Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRB@ Cluster

gene cluster GIFtS: 34
GCID: GC07P142700

T cell receptor beta locus

(Previous symbol: TCRB)

Explore 117 diseases affiliated with
TRB@ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T Cell Receptor Beta Locus¹ ²
TCRB¹ ² ⁵
TRB¹ ²
T-Cell Antigen Receptor, Beta Polypeptide, T-Cell Receptor, Beta Cluster²
T-Cell Receptor, Beta Cluster²

External Ids:	HGNC: 12155¹	Entrez Gene: 6957²	OMIM: 186930⁵	UniProtKB: P04435³

Export aliases for TRB@ gene to outside databases

Previous GC identifers: GC07U990096 GC07M140532 GC07P141602 GC07P141678 GC07P141648 GC07Pg41337 GC07P142320 GC07P142362 GC07P142417 GC07P142470 GC07P142631

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRB@:

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major

histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a

dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell

receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma

rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange

the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta

locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the

beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment

is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many

different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is

attained by junctional diversity, resulting from the random additional of nucleotides by terminal

deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of

encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of

which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell

receptor beta locus have been associated with T-cell lymphomas. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TRB@
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TRB@

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRB@

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34 HGNC cytogenetic band: 7q34

TRB@ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRB@ gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P142700: view genomic region (about GC identifiers)

Start:	141,998,851 bp from pter	End:	142,510,972 bp from pter
Size:	512,122 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 141,337,044-141,912,827

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TVB2_HUMAN, P04435 (See protein sequence)

Recommended Name: T-cell receptor beta chain V region CTL-L17 precursor

Size: 133 amino acids; 14999 Da

Miscellaneous: This sequence was derived from a human cytotoxic T-lymphocyte that is T3+, T4+, T8-

Explore the universe of human proteins at neXtProt for TRB@: NX_P04435

TRB@ Protein expression data from MOPED and PaxDb: --
Reactome Protein details: P04435
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TRB@
	GenScript Custom Purified and Recombinant Proteins Services for TRB@
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

TRB@ Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TRB@
	GenScript Custom Superior Antibodies Services for TRB@
	Novus Biologicals TRB@ Antibodies
	Search for Antibodies for TRB@ at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibody for TRB@

Assay Products for TRB@:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRB@
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRB@ for domains About GeneDecksing

4 InterPro domains/families:

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry P04435

ProtoNet protein and cluster: P04435

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRB@
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRB@
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		Browse OriGene 29mer shRNA kits Browse OriGene siRNA
		Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRB@

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TRB@

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRB@ (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for TRB@
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRB@
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRB@

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRB@
		Search LifeMap BioReagents cell lines for TRB@

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TRB@

Animal Models:
     Mouse knock-outs for TRB@: Tcrb^tm1Slek Tcrb^tm4Slek Tcrb^tm1Mom Tcrb^tm2Slek Tcrb^tm1Habu Tcrb^tm7Slek
                                               Tcrb^tm3Slek Tcrb^tm5Slek
     14 MGI mutant phenotypes (inferred from 19 alleles) (MGI details for Tcrb):

cardiovascular system	cellular	digestive/alimentary	growth/size	hematopoietic system
immune system	integument	liver/biliary system	mortality/aging	nervous system
normal	renal/urinary system	respiratory system	tumorigenesis

TRB@ for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_NFAT in immune response

Immune response_NFAT in immune response

1.00

Immune response NFAT in immune response

0.91

Immune response_ICOS pathway in T-helper cell

Immune response_ICOS pathway in T-helper cell

1.00

Immune response ICOS pathway in T-helper cell

0.91

Signal transduction_IP3 signaling

Signal transduction_IP3 signaling

1.00

Signal transduction IP3 signaling

0.92

Immune response_Function of MEF2 in T lymphocytes

Immune response_Function of MEF2 in T lymphocytes

1.00

Immune response Function of MEF2 in T lymphocytes

0.90

G-protein signaling Regulation of RAC1 activity

G-protein signaling Regulation of RAC1 activity

1.00

G-protein signaling_Regulation of RAC1 activity

0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 EMD Millipore Pathways for TRB@ (see all 15)

	Immune response Antigen presentation by MHC class II
	Signal transduction IP3 signaling
	Immune response NFAT in immune response
	Immune response Antigen presentation by MHC class I
	Immune response CD28 signaling

5/15 GeneGo (Thomson Reuters) Pathways for TRB@ (see all 15)

	G-protein signaling Regulation of RAC1 activity
	Immune response Antigen presentation by MHC class II
	Immune response CD28 signaling
	Immune response IL-12-induced IFN-gamma production
	G-protein signaling N-RAS regulation pathway

2 BioSystems Pathways for TRB@

	Cytokines and Inflammatory Response
	TCR Signaling Pathway

5/10 Reactome Pathways for TRB@ (see all 10)

	Costimulation by the CD28 family
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Translocation of ZAP-70 to Immunological synapse
	Downstream TCR signaling

TRB@ for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRB@

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRB@ for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRB@
10/15 Novoseek chemical compound relationships for TRB@ gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bgl ii	50.6	3	1979939 (1), 7567936 (1), 1679291 (1)
enterotoxin	42.5	3	8486394 (1), 8613483 (1), 9500785 (1)
bamhi	26.6	1	7567936 (1)
hind iii	24.1	2	7567936 (1), 11422051 (1)
ecori	23.7	1	7567936 (1)
paraffin	21.9	1	7959674 (1)
cyclosporin a	12.1	2	1591215 (1), 8500270 (1)
oligonucleotide	6.06	3	7823247 (1), 8599453 (1), 1848269 (1)
polyacrylamide	4.36	1	8882133 (1)
calcium	0.542	1	2052609 (1)

Search CenterWatch for drugs/clinical trials and news about TRB@

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRB@
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRB@
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		Browse OriGene 29mer shRNA kits Browse OriGene siRNA
		Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRB@

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRB@ (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for TRB@
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRB@
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRB@

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat TRB@
		Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRB@
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRB@

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for TRB@:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for TRB@

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat TRB@
		Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRB@
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRB@

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TRB@

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TRB@ gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tcrb⁵	T cell receptor beta chain	--		6 -

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2072625^1,2	C	--	136809233(+)	`CAGGCA/GCTGTG`	1	--	int¹		0	--	--	--	--
rs148453853^1,2		--	142372174(+)	`TACTAC/TGTTGA`	1	--	us2k¹		0	--	--	--	--
rs184425337^1,2		--	142372206(+)	`ATCTTC/TGTCTT`	1	--	us2k¹		0	--	--	--	--
rs188871929^1,2		--	142372216(+)	`TGTGCC/TGGTTT`	1	--	us2k¹		0	--	--	--	--
rs192651757^1,2		--	142372316(+)	`CAGTCA/GTGGGA`	1	--	us2k¹		0	--	--	--	--
rs2187633^1,2	C,F,A,	--	142372329(+)	`ACTGCC/TGTGCA`	1	--	us2k¹		10		WA NA CSA EA	370
rs2156964^1,2	C,F,	--	142372587(+)	`AACACC/TCCCCT`	1	--	us2k¹		6		WA NA EA	364
rs10231856^1,2	C,F,H,	--	142372671(+)	`CAACTC/GTGCCA`	1	--	us2k¹		7		NS EA NA WA	542
rs184685381^1,2		--	142372720(+)	`AACAGC/TTACCC`	1	--	us2k¹		0	--	--	--	--
rs10247233^1,2	C,F,A,	--	142372764(+)	`CCCTCA/GCCAAT`	1	--	us2k¹		12		EA NA WA CSA	583

HapMap Linkage Disequilibrium report for TRB@ (141998851 - 142248851 bp, first 250kb of TRB@)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRB@: --
Human Gene Mutation Database (HGMD): TRB@

Locus Specific Mutation Databases (LSDB): TRB@

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRB@

DNA2.0 Custom Variant and Variant Library Synthesis for TRB@

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRB@ for disorders           About GeneDecksing

OMIM gene information: 186930    OMIM disorders: --

20/117 diseases for TRB@ (see all 117):    About MalaCards

pure red-cell aplasia graft versus host disease relapsing-remitting multiple sclerosis b-cell non-hodgkin lymphoma

churg-strauss syndrome connective tissue disease non-hodgkin lymphoma mixed connective tissue disease

severe combined immunodeficiency lymphomatoid papulosis mycosis fungoides dermatitis herpetiformis

large granular lymphocyte leukemia eosinophilic fasciitis anaplastic large cell lymphoma guttate psoriasis

pemphigus foliaceus malt lymphoma combined immunodeficiency leukemia/lymphoma

10/92 Novoseek disease relationships for TRB@ gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma t-cell	75.5	9	2154349 (2), 18952689 (1), 8100721 (1), 2163138 (1) (see all 8)
lymphoma t-cell cutaneous	69.7	9	16741518 (2), 1836348 (1), 12682631 (1), 2153627 (1) (see all 8)
granulomatous slack skin	69.4	1	1316105 (1)
lymphoma t-cell peripheral	65.8	1	16237215 (1)
lymphoma	64.4	15	2207314 (1), 8231259 (1), 8160632 (1), 9723588 (1) (see all 14)
sezary syndrome	64.4	3	7492785 (1), 1848269 (1), 16741518 (1)
lymphoma large cell	62.9	4	2169708 (1), 1493464 (1), 8396607 (1), 7505507 (1)
lymphoproliferative disorders	62.4	1	1953508 (1)
lymphocytosis	59.9	3	7890378 (1), 9519776 (1), 1695480 (1)
mycosis fungoides	58.1	7	8396607 (1), 2036034 (1), 1731519 (1), 8133398 (1) (see all 6)

Genetic Association Database (GAD): TRB@
Human Genome Epidemiology (HuGE) Navigator: TRB@ (15 documents)

Export disorders for TRB@ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRB@ gene, integrated from 9 sources (see all 386):
(articles sorted by number of sources associating them with TRB@)

Utopia: connect your pdf to the dynamic
world of online information

Analysis of the insertion/deletion related polymorphism within T cell antigen receptor beta variable genes in primary Sjogren's syndrome. (PubMed id 15708895)^{1, 4, 9} Lawson C.A....Boylston A.W. (2005)
Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host. (PubMed id 12635936)^{1, 4} Kunstmann E....Epplen J.T. (2003)
Analysis of two T-cell receptor BV gene segment polymorphisms in caucasoid Brazilian patients with rheumatoid arthritis. (PubMed id 14687707)^{1, 4} Dresch C....Chies J.A. (2003)
T-cell receptor polymorphism in primary biliary cirrhosis. (PubMed id 14621425)^{1, 4} Selmi C....Podda M. (2003)
Malaria is not responsible for the selection of TCR beta-subunit variable gene haplotypes in The Gambia. (PubMed id 11862389)^{1, 4} Donaldson I.J....Boylston A.W. (2002)
Unique TCR beta-subunit variable gene haplotypes in Africans. (PubMed id 11862388)^{1, 4} Donaldson I.J....Boylston A.W. (2002)
TCRBV3S1 and TCRBV18 gene segment polymorphisms in Brazilian Caucasoid and Black populations. (PubMed id 11841483)^{1, 4} Dresch C....Chies J.A. (2002)
Association study of proposed candidate genes/regions in a population of Spanish asthmatics. (PubMed id 11142503)^{1, 4} Soriano J.B....Lazaro C. (2000)
The complete primary structure of the T-cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone. (PubMed id 2426193)^{1, 2} Leiden J.M.... Strominger J.L. (1986)
Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells. (PubMed id 3983641)^{1, 3} Isobe M....Croce C.M. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRB@	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TRB@	Genetics and Cytogenetics in Oncology and Haematology
IMGT entry for TRB@	The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property for TRB@ gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRB@ gene:
Search GeneIP for patents involving TRB@

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	Browse OriGene 29mer shRNA kits in GFP-retroviral vector		Browse OriGene genome-wide validated SYBR primer pairs
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		Browse 3'-UTR reporter clones for miRNA target validation
	Browse OriGene untagged cDNA clones in CMV expression vector		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRB@
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TRB@		OriGene Custom Protein Services for TRB@
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRB@
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRB@
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRB@
	Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRB@
	Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRB@
	Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRB@

	GenScript Custom Purified and Recombinant Proteins Services for TRB@		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TRB@
	GenScript Custom Assay Services for TRB@		GenScript Custom Superior Antibodies Services for TRB@
	GenScript Custom overexpressing Cell Line Services for TRB@		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for TRB@
	Search Chromatin IP Primers for TRB@
	Search RT² qPCR Primer Assays in human, mouse, rat TRB@
	Search GNC Networks for TRB@
	SABiosciences Custom PCR Arrays for TRB@

Search Tocris compounds for TRB@

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TRB@ antibodies

	Search for Antibodies for TRB@ at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TRB@
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for TRB@

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TRB@

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TRB@
	Browse SwitchGear Promoter luciferase reporter plasmids for TRB@

ThermoFisher Antibody for TRB@

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRB@

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TRB@ gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TRB@ Cluster

T cell receptor beta locus

Aliases
for TRB@ gene

Summaries
for TRB@ gene

Genomic Views
for TRB@ gene

Proteins
for TRB@ gene

Protein Domains /
Families
for TRB@ gene

Function
for TRB@ gene

Pathways & Interactions
for TRB@ gene

Drugs & Compounds
for TRB@ gene

Transcripts
for TRB@ gene

Expression
for TRB@ gene

Orthologs
for TRB@ gene

Paralogs
for TRB@ gene

Genomic Variants
for TRB@ gene

Disorders / Diseases
for TRB@ gene

Publications
for TRB@ gene

External Searches for TRB@ gene

Genome Databases showing TRB@ gene

Other Databases showing TRB@ gene

Specialized Databases showing TRB@ gene

Intellectual Property
for TRB@ gene

Products
for TRB@ gene

View Random Gene

stable disease
Lymphoma Large Cell
Pleurisy
Genetic Susceptibility
Herpes Simplex
Lymphoma T-Cell
Cystic Fibrosis
Dermatitis Herpetiformis
Thymoma
Red Cell Aplasia
T Cell Leukemia Lymphoma Adult
LUNG CARCINOMA
Skin Diseases
Sjogrens Syndrome Primary
Mycosis Fungoides
Cancer
Diabetes Mellitus Insulin-Dependent
Lymphocytosis
Lymphoma
GASTRIC CARCINOMA
Hepatitis B Chronic
Myeloproliferative Disorders
effusion
Sarcoidosis Pulmonary
Multiple Sclerosis
Inflammation
Demyelinating Diseases
Proteinuria
immunodeficiency
Neutropenia
Psoriasis
Hepatitis B
MYELOMA
Hypergammaglobulinemia
Sarcoidosis
Rheumatoid Arthritis
Hepatitis Autoimmune
Tumors
Trisomy
Metastasis
Kawasaki Disease
Multiple Sclerosis Relapsing-Remitting
Lymphoblastic Leukemia Acute
Autoimmunity
Celiac Disease
Pseudolymphoma
Lymphoma T-Cell Cutaneous
virus infection
Chagas Disease
Myeloid Leukemia
Leukemia Lymphocytic Large Granular
Encephalomyelitis
Melanoma
Lymphadenopathy
Autoimmune Diseases
Vasculitis
Leukemia Lymphocytic Chronic
Hyperplasia
Arthritis Juvenile Rheumatoid
Demyelination
Hodgkin Disease
ACUTE LEUKEMIA
Minimal Residual Disease
Leukemia
Myeloid Leukemia Chronic
Severe Combined Immunodeficiency
Sjogrens Syndrome
CMV INFECTION
Lymphoma Lymphoblastic
Cancer Lung
Connective Tissue Diseases
Influenza
Sezary Syndrome
Arthritis Psoriatic
Lymphoma B-Cell
Ascites
HIV Infections
MALT Lymphoma
T-ALL
Lymphoproliferative Disorders
SKIN LESION
Graves Disease
Chromosomal Aberrations
Anemia Aplastic
Graft-Versus-Host Disease
Lymphoma Non-Hodgkins
Granulomatous Slack Skin
Lymphoma T-Cell Peripheral
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC
Lupus Erythematosus Systemic
Arthritis

Advanced Search

Export list of displayed genes

TRB@ Cluster

T cell receptor beta locus

Aliasesfor TRB@ gene

Summariesfor TRB@ gene

Genomic Viewsfor TRB@ gene

Proteinsfor TRB@ gene

Protein Domains /Familiesfor TRB@ gene

Functionfor TRB@ gene

Pathways & Interactionsfor TRB@ gene

Drugs & Compoundsfor TRB@ gene

Transcriptsfor TRB@ gene

Expression for TRB@ gene

Orthologsfor TRB@ gene

Paralogsfor TRB@ gene

Genomic Variantsfor TRB@ gene

Disorders / Diseasesfor TRB@ gene

Publicationsfor TRB@ gene

External Searches for TRB@ gene

Genome Databases showing TRB@ gene

Other Databases showing TRB@ gene

Specialized Databases showing TRB@ gene

Intellectual Propertyfor TRB@ gene

Productsfor TRB@ gene

View Random Gene

Aliases
for TRB@ gene

Summaries
for TRB@ gene

Genomic Views
for TRB@ gene

Proteins
for TRB@ gene

Protein Domains /
Families
for TRB@ gene

Function
for TRB@ gene

Pathways & Interactions
for TRB@ gene

Drugs & Compounds
for TRB@ gene

Transcripts
for TRB@ gene

Expression
for TRB@ gene

Orthologs
for TRB@ gene

Paralogs
for TRB@ gene

Genomic Variants
for TRB@ gene

Disorders / Diseases
for TRB@ gene

Publications
for TRB@ gene

Intellectual Property
for TRB@ gene

Products
for TRB@ gene