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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRBV12-3 Gene

uncategorized   GIFtS: 22
GCID: GC07Pg41640

T cell receptor beta variable 12-3
  Search for TRBV12-3
in
MalaCards
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 Human Malady Compendium 
Biological research products
for TRBV12-3    

Aliases
for TRBV12-3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
T Cell Receptor Beta Variable 12-31 2
TCRBV8S11 2 3
TCRBV12S31 2
TRBV1231 2

External Ids:    HGNC: 121851   Entrez Gene: 285772   UniProtKB: P017333   

Export aliases for TRBV12-3 gene to outside databases

Previous GC identifers: GC07U990200 GC07P141633 GC07P141711 GC07P141712 GC07P141755 GC07P141949


Summaries
for TRBV12-3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TRBV12-3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRBV12-3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRBV12-3


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q34   HGNC cytogenetic band: 7q34

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07Pg41640:  view genomic region     (about GC identifiers)

Start:
 141,640,805 bp from start of contig CRA_TCAGchr7v2      End:
 141,641,251 bp from start of contig CRA_TCAGchr7v2
Size:
 447 bases      Orientation:
 plus strand

Proteins
for TRBV12-3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TVB1_HUMAN, P01733 (See protein sequence)
Recommended Name: T-cell receptor beta chain V region YT35 precursor  
Size: 135 amino acids; 15097 Da
Secondary accessions: A0A5A7

Explore the universe of human proteins at neXtProt for TRBV12-3: NX_P01733

TRBV12-3 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

Reactome Protein details: P01733
Human Recombinant Protein Products: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--


TRBV12-3 for ontologies           About GeneDecksing



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Protein Domains /
Families
for TRBV12-3 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
TRBV12-3 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry P01733

ProtoNet protein and cluster: P01733

2 Blocks protein families:
IPB003599 Immunoglobulin subtype
IPB013106 Immunoglobulin V-set



Function
for TRBV12-3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0042287MHC protein binding NAS6336315
GO:0042605peptide antigen binding NAS6336315


TRBV12-3 for ontologies           About GeneDecksing



Pathways & Interactions
for TRBV12-3 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Translocation of ZAP-70 to Immunological synapse
Translocation of ZAP-70 to Immunological synapse1.00
PD-1 signaling0.76
Phosphorylation of CD3 and TCR zeta chains0.85
Generation of second messenger molecules0.64
2Immune System
Immune System1.00
Adaptive Immune System0.59
3TCR signaling
TCR signaling1.00
Downstream TCR signaling0.75
4CD28 co-stimulation
Costimulation by the CD28 family0.41
5Cleavage of Alpha-1-Microglobulin
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

Pathway sources
See GeneCards unified pathways
Show all pathways


5/10        Reactome Pathways for TRBV12-3 (see all 10)
    Costimulation by the CD28 family
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Translocation of ZAP-70 to Immunological synapse
Downstream TCR signaling



TRBV12-3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRBV12-3

1 Interacting protein for TRBV12-3 (P017332) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
--P068862MINT-4328965
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS6336315
GO:0031295T cell costimulation TAS--
GO:0050776regulation of immune response TAS--
GO:0050852T cell receptor signaling pathway TAS--


TRBV12-3 for ontologies           About GeneDecksing



Drugs & Compounds
for TRBV12-3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for TRBV12-3


Transcripts
for TRBV12-3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

miRNA
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Inhib. RNA
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Clone
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Primer
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24/76 AceView cDNA sequences (see all 76):

CR610034 CR623178 CR606882 CR591596 CR602039 CR620061 CR626342 CR622874 
BX112874 CR614480 CR609731 CR623833 CR598684 CR608304 CR599262 CR620981 
CR596519 CR622128 AA380534 AA383854 AY232285 X00437 AK097858 AA380633 

GeneLoc Exon Structure


Expression
for TRBV12-3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
 See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

See TRBV12-3 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for TRBV12-3
Primer
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In Situ
Assay Products: 
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Orthologs
for TRBV12-3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

Paralogs
for TRBV12-3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for TRBV12-3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for TRBV12-3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for TRBV12-3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRBV12-3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TRBV12-3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 3 Rowen L.... Hood L. (1996)
  2. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. (PubMed id 6336315)1, 2 Yanagi Y....Mak T.W. (1984)
  3. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (2009)
  4. Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. (PubMed id 17652306)1 Qi Q. and August A. (2007)
  5. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. (PubMed id 15489916)1 Palacios E.H. and Weiss A. (2004)
  6. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
  7. Adapters in lymphocyte signaling. (PubMed id 11827988)1 Leo A....Schraven B. (2002)
  8. The mechanism of phospholipase C-gamma1 regulation. (PubMed id 11048639)1 Kim M.J....Suh P.G. (2000)
  9. Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372)1 Williams S.C....Winter G. (1996)
  10. Analysis of a human V beta gene subfamily. (PubMed id 3772297)1 Siu G....Hood L.E. (1986)

External Searches for TRBV12-3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing TRBV12-3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28577 HGNC: 12185 AceView: TRB_ euGenes: HUgn28577 ECgene: TRBV12-3
H-InvDB: TRBV12-3

Other Databases showing TRBV12-3 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing TRBV12-3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRBV12-3 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRBV12-3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+TRBV12-3&species=Homo+sapiens

Intellectual Property
for TRBV12-3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRBV12-3 gene:
Search GeneIP for patents involving TRBV12-3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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