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Aliases for TRAV4 Gene

Aliases for TRAV4 Gene

  • T Cell Receptor Alpha Variable 4 2 3 5
  • TCRAV20S1 3
  • TCRAV4S1 3

External Ids for TRAV4 Gene

Previous GeneCards Identifiers for TRAV4 Gene

  • GC14U990325
  • GC14P020195
  • GC14P020196
  • GC14P021274
  • GC14P022205

Summaries for TRAV4 Gene

Entrez Gene Summary for TRAV4 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV4 Gene

TRAV4 (T Cell Receptor Alpha Variable 4) is a Protein Coding gene. An important paralog of this gene is TRAV26-1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV4 Gene

Genomics for TRAV4 Gene

Regulatory Elements for TRAV4 Gene

Enhancers for TRAV4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F021735 1.2 ENCODE 0.8 -0.1 -119 0.2 TRAV4 TRAV3
GH14F021734 0.6 ENCODE 0.8 -1.5 -1488 0.1 CTCF MAFF ZNF654 ZNF143 MAFG RAD21 ZNF2 TRAV4 TRAV3
GH14F021748 0.7 ENCODE 0.4 +12.9 12850 0.2 CTCF ZNF654 DMAP1 ZNF644 RAD21 SMC3 ZNF143 MIXL1 TRAV8-5 TRAV5 TRAV4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRAV4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV4 Gene

21,736,152 bp from pter
21,736,982 bp from pter
831 bases
Plus strand

Genomic View for TRAV4 Gene

Genes around TRAV4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV4 Gene

Proteins for TRAV4 Gene

  • Protein details for TRAV4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein TRAV4
    Protein Accession:

    Protein attributes for TRAV4 Gene

    109 amino acids
    Molecular mass:
    12215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV4 Gene

Post-translational modifications for TRAV4 Gene

No Post-translational modifications

Other Protein References for TRAV4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV4 Gene

Domains & Families for TRAV4 Gene

Gene Families for TRAV4 Gene

Protein Domains for TRAV4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV4 Gene

Function for TRAV4 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV4 Gene

Localization for TRAV4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV4 Gene

Pathways & Interactions for TRAV4 Gene

SuperPathways for TRAV4 Gene

No Data Available

Interacting Proteins for TRAV4 Gene

Gene Ontology (GO) - Biological Process for TRAV4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRAV4 Gene

Transcripts for TRAV4 Gene

mRNA/cDNA for TRAV4 Gene

(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV4 Gene

No ASD Table

Relevant External Links for TRAV4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAV4 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV4 Gene

This gene is overexpressed in Whole Blood (x23.9), Small Intestine - Terminal Ileum (x7.1), and Spleen (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of TRAV4 Gene:

genes like me logo Genes that share expression patterns with TRAV4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV4 Gene

Orthologs for TRAV4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV4 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
Species where no ortholog for TRAV4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV4 Gene

Gene Tree for TRAV4 (if available)
Gene Tree for TRAV4 (if available)

Paralogs for TRAV4 Gene

Paralogs for TRAV4 Gene

genes like me logo Genes that share paralogs with TRAV4: view

Variants for TRAV4 Gene

Relevant External Links for TRAV4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV4 Gene

Disorders for TRAV4 Gene

No disorders were found for TRAV4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV4 Gene

Publications for TRAV4 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64
  2. Role of TRAV locus in low caries experience. (PMID: 23657505) BriseA+o-Ruiz J. … Vieira A.R. (Hum. Genet. 2013) 3 64

Products for TRAV4 Gene

Sources for TRAV4 Gene

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