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Aliases for TRAV8-4 Gene

Aliases for TRAV8-4 Gene

  • T Cell Receptor Alpha Variable 8-4 2 3
  • TCRAV1S2 3
  • TCRAV8S4 3
  • TRAV84 3

External Ids for TRAV8-4 Gene

Previous GeneCards Identifiers for TRAV8-4 Gene

  • GC14U990319
  • GC14P020353
  • GC14P020354
  • GC14P021432
  • GC14P022363

Summaries for TRAV8-4 Gene

GeneCards Summary for TRAV8-4 Gene

TRAV8-4 (T Cell Receptor Alpha Variable 8-4) is a Protein Coding gene. An important paralog of this gene is TRAV8-7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV8-4 Gene

Genomics for TRAV8-4 Gene

Genomic Location for TRAV8-4 Gene

21,894,433 bp from pter
21,895,030 bp from pter
598 bases
Plus strand

Genomic View for TRAV8-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAV8-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV8-4 Gene

No data available for Regulatory Elements for TRAV8-4 Gene

Proteins for TRAV8-4 Gene

  • Protein details for TRAV8-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell receptor alpha chain V region PY14
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TRAV8-4 Gene

    135 amino acids
    Molecular mass:
    14708 Da
    Quaternary structure:
    No Data Available
    • The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions
    • This alpha chain V region shows sequence homology to its beta chain counterpart
    • This clone was isolated from a human leukemic T-cell line, Jurkat

neXtProt entry for TRAV8-4 Gene

Proteomics data for TRAV8-4 Gene at MOPED

Post-translational modifications for TRAV8-4 Gene

No Post-translational modifications

Other Protein References for TRAV8-4 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for TRAV8-4 Gene

Domains for TRAV8-4 Gene

Gene Families for TRAV8-4 Gene

Protein Domains for TRAV8-4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV8-4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV8-4 Gene

Function for TRAV8-4 Gene

Gene Ontology (GO) - Molecular Function for TRAV8-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042287 MHC protein binding --
GO:0042605 peptide antigen binding --
genes like me logo Genes that share ontologies with TRAV8-4: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV8-4 Gene

Localization for TRAV8-4 Gene

Gene Ontology (GO) - Cellular Components for TRAV8-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
genes like me logo Genes that share ontologies with TRAV8-4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TRAV8-4 Gene

Pathways for TRAV8-4 Gene

SuperPathways for TRAV8-4 Gene

No Data Available

Interacting Proteins for TRAV8-4 Gene

Selected Interacting proteins: P01737-TVA3_HUMAN for TRAV8-4 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TRAV8-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response --
GO:0031295 T cell costimulation --
GO:0050776 regulation of immune response --
GO:0050852 T cell receptor signaling pathway --
genes like me logo Genes that share ontologies with TRAV8-4: view

No data available for Pathways by source for TRAV8-4 Gene

Transcripts for TRAV8-4 Gene

mRNA/cDNA for TRAV8-4 Gene

(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV8-4 Gene

No ASD Table

Relevant External Links for TRAV8-4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV8-4 Gene

mRNA expression in normal human tissues for TRAV8-4 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV8-4 Gene

This gene is overexpressed in Whole Blood (28.6), Spleen (5.6), and Small Intestine - Terminal Ileum (4.9).
genes like me logo Genes that share expressions with TRAV8-4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TRAV8-4 Gene

Orthologs for TRAV8-4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAV8-4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
(Canis familiaris)
Mammalia -- 36
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
-- 36
  • 59 (a)
-- 36
  • 49 (a)
-- 36
  • 56 (a)
-- 36
  • 58 (a)
(Mus musculus)
Mammalia Trav9-4 36
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
-- 36
  • 38 (a)
-- 36
  • 26 (a)
-- 36
  • 36 (a)
Species with no ortholog for TRAV8-4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV8-4 Gene

Gene Tree for TRAV8-4 (if available)
Gene Tree for TRAV8-4 (if available)

Paralogs for TRAV8-4 Gene

genes like me logo Genes that share paralogs with TRAV8-4: view

Variants for TRAV8-4 Gene

Relevant External Links for TRAV8-4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TRAV8-4 Gene

Disorders for TRAV8-4 Gene

No disorders were found for TRAV8-4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TRAV8-4 Gene

Publications for TRAV8-4 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3
  2. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PMID: 19349973) Wollscheid B. … Watts J.D. (Nat. Biotechnol. 2009) 4
  3. Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. (PMID: 3873654) Yanagi Y. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 1985) 4

Products for TRAV8-4 Gene

Sources for TRAV8-4 Gene

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