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Aliases for TRAV38-1 Gene

Aliases for TRAV38-1 Gene

  • T Cell Receptor Alpha Variable 38-1 2 3 5
  • TCRAV14S2 3
  • TCRAV38S1 3
  • TRAV381 3

External Ids for TRAV38-1 Gene

Previous GeneCards Identifiers for TRAV38-1 Gene

  • GC14U990281
  • GC14P020729
  • GC14P021809
  • GC14P022740
  • GC14P022769
  • GC14P022854

Summaries for TRAV38-1 Gene

Entrez Gene Summary for TRAV38-1 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV38-1 Gene

TRAV38-1 (T Cell Receptor Alpha Variable 38-1) is a Protein Coding gene. An important paralog of this gene is TRAV38-2DV8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV38-1 Gene

Genomics for TRAV38-1 Gene

Regulatory Elements for TRAV38-1 Gene

Enhancers for TRAV38-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022265 0.9 Ensembl ENCODE 7.6 -6.2 -6168 1.2 CTCF ESRRA HLF RAD21 ZFP69B GATA3 ZNF692 FOSL2 FOS TRAV38-1 TRAV37
GH14F022254 0.2 ENCODE 6.7 -16.9 -16891 1.5 TRAV38-1 TRAV37 TRAV36DV7
GH14F022268 1 Ensembl ENCODE 0.8 -3.0 -2968 0.4 PKNOX1 FEZF1 GATA3 ZNF366 PATZ1 EED FOSL2 FOS KLF8 JUNB TRAV37 TRAV38-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV38-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV38-1 Gene

Chromosome:
14
Start:
22,271,968 bp from pter
End:
22,272,563 bp from pter
Size:
596 bases
Orientation:
Plus strand

Genomic View for TRAV38-1 Gene

Genes around TRAV38-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV38-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV38-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV38-1 Gene

Proteins for TRAV38-1 Gene

  • Protein details for TRAV38-1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J264
    Recommended name:
    Protein TRAV38-1
    Protein Accession:
    A0A0B4J264

    Protein attributes for TRAV38-1 Gene

    Size:
    116 amino acids
    Molecular mass:
    13297 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV38-1 Gene

Post-translational modifications for TRAV38-1 Gene

No Post-translational modifications

Other Protein References for TRAV38-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV38-1 Gene

Domains & Families for TRAV38-1 Gene

Gene Families for TRAV38-1 Gene

Protein Domains for TRAV38-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV38-1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV38-1 Gene

Function for TRAV38-1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV38-1 Gene

Localization for TRAV38-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV38-1 Gene

Pathways & Interactions for TRAV38-1 Gene

SuperPathways for TRAV38-1 Gene

No Data Available

Interacting Proteins for TRAV38-1 Gene

Gene Ontology (GO) - Biological Process for TRAV38-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV38-1 Gene

Transcripts for TRAV38-1 Gene

mRNA/cDNA for TRAV38-1 Gene

(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV38-1 Gene

No ASD Table

Relevant External Links for TRAV38-1 Gene

GeneLoc Exon Structure for
TRAV38-1
ECgene alternative splicing isoforms for
TRAV38-1

Expression for TRAV38-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAV38-1 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV38-1 Gene

This gene is overexpressed in Whole Blood (x32.4), Small Intestine - Terminal Ileum (x5.4), and Spleen (x4.9).
genes like me logo Genes that share expression patterns with TRAV38-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV38-1 Gene

Orthologs for TRAV38-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV38-1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 69 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
Species where no ortholog for TRAV38-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV38-1 Gene

ENSEMBL:
Gene Tree for TRAV38-1 (if available)
TreeFam:
Gene Tree for TRAV38-1 (if available)

Paralogs for TRAV38-1 Gene

Paralogs for TRAV38-1 Gene

genes like me logo Genes that share paralogs with TRAV38-1: view

Variants for TRAV38-1 Gene

Relevant External Links for TRAV38-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV38-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV38-1 Gene

Disorders for TRAV38-1 Gene

No disorders were found for TRAV38-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV38-1 Gene

Publications for TRAV38-1 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAV38-1 Gene

Sources for TRAV38-1 Gene

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