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Aliases for TRAV21 Gene

Aliases for TRAV21 Gene

  • T Cell Receptor Alpha Variable 21 2 3 5
  • TCRAV21S1 3
  • TCRAV23S1 3

External Ids for TRAV21 Gene

Previous GeneCards Identifiers for TRAV21 Gene

  • GC14U990299
  • GC14P020510
  • GC14P021590
  • GC14P022523
  • GC14P022527
  • GC14P022597
  • GC14P022716
  • GC14P022824

Summaries for TRAV21 Gene

Entrez Gene Summary for TRAV21 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV21 Gene

TRAV21 (T Cell Receptor Alpha Variable 21) is a Protein Coding gene. An important paralog of this gene is TRAV17.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV21 Gene

Genomics for TRAV21 Gene

Regulatory Elements for TRAV21 Gene

Enhancers for TRAV21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022051 0.9 Ensembl ENCODE 0.8 +0.1 63 1.2 HDAC1 PKNOX1 TAL1 ZNF175 CEBPG FOSL1 GATA2 NCOR1 SCRT2 EED TRAV21 ENSG00000276428
GH14F022046 0.6 ENCODE 0.4 -5.3 -5327 2.1 CTCF STAT1 ZNF654 PKNOX1 SMAD5 FOXA3 RAD21 JUND POLR2A IKZF1 TRAV20 TRAV21
GH14F022065 1 ENCODE 0.4 +13.3 13309 0.8 SMAD5 POLR2A NFE2L1 MAFG NFE2 NFE2L2 ENSG00000276428 TRAV21
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRAV21 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV21 Gene

Chromosome:
14
Start:
22,052,514 bp from pter
End:
22,053,056 bp from pter
Size:
543 bases
Orientation:
Plus strand

Genomic View for TRAV21 Gene

Genes around TRAV21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV21 Gene

Proteins for TRAV21 Gene

  • Protein details for TRAV21 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J279
    Recommended name:
    Protein TRAV21
    Protein Accession:
    A0A0B4J279

    Protein attributes for TRAV21 Gene

    Size:
    112 amino acids
    Molecular mass:
    12289 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRAV21 Gene

neXtProt entry for TRAV21 Gene

Post-translational modifications for TRAV21 Gene

No Post-translational modifications

Other Protein References for TRAV21 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV21 Gene

Domains & Families for TRAV21 Gene

Gene Families for TRAV21 Gene

Protein Domains for TRAV21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV21: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV21 Gene

Function for TRAV21 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV21 Gene

Localization for TRAV21 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV21 Gene

Pathways & Interactions for TRAV21 Gene

SuperPathways for TRAV21 Gene

No Data Available

Interacting Proteins for TRAV21 Gene

Gene Ontology (GO) - Biological Process for TRAV21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV21 Gene

Transcripts for TRAV21 Gene

mRNA/cDNA for TRAV21 Gene

(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV21 Gene

No ASD Table

Relevant External Links for TRAV21 Gene

GeneLoc Exon Structure for
TRAV21
ECgene alternative splicing isoforms for
TRAV21

Expression for TRAV21 Gene

mRNA expression in normal human tissues for TRAV21 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV21 Gene

This gene is overexpressed in Whole Blood (x28.5) and Spleen (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of TRAV21 Gene:

TRAV21
genes like me logo Genes that share expression patterns with TRAV21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV21 Gene

Orthologs for TRAV21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV21 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TRAV21 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trav4-4-dv10 35
  • 40 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 39 (a)
ManyToMany
Species where no ortholog for TRAV21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV21 Gene

ENSEMBL:
Gene Tree for TRAV21 (if available)
TreeFam:
Gene Tree for TRAV21 (if available)

Paralogs for TRAV21 Gene

Pseudogenes.org Pseudogenes for TRAV21 Gene

genes like me logo Genes that share paralogs with TRAV21: view

Variants for TRAV21 Gene

Relevant External Links for TRAV21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV21 Gene

Disorders for TRAV21 Gene

No disorders were found for TRAV21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV21 Gene

Publications for TRAV21 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAV21 Gene

Sources for TRAV21 Gene

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