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Aliases for TRD Gene

Aliases for TRD Gene

  • T Cell Receptor Delta Locus 2 3
  • TCRD, TRD@ 2 3
  • T-Cell Antigen Receptor, Delta Polypeptide 3
  • T-Cell Receptor, Delta (V,D,J,C) 3
  • TCRDV1 3
  • TCRD 3
  • TRD@ 3

External Ids for TRD Gene

Previous HGNC Symbols for TRD Gene

  • TCRD
  • TRD@

Previous GeneCards Identifiers for TRD Gene

  • GC00U990375
  • GC14P022893
  • GC14P023691

Summaries for TRD Gene

GeneCards Summary for TRD Gene

TRD (T Cell Receptor Delta Locus) is a Protein Coding gene. Diseases associated with TRD include Precursor T-Cell Acute Lymphoblastic Leukemia and Chronic Active Epstein-Barr Virus Infection.

Gene Wiki entry for TRD Gene

Additional gene information for TRD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRD Gene

Genomics for TRD Gene

GeneHancer (GH) Regulatory Elements for TRD Gene

Promoters and enhancers for TRD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022421 Enhancer 0.6 ENCODE dbSUPER 550.8 -0.1 -123 1.2 POLR2A EBF1 TRD TRDV2 MMP14 METTL3 ENSG00000251002 TRA
GH14I022427 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +6.2 6247 3.2 ELF3 FOXA2 MLX ZFP64 RAD21 DNMT3B ETS1 ZNF766 THAP11 HMG20B TRD TRDD1 ENSG00000251002 TRA
GH14I022432 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +12.0 12049 4.7 CTCF NFIB MZF1 EBF1 BATF RAD21 ZSCAN5C PRDM10 RUNX3 NR2F1 METTL3 TRDD1 TRD ENSG00000251002 TRA
GH14I022456 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.3 +36.8 36777 6.2 HDAC1 FOXA2 ZNF766 ATF7 BCLAF1 IKZF2 RUNX3 CREM NCOA1 JUNB TRDJ3 PRMT5-AS1 METTL3 EFS MMP14 TRDC TRDJ2 ENSG00000251002 LOC105370401 TRD
GH14I022425 Enhancer 0.4 dbSUPER 0.8 +4.0 4021 1.2 POLR2A CREB1 TRD TRDD1 ENSG00000251002 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRD on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRD Gene

Genomic Locations for TRD Gene
chr14:22,422,546-22,466,577
(GRCh38/hg38)
Size:
44,032 bases
Orientation:
Plus strand
chr14:22,891,537-22,935,569
(GRCh37/hg19)

Genomic View for TRD Gene

Genes around TRD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRD Gene

Proteins for TRD Gene

Post-translational modifications for TRD Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRD Gene

Domains & Families for TRD Gene

Gene Families for TRD Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRD: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRD Gene

Function for TRD Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRD Gene

Localization for TRD Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRD Gene

Pathways & Interactions for TRD Gene

No Data Available

Interacting Proteins for TRD Gene

Gene Ontology (GO) - Biological Process for TRD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRD Gene

Drugs & Compounds for TRD Gene

(37) Drugs for TRD Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bupropion Approved Pharma 344
Dopamine Approved Pharma Full agonist, Agonist 4008
Ketamine Approved, Vet_approved Pharma Channel blocker 634
Naltrexone Approved, Investigational, Vet_approved Pharma Antagonist Opioid receptor antagonist 406
Norepinephrine Approved Pharma 737

(1) Additional Compounds for TRD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRD: view

Transcripts for TRD Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRD Gene

No ASD Table

Relevant External Links for TRD Gene

GeneLoc Exon Structure for
TRD
ECgene alternative splicing isoforms for
TRD

No data available for mRNA/cDNA for TRD Gene

Expression for TRD Gene

NURSA nuclear receptor signaling pathways regulating expression of TRD Gene:

TRD
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRD Gene

Orthologs for TRD Gene

No data available for Orthologs and Evolution for TRD Gene

Paralogs for TRD Gene

No data available for Paralogs for TRD Gene

Variants for TRD Gene

Additional Variant Information for TRD Gene

Human Gene Mutation Database (HGMD)
TRD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRD Gene

Disorders for TRD Gene

MalaCards: The human disease database

(5) MalaCards diseases for TRD Gene - From: HGMD, Orphanet, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TRD in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TRD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRD Gene

Publications for TRD Gene

  1. Lymphoid differentiation pathways can be traced by TCR delta rearrangements. (PMID: 16081821) Fronková E … Hrusák O (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 22 58
  2. Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells. (PMID: 14656882) Szczepanski T … van Dongen JJ (Blood 2004) 3 22 58
  3. Use of a variable alpha region to create a functional T-cell receptor delta chain. (PMID: 2456576) Guglielmi P … Bensussan A (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 58
  4. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. (PMID: 2439914) Chien YH … Davis MM (Nature 1987) 2 3 58
  5. The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury. (PMID: 28368347) Kim A … Vandervord J (International journal of molecular sciences 2017) 3 58

Products for TRD Gene

Sources for TRD Gene

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