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Aliases for TRBC2 Gene

Aliases for TRBC2 Gene

  • T-Cell Receptor Beta Constant 2 2 5
  • T Cell Receptor Beta Constant 2 2 3
  • TCRBC2 3 4
  • V_segment Translation Product 3

External Ids for TRBC2 Gene

Previous GeneCards Identifiers for TRBC2 Gene

  • GC07U990261
  • GC07P141892
  • GC07P141961
  • GC07P141986
  • GC07P142020
  • GC07P142208
  • GC07Pg41904
  • GC07Pg41917
  • GC07P136837
  • GC07P142535
  • GC07P142548
  • GC07P142562
  • GC07P142591
  • GC07P142658
  • GC07P142727
  • GC07P142792
  • GC07P142820
  • GC07P142883
  • GC07P143056
  • GC07P143164
  • GC07P143363

Summaries for TRBC2 Gene

GeneCards Summary for TRBC2 Gene

TRBC2 (T-Cell Receptor Beta Constant 2) is a Protein Coding gene. An important paralog of this gene is TRBC1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRBC2 Gene

Genomics for TRBC2 Gene

Regulatory Elements for TRBC2 Gene

Enhancers for TRBC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G142803 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.7 +3.4 3446 1.6 HDGF TAL1 TSC22D4 TCF12 EGR1 NCOR1 POLR2A EED RELB IKZF2 TRBV30 OR9A2 CASP2 TAS2R39 EPHB6 TRBC2 GC07M142813
GH07G142799 1.1 Ensembl dbSUPER 0.7 -1.9 -1941 1.8 TBP ARNT BMI1 ZNF2 RAD21 EGR1 SCRT2 ZNF143 RCOR1 ZNF654 TRBV28 TRBJ2-7 TRBC2
GH07G142805 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +7.7 7697 5.7 HDGF PKNOX1 WRNIP1 TCF12 GATA2 ELK1 ZNF143 FOS ZNF263 MCM5 TRBV30 TRPV6 GSTK1 EPHB6 TCAF1P1 TRPV5 CASP2 GC07M142813 TRBC2
GH07G142800 0.8 Ensembl dbSUPER 0.7 +0.5 460 2.6 CTCF SMARCA4 ID3 NFE2 MLLT1 TRBV30 PRSS3P1 EPHB6 TRBC2 GC07M142813
GH07G142811 0.4 dbSUPER 0.4 +10.6 10637 0.0 ZNF263 RFX1 TRBV30 GC07M142813 TRBC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRBC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRBC2 Gene

Chromosome:
7
Start:
142,801,041 bp from pter
End:
142,802,748 bp from pter
Size:
1,708 bases
Orientation:
Plus strand

Genomic View for TRBC2 Gene

Genes around TRBC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBC2 Gene

Proteins for TRBC2 Gene

  • Protein details for TRBC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A5B9-TRBC2_HUMAN
    Recommended name:
    T-cell receptor beta-2 chain C region
    Protein Accession:
    A0A5B9

    Protein attributes for TRBC2 Gene

    Size:
    178 amino acids
    Molecular mass:
    19969 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRBC2 Gene

neXtProt entry for TRBC2 Gene

Post-translational modifications for TRBC2 Gene

Other Protein References for TRBC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBC2 Gene

Domains & Families for TRBC2 Gene

Gene Families for TRBC2 Gene

Protein Domains for TRBC2 Gene

Suggested Antigen Peptide Sequences for TRBC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRBC2: view

No data available for UniProtKB/Swiss-Prot for TRBC2 Gene

Function for TRBC2 Gene

Gene Ontology (GO) - Molecular Function for TRBC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with TRBC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBC2 Gene

Localization for TRBC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBC2 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TRBC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with TRBC2: view

No data available for Subcellular locations from COMPARTMENTS for TRBC2 Gene

Pathways & Interactions for TRBC2 Gene

SuperPathways for TRBC2 Gene

No Data Available

Interacting Proteins for TRBC2 Gene

Selected Interacting proteins: A0A5B9-TRBC2_HUMAN for TRBC2 Gene via IID

Symbol External ID(s) Details
CD1D

Gene Ontology (GO) - Biological Process for TRBC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006958 complement activation, classical pathway IBA --
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with TRBC2: view

No data available for Pathways by source and SIGNOR curated interactions for TRBC2 Gene

Transcripts for TRBC2 Gene

mRNA/cDNA for TRBC2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRBC2 Gene

No ASD Table

Relevant External Links for TRBC2 Gene

GeneLoc Exon Structure for
TRBC2
ECgene alternative splicing isoforms for
TRBC2

Expression for TRBC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRBC2 Gene

mRNA differential expression in normal tissues according to GTEx for TRBC2 Gene

This gene is overexpressed in Whole Blood (x23.9), Spleen (x7.1), and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for TRBC2 Gene

This gene is overexpressed in CD4 Tcells (56.6) and CD8 Tcells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRBC2 Gene



Protein tissue co-expression partners for TRBC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRBC2 Gene:

TRBC2
genes like me logo Genes that share expression patterns with TRBC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBC2 Gene

Orthologs for TRBC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRBC2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Trbc1 35
  • 80 (a)
OneToMany
Trbc2 35
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRBC2 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRBC2 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRBC2 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRBC2 35
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TRBC2 35
  • 27 (a)
OneToOne
Species where no ortholog for TRBC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRBC2 Gene

ENSEMBL:
Gene Tree for TRBC2 (if available)
TreeFam:
Gene Tree for TRBC2 (if available)

Paralogs for TRBC2 Gene

Paralogs for TRBC2 Gene

(8) SIMAP similar genes for TRBC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRBC2: view

Variants for TRBC2 Gene

Relevant External Links for TRBC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBC2 Gene

Disorders for TRBC2 Gene

No disorders were found for TRBC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRBC2 Gene

Publications for TRBC2 Gene

  1. Sequence and evolution of the human T-cell antigen receptor beta- chain genes. (PMID: 3860845) Tunnacliffe A. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 64
  2. Sequence and evolution of the human germline V lambda repertoire. (PMID: 8951372) Williams S.C. … Winter G. (J. Mol. Biol. 1996) 2 3 64
  3. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L. … Hood L. (Science 1996) 3 4 64

Products for TRBC2 Gene

Sources for TRBC2 Gene

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