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TRBV19 Gene

protein-coding   GIFtS: 20
GCID: GC07P142764

T Cell Receptor Beta Variable 19

  Search for TRBV19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T Cell Receptor Beta Variable 191 2
TCRBV17S1A1T2
TCRBV19S12

External Ids:    HGNC: 121941   Entrez Gene: 285682   Ensembl: ENSG000002117467   

Export aliases for TRBV19 gene to outside databases

Previous GC identifers: GC07U990191 GC07P141691 GC07P141768 GC07P141814 GC07P141671 GC07P142035 GC07P142049 GC07P142066 GC07P142081 GC07P142093 GC07P142110 GC07P142133 GC07P142327 GC07P142329 GC07P142384 GC07P142420 GC07P142471 GC07P142632 GC07P142701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRBV19 Gene:
TRBV19 (T cell receptor beta variable 19) is a protein-coding gene. An important paralog of this gene is TRBV11-1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  NT_187562.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TRBV19
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRBV19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TRBV19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRBV19 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142764:  view genomic region     (about GC identifiers)

Start:
142,326,363 bp from pter      End:
142,327,046 bp from pter
Size:
684 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571040 802,791-803,266      Chr7+,CRA_TCAG 141,699,293-141,699,768     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --
Explore proteomics data for TRBV19 at MOPED


See TRBV19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000374916  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TRB: T cell receptors / TRB locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
TRBV19 for ontologies           About GeneDecksing


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRBV19
Interactions:

    Search GeneGlobe Interaction Network for TRBV19

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TRBV19



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Unigene Cluster for TRBV19:

T cell receptor beta variable 19
Hs.511720  [show with all ESTs]
Unigene Representative Sequence: BC073930
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390393(uc003vzo.2)
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Additional mRNA sequence: 

AB305815.1 AB305838.1 AB305839.1 AB305841.1 AB305857.1 AB305918.1 AB305919.1 AB305934.1 
AB305938.1 AB305949.1 AB305963.1 AB305970.1 AB305971.1 AB305972.1 AB305976.1 AB305980.1 
AB305983.1 AB305984.1 AB306154.1 AB306192.1 AB306212.1 AF009788.1 AF020644.1 AF020646.1 
AF020648.1 AF020650.1 AF043180.1 AF200428.1 AJ296350.1 AY239356.1 AY247832.1 AY534310.1 
AY751863.1 AY751888.1 AY751910.1 AY751930.1 BC073930.1 HM467901.1 L34719.1 L34733.1 
M27388.1 M97725.1 S63251.1 U39120.1 U39129.1 U39130.1 U39138.1 U39143.1 
U41098.1 X61629.1 X74851.1 X86109.1 X86113.1 X86118.1 X86119.1 X86120.1 
X86122.1 X86123.1 X86127.1 Y10199.1 Y10201.1 Z47376.1 Z77841.1 Z77849.1 

12 DOTS entries:

DT.121076352  DT.92456573  DT.121076103  DT.95195288  DT.98132111  DT.95124795  DT.95325844  DT.121076615 
DT.121076703  DT.91963304  DT.91989657  DT.121076145 

Selected AceView cDNA sequences (see all 76):

CR602039 CR626342 CR623833 CR606882 CR609731 CR608304 CR596519 CR622128 
CR622874 CR610034 CR591596 CR620981 CR614480 CR620061 CR598684 CR623178 
CR599262 BX112874 AL559249 AA383854 AA380633 AA909476 X00437 AY232284 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRBV19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRBV19 Expression
About this image

TRBV19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TRBV19 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.511720
    Custom PCR Arrays for TRBV19
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TRBV19 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
platypus
(Ornithorhynchus anatinus)
Mammalia TRBV196
T cell receptor beta variable 19
37(a)
1 ↔ 1
Contig25624(5689-6263)
chicken
(Gallus gallus)
Aves --
--
(see all 3)
Uncharacterized protein
(see all 3)
45(a)
38(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
1(77587818-77601499)
1(77553298-77554871)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
29(a)
27(a)
many ↔ many
many ↔ many
GL343499.1(502420-503182)
GL343499.1(489244-493799)


ENSEMBL Gene Tree for TRBV19 (if available)
TreeFam Gene Tree for TRBV19 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TRBV19 gene
TRBV11-12  TRBV92  TRBV3-12  TRBV7-32  TRBV6-52  TRBV21OR9-22  TRBV7-42  TRBV6-62  
TRBV25-12  TRBV5-12  TRBV23OR9-22  TRBV4-12  TRBV7-12  TRBV6-82  TRBV5-72  TRBV10-12  
TRBV6-12  TRBV7-72  TRBV23-12  TRBV5-32  TRBV282  TRBV22  TRBV6-72  TRBV6-42  
TRBV272  TRBV5-52  TRBV5-62  TRBV7-62  TRBV10-22  TRBV7-82  TRBV24-12  TRBV6-92  
TRBV5-42  TRBV4-22  

TRBV19 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRBV19
DNA2.0 Custom Variant and Variant Library Synthesis for TRBV19

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TRBV19 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TRBV19)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 3 Rowen L.... Hood L. (Science 1996)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Allelic variants of human TCR BV17S1 defined by restriction fragment length polymorphism, single strand conformation polymorphism, and amplification refractory mutation system analyses. (PubMed id 8872162)1 Li Y....Friedman S.M. (Hum. Immunol. 1996)
  4. Nucleotide sequence analysis of 77.7 kb of the human V beta T-cell receptor gene locus: direct primer-walking using cosmid template DNAs. (PubMed id 8020962)1 Slightom J.L.... Hood L. (Genomics 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28568 HGNC: 12194 AceView: TRB_ Ensembl:ENSG00000211746 euGenes: HUgn28568
ECgene: TRBV19 H-InvDB: TRBV19

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TRBV19 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRBV19 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TRBV19 gene:
Search GeneIP for patents involving TRBV19

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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