR1 SMAD5 NR2F1 MAX ZNF791 FOXK2 POLR2A EED IKZF1 METTL3 MMP14 ACIN1 C14orf93 CHD8 PRMT5 TRDD3 TRDD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRDD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRDD2 Gene

Chromosome:
14
Start:
22,439,007 bp from pter
End:
22,439,015 bp from pter
Size:
9 bases
Orientation:
Plus strand

Genomic View for TRDD2 Gene

Genes around TRDD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDD2 Gene

Proteins for TRDD2 Gene

Post-translational modifications for TRDD2 Gene

No Post-translational modifications

Other Protein References for TRDD2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRDD2 Gene

Domains & Families for TRDD2 Gene

Gene Families for TRDD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDD2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRDD2 Gene

Function for TRDD2 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRDD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRDD2 Gene

Localization for TRDD2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRDD2 Gene

Pathways & Interactions for TRDD2 Gene

SuperPathways for TRDD2 Gene

No Data Available

Interacting Proteins for TRDD2 Gene

Gene Ontology (GO) - Biological Process for TRDD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRDD2 Gene

Drugs & Compounds for TRDD2 Gene

No Compound Related Data Available

Transcripts for TRDD2 Gene

mRNA/cDNA for TRDD2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRDD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRDD2 Gene

No ASD Table

Relevant External Links for TRDD2 Gene

GeneLoc Exon Structure for
TRDD2
ECgene alternative splicing isoforms for
TRDD2

Expression for TRDD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRDD2 Gene:

TRDD2
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRDD2 Gene

Orthologs for TRDD2 Gene

Evolution for TRDD2 Gene

ENSEMBL:
Gene Tree for TRDD2 (if available)
TreeFam:
Gene Tree for TRDD2 (if available)

No data available for Orthologs for TRDD2 Gene

Paralogs for TRDD2 Gene

No data available for Paralogs for TRDD2 Gene

Variants for TRDD2 Gene

Relevant External Links for TRDD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRDD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRDD2 Gene

Disorders for TRDD2 Gene

No disorders were found for TRDD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRDD2 Gene

Publications for TRDD2 Gene

  1. Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus. (PMID: 3413078) Takihara Y … Mak TW (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 60

Products for TRDD2 Gene

Sources for TRDD2 Gene

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