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Aliases for TRAV36DV7 Gene

Aliases for TRAV36DV7 Gene

  • T-Cell Receptor Alpha Variable 36/Delta Variable 7 2 5
  • T Cell Receptor Alpha Variable 36/Delta Variable 7 2 3
  • T Cell Receptor Alpha/Delta Variable 36/DV7 3
  • TRAV36/DV7 3
  • TCRAV28S1 3
  • HADV36S1 3

External Ids for TRAV36DV7 Gene

Previous GeneCards Identifiers for TRAV36DV7 Gene

  • GC14U990283
  • GC14P020684
  • GC14P021764
  • GC14P022695
  • GC14P022698
  • GC14P022745
  • GC14P022853
  • GC14P022229

Summaries for TRAV36DV7 Gene

Entrez Gene Summary for TRAV36DV7 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV36DV7 Gene

TRAV36DV7 (T-Cell Receptor Alpha Variable 36/Delta Variable 7) is a Protein Coding gene. An important paralog of this gene is TRAV20.

Additional gene information for TRAV36DV7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV36DV7 Gene

Genomics for TRAV36DV7 Gene

Regulatory Elements for TRAV36DV7 Gene

Enhancers for TRAV36DV7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H022225 0.8 Ensembl ENCODE 0.7 -0.4 -368 2 CTCF MAX IKZF2 RAD21 TRAV26-2 TRAV36DV7 TRAV35
GH14H022230 0.4 ENCODE 0.7 +4.3 4334 0 MAFK TRAV26-2 TRAV36DV7 TRAV37
GH14H022252 0.4 ENCODE 0.3 +26.2 26200 0 HLF OR6E1P TRAV37 TRAV36DV7
GH14H022254 0.2 ENCODE 0.3 +28.3 28332 1 TRAV38-1 TRAV37 TRAV36DV7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV36DV7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV36DV7 Gene

Chromosome:
14
Start:
22,226,746 bp from pter
End:
22,227,254 bp from pter
Size:
509 bases
Orientation:
Plus strand

Genomic View for TRAV36DV7 Gene

Genes around TRAV36DV7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV36DV7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV36DV7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV36DV7 Gene

Proteins for TRAV36DV7 Gene

  • Protein details for TRAV36DV7 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A075B6V5
    Recommended name:
    T-cell receptor alpha variable 36/delta variable 7
    Protein Accession:
    A0A075B6V5

    Protein attributes for TRAV36DV7 Gene

    Size:
    113 amino acids
    Molecular mass:
    12697 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV36DV7 Gene

Post-translational modifications for TRAV36DV7 Gene

No Post-translational modifications

Other Protein References for TRAV36DV7 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV36DV7 Gene

Domains & Families for TRAV36DV7 Gene

Gene Families for TRAV36DV7 Gene

Protein Domains for TRAV36DV7 Gene

Suggested Antigen Peptide Sequences for TRAV36DV7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV36DV7: view

No data available for UniProtKB/Swiss-Prot for TRAV36DV7 Gene

Function for TRAV36DV7 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRAV36DV7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV36DV7 Gene

Localization for TRAV36DV7 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAV36DV7 Gene

Pathways & Interactions for TRAV36DV7 Gene

SuperPathways for TRAV36DV7 Gene

No Data Available

Interacting Proteins for TRAV36DV7 Gene

Gene Ontology (GO) - Biological Process for TRAV36DV7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV36DV7 Gene

Drugs & Compounds for TRAV36DV7 Gene

No Compound Related Data Available

Transcripts for TRAV36DV7 Gene

mRNA/cDNA for TRAV36DV7 Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRAV36DV7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV36DV7 Gene

No ASD Table

Relevant External Links for TRAV36DV7 Gene

GeneLoc Exon Structure for
TRAV36DV7
ECgene alternative splicing isoforms for
TRAV36DV7

Expression for TRAV36DV7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV36DV7 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV36DV7 Gene

This gene is overexpressed in Whole Blood (x24.6), Spleen (x6.1), and Small Intestine - Terminal Ileum (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of TRAV36DV7 Gene:

TRAV36DV7
genes like me logo Genes that share expression patterns with TRAV36DV7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV36DV7 Gene

Orthologs for TRAV36DV7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV36DV7 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
OneToMany
Species where no ortholog for TRAV36DV7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV36DV7 Gene

ENSEMBL:
Gene Tree for TRAV36DV7 (if available)
TreeFam:
Gene Tree for TRAV36DV7 (if available)

Paralogs for TRAV36DV7 Gene

genes like me logo Genes that share paralogs with TRAV36DV7: view

Variants for TRAV36DV7 Gene

Relevant External Links for TRAV36DV7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV36DV7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV36DV7 Gene

Disorders for TRAV36DV7 Gene

No disorders were found for TRAV36DV7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV36DV7 Gene

Publications for TRAV36DV7 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 60

Products for TRAV36DV7 Gene

Sources for TRAV36DV7 Gene

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