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Aliases for TRB Gene

Aliases for TRB Gene

  • T Cell Receptor Beta Locus 2 3
  • T-Cell Antigen Receptor, Beta Polypeptide, T-Cell Receptor, Beta Cluster 2 3
  • T-Cell Receptor, Beta Cluster 3
  • TCRB 3
  • TRB@ 3

External Ids for TRB Gene

Previous HGNC Symbols for TRB Gene

  • TCRB
  • TRB@

Previous GeneCards Identifiers for TRB Gene

  • GC07P142763
  • GC07P142839
  • GC07P142876
  • GC07P143009
  • GC07P143157
  • GC07P143354

Summaries for TRB Gene

Entrez Gene Summary for TRB Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRB Gene

TRB (T Cell Receptor Beta Locus) is a Protein Coding gene. Diseases associated with TRB include Precursor T-Cell Acute Lymphoblastic Leukemia and Granulomatous Slack Skin Disease. Among its related pathways are G-protein signaling N-RAS regulation pathway and Immune response NFAT in immune response.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRB Gene

Genomics for TRB Gene

Regulatory Elements for TRB Gene

Enhancers for TRB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F142299 0.4 Ensembl 0.8 +0.5 490 0.2 OSR2 KLF8 TRB TRBV1 TRBV2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRB on UCSC Golden Path with GeneCards custom track

Genomic Location for TRB Gene

142,299,011 bp from pter
142,813,287 bp from pter
514,277 bases
Plus strand

Genomic View for TRB Gene

Genes around TRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRB Gene

Proteins for TRB Gene

  • Protein details for TRB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    TRB protein
    Protein Accession:

    Protein attributes for TRB Gene

    174 amino acids
    Molecular mass:
    19651 Da
    Quaternary structure:
    No Data Available
  • Protein details for TRB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    TRB protein
    Protein Accession:

    Protein attributes for TRB Gene

    200 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRB Gene

Post-translational modifications for TRB Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRB Gene

Domains & Families for TRB Gene

Gene Families for TRB Gene

Protein Domains for TRB Gene

Suggested Antigen Peptide Sequences for TRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRB: view

No data available for UniProtKB/Swiss-Prot for TRB Gene

Function for TRB Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRB Gene

Localization for TRB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRB Gene

Drugs & Compounds for TRB Gene

(5) Drugs for TRB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for TRB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRB: view

Transcripts for TRB Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRB Gene

No ASD Table

Relevant External Links for TRB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for TRB Gene

Expression for TRB Gene

NURSA nuclear receptor signaling pathways regulating expression of TRB Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRB Gene

Orthologs for TRB Gene

No data available for Orthologs and Evolution for TRB Gene

Paralogs for TRB Gene

No data available for Paralogs for TRB Gene

Variants for TRB Gene

Relevant External Links for TRB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRB Gene

Disorders for TRB Gene

MalaCards: The human disease database

(11) MalaCards diseases for TRB Gene - From: Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • t-all
granulomatous slack skin disease
  • granulomatous slack skin
b-cell expansion with nfkb and t-cell anergy
  • benta
acute t cell leukemia
  • precursor t lymphoblastic leukemia
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
- elite association - COSMIC cancer census association via MalaCards
Search TRB in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRB Gene

Publications for TRB Gene

  1. Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias. (PMID: 16741518) Morgan S.M. … Smith J.L. (J. Invest. Dermatol. 2006) 3 22 64
  2. Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells. (PMID: 3983641) Isobe M. … Croce C.M. (Science 1985) 2 3 64
  3. Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress. (PMID: 26753883) Malcolm T.I. … Turner S.D. (Nat Commun 2016) 3 64
  4. CDR3 motif generation and selection in the BV19-utilizing subset of the human CD8 T cell repertoire. (PMID: 26963408) Yassai M.B. … Gorski J. (Mol. Immunol. 2016) 3 64
  5. The macrophage-TCRI+I^ is a cholesterol-responsive combinatorial immune receptor and implicated in atherosclerosis. (PMID: 25446098) Fuchs T. … Kaminski W.E. (Biochem. Biophys. Res. Commun. 2015) 3 64

Products for TRB Gene

Sources for TRB Gene

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