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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRBV19 Gene

protein-coding   GIFtS: 21
GCID: GC07P142701

T Cell Receptor Beta Variable 19

  Search for TRBV19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T Cell Receptor Beta Variable 191 2
TCRBV17S1A1T2
TCRBV19S12

External Ids:    HGNC: 121941   Entrez Gene: 285682   Ensembl: ENSG000002117467   

Export aliases for TRBV19 gene to outside databases

Previous GC identifers: GC07U990191 GC07P141691 GC07P141768 GC07P141814 GC07P141671 GC07P142035 GC07P142049 GC07P142066 GC07P142081 GC07P142093 GC07P142110 GC07P142133 GC07P142327 GC07P142329 GC07P142384 GC07P142420 GC07P142471 GC07P142632


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRBV19 Gene: 
TRBV19 (T cell receptor beta variable 19) is a protein-coding gene. An important paralog of this gene is TRBV11-1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRBV19
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRBV19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TRBV19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRBV19 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142701:  view genomic region     (about GC identifiers)

Start:
142,326,363 bp from pter      End:
142,327,046 bp from pter
Size:
684 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571040 802,791-803,266      Chr7+,CRA_TCAG 141,699,293-141,699,768     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --
Explore proteomics data for TRBV19 at MOPED 

TRBV19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TRBV19 Protein Expression

ENSEMBL proteins: 
 ENSP00000374916  

Human Recombinant Protein Products for TRBV19: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRB: T cell receptors / TRB locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
TRBV19 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRBV19

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TRBV19

Search CenterWatch for drugs/clinical trials and news about TRBV19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for TRBV19:

T cell receptor beta variable 19
Hs.511720  [show with all ESTs]
Unigene Representative Sequence: BC073930
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390393(uc003vzo.2)
miRNA
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Additional mRNA sequence: 

AB305815.1 AB305838.1 AB305839.1 AB305841.1 AB305857.1 AB305918.1 AB305919.1 AB305934.1 
AB305938.1 AB305949.1 AB305963.1 AB305970.1 AB305971.1 AB305972.1 AB305976.1 AB305980.1 
AB305983.1 AB305984.1 AB306154.1 AB306192.1 AB306212.1 AF009788.1 AF020644.1 AF020646.1 
AF020648.1 AF020650.1 AF043180.1 AF200428.1 AJ296350.1 AY239356.1 AY247832.1 AY534310.1 
AY751863.1 AY751888.1 AY751910.1 AY751930.1 BC073930.1 HM467901.1 L34719.1 L34733.1 
M27388.1 M97725.1 S63251.1 U39120.1 U39129.1 U39130.1 U39138.1 U39143.1 
U41098.1 X61629.1 X74851.1 X86109.1 X86113.1 X86118.1 X86119.1 X86120.1 
X86122.1 X86123.1 X86127.1 Y10199.1 Y10201.1 Z47376.1 Z77841.1 Z77849.1 

12 DOTS entries:

DT.121076352  DT.92456573  DT.121076103  DT.95195288  DT.98132111  DT.95124795  DT.95325844  DT.121076615 
DT.121076703  DT.91963304  DT.91989657  DT.121076145 

24/76 AceView cDNA sequences (see all 76):

CR599262 CR623178 CR591596 CR608304 CR614480 BX112874 CR610034 CR602039 
CR609731 CR620981 CR620061 CR598684 CR626342 CR596519 CR623833 CR622874 
CR622128 CR606882 AA909476 AK097858 AY232285 AA380534 AA383854 AL559249 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRBV19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRBV19 Expression
About this image


See TRBV19 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.511720
    SABiosciences Custom PCR Arrays for TRBV19
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRBV19

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRBV19 gene from 3/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
platypus
(Ornithorhynchus anatinus)
Mammalia TRBV196
T cell receptor beta variable 19
37(a)
1 ↔ 1
Contig25624(5689-6263)
chicken
(Gallus gallus)
Aves --
--
(see all 3)
--
42(a)
36(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
1(77587818-77601499)
1(77553298-77554871)
lizard
(Anolis carolinensis)
Reptilia --
--
--
30(a)
27(a)
many ↔ many
many ↔ many
GL343499.1(502420-503182)
GL343499.1(489244-493799)


ENSEMBL Gene Tree for TRBV19 (if available)
TreeFam Gene Tree for TRBV19 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRBV19 gene
TRBV11-12  TRBV92  TRBV3-12  TRBV7-32  TRBV6-52  TRBV21OR9-22  TRBV7-42  TRBV6-62  
TRBV25-12  TRBV5-12  TRBV23OR9-22  TRBV4-12  TRBV7-12  TRBV6-82  TRBV5-72  TRBV10-12  
TRBV6-12  TRBV7-72  TRBV23-12  TRBV5-32  TRBV282  TRBV22  TRBV6-72  TRBV6-42  
TRBV272  TRBV5-52  TRBV5-62  TRBV7-62  TRBV10-22  TRBV7-82  TRBV24-12  TRBV6-92  
TRBV5-42  TRBV4-22  

TRBV19 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRBV19
DNA2.0 Custom Variant and Variant Library Synthesis for TRBV19

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRBV19 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRBV19)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 3 Rowen L.... Hood L. (1996)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  3. Allelic variants of human TCR BV17S1 defined by restriction fragment length polymorphism, single strand conformation polymorphism, and amplification refractory mutation system analyses. (PubMed id 8872162)1 Li Y....Friedman S.M. (1996)
  4. Nucleotide sequence analysis of 77.7 kb of the human V beta T-cell receptor gene locus: direct primer-walking using cosmid template DNAs. (PubMed id 8020962)1 Slightom J.L.... Hood L. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28568 HGNC: 12194 AceView: TRB_ Ensembl:ENSG00000211746 euGenes: HUgn28568
ECgene: TRBV19 H-InvDB: TRBV19

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRBV19 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRBV19 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRBV19 gene:
Search GeneIP for patents involving TRBV19

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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