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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRB Gene

protein-coding   GIFtS: 21
GCID: GC07P142763

T Cell Receptor Beta Locus


(Previous symbols: TCRB, TRB@)
  Search for TRB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T Cell Receptor Beta Locus1 2     T-Cell Antigen Receptor1
TCRB1 2     T-Cell Receptor1
TRB@1 2     T-Cell Antigen Receptor, Beta Polypeptide, T-Cell Receptor, Beta Cluster2
Beta Cluster1     T-Cell Receptor, Beta Cluster2
Beta Polypeptide1     CTRB15

External Ids:    HGNC: 121551   Entrez Gene: 69572   OMIM: 1188905   

Export aliases for TRB gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRB Gene:
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major
histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor
is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T
cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and
gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to
rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta
locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell
development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J
segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level.
Recombination of many different V segments with several J segments provides a wide range of antigen recognition.
Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by
terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be
incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen
genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities
involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (provided by RefSeq, Jul
2008)

GeneCards Summary for TRB Gene: 
TRB (T cell receptor beta locus) is a protein-coding gene. Among its related super-pathways are Immune response CD28 signaling and Signal transduction Erk Interactions- Inhibition of Erk.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRB
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRB promoter sequence
   Search SABiosciences Chromatin IP Primers for TRB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   HGNC cytogenetic band: 7q34

TRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142763:  view genomic region     (about GC identifiers)

Start:
141,998,851 bp from pter      End:
142,510,972 bp from pter
Size:
512,122 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571040 441,002-1,016,331      Chr7+,CRA_TCAG 141,337,044-141,912,827     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRB: T cell receptors / TRB locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     14 MGI mutant phenotypes (inferred from 19 alleles(MGI details for Tcrb):
 cardiovascular system  cellular  digestive/alimentary  growth/size  hematopoietic system 
 immune system  integument  liver/biliary system  mortality/aging  nervous system 
 normal  renal/urinary system  respiratory system  tumorigenesis 

TRB for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TRB: Tcrbtm1Slek Tcrbtm4Slek Tcrbtm1Mom Tcrbtm2Slek Tcrbtm1Habu Tcrbtm7Slek
                                                     Tcrbtm3Slek Tcrbtm5Slek

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TRB About   (see all 17)                                                                                              See pathways by source

SuperPathContained pathways About
1Immune response CD28 signaling
Immune response CD28 signaling0.92
2Signal transduction Erk Interactions: Inhibition of Erk
Signal transduction Erk Interactions: Inhibition of Erk0.92
3Immune response Antigen presentation by MHC class I
Immune response Antigen presentation by MHC class I0.92
4Signal transduction IP3 signaling
Signal transduction IP3 signaling0.92
5Immune response ICOS pathway in T-helper cell
Immune response ICOS pathway in T-helper cell0.91

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/15 EMD Millipore Pathways for TRB (see all 15)
    Immune response Antigen presentation by MHC class II
Signal transduction IP3 signaling
Immune response NFAT in immune response
Immune response Antigen presentation by MHC class I
Immune response CD28 signaling


5/15 GeneGo (Thomson Reuters) Pathways for TRB (see all 15)
    G-protein signaling Regulation of RAC1 activity
Immune response Antigen presentation by MHC class II
Immune response CD28 signaling
Immune response IL-12-induced IFN-gamma production
G-protein signaling N-RAS regulation pathway

2 BioSystems Pathways for TRB
    Cytokines and Inflammatory Response
TCR Signaling Pathway



TRB for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRB

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRB for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRB

10/15 Novoseek inferred chemical compound relationships for TRB gene (see all 15)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
bgl ii 50.6 3 1979939 (1), 7567936 (1), 1679291 (1)
enterotoxin 42.5 3 8486394 (1), 8613483 (1), 9500785 (1)
bamhi 26.6 1 7567936 (1)
hind iii 24.1 2 7567936 (1), 11422051 (1)
ecori 23.7 1 7567936 (1)
paraffin 21.9 1 7959674 (1)
cyclosporin a 12.1 2 1591215 (1), 8500270 (1)
oligonucleotide 6.06 3 7823247 (1), 8599453 (1), 1848269 (1)
polyacrylamide 4.36 1 8882133 (1)
calcium 0.542 1 2052609 (1)

Search CenterWatch for drugs/clinical trials and news about TRB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

miRNA
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Inhib. RNA
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Browse OriGene RNAi
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRB
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Primer
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

    SABiosciences Custom PCR Arrays for TRB
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TRB gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcrb5 T cell receptor beta chain   --   6 -

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): TRB
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TRB
DNA2.0 Custom Variant and Variant Library Synthesis for TRB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRB for disorders           About MalaCards
OMIM gene information: 118890    OMIM disorders: --


TRB for disorders           About GeneDecksing

10/92 Novoseek inferred disease relationships for TRB gene (see all 92)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma t-cell 75.5 9 2154349 (2), 18952689 (1), 8100721 (1), 2163138 (1) (see all 8)
lymphoma t-cell cutaneous 69.7 9 16741518 (2), 1836348 (1), 12682631 (1), 2153627 (1) (see all 8)
granulomatous slack skin 69.4 1 1316105 (1)
lymphoma t-cell peripheral 65.8 1 16237215 (1)
lymphoma 64.4 15 2207314 (1), 8231259 (1), 8160632 (1), 9723588 (1) (see all 14)
sezary syndrome 64.4 3 7492785 (1), 1848269 (1), 16741518 (1)
lymphoma large cell 62.9 4 2169708 (1), 1493464 (1), 8396607 (1), 7505507 (1)
lymphoproliferative disorders 62.4 1 1953508 (1)
lymphocytosis 59.9 3 7890378 (1), 9519776 (1), 1695480 (1)
mycosis fungoides 58.1 7 8396607 (1), 2036034 (1), 1731519 (1), 8133398 (1) (see all 6)


Export disorders for TRB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRB gene, integrated from 9 sources (see all 383):
(articles sorted by number of sources associating them with TRB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells. (PubMed id 3983641)1, 3 Isobe M....Croce C.M. (1985)
  2. Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias. (PubMed id 16741518)1, 9 Morgan S.M....Smith J.L. (2006)
  3. Analysis of the insertion/deletion related polymorphism within T cell antigen receptor beta variable genes in primary Sjogren's syndrome. (PubMed id 15708895)1, 9 Lawson C.A....Boylston A.W. (2005)
  4. Mutations of the T-cell receptor constant region after in utero stem cell transplantation. (PubMed id 15138733)1, 9 Pirovano S....Imberti L. (2004)
  5. Analysis of the T-cell receptor beta-chain variable-region (Vbeta) repertoire in chronic human Chagas' disease. (PubMed id 12366778)1, 9 Fernandez-Mestre M.T....Layrisse Z. (2002)
  6. Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes. (PubMed id 2144610)1, 9 Gottschalk L.R. and Leiden J.M. (1990)
  7. The impact of a large and frequent deletion in the hum an TCR b locus on antiviral immunity. (PubMed id 22323539)1 Brennan R.M....Burrows S.R. (2012)
  8. Effect of granulocyte colony-stimulating factor mobili zation on the expression patterns, clonality and signal transduction of TRAV and TRBV repertoire. (PubMed id 22658922)1 Xuan L....Liu Q. (2012)
  9. DNA double-strand breaks relieve USF-mediated repressi on of Db2 germline transcription in developing thymocytes. (PubMed id 22287717)1 Stone J.L....Sikes M.L. (2012)
  10. Wilms' tumor protein 1 (WT1) peptide vaccination in AM L patients: predominant TCR CDR3b sequence associated with remission in one pati ent is detectable in other vaccinated patients. (PubMed id 21898091)1 Ochsenreither S....Keilholz U. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6957 HGNC: 12155 euGenes: HUgn6957 ECgene: TRB H-InvDB: TRB

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRB Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRB gene:
Search GeneIP for patents involving TRB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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