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Aliases for TRAV22 Gene

Aliases for TRAV22 Gene

  • T-Cell Receptor Alpha Variable 22 2 5
  • T Cell Receptor Alpha Variable 22 2 3
  • TCRAV13S1 3
  • TCRAV22S1 3

External Ids for TRAV22 Gene

Previous GeneCards Identifiers for TRAV22 Gene

  • GC14U990298
  • GC14P020529
  • GC14P021608
  • GC14P022540
  • GC14P022547
  • GC14P022598
  • GC14P022717
  • GC14P022825

Summaries for TRAV22 Gene

Entrez Gene Summary for TRAV22 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV22 Gene

TRAV22 (T-Cell Receptor Alpha Variable 22) is a Protein Coding gene. An important paralog of this gene is TRAV41.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV22 Gene

Genomics for TRAV22 Gene

Regulatory Elements for TRAV22 Gene

Enhancers for TRAV22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022070 1.3 Ensembl ENCODE dbSUPER 0.7 +0.5 458 1.7 TBL1XR1 MAX CEBPG RBBP5 EBF1 ZNF316 NFYB EED NFE2 IKZF2 TRAV22 TRAV23DV6
GH14G022068 1 dbSUPER 0.7 -1.4 -1428 1.0 PKNOX1 SIN3A NSD2 GATA2 FOS SP3 JUNB TSHZ1 TBX21 ZNF518A ENSG00000276428 TRAV22
GH14G022080 0.7 dbSUPER 0.4 +10.5 10542 1.7 PKNOX1 FOXA2 HLF JUNB GATAD2B DPF2 MNT POLR2A CEBPA TARDBP TRAV23DV6 TRAV22
GH14G022084 0.6 ENCODE 0.4 +14.0 14043 0.2 CTCF ZNF654 RAD21 ZNF316 MAFF SMC3 ZNF143 EMSY MAFK MIXL1 TRAV23DV6 TRAV22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV22 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV22 Gene

Chromosome:
14
Start:
22,070,557 bp from pter
End:
22,071,208 bp from pter
Size:
652 bases
Orientation:
Plus strand

Genomic View for TRAV22 Gene

Genes around TRAV22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV22 Gene

Proteins for TRAV22 Gene

  • Protein details for TRAV22 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J277
    Recommended name:
    T-cell receptor alpha variable 22
    Protein Accession:
    A0A0B4J277

    Protein attributes for TRAV22 Gene

    Size:
    110 amino acids
    Molecular mass:
    12145 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRAV22 Gene

neXtProt entry for TRAV22 Gene

Post-translational modifications for TRAV22 Gene

No Post-translational modifications

Other Protein References for TRAV22 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV22 Gene

Domains & Families for TRAV22 Gene

Gene Families for TRAV22 Gene

Protein Domains for TRAV22 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV22: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV22 Gene

Function for TRAV22 Gene

Animal Model Products

miRNA for TRAV22 Gene

miRTarBase miRNAs that target TRAV22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAV22 Gene

Localization for TRAV22 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV22 Gene

Pathways & Interactions for TRAV22 Gene

SuperPathways for TRAV22 Gene

No Data Available

Interacting Proteins for TRAV22 Gene

Gene Ontology (GO) - Biological Process for TRAV22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV22 Gene

Drugs & Compounds for TRAV22 Gene

No Compound Related Data Available

Transcripts for TRAV22 Gene

mRNA/cDNA for TRAV22 Gene

(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV22 Gene

No ASD Table

Relevant External Links for TRAV22 Gene

GeneLoc Exon Structure for
TRAV22
ECgene alternative splicing isoforms for
TRAV22

Expression for TRAV22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV22 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV22 Gene

This gene is overexpressed in Whole Blood (x22.0) and Spleen (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of TRAV22 Gene:

TRAV22
genes like me logo Genes that share expression patterns with TRAV22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV22 Gene

Orthologs for TRAV22 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAV22 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
TRA@ 35
  • 62 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trav13-2 35
  • 64 (a)
OneToMany
Trav13d-1 35
  • 64 (a)
OneToMany
Trav13-4-dv7 35
  • 60 (a)
OneToMany
Trav13d-3 35
  • 54 (a)
OneToMany
Trav13n-3 35
  • 54 (a)
OneToMany
B230359F08Rik 35
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
OneToMany
Species where no ortholog for TRAV22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV22 Gene

ENSEMBL:
Gene Tree for TRAV22 (if available)
TreeFam:
Gene Tree for TRAV22 (if available)

Paralogs for TRAV22 Gene

Pseudogenes.org Pseudogenes for TRAV22 Gene

genes like me logo Genes that share paralogs with TRAV22: view

Variants for TRAV22 Gene

Relevant External Links for TRAV22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV22 Gene

Disorders for TRAV22 Gene

No disorders were found for TRAV22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV22 Gene

Publications for TRAV22 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAV22 Gene

Sources for TRAV22 Gene

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