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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRBV3-1 Gene

protein-coding   GIFtS: 24
GCID: GC07P142738

T Cell Receptor Beta Variable 3-1

  Search for TRBV3-1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
T Cell Receptor Beta Variable 3-11 2
TCRBV3S12
TCRBV9S1A1T2
TRBV312

External Ids:    HGNC: 122121   Entrez Gene: 286192   Ensembl: ENSG000002377027   UniProtKB: A0A5764   
ORGUL members:         
NONCODE14:n333741      

Export aliases for TRBV3-1 gene to outside databases

Previous GC identifers: GC07U990242 GC07P141338 GC07P141415 GC07P141461 GC07P141654 GC07P142157 GC07P142183 GC07P142311 GC07P142339 GC07P142406 GC07P142454 GC07P142580 GC07P142671


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRBV3-1 Gene: 
TRBV3-1 (T cell receptor beta variable 3-1) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is TRBV11-1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRBV3-1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRBV3-1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRBV3-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TRBV3-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRBV3-1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142738:  view genomic region     (about GC identifiers)

Start:
142,008,365 bp from pter      End:
142,008,871 bp from pter
Size:
507 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571040 450,563-451,022      Chr7+,CRA_TCAG 141,346,637-141,347,096     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/TrEMBL: A0A576 (See protein sequence)
Recommended Name: V_segment translation product  
Size: 114 amino acids; 12928 Da

Explore proteomics data for TRBV3-1 at MOPED 

TRBV3-1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TRBV3-1 Protein Expression

ENSEMBL proteins: 
 ENSP00000374910  

Human Recombinant Protein Products for TRBV3-1: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRB: T cell receptors / TRB locus

3 InterPro protein domains:
 IPR007110 Ig-like_dom
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry A0A576

ProtoNet protein and cluster: A0A576


TRBV3-1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
TRBV3-1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRBV3-1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Search CenterWatch for drugs/clinical trials and news about TRBV3-1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390387(uc003vxf.3)
miRNA
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2 AceView cDNA sequences:

BE245824 CB987138 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRBV3-1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRBV3-1 Expression
About this image


See TRBV3-1 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for TRBV3-1
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRBV3-1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRBV3-1 gene from 3/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia TRBV3-16
--
--
53(a)
51(a)
1 ↔ 1
possible ortholog
16(6949018-6960395)
16(6944024-6945966)
chicken
(Gallus gallus)
Aves --
--
(see all 3)
--
26(a)
22(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
1(77587818-77601499)
1(77553298-77554871)
lizard
(Anolis carolinensis)
Reptilia --
--
--
37(a)
25(a)
many ↔ many
many ↔ many
GL343499.1(502420-503182)
GL343499.1(489244-493799)


ENSEMBL Gene Tree for TRBV3-1 (if available)
TreeFam Gene Tree for TRBV3-1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRBV3-1 gene
TRBV11-12  TRBV192  TRBV92  TRBV7-32  TRBV6-52  TRBV21OR9-22  TRBV7-42  TRBV6-62  
TRBV25-12  TRBV5-12  TRBV23OR9-22  TRBV4-12  TRBV7-12  TRBV6-82  TRBV5-72  TRBV10-12  
TRBV6-12  TRBV7-72  TRBV23-12  TRBV5-32  TRBV282  TRBV22  TRBV6-72  TRBV6-42  
TRBV272  TRBV5-52  TRBV5-62  TRBV7-62  TRBV10-22  TRBV7-82  TRBV24-12  TRBV6-92  
TRBV5-42  TRBV4-22  

TRBV3-1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TRBV3-1
PGOHUM00000261649


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRBV3-1
DNA2.0 Custom Variant and Variant Library Synthesis for TRBV3-1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRBV3-1 for disorders           About MalaCards

TRBV3-1 for disorders           About GeneDecksing

Genetic Association Database (GAD): TRBV3-1
Human Genome Epidemiology (HuGE) Navigator: TRBV3-1 (1 document)

Export disorders for TRBV3-1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRBV3-1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRBV3-1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. TCRBV20S1 and TCRBV3S1 gene segment polymorphisms in systemic sclerosis. (PubMed id 18412309)1, 4 Bredemeier M....Xavier R.M. (2008)
  2. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 3 Rowen L.... Hood L. (1996)
  3. A polymorphism in a staphylococcal enterotoxin recept or gene (T cell receptor BV3 recombination signal sequence) is not associated w ith unexplained sudden unexpected death in infancy in an Australian cohort. (PubMed id 20362046)1 Highet A.R....Goldwater P.N. (2010)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. TCRBV3S1 and TCRBV18 gene segment polymorphisms in Brazilian Caucasoid and Black populations. (PubMed id 11841483)1 Dresch C....Chies J.A. (2002)
  6. A genetically determined insertion/deletion related p olymorphism in human T cell receptor beta chain (TCRB) includes functional vari able gene segments. (PubMed id 7931073)1 Zhao T.M....Robinson M.A. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28619 HGNC: 12212 AceView: TRBV3-1 Ensembl:ENSG00000237702 euGenes: HUgn28619
ECgene: TRBV3-1 H-InvDB: TRBV3-1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRBV3-1 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRBV3-1 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRBV3-1 gene:
Search GeneIP for patents involving TRBV3-1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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