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TRBV12-3 Gene

protein-coding   GIFtS: 21
GCID: GC07Pg41640

T Cell Receptor Beta Variable 12-3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T Cell Receptor Beta Variable 12-31 2
TCRBV8S12 3
TCRBV12S32
TRBV1232

External Ids:    HGNC: 121851   Entrez Gene: 285772   UniProtKB: P017333   

Export aliases for TRBV12-3 gene to outside databases

Previous GC identifers: GC07U990200 GC07P141633 GC07P141711 GC07P141712 GC07P141755 GC07P141949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRBV12-3 Gene:
TRBV12-3 (T cell receptor beta variable 12-3) is a protein-coding gene. GO annotations related to this gene include peptide antigen binding and MHC protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TRBV12-3
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRBV12-3


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q34   HGNC cytogenetic band: 7q34

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07Pg41640:       (about GC identifiers)

Start:
141,640,805 bp from start of contig CRA_TCAGchr7v2      End:
141,641,251 bp from start of contig CRA_TCAGchr7v2
Size:
447 bases      Orientation:
plus strand

1 alternative location:
Chr7+,NW_003571040 744,248-744,694     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TVB1_HUMAN, P01733 (See protein sequence)
Recommended Name: T-cell receptor beta chain V region YT35 precursor  
Size: 135 amino acids; 15097 Da
Secondary accessions: A0A5A7

Explore the universe of human proteins at neXtProt for TRBV12-3: NX_P01733

Reactome Protein details: P01733

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TRB: T cell receptors / TRB locus

4 InterPro protein domains:
 IPR007110 Ig-like_dom
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry P01733

ProtoNet protein and cluster: P01733

2 Blocks protein domains:
IPB003599 Immunoglobulin subtype
IPB013106 Immunoglobulin V-set



Find genes that share domains with TRBV12-3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0042287MHC protein binding NAS6336315
GO:0042605peptide antigen binding NAS6336315
     
Find genes that share ontologies with TRBV12-3           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--

Find genes that share ontologies with TRBV12-3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TRBV12-3 About    
See pathways by source

SuperPathContained pathways About
1Translocation of ZAP-70 to Immunological synapse
Translocation of ZAP-70 to Immunological synapse0.83
PD-1 signaling0.72
Phosphorylation of CD3 and TCR zeta chains0.83
Generation of second messenger molecules0.62
2TCR signaling (REACTOME)
Downstream TCR signaling0.73
TCR signaling0.73
3CD28 co-stimulation
Costimulation by the CD28 family0.44
4Class I MHC mediated antigen processing and presentation
Adaptive Immune System0.41
5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Find genes that share SuperPaths with TRBV12-3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


Selected Reactome Pathways for TRBV12-3 (see all 6)
    Translocation of ZAP-70 to Immunological synapse
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains


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Interactions:

    Search GeneGlobe Interaction Network for TRBV12-3

1 Interacting protein for TRBV12-3 (P017332) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
--P068862MINT-4328965
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS6336315
GO:0031295T cell costimulation TAS--
GO:0050776regulation of immune response TAS--
GO:0050852T cell receptor signaling pathway TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TRBV12-3 (TVB1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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miRNA
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Primer
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Selected AceView cDNA sequences (see all 76):

CR609731 CR608304 CR620981 CR623833 CR622128 CR591596 CR596519 BX112874 
CR622874 CR598684 CR626342 CR620061 CR599262 CR602039 CR623178 CR614480 
CR610034 CR606882 AK097858 AA380633 AY232285 AA383854 AL559249 AA909476 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

TRBV12-3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRBV12-3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TRBV12-3 gene
Selected SIMAP similar genes for TRBV12-3 using alignment to 1 protein entry:     TVB1_HUMAN(see all similar genes):
TCRBV8S2A1T    BV08S1J2.7    TCRBV8S3    BV08S2J2.2    TCRBV6S5A1N1    TCRBV18S1
TCRBV6S4A1    TCRBV6S5A2    TCRBV6S2A1N1T    BV16S1J2.2    BV25S1J1.2    TCRB
TCRBV16S1A1N1    TCRBV21S1    TCRBV21S2A2    TCRBV21S3A2N2T    TCRBV6S1A1N1    TCRBV6S3A1N1T

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRBV12-3
DNA2.0 Custom Variant and Variant Library Synthesis for TRBV12-3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TRBV12-3 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with TRBV12-3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 3 Rowen L.... Hood L. (Science 1996)
  2. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. (PubMed id 6336315)1, 2 Yanagi Y....Mak T.W. (Nature 1984)
  3. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
  4. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (Nat. Biotechnol. 2009)
  5. Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. (PubMed id 17652306)1 Qi Q. and August A. (Sci. STKE 2007)
  6. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. (PubMed id 15123239)1 Boisguerin P....Volkmer-Engert R. (amp 2004)
  7. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. (PubMed id 15489916)1 Palacios E.H. and Weiss A. (Oncogene 2004)
  8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  9. Adapters in lymphocyte signaling. (PubMed id 11827988)1 Leo A....Schraven B. (J. Clin. Invest. 2002)
  10. The mechanism of phospholipase C-gamma1 regulation. (PubMed id 11048639)1 Kim M.J....Suh P.G. (amp 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28577 HGNC: 12185 AceView: TRB_ euGenes: HUgn28577 ECgene: TRBV12-3
H-InvDB: TRBV12-3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TRBV12-3 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRBV12-3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+TRBV12-3&species=Homo+sapiens

(Patent information from GeneIP,
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Patent Information for TRBV12-3 gene:
Search GeneIP for patents involving TRBV12-3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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