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Aliases for TRAV38-2DV8 Gene

Aliases for TRAV38-2DV8 Gene

  • T Cell Receptor Alpha Variable 38-2/Delta Variable 8 2 3 5
  • T Cell Receptor Alpha/Delta Variable 38-2/DV8 2 3
  • TRAV38-2/DV8 3
  • TRAV382DV8 3
  • TCRAV14S1 3
  • HADV38S2 3

External Ids for TRAV38-2DV8 Gene

Previous GeneCards Identifiers for TRAV38-2DV8 Gene

  • GC14U990280
  • GC14P020739
  • GC14P021818
  • GC14P022750
  • GC14P022786
  • GC14P022856

Summaries for TRAV38-2DV8 Gene

Entrez Gene Summary for TRAV38-2DV8 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV38-2DV8 Gene

TRAV38-2DV8 (T Cell Receptor Alpha Variable 38-2/Delta Variable 8) is a Protein Coding gene. An important paralog of this gene is TRAV38-1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV38-2DV8 Gene

Genomics for TRAV38-2DV8 Gene

Regulatory Elements for TRAV38-2DV8 Gene

Enhancers for TRAV38-2DV8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022332 1.3 Ensembl ENCODE 4.7 +52.9 52866 2.5 HDGF PKNOX1 ATF1 ARID4B FEZF1 ZNF2 FOS JUNB TSHZ1 PPARG TRAV38-2DV8 LOC100420343 TRAV41
GH14F022382 1.1 ENCODE 4.5 +103.1 103140 4.0 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MMP14 SUPT16H METTL3 OR6J1 SLC7A7 MRPL52 TRAV38-2DV8 ENSG00000259042 LOC100420343
GH14F022392 0.8 Ensembl ENCODE 4.5 +110.2 110234 0.3 HDGF IKZF1 EED NBN TRAV38-2DV8 ENSG00000259042 LOC100420343
GH14F022399 0.6 ENCODE 5.2 +119.5 119533 1.5 CEBPA HLF CEBPB CEBPG ZIC2 MMP14 TRAV38-2DV8 ENSG00000259042 LOC100420343
GH14F022280 1 Ensembl ENCODE 0.8 +0.8 783 2.6 HDAC1 PKNOX1 YBX1 PLRG1 RAD21 ZNF48 ZNF316 PRDM10 NFE2 FOS SUPT16H RAB2B TRAV38-2DV8 TRAV39
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV38-2DV8 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV38-2DV8 Gene

Chromosome:
14
Start:
22,281,105 bp from pter
End:
22,281,748 bp from pter
Size:
644 bases
Orientation:
Plus strand

Genomic View for TRAV38-2DV8 Gene

Genes around TRAV38-2DV8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV38-2DV8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV38-2DV8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV38-2DV8 Gene

Proteins for TRAV38-2DV8 Gene

  • Protein details for TRAV38-2DV8 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0JD32
    Recommended name:
    HADV38S2
    Protein Accession:
    A0JD32

    Protein attributes for TRAV38-2DV8 Gene

    Size:
    116 amino acids
    Molecular mass:
    13278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV38-2DV8 Gene

Post-translational modifications for TRAV38-2DV8 Gene

No Post-translational modifications

Other Protein References for TRAV38-2DV8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV38-2DV8 Gene

Domains & Families for TRAV38-2DV8 Gene

Gene Families for TRAV38-2DV8 Gene

Protein Domains for TRAV38-2DV8 Gene

Suggested Antigen Peptide Sequences for TRAV38-2DV8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV38-2DV8: view

No data available for UniProtKB/Swiss-Prot for TRAV38-2DV8 Gene

Function for TRAV38-2DV8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV38-2DV8 Gene

Localization for TRAV38-2DV8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV38-2DV8 Gene

Pathways & Interactions for TRAV38-2DV8 Gene

SuperPathways for TRAV38-2DV8 Gene

No Data Available

Interacting Proteins for TRAV38-2DV8 Gene

Gene Ontology (GO) - Biological Process for TRAV38-2DV8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV38-2DV8 Gene

Transcripts for TRAV38-2DV8 Gene

mRNA/cDNA for TRAV38-2DV8 Gene

(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV38-2DV8 Gene

No ASD Table

Relevant External Links for TRAV38-2DV8 Gene

GeneLoc Exon Structure for
TRAV38-2DV8
ECgene alternative splicing isoforms for
TRAV38-2DV8

Expression for TRAV38-2DV8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAV38-2DV8 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV38-2DV8 Gene

This gene is overexpressed in Whole Blood (x21.3), Artery - Tibial (x5.3), and Artery - Coronary (x5.1).
genes like me logo Genes that share expression patterns with TRAV38-2DV8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV38-2DV8 Gene

Orthologs for TRAV38-2DV8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV38-2DV8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 75 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
Species where no ortholog for TRAV38-2DV8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV38-2DV8 Gene

ENSEMBL:
Gene Tree for TRAV38-2DV8 (if available)
TreeFam:
Gene Tree for TRAV38-2DV8 (if available)

Paralogs for TRAV38-2DV8 Gene

Paralogs for TRAV38-2DV8 Gene

genes like me logo Genes that share paralogs with TRAV38-2DV8: view

Variants for TRAV38-2DV8 Gene

Relevant External Links for TRAV38-2DV8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV38-2DV8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV38-2DV8 Gene

Disorders for TRAV38-2DV8 Gene

No disorders were found for TRAV38-2DV8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV38-2DV8 Gene

Publications for TRAV38-2DV8 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAV38-2DV8 Gene

Sources for TRAV38-2DV8 Gene

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