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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRBC2 Gene

protein-coding   GIFtS: 24
GCID: GC07P142727

T Cell Receptor Beta Constant 2

  Search for TRBC2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T Cell Receptor Beta Constant 21 2
TCRBC22 3

External Ids:    HGNC: 121571   Entrez Gene: 286382   Ensembl: ENSG000002117727   OMIM: 6154455   UniProtKB: A0A5B93   

Export aliases for TRBC2 gene to outside databases

Previous GC identifers: GC07U990261 GC07P141892 GC07P141961 GC07P141986 GC07P142020 GC07P142208 GC07Pg41904 GC07Pg41917 GC07P136837 GC07P142535 GC07P142548 GC07P142562 GC07P142591 GC07P142658


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRBC2 Gene: 
TRBC2 (T cell receptor beta constant 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRBC2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRBC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRBC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TRBC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRBC2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142727:  view genomic region     (about GC identifiers)

Start:
142,498,725 bp from pter      End:
142,500,432 bp from pter
Size:
1,708 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571040 1,004,085-1,005,573      Chr7+,CRA_TCAG 141,900,582-141,902,070     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRBC2_HUMAN, A0A5B9 (See protein sequence)
Recommended Name: T-cell receptor beta-2 chain C region  
Size: 178 amino acids; 19969 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
6/7 PDB 3D structures from and Proteopedia for TRBC2 (see all 7):
2BNQ (3D)        2EYR (3D)        2EYS (3D)        2EYT (3D)        3O6F (3D)        3O8X (3D)    

Explore the universe of human proteins at neXtProt for TRBC2: NX_A0A5B9

Explore proteomics data for TRBC2 at MOPED 

TRBC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TRBC2 Protein Expression

ENSEMBL proteins: 
 ENSP00000417300  

Human Recombinant Protein Products for TRBC2: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TRBC2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRB: T cell receptors / TRB locus

3 InterPro protein domains:
 IPR007110 Ig-like_dom
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry A0A5B9

ProtoNet protein and cluster: A0A5B9

UniProtKB/Swiss-Prot: TRBC2_HUMAN, A0A5B9
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


TRBC2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
TRBC2 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRBC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for TRBC2 (ENSP000004173004) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
InteractantInteraction Details
GeneCardExternal ID(s)
B2MENSP000003408584STRING: ENSP00000340858
CD4ENSP000000116534STRING: ENSP00000011653
ENSG00000235657ENSP000003885264STRING: ENSP00000388526
PTCRAENSP000003044474STRING: ENSP00000304447
ENSG00000206493ENSP000003730914STRING: ENSP00000373091
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRBC2

Search CenterWatch for drugs/clinical trials and news about TRBC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000466254(uc003wbe.4 uc022anx.1 uc003wbi.4 uc022any.1 uc003wbm.4 uc003wbn.4 uc010los.3)

miRNA
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24/76 AceView cDNA sequences (see all 76):

CR610034 CR609731 BX112874 CR599262 CR614480 CR622874 CR626342 CR620981 
CR608304 CR623178 CR620061 CR623833 CR596519 CR591596 CR622128 CR598684 
CR602039 CR606882 AY232285 AY232284 AL559249 AK097858 AA909476 AA380633 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRBC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRBC2 Expression
About this image


See TRBC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRBC2
    SABiosciences Custom PCR Arrays for TRBC2
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRBC2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRBC2 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves TRBC26
T cell receptor beta constant 2
31(a)
1 ↔ 1
1(77558924-77574200)
lizard
(Anolis carolinensis)
Reptilia --
TRBC26
Uncharacterized protein
9(a)
34(a)
possible ortholog
1 ↔ 1
GL343252.1(78072-83161)
GL343499.1(431047-445005)
zebrafish
(Danio rerio)
Actinopterygii FP016018.26
TRBC26
(see all 4)
T cell receptor beta constant 2
(see all 4)

30(a)
(see all 4)
possible ortholog
1 ↔ 1
(see all 4)
3(59518822-59519203)
17(48645190-48658617)
        Species with no ortholog for TRBC2

ENSEMBL Gene Tree for TRBC2 (if available)
TreeFam Gene Tree for TRBC2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRBC2 gene
8 SIMAP similar genes for TRBC2 using alignment to 1 protein entry:     TRBC2_HUMAN:
TRBC1    B2M    C1 segment    IGKC    IGLC6    IGLC7
DKFZp667J0810    IGL@

TRBC2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRBC2
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRBC2 for disorders           About MalaCards
OMIM gene information: 615445    OMIM disorders: --


TRBC2 for disorders           About GeneDecksing


Export disorders for TRBC2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRBC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRBC2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Sequence and evolution of the human T-cell antigen receptor beta- chain genes. (PubMed id 3860845)1, 2, 3 Tunnacliffe A.... Rabbitts T.H. (1985)
  2. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 2 Rowen L.... Hood L. (1996)
  3. Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372)1, 3 Williams S.C....Winter G. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28638 HGNC: 12157 AceView: TRB_ Ensembl:ENSG00000211772 euGenes: HUgn28638
ECgene: TRBC2 H-InvDB: TRBC2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRBC2 Pharmacogenomics, SNPs, Pathways
IMGT entry for TRBC2 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+TRBC2&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRBC2 gene:
Search GeneIP for patents involving TRBC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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