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Aliases for TRAV8-4 Gene

Aliases for TRAV8-4 Gene

  • T Cell Receptor Alpha Variable 8-4 2 3 5
  • TCRAV1S2 3
  • TCRAV8S4 3
  • TRAV84 3

External Ids for TRAV8-4 Gene

Previous GeneCards Identifiers for TRAV8-4 Gene

  • GC14U990319
  • GC14P020353
  • GC14P020354
  • GC14P021432
  • GC14P022363

Summaries for TRAV8-4 Gene

Entrez Gene Summary for TRAV8-4 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV8-4 Gene

TRAV8-4 (T Cell Receptor Alpha Variable 8-4) is a Protein Coding gene. GO annotations related to this gene include peptide antigen binding and MHC protein binding. An important paralog of this gene is TRAV8-2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV8-4 Gene

Genomics for TRAV8-4 Gene

Regulatory Elements for TRAV8-4 Gene

Enhancers for TRAV8-4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TRAV8-4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV8-4 Gene

Chromosome:
14
Start:
21,894,433 bp from pter
End:
21,895,030 bp from pter
Size:
598 bases
Orientation:
Plus strand

Genomic View for TRAV8-4 Gene

Genes around TRAV8-4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV8-4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV8-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV8-4 Gene

Proteins for TRAV8-4 Gene

  • Protein details for TRAV8-4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J246
    Recommended name:
    Protein TRAV8-4
    Protein Accession:
    A0A0B4J246

    Protein attributes for TRAV8-4 Gene

    Size:
    113 amino acids
    Molecular mass:
    12377 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV8-4 Gene

Post-translational modifications for TRAV8-4 Gene

No Post-translational modifications

Other Protein References for TRAV8-4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV8-4 Gene

Domains & Families for TRAV8-4 Gene

Gene Families for TRAV8-4 Gene

Protein Domains for TRAV8-4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV8-4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV8-4 Gene

Function for TRAV8-4 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV8-4 Gene

Localization for TRAV8-4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV8-4 Gene

Pathways & Interactions for TRAV8-4 Gene

SuperPathways for TRAV8-4 Gene

No Data Available

Interacting Proteins for TRAV8-4 Gene

Gene Ontology (GO) - Biological Process for TRAV8-4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV8-4 Gene

Drugs & Compounds for TRAV8-4 Gene

No Compound Related Data Available

Transcripts for TRAV8-4 Gene

mRNA/cDNA for TRAV8-4 Gene

(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV8-4 Gene

No ASD Table

Relevant External Links for TRAV8-4 Gene

GeneLoc Exon Structure for
TRAV8-4
ECgene alternative splicing isoforms for
TRAV8-4

Expression for TRAV8-4 Gene

mRNA expression in normal human tissues for TRAV8-4 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV8-4 Gene

This gene is overexpressed in Whole Blood (x28.6), Spleen (x5.6), and Small Intestine - Terminal Ileum (x4.9).
genes like me logo Genes that share expression patterns with TRAV8-4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV8-4 Gene

Orthologs for TRAV8-4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAV8-4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Trav9-4 35
  • 65 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for TRAV8-4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV8-4 Gene

ENSEMBL:
Gene Tree for TRAV8-4 (if available)
TreeFam:
Gene Tree for TRAV8-4 (if available)

Paralogs for TRAV8-4 Gene

genes like me logo Genes that share paralogs with TRAV8-4: view

Variants for TRAV8-4 Gene

Relevant External Links for TRAV8-4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV8-4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV8-4 Gene

Disorders for TRAV8-4 Gene

No disorders were found for TRAV8-4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV8-4 Gene

Publications for TRAV8-4 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 65

Products for TRAV8-4 Gene

Sources for TRAV8-4 Gene

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