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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRD Gene

protein-coding   GIFtS: 15
GCID: GC14P022893

T Cell Receptor Delta Locus


(Previous symbols: TCRD, TRD@)
  Search for TRD
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T Cell Receptor Delta Locus1 2
TCRD1 2
TRD@1 2
TCRDV12
T-Cell Antigen Receptor, Delta Polypeptide2
T-Cell Receptor, Delta (V,D,J,C)2

External Ids:    HGNC: 122521   Entrez Gene: 69642   

Export aliases for TRD gene to outside databases

Previous GC identifer: GC00U990375


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRD Gene: 
TRD (T cell receptor delta locus) is a protein-coding gene.

Gene Wiki entry for TRD (TRD@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRD
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   HGNC cytogenetic band: 14q11.2

TRD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRD gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P022893:  view genomic region     (about GC identifiers)

Start:
22,891,537 bp from pter      End:
22,935,569 bp from pter
Size:
44,033 bases      Orientation:
plus strand
TRD has overlapping exons with:
ORGUL069913 TRAV39 TRAV31

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRD: T cell receptors / TRD locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tcrd):
 cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
 immune system  integument  liver/biliary system  mortality/aging  renal/urinary system 
 respiratory system  tumorigenesis 

TRD for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TRD: Tcrdtm1Fwa Tcrdtm1Mom

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRD

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRD for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRD

2 Novoseek inferred chemical compound relationships for TRD gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 6-phosphate 13.4 1 11724354 (1)
polyacrylamide 11.3 1 16404354 (1)

Search CenterWatch for drugs/clinical trials and news about TRD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

miRNA
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Inhib. RNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


TRD expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Thymus (Hematopoietic System)
         Double Positive Thymocytes Thymus
 
 Blood (Cardiovascular System)
         Double Positive Thymocytes Thymus
    SABiosciences Custom PCR Arrays for TRD
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TRD gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcrd5 T cell receptor delta chain   --   14 -

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): TRD
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRD
DNA2.0 Custom Variant and Variant Library Synthesis for TRD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRD for disorders           About MalaCards

TRD for disorders           About GeneDecksing

10/11 Novoseek inferred disease relationships for TRD gene (see all 11)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
minimal residual disease 84.5 10 12774926 (1), 12970784 (1), 16247752 (1), 10025893 (1) (see all 8)
t-all 79.7 11 10025894 (2), 19176062 (1), 16404354 (1), 1402666 (1) (see all 8)
lymphoblastic leukemia acute 73.4 10 12774926 (2), 10025893 (1), 1328776 (1), 7606000 (1) (see all 7)
leukemia 56.8 10 8391615 (1), 2011404 (1), 1328863 (1), 8756082 (1) (see all 9)
acute leukemia 45.4 1 8756082 (1)
lymphoblastic leukemia acute childhood 42.7 3 16404354 (1), 12860036 (1), 11876997 (1)
lymphoma 31.5 3 8756082 (2), 9209365 (1)
synovitis 20.7 1 1825059 (1)
chromosomal aberrations 8.44 1 8827877 (1)
rheumatoid arthritis 3.87 3 9098458 (2), 1396965 (1)


Export disorders for TRD gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRD gene, integrated from 9 sources (see all 144):
(articles sorted by number of sources associating them with TRD)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Use of a variable alpha region to create a functional T-cell receptor delta chain. (PubMed id 2456576)1, 3 Guglielmi P....Bensussan A. (1988)
  2. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. (PubMed id 2439914)1, 3 Chien Y.H....Davis M.M. (1987)
  3. Lymphoid differentiation pathways can be traced by TCR delta rearrangements. (PubMed id 16081821)1, 9 Fronkova E....Hrusak O. (2005)
  4. Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells. (PubMed id 14656882)1, 9 Szczepanski T....van Dongen J.J. (2004)
  5. Human CD3g, but not CD3d, haploinsufficiency different ially impairs gd versus ab surface TCR expression. (PubMed id 23336327)1 Munoz-Ruiz M....Regueiro J.R. (2013)
  6. An abnormal phenotype of lung Vg9Vd2 T cells impairs t heir responsiveness in tuberculosis patients. (PubMed id 23770719)1 El Daker S....Martino A. (2013)
  7. Antibody-dependent anti-cytomegalovirus activity of hu man gd T cells expressing CD16 (FcgRIIIa). (PubMed id 22180442)1 Couzi L....Dechanet-Merville J. (2012)
  8. Activated human gd T cells induce peptide-specific CD8 + T-cell responses to tumor-associated self-antigens. (PubMed id 21928126)1 Altvater B....Rossig C. (2012)
  9. Granulocyte colony-stimulating factor affects the dist ribution and clonality of TRGV and TRDV repertoire of T cells and graft-versus-h ost disease. (PubMed id 22171570)1 Xuan L....Liu Q. (2011)
  10. Nonhepatosplenic I^I' T-cell lymphomas represent a spec trum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presenta tion. (PubMed id 21753698)1 Garcia-Herrera A....Martinez A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6964 HGNC: 12252 euGenes: HUgn6964 ECgene: TRD H-InvDB: TRD

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRD Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRD gene:
Search GeneIP for patents involving TRD

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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