Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRBC1 Gene

Aliases for TRBC1 Gene

  • T Cell Receptor Beta Constant 1 2 3 5
  • V_segment Translation Product 3
  • BV05S1J2.2 3
  • TCRBC1 3
  • TCRB 3

External Ids for TRBC1 Gene

Previous GeneCards Identifiers for TRBC1 Gene

  • GC07U990262
  • GC07P141883
  • GC07P141962
  • GC07P141978
  • GC07P142007
  • GC07P141757
  • GC07P141672
  • GC07P142213
  • GC07P142227
  • GC07P142239
  • GC07P142251
  • GC07P142264
  • GC07P142278
  • GC07P142289
  • GC07Pg41892
  • GC07Pg41908
  • GC07P142297
  • GC07Pg41923
  • GC07Pg41929
  • GC07Pg41935
  • GC07Pg41941
  • GC07P9T0995
  • GC07P9T0100
  • GC07P142868
  • GC07P142924
  • GC07P143133
  • GC07P143200

Summaries for TRBC1 Gene

GeneCards Summary for TRBC1 Gene

TRBC1 (T Cell Receptor Beta Constant 1) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. An important paralog of this gene is TRBC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRBC1 Gene

Genomics for TRBC1 Gene

Regulatory Elements for TRBC1 Gene

Enhancers for TRBC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F142793 0.2 Ensembl 0.8 +2.0 2007 0.2 TRBC1 TRBD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRBC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRBC1 Gene

Chromosome:
7
Start:
142,791,694 bp from pter
End:
142,793,368 bp from pter
Size:
1,675 bases
Orientation:
Plus strand

Genomic View for TRBC1 Gene

Genes around TRBC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBC1 Gene

Proteins for TRBC1 Gene

  • Protein details for TRBC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01850-TRBC1_HUMAN
    Recommended name:
    T-cell receptor beta-1 chain C region
    Protein Accession:
    P01850
    Secondary Accessions:
    • A0A5B8
    • A6NH51

    Protein attributes for TRBC1 Gene

    Size:
    177 amino acids
    Molecular mass:
    19899 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA25134.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRBC1 Gene

neXtProt entry for TRBC1 Gene

Post-translational modifications for TRBC1 Gene

  • Glycosylation at Asn 70
  • Modification sites at PhosphoSitePlus

Other Protein References for TRBC1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBC1 Gene

Domains & Families for TRBC1 Gene

Gene Families for TRBC1 Gene

Protein Domains for TRBC1 Gene

Suggested Antigen Peptide Sequences for TRBC1 Gene

Graphical View of Domain Structure for InterPro Entry

P01850

UniProtKB/Swiss-Prot:

TRBC1_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TRBC1: view

Function for TRBC1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBC1 Gene

Localization for TRBC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBC1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TRBC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane NAS 6336315
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRBC1: view

No data available for Subcellular locations from COMPARTMENTS for TRBC1 Gene

Pathways & Interactions for TRBC1 Gene

genes like me logo Genes that share pathways with TRBC1: view

Gene Ontology (GO) - Biological Process for TRBC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 6336315
GO:0031295 T cell costimulation TAS --
GO:0050776 regulation of immune response TAS --
GO:0050852 T cell receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TRBC1: view

No data available for SIGNOR curated interactions for TRBC1 Gene

Drugs & Compounds for TRBC1 Gene

(1) Drugs for TRBC1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-Indolebutyric acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRBC1: view

Transcripts for TRBC1 Gene

mRNA/cDNA for TRBC1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRBC1 Gene

No ASD Table

Relevant External Links for TRBC1 Gene

GeneLoc Exon Structure for
TRBC1
ECgene alternative splicing isoforms for
TRBC1

Expression for TRBC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRBC1 Gene

Protein differential expression in normal tissues from HIPED for TRBC1 Gene

This gene is overexpressed in Tlymphocyte (51.6), CD4 Tcells (8.8), and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRBC1 Gene



Protein tissue co-expression partners for TRBC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRBC1 Gene:

TRBC1
genes like me logo Genes that share expression patterns with TRBC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRBC1 Gene

Orthologs for TRBC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRBC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRBV25-1 35
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRBV25-1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 38 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
Species where no ortholog for TRBC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRBC1 Gene

ENSEMBL:
Gene Tree for TRBC1 (if available)
TreeFam:
Gene Tree for TRBC1 (if available)

Paralogs for TRBC1 Gene

Paralogs for TRBC1 Gene

(9) SIMAP similar genes for TRBC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRBC1: view

Variants for TRBC1 Gene

Relevant External Links for TRBC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBC1 Gene

Disorders for TRBC1 Gene

Relevant External Links for TRBC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRBC1

No disorders were found for TRBC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRBC1 Gene

Publications for TRBC1 Gene

  1. Sequence and evolution of the human T-cell antigen receptor beta- chain genes. (PMID: 3860845) Tunnacliffe A. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 64
  2. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L. … Hood L. (Science 1996) 3 4 64
  3. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. (PMID: 6336315) Yanagi Y. … Mak T.W. (Nature 1984) 3 4 64
  4. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3 64
  5. The shaping of T cell receptor recognition by self-tolerance. (PMID: 19167249) Gras S. … Rossjohn J. (Immunity 2009) 4 64

Products for TRBC1 Gene

Sources for TRBC1 Gene

Content
Loading form....