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TRBC1 Gene

protein-coding   GIFtS: 29
GCID: GC07P9T0100

T Cell Receptor Beta Constant 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T Cell Receptor Beta Constant 11 2
BV05S1J2.22
TCRB2
TCRBC12

External Ids:    HGNC: 121561   Entrez Gene: 286392   OMIM: 1869305   UniProtKB: P018503   

Export aliases for TRBC1 gene to outside databases

Previous GC identifers: GC07U990262 GC07P141883 GC07P141962 GC07P141978 GC07P142007 GC07P141757 GC07P141672 GC07P142213 GC07P142227 GC07P142239 GC07P142251 GC07P142264 GC07P142278 GC07P142289 GC07Pg41892 GC07Pg41908 GC07P142297 GC07Pg41923 GC07Pg41929 GC07Pg41935 GC07Pg41941 GC07P9T0995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRBC1 Gene:
TRBC1 (T cell receptor beta constant 1) is a protein-coding gene. Diseases associated with TRBC1 include angioimmunoblastic t-cell lymphoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TRBC1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TRBC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRBC1


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q34   HGNC cytogenetic band: 7q34

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P9T0100:       (about GC identifiers)

Start:
994,738 bp from start of contig NW_003571040      End:
996,185 bp from start of contig NW_003571040
Size:
1,448 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 141,891,236-141,892,683     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRBC1_HUMAN, P01850 (See protein sequence)
Recommended Name: T-cell receptor beta-1 chain C region  
Size: 177 amino acids; 19899 Da
Sequence caution: Sequence=CAA25134.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for TRBC1 (see all 52):
1FYT (3D)        1J8H (3D)        1KGC (3D)        1KTK (3D)        1MI5 (3D)        1OGA (3D)    
Secondary accessions: A0A5B8 A6NH51

Explore the universe of human proteins at neXtProt for TRBC1: NX_P01850

Explore proteomics data for TRBC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64, Lys115
  • Glycosylation2 at Asn70

  • See TRBC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    Reactome Protein details: P01850

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRB: T cell receptors / TRB locus

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P01850

    ProtoNet protein and cluster: P01850

    UniProtKB/Swiss-Prot: TRBC1_HUMAN, P01850
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    TRBC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRBC1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRBC1_HUMAN, P01850: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane NAS6336315
    GO:0016021integral component of membrane IEA--

    TRBC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRBC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62
    2TCR signaling (REACTOME)
    Downstream TCR signaling0.73
    TCR signaling0.73
    3CD28 co-stimulation
    Costimulation by the CD28 family0.44
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for TRBC1 (see all 6)
        Translocation of ZAP-70 to Immunological synapse
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Downstream TCR signaling
    PD-1 signaling
    Phosphorylation of CD3 and TCR zeta chains



    TRBC1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRBC1
    Interactions:

        Search GeneGlobe Interaction Network for TRBC1

    1 Interacting protein for TRBC1 (P018501, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRACP018481, 2, 3EBI-1034839,EBI-1034847 MINT-25097 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS6336315
    GO:0031295T cell costimulation TAS--
    GO:0050776regulation of immune response TAS--
    GO:0050852T cell receptor signaling pathway TAS--

    TRBC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRBC1

    1 DrugBank Compound for TRBC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-Indolebutyric Acid-- 133-32-4target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    miRNA
    Products:
         
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    Primer
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    Selected AceView cDNA sequences (see all 76):

    CR610034 CR623833 CR620061 CR602039 CR599262 CR596519 CR620981 CR626342 
    CR622128 CR614480 BX112874 CR622874 CR598684 CR623178 CR608304 CR609731 
    CR591596 CR606882 AA380633 AA380534 AK097858 AL559249 AY232284 AA909476 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRBC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRBC1 Expression
    About this image

    TRBC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRBC1 Protein Expression
        Custom PCR Arrays for TRBC1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRBC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRBC1 gene
    9 SIMAP similar genes for TRBC1 using alignment to 1 protein entry:     TRBC1_HUMAN:
    TRBC2    B2M    C1 segment    IGKC    IGLC1    IGLC6
    IGLC7    DKFZp667J0810    IGLC2

    TRBC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TRBC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRBC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186930    OMIM disorders: --

    1 disease for TRBC1:    
    About MalaCards
    angioimmunoblastic t-cell lymphoma


    TRBC1 for disorders           About GeneDecksing


    Export disorders for TRBC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRBC1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TRBC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and evolution of the human T-cell antigen receptor beta- chain genes. (PubMed id 3860845)1, 2, 3 Tunnacliffe A.... Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    2. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1, 2 Rowen L.... Hood L. (Science 1996)
    3. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. (PubMed id 6336315)1, 2 Yanagi Y....Mak T.W. (Nature 1984)
    4. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    5. The shaping of T cell receptor recognition by self-tolerance. (PubMed id 19167249)2 Gras S....Rossjohn J. (Immunity 2009)
    6. Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. (PubMed id 17652306)1 Qi Q. and August A. (Sci. STKE 2007)
    7. In angioimmunoblastic T-cell lymphoma, neoplastic T cells may be a minor cell population. A molecular single-cell and immunohistochemical study. (PubMed id 15480765)1 Willenbrock K.... Hansmann M.L. (Virchows Arch. 2005)
    8. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. (PubMed id 15489916)1 Palacios E.H. and Weiss A. (Oncogene 2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. A structural basis for immunodominant human T cell receptor recognition. (PubMed id 12796775)2 Stewart-Jones G.B.E....Jones E.Y. (Nat. Immunol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28639 HGNC: 12156 AceView: TRB_ euGenes: HUgn28639 ECgene: TRBC1
    H-InvDB: TRBC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRBC1 Pharmacogenomics, SNPs, Pathways
    IMGT entry for TRBC1 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+TRBC1&species=Homo+sapiens

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRBC1 gene:
    Search GeneIP for patents involving TRBC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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