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Aliases for TRD Gene

Aliases for TRD Gene

  • T Cell Receptor Delta Locus 2 3
  • T-Cell Antigen Receptor, Delta Polypeptide 3
  • T-Cell Receptor, Delta (V,D,J,C) 3
  • TCRDV1 3
  • TCRD 3
  • TRD@ 3

External Ids for TRD Gene

Previous HGNC Symbols for TRD Gene

  • TCRD
  • TRD@

Previous GeneCards Identifiers for TRD Gene

  • GC00U990375
  • GC14P022893
  • GC14P023691

Summaries for TRD Gene

GeneCards Summary for TRD Gene

TRD (T Cell Receptor Delta Locus) is a Protein Coding gene. Diseases associated with TRD include Precursor T-Cell Acute Lymphoblastic Leukemia and Chronic Active Epstein-Barr Virus Infection.

Gene Wiki entry for TRD Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRD Gene

Genomics for TRD Gene

Regulatory Elements for TRD Gene

Enhancers for TRD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022427 1.5 FANTOM5 Ensembl ENCODE 0.4 +6.2 6248 3.2 HDGF PKNOX1 ARNT MLX ZFP64 GATA2 FOS NCOA1 MXD4 CREB3 LOC105370402 TRD
GH14F022421 0.7 Ensembl ENCODE 0.8 -0.1 -123 1.2 EBF1 CHD7 MMP14 METTL3 TRD TRDV2
GH14F022426 0.4 Ensembl 0.8 +3.8 3755 0.2 ZNF121 TRD LOC105370402
GH14F022428 0.4 Ensembl 0.8 +4.2 4155 0.2 ZNF121 TRD LOC105370402
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRD on UCSC Golden Path with GeneCards custom track

Genomic Location for TRD Gene

Chromosome:
14
Start:
22,422,546 bp from pter
End:
22,466,577 bp from pter
Size:
44,032 bases
Orientation:
Plus strand

Genomic View for TRD Gene

Genes around TRD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRD Gene

Proteins for TRD Gene

Post-translational modifications for TRD Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRD Gene

Domains & Families for TRD Gene

Gene Families for TRD Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRD: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRD Gene

Function for TRD Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRD Gene

Localization for TRD Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRD Gene

Pathways & Interactions for TRD Gene

No Data Available

Interacting Proteins for TRD Gene

Gene Ontology (GO) - Biological Process for TRD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRD Gene

Drugs & Compounds for TRD Gene

(36) Drugs for TRD Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bupropion Approved Pharma 319
Dopamine Approved Pharma Full agonist, Agonist 3759
Ketamine Approved, Vet_approved Pharma Channel blocker 528
Naltrexone Approved, Investigational, Vet_approved Pharma Antagonist Opioid receptor antagonist 378
Norepinephrine Approved Pharma 683

(1) Additional Compounds for TRD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRD: view

Transcripts for TRD Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRD Gene

No ASD Table

Relevant External Links for TRD Gene

GeneLoc Exon Structure for
TRD
ECgene alternative splicing isoforms for
TRD

No data available for mRNA/cDNA for TRD Gene

Expression for TRD Gene

NURSA nuclear receptor signaling pathways regulating expression of TRD Gene:

TRD
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRD Gene

Orthologs for TRD Gene

No data available for Orthologs and Evolution for TRD Gene

Paralogs for TRD Gene

No data available for Paralogs for TRD Gene

Variants for TRD Gene

Relevant External Links for TRD Gene

Human Gene Mutation Database (HGMD)
TRD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRD Gene

Disorders for TRD Gene

MalaCards: The human disease database

(5) MalaCards diseases for TRD Gene - From: Orphanet, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TRD in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRD
genes like me logo Genes that share disorders with TRD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRD Gene

Publications for TRD Gene

  1. Lymphoid differentiation pathways can be traced by TCR delta rearrangements. (PMID: 16081821) FronkovA! E. … HrusA!k O. (J. Immunol. 2005) 3 22 64
  2. Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells. (PMID: 14656882) Szczepanski T. … van Dongen J.J. (Blood 2004) 3 22 64
  3. Use of a variable alpha region to create a functional T-cell receptor delta chain. (PMID: 2456576) Guglielmi P. … Bensussan A. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 64
  4. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. (PMID: 2439914) Chien Y.H. … Davis M.M. (Nature 1987) 2 3 64
  5. The promise of I^I' T cells and the I^I' T cell receptor for cancer immunotherapy. (PMID: 25864915) Legut M. … Sewell A.K. (Cell. Mol. Immunol. 2015) 3 64

Products for TRD Gene

Sources for TRD Gene

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