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Aliases for TRAV40 Gene

Aliases for TRAV40 Gene

  • T Cell Receptor Alpha Variable 40 2 3
  • T-Cell Receptor Alpha Variable 40 5
  • TCRAV31S1 3
  • TCRAV40S1 3

External Ids for TRAV40 Gene

Previous GeneCards Identifiers for TRAV40 Gene

  • GC14U990278
  • GC14P020773
  • GC14P021852
  • GC14P022783
  • GC14P022784
  • GC14P022855

Summaries for TRAV40 Gene

Entrez Gene Summary for TRAV40 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV40 Gene

TRAV40 (T Cell Receptor Alpha Variable 40) is a Protein Coding gene. An important paralog of this gene is TRAV9-2.

Additional gene information for TRAV40 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV40 Gene

Genomics for TRAV40 Gene

GeneHancer (GH) Regulatory Elements for TRAV40 Gene

Promoters and enhancers for TRAV40 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022314 Enhancer 0.7 ENCODE 550.8 -0.1 -116 0.2 SMARCA5 CTCF ZNF654 ATF1 TEAD1 TRIM22 RAD21 ATF2 TEAD3 SMC3 TRAV40 TRAV39 TRA
GH14I022319 Enhancer 0.7 ENCODE 0.4 +5.5 5474 0.2 CTCF ZNF654 TEAD1 TRIM22 REST RAD21 RFX5 NFIL3 ZNF121 ZNF664 TRAV41 TRAV40 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAV40 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV40 Gene

Genomic Locations for TRAV40 Gene
430 bases
Plus strand

Genomic View for TRAV40 Gene

Genes around TRAV40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV40 Gene

Proteins for TRAV40 Gene

  • Protein details for TRAV40 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell receptor alpha variable 40
    Protein Accession:

    Protein attributes for TRAV40 Gene

    105 amino acids
    Molecular mass:
    11556 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV40 Gene

Post-translational modifications for TRAV40 Gene

No Post-translational modifications

Other Protein References for TRAV40 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV40 Gene

Domains & Families for TRAV40 Gene

Gene Families for TRAV40 Gene

Protein Domains for TRAV40 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV40: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV40 Gene

Function for TRAV40 Gene

Phenotypes From GWAS Catalog for TRAV40 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV40 Gene

Localization for TRAV40 Gene

Gene Ontology (GO) - Cellular Components for TRAV40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with TRAV40: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRAV40 Gene

Pathways & Interactions for TRAV40 Gene

SuperPathways for TRAV40 Gene

No Data Available

Interacting Proteins for TRAV40 Gene

Gene Ontology (GO) - Biological Process for TRAV40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with TRAV40: view

No data available for Pathways by source and SIGNOR curated interactions for TRAV40 Gene

Drugs & Compounds for TRAV40 Gene

No Compound Related Data Available

Transcripts for TRAV40 Gene

mRNA/cDNA for TRAV40 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV40 Gene

No ASD Table

Relevant External Links for TRAV40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV40 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAV40 Gene:

genes like me logo Genes that share expression patterns with TRAV40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV40 Gene

Orthologs for TRAV40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAV40 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
-- 34
  • 44 (a)
-- 34
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
-- 34
  • 37 (a)
-- 34
  • 34 (a)
-- 34
  • 33 (a)
-- 34
  • 32 (a)
-- 34
  • 31 (a)
-- 34
  • 30 (a)
-- 34
  • 25 (a)
-- 34
  • 24 (a)
-- 34
  • 21 (a)
(Mus musculus)
Mammalia Trav12-3 34
  • 32 (a)
(Bos Taurus)
Mammalia -- 34
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 27 (a)
-- 34
  • 20 (a)
Species where no ortholog for TRAV40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV40 Gene

Gene Tree for TRAV40 (if available)
Gene Tree for TRAV40 (if available)

Paralogs for TRAV40 Gene

genes like me logo Genes that share paralogs with TRAV40: view

Variants for TRAV40 Gene

Additional Variant Information for TRAV40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV40 Gene

Disorders for TRAV40 Gene

Additional Disease Information for TRAV40

Human Genome Epidemiology Navigator

No disorders were found for TRAV40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV40 Gene

Publications for TRAV40 Gene

  1. Molecular analysis of T-cell receptor transcripts in a human T-cell leukemia bearing a t(1;14) and an inv(7); cell surface expression of a TCR-beta chain in the absence of alpha chain. (PMID: 8412327) Bernard O … Azogui O (Leukemia 1993) 2 3 58
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for TRAV40 Gene

Sources for TRAV40 Gene

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