TRBC2 Gene
protein-coding GIFtS : 23 GCID: GC07 P142658
T cell receptor beta constant 2
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Aliasesfor TRBC2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases T Cell Receptor Beta Constant 2 1 2 TCRBC21 2 3
Export aliases for TRBC2 gene to outside databases Previous GC identifers: GC07U990261 GC07P141892 GC07P141961 GC07P141986 GC07P142020 GC07P142208 GC07Pg41904 GC07Pg41917 GC07P136837 GC07P142535 GC07P142548 GC07P142562 GC07P142591
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Summariesfor TRBC2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
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Genomic Viewsfor TRBC2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TRBC2 Other transcription factors Search SABiosciences Chromatin IP Primers for TRBC2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRBC2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34 TRBC2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P142658: view genomic region
(about GC identifiers )
Start: 142,498,725 bp from pter End:
142,500,432 bp from pter
Size: 1,708 bases Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 141,900,582-141,902,070
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Proteinsfor TRBC2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TRBC2_HUMAN, A0A5B9 See
protein sequence )Recommended Name: Size : 178 amino acids; 19969 DaSubcellular location : Membrane; Single-pass membrane protein (Potential)6/7 PDB 3D structures from (see all 7 ):2BNQ (3D) 2EYR (3D) 2EYS (3D) 2EYT (3D) 3O6F (3D) 3O8X (3D) Explore the universe of human proteins at neXtProt for TRBC2: NX_A0A5B9 TRBC2 Protein expression data from MOPED and PaxDb : About this image
ENSEMBL proteins: ENSP00000417300 Human Recombinant Protein Products for TRBC2: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
About GeneDecksing TRBC2 Antibody Products: Assay Products for TRBC2:
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Protein
Domains /for TRBC2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry A0A5B9 ProtoNet protein and cluster: A0A5B9
UniProtKB/Swiss-Prot: TRBC2_HUMAN, A0A5B9 Similarity : Contains 1 Ig-like (immunoglobulin-like) domain
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Functionfor TRBC2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004872 receptor activity
-- --
About GeneDecksing Animal Models:
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Pathways & Interactionsfor TRBC2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRBC2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)21/30 Interacting proteins for TRBC2 (ENSP00000417300 4 via UniProtKB, MINT, STRING , and/or I2D (see all 30 ) (see top 5 )About this table
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Drugs & Compoundsfor TRBC2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TRBC2 TRBC2
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Transcriptsfor TRBC2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000466254 (uc003wbe.4 uc022anx.1 uc003wbi.4 uc022any.1 uc003wbm.4 uc003wbn.4 uc010los.3 )24/76 AceView cDNA sequences (see all 76 ):
CR614480 CR606882 CR591596 CR602039 CR610034 CR596519 CR598684 CR622128 CR620981 CR609731 CR626342 CR608304 CR623833 CR622874 CR623178 BX112874 CR599262 CR620061 AA383854 X00437 AA380534 AA380633 AY232285 AA909476 GeneLoc Exon Structure
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Expression for TRBC2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TRBC2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image See TRBC2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRBC2 SABiosciences Custom PCR Arrays for TRBC2
Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRBC2 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRBC2 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRBC2
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Orthologsfor TRBC2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for TRBC2 gene from 2/5 species (see all 5 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia TRBC26
--
33(a)
1 ↔ 1
GL343499.1(439993-445005)
zebrafish Actinopterygii CABZ01043013.16
--
27(a)
1 ↔ 1
17(48645190-48658617)
Species with no ortholog for TRBC2 ENSEMBL Gene Tree for TRBC2 (if available)TreeFam Gene Tree for TRBC2 (if available)
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Paralogsfor TRBC2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TRBC2 gene IGLL5 2 IGKC 2 IGLC1 2 IGLL1 2 IGLC3 2 IGLC7 2 IGLC2 2 8 SIMAP similar genes for TRBC2 using alignment to 1 protein entry: TRBC2_HUMAN :TRBC1 B2M C1 segment IGKC IGLC6 IGLC7 DKFZp667J0810 IGL@ About GeneDecksing
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Genomic Variantsfor TRBC2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor TRBC2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
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Publicationsfor TRBC2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRBC2 gene integrated from 9 sources :(articles sorted by number of sources associating them with TRBC2) Utopia : connect your pdf to the dynamic
Sequence and evolution of the human T-cell antigen receptor beta- chain genes. (PubMed id 3860845) 1 , 2 , 3(1985) The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574) 1 , 2 (1996) Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372) 1 , 3(1996)
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External Searches for TRBC2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TRBC2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TRBC2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TRBC2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for TRBC2 Pharmacogenomics, SNPs, Pathways IMGT entry for TRBC2The international I mM unoG eneT ics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species. IMGT/GENE-DB http://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+TRBC2&species=Homo+sapiens
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About This Section Patent Information for TRBC2 gene: TRBC2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRBC2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRBC2 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRBC2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRBC2 Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRBC2 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRBC2 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRBC2
Search Tocris compounds for TRBC2
Search ThermoFisher Antibodies for TRBC2
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRBC2
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and Proteopedia 
for TRBC2 (
Browse Tocris compounds for 
