Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRAV24 Gene

Aliases for TRAV24 Gene

  • T Cell Receptor Alpha Variable 24 2 3 5
  • TCRAV24S1 3
  • TCRAV18S1 3

External Ids for TRAV24 Gene

Previous GeneCards Identifiers for TRAV24 Gene

  • GC14U990296
  • GC14P020563
  • GC14P021643
  • GC14P022575
  • GC14P022576
  • GC14P022605
  • GC14P022732
  • GC14P022831

Summaries for TRAV24 Gene

Entrez Gene Summary for TRAV24 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV24 Gene

TRAV24 (T Cell Receptor Alpha Variable 24) is a Protein Coding gene. Among its related pathways are G-protein signaling N-RAS regulation pathway and Immune response NFAT in immune response. An important paralog of this gene is TRAV36DV7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV24 Gene

Genomics for TRAV24 Gene

Regulatory Elements for TRAV24 Gene

Enhancers for TRAV24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022100 0.9 ENCODE 0.8 -4.9 -4935 0.2 ELF3 HDGF PKNOX1 ARID4B ZNF48 ZSCAN9 RAD21 ZNF143 MIXL1 THAP11 TRAV24 TRDV1
GH14F022104 0.8 ENCODE 0.8 -0.2 -163 1.1 SOX13 ESRRA SAP130 ARID4B ZNF384 ZNF644 DNMT3B RARA GATA3 PRDM10 RBM23 TRAV8-4 TRAV24 TRDV1
GH14F022095 1 Ensembl ENCODE 0.4 -8.3 -8269 3.2 ZFP64 CHD4 ZBTB40 ZNF7 POLR2A EED SRF MTA2 CBFB ZBED1 TRDV1 TRAV24
GH14F022112 0.6 ENCODE 0.4 +6.9 6870 0.1 CTCF ZIC2 RAD21 ZFHX2 GATA3 GLIS1 ZNF143 SMC3 EGR2 TRAV25 TRAV24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV24 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV24 Gene

22,105,343 bp from pter
22,105,846 bp from pter
504 bases
Plus strand

Genomic View for TRAV24 Gene

Genes around TRAV24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV24 Gene

Proteins for TRAV24 Gene

  • Protein details for TRAV24 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein TRAV24
    Protein Accession:

    Protein attributes for TRAV24 Gene

    114 amino acids
    Molecular mass:
    12919 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV24 Gene

Post-translational modifications for TRAV24 Gene

No Post-translational modifications

Other Protein References for TRAV24 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV24 Gene

Domains & Families for TRAV24 Gene

Gene Families for TRAV24 Gene

Protein Domains for TRAV24 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV24: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV24 Gene

Function for TRAV24 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV24 Gene

Localization for TRAV24 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV24 Gene

Transcripts for TRAV24 Gene

mRNA/cDNA for TRAV24 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV24 Gene

No ASD Table

Relevant External Links for TRAV24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAV24 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV24 Gene

This gene is overexpressed in Whole Blood (x32.5).

NURSA nuclear receptor signaling pathways regulating expression of TRAV24 Gene:

genes like me logo Genes that share expression patterns with TRAV24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV24 Gene

Orthologs for TRAV24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 35
  • 66 (a)
-- 35
  • 61 (a)
(Canis familiaris)
Mammalia TRAV24 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
-- 35
  • 48 (a)
-- 35
  • 46 (a)
-- 35
  • 44 (a)
-- 35
  • 44 (a)
-- 35
  • 44 (a)
-- 35
  • 43 (a)
-- 35
  • 41 (a)
-- 35
  • 35 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
Species where no ortholog for TRAV24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV24 Gene

Gene Tree for TRAV24 (if available)
Gene Tree for TRAV24 (if available)

Paralogs for TRAV24 Gene

Variants for TRAV24 Gene

Relevant External Links for TRAV24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV24 Gene

Disorders for TRAV24 Gene

Relevant External Links for TRAV24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRAV24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV24 Gene

Publications for TRAV24 Gene

  1. Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. (PMID: 12594262) Capone M. … Casorati G. (J. Immunol. 2003) 2 3 64
  2. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64
  3. Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. (PMID: 19411762) Song L. … Metelitsa L.S. (J. Clin. Invest. 2009) 3 64
  4. Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells. (PMID: 19734232) Li X. … Tsuji M. (J. Immunol. 2009) 3 64

Products for TRAV24 Gene

Sources for TRAV24 Gene

Loading form....