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Aliases for TRDC Gene

Aliases for TRDC Gene

  • T-Cell Receptor Delta Constant 2 5
  • T Cell Receptor Delta Constant 2 3
  • TCRD 3

External Ids for TRDC Gene

Previous GeneCards Identifiers for TRDC Gene

  • GC14U990276
  • GC14P020922
  • GC14P022001
  • GC14P022932
  • GC14P003050
  • GC14P022940
  • GC14P022427
  • GC14P022272

Summaries for TRDC Gene

Entrez Gene Summary for TRDC Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRDC Gene

TRDC (T-Cell Receptor Delta Constant) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDC Gene

Genomics for TRDC Gene

Regulatory Elements for TRDC Gene

Enhancers for TRDC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022456 1.7 Ensembl ENCODE dbSUPER 0.7 -3.6 -3609 6.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 METTL3 PABPN1 HOMEZ BCL2L2 TRDJ3 TRDC
GH14G022463 1.1 ENCODE dbSUPER 0.7 +3.0 2994 4.6 PKNOX1 TBL1XR1 WRNIP1 BMI1 ZNF23 FOS RELB ETV6 IKZF2 CREM TRDC TRDV3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRDC on UCSC Golden Path with GeneCards custom track

Genomic Location for TRDC Gene

Chromosome:
14
Start:
22,462,932 bp from pter
End:
22,466,577 bp from pter
Size:
3,646 bases
Orientation:
Plus strand

Genomic View for TRDC Gene

Genes around TRDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDC Gene

Proteins for TRDC Gene

  • Protein details for TRDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B7Z8K6-TRDC_HUMAN
    Recommended name:
    T-cell receptor delta chain C region
    Protein Accession:
    B7Z8K6

    Protein attributes for TRDC Gene

    Size:
    153 amino acids
    Molecular mass:
    17085 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA61033.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAH13992.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRDC Gene

neXtProt entry for TRDC Gene

Post-translational modifications for TRDC Gene

Other Protein References for TRDC Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRDC Gene

Domains & Families for TRDC Gene

Gene Families for TRDC Gene

Protein Domains for TRDC Gene

Suggested Antigen Peptide Sequences for TRDC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDC: view

No data available for UniProtKB/Swiss-Prot for TRDC Gene

Function for TRDC Gene

Gene Ontology (GO) - Molecular Function for TRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with TRDC: view

Animal Model Products

miRNA for TRDC Gene

miRTarBase miRNAs that target TRDC

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRDC Gene

Localization for TRDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRDC Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with TRDC: view

No data available for Subcellular locations from COMPARTMENTS for TRDC Gene

Pathways & Interactions for TRDC Gene

No Data Available

Interacting Proteins for TRDC Gene

Selected Interacting proteins: B7Z8K6-TRDC_HUMAN for TRDC Gene via IID

Symbol External ID(s) Details
TRGC1

Gene Ontology (GO) - Biological Process for TRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006958 complement activation, classical pathway IBA --
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with TRDC: view

No data available for Pathways by source and SIGNOR curated interactions for TRDC Gene

Drugs & Compounds for TRDC Gene

No Compound Related Data Available

Transcripts for TRDC Gene

mRNA/cDNA for TRDC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRDC Gene

No ASD Table

Relevant External Links for TRDC Gene

GeneLoc Exon Structure for
TRDC
ECgene alternative splicing isoforms for
TRDC

Expression for TRDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRDC Gene

mRNA differential expression in normal tissues according to GTEx for TRDC Gene

This gene is overexpressed in Whole Blood (x28.4) and Spleen (x7.2).

Protein differential expression in normal tissues from HIPED for TRDC Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRDC Gene



Protein tissue co-expression partners for TRDC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRDC Gene:

TRDC
genes like me logo Genes that share expression patterns with TRDC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRDC Gene

Orthologs for TRDC Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRDC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRD@ 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRDC 35
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRDC 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 30 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
-- 35
  • 26 (a)
OneToMany
-- 35
  • 24 (a)
OneToMany
Species where no ortholog for TRDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRDC Gene

ENSEMBL:
Gene Tree for TRDC (if available)
TreeFam:
Gene Tree for TRDC (if available)

Paralogs for TRDC Gene

(1) SIMAP similar genes for TRDC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRDC: view

No data available for Paralogs for TRDC Gene

Variants for TRDC Gene

Relevant External Links for TRDC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRDC Gene

Disorders for TRDC Gene

No disorders were found for TRDC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRDC Gene

Publications for TRDC Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Structure of a human gammadelta T-cell antigen receptor. (PMID: 11459064) Allison T.J. … Garboczi D.N. (Nature 2001) 3 4 64
  3. Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus. (PMID: 3413078) Takihara Y. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 1988) 3 4 64

Products for TRDC Gene

Sources for TRDC Gene

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