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Aliases for TRB Gene

Aliases for TRB Gene

  • T Cell Receptor Beta Locus 2 3
  • T-Cell Antigen Receptor, Beta Polypeptide, T-Cell Receptor, Beta Cluster 3
  • T-Cell Receptor, Beta Cluster 3
  • T-Cell Antigen Receptor 2
  • Beta Polypeptide 2
  • T-Cell Receptor 2
  • Beta Cluster 2
  • TCRB 3
  • TRB@ 3

External Ids for TRB Gene

Previous HGNC Symbols for TRB Gene

  • TCRB
  • TRB@

Previous GeneCards Identifiers for TRB Gene

  • GC07P142763
  • GC07P142839
  • GC07P142876

Summaries for TRB Gene

Entrez Gene Summary for TRB Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRB Gene

TRB (T Cell Receptor Beta Locus) is a Protein Coding gene. Diseases associated with TRB include granulomatous slack skin disease and acute t cell leukemia. Among its related pathways are G-protein signaling_Regulation of RAC1 activity and Immune response Antigen presentation by MHC class II.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRB Gene

Genomics for TRB Gene

Genomic Location for TRB Gene

142,299,011 bp from pter
142,813,287 bp from pter
514,277 bases
Plus strand

Genomic View for TRB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TRB Gene

No data available for Regulatory Elements for TRB Gene

Proteins for TRB Gene

  • Protein details for TRB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    TRB protein
    Protein Accession:

    Protein attributes for TRB Gene

    174 amino acids
    Molecular mass:
    19651 Da
    Quaternary structure:
    No Data Available
  • Protein details for TRB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    TRB protein
    Protein Accession:

    Protein attributes for TRB Gene

    200 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRB Gene

Proteomics data for TRB Gene at MOPED

Post-translational modifications for TRB Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRB Gene

Domains & Families for TRB Gene

Gene Families for TRB Gene

Protein Domains for TRB Gene

Suggested Antigen Peptide Sequences for TRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRB: view

No data available for UniProtKB/Swiss-Prot for TRB Gene

Function for TRB Gene

genes like me logo Genes that share phenotypes with TRB: view

Animal Models for TRB Gene

MGI Knock Outs for TRB:

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for TRB Gene

Localization for TRB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRB Gene

Drugs & Compounds for TRB Gene

(5) Drugs for TRB Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2525
Cyclosporin A Pharma Inhibition, Inhibitor Immunosuppressive agent, Calcineurin inhibitor 0
Calcium Nutra 0
threonine Nutra 16
tyrosine Nutra 547

(10) Additional Compounds for TRB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (6)Annulene
  • Annulene
  • Aromatic alkane
  • Benzeen
  • Benzen
Bgl II
genes like me logo Genes that share compounds with TRB: view

Transcripts for TRB Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRB Gene

No ASD Table

Relevant External Links for TRB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for TRB Gene

Expression for TRB Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRB Gene

Orthologs for TRB Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TRB Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tcrb 16
Species with no ortholog for TRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for TRB Gene

Paralogs for TRB Gene

No data available for Paralogs for TRB Gene

Variants for TRB Gene

Relevant External Links for TRB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRB Gene

Disorders for TRB Gene

MalaCards: The human disease database

(11) MalaCards diseases for TRB Gene - From: Orphanet, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
granulomatous slack skin disease
  • granulomatous slack skin
acute t cell leukemia
  • precursor t lymphoblastic leukemia
precursor t-cell acute lymphoblastic leukemia
  • t-all
stromal keratitis
pure red-cell aplasia
  • pure red cell aplasia
- elite association
Search TRB in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRB Gene

Publications for TRB Gene

  1. T-cell enumeration from dried blood spots by quantifying rearranged T-cell receptor-beta genes. (PMID: 20109463) Redd A.D. … Quinn T.C. (J. Immunol. Methods 2010) 23 67
  2. Rapid detection of clonal expansion of T-cell receptor-beta gene in patients with HBV using the real-time PCR with DNA melting curve analysis. (PMID: 20070405) Yang J.Z. … Li L.J. (Hepatol. Res. 2010) 23 67
  3. Flow cytometric quantitation of natural killer cells and T lymphocytes expressing T-cell receptors alpha/beta and gamma/delta is not helpful in distinguishing benign from malignant body cavity effusions. (PMID: 18803280) Cornfield D.B. … Gheith S.M. (Cytometry B Clin Cytom 2009) 23 67
  4. Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients. (PMID: 19317896) Serana F. … Imberti L. (J Transl Med 2009) 23 67
  5. Genomic analysis reveals extensive gene duplication within the bovine TRB locus. (PMID: 19393068) Connelley T. … Morrison W.I. (BMC Genomics 2009) 23 67

Products for TRB Gene

Sources for TRB Gene

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