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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRBV6-6 Gene

protein-coding   GIFtS: 16
GCID: GC07M142162

T cell receptor beta variable 6-6
  Search for TRBV6-6
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRBV6-6    

Aliases
for TRBV6-6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
T Cell Receptor Beta Variable 6-61 2
TCRBV13S6A2T1 2
TCRBV6S61 2
TRBV661 2

External Ids:    HGNC: 122311   Entrez Gene: 286012   Ensembl: ENSG000002117247   
ORGUL members:         
NONCODE:n335830 n335866 n333306 n333744 n337617    

Export aliases for TRBV6-6 gene to outside databases

Previous GC identifers: GC07U990224 GC07P141522 GC07P141598 GC07P141645 GC07P141838


Summaries
for TRBV6-6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TRBV6-6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRBV6-6
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRBV6-6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TRBV6-6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRBV6-6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M142162:  view genomic region     (about GC identifiers)

Start:
 142,161,931 bp from pter      End:
 142,162,407 bp from pter
Size:
 477 bases      Orientation:
 minus strand

1 alternative location:
Chr7+,CRA_TCAG 141,529,783-141,530,215     
ORGUL member locations:
Legend (see complete legend)

  • n333306
  • n333744
  • n335830
  • n335866
  • n337617
142161920 142162164 142162408 chr7

Proteins
for TRBV6-6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
TRBV6-6 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374894  

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Protein Domains /
Families
for TRBV6-6 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for TRBV6-6 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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Cell Line
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In Situ Assay
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Pathways & Interactions
for TRBV6-6 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRBV6-6

Drugs & Compounds
for TRBV6-6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRBV6-6
Search CenterWatch for drugs/clinical trials and news about TRBV6-6 

Transcripts
for TRBV6-6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390371(uc011krw.2 uc011krx.2)

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRBV6-6

2 AceView cDNA sequences:

T28931 AA352628 

GeneLoc Exon Structure


Expression
for TRBV6-6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRBV6-6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See TRBV6-6 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for TRBV6-6
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TRBV6-6

Orthologs
for TRBV6-6 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for TRBV6-6 gene from 2/4 species (see all 4)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves --
--
(see all 4)		 Uncharacterized protein
(see all 4)		 38(a)
31(a)
(see all 4)		 many ↔ many
many ↔ many
(see all 4)		 1(81231197-81231811)
1(81251138-81251518)
lizard
(Anolis carolinensis)		 Reptilia --
 --
 33(a)
 1 → many
 GL343499.1(502420-503152)


ENSEMBL Gene Tree for TRBV6-6 (if available)
TreeFam Gene Tree for TRBV6-6 (if available) 

Paralogs
for TRBV6-6 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRBV6-6 gene
TRBV11-12  TRBV3-12  TRBV192  TRBV92  TRBV7-32  TRBV6-52  TRBV21OR9-22  TRBV7-42  
TRBV25-12  TRBV23OR9-22  TRBV5-12  TRBV4-12  TRBV7-12  TRBV6-82  TRBV5-72  TRBV6-12  
TRBV10-12  TRBV7-72  TRBV23-12  TRBV5-32  TRBV282  TRBV6-42  TRBV22  TRBV6-72  
TRBV272  TRBV5-52  TRBV5-62  TRBV7-62  TRBV25OR9-22  TRBV10-22  TRBV5-42  TRBV24-12  
TRBV7-82  TRBV6-92  TRBV4-22  

TRBV6-6 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for TRBV6-6
PGOHUM00000250972 PGOHUM00000261695


Genomic Variants
for TRBV6-6 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRBV6-6
DNA2.0 Custom Variant and Variant Library Synthesis for TRBV6-6

Disorders / Diseases
for TRBV6-6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for TRBV6-6 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed article for TRBV6-6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRBV6-6)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 3 Rowen L.... Hood L. (1996)

External Searches for TRBV6-6 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing TRBV6-6 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28601 HGNC: 12231 AceView: TRBV6-6 Ensembl:ENSG00000211724 euGenes: HUgn28601
ECgene: TRBV6-6 H-InvDB: TRBV6-6

Other Databases showing TRBV6-6 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing TRBV6-6 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRBV6-6 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRBV6-6 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for TRBV6-6 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRBV6-6 gene:
Search GeneIP for patents involving TRBV6-6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for TRBV6-6 gene

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Advanced Cell Diagnostics
About This Section

 
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