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Aliases for TRAV20 Gene

Aliases for TRAV20 Gene

  • T-Cell Receptor Alpha Variable 20 2 5
  • T Cell Receptor Alpha Variable 20 2 3
  • TCRAV20S1 3
  • TCRAV30S1 3

External Ids for TRAV20 Gene

Previous GeneCards Identifiers for TRAV20 Gene

  • GC14U990300
  • GC14P020499
  • GC14P021578
  • GC14P022509
  • GC14P022524
  • GC14P022589
  • GC14P022715
  • GC14P022823

Summaries for TRAV20 Gene

Entrez Gene Summary for TRAV20 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV20 Gene

TRAV20 (T-Cell Receptor Alpha Variable 20) is a Protein Coding gene. An important paralog of this gene is TRAV7.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV20 Gene

Genomics for TRAV20 Gene

Regulatory Elements for TRAV20 Gene

Enhancers for TRAV20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022039 1 ENCODE dbSUPER 0.7 -0.1 -62 1.3 HDGF CTCF RAD21 ARID3A POLR2A EED ETV6 RELB IKZF2 MIXL1 TRAV20 LOC100419912
GH14G022051 1.3 Ensembl ENCODE dbSUPER 0.4 +11.7 11737 0.8 HDAC1 PKNOX1 TCF12 GATA2 EGR1 RELB CEBPB ZNF589 SMARCA4 KLF16 TRAV21 TRAV20
GH14G022046 1 ENCODE dbSUPER 0.4 +6.6 6594 2.1 CTCF TFAP4 PKNOX1 FOXA2 RAD21 FOXK2 POLR2A EED PRDM10 BCLAF1 TRAV20 TRAV21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV20 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV20 Gene

Chromosome:
14
Start:
22,040,594 bp from pter
End:
22,041,153 bp from pter
Size:
560 bases
Orientation:
Plus strand

Genomic View for TRAV20 Gene

Genes around TRAV20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV20 Gene

Proteins for TRAV20 Gene

  • Protein details for TRAV20 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J274
    Recommended name:
    T-cell receptor alpha variable 20
    Protein Accession:
    A0A0B4J274

    Protein attributes for TRAV20 Gene

    Size:
    112 amino acids
    Molecular mass:
    12682 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRAV20 Gene

neXtProt entry for TRAV20 Gene

Post-translational modifications for TRAV20 Gene

No Post-translational modifications

Other Protein References for TRAV20 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV20 Gene

Domains & Families for TRAV20 Gene

Gene Families for TRAV20 Gene

Protein Domains for TRAV20 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV20: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV20 Gene

Function for TRAV20 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV20 Gene

Localization for TRAV20 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV20 Gene

Pathways & Interactions for TRAV20 Gene

SuperPathways for TRAV20 Gene

No Data Available

Interacting Proteins for TRAV20 Gene

Gene Ontology (GO) - Biological Process for TRAV20 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV20 Gene

Drugs & Compounds for TRAV20 Gene

No Compound Related Data Available

Transcripts for TRAV20 Gene

mRNA/cDNA for TRAV20 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV20 Gene

No ASD Table

Relevant External Links for TRAV20 Gene

GeneLoc Exon Structure for
TRAV20
ECgene alternative splicing isoforms for
TRAV20

Expression for TRAV20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV20 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV20 Gene

This gene is overexpressed in Whole Blood (x29.8), Spleen (x5.6), and Small Intestine - Terminal Ileum (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of TRAV20 Gene:

TRAV20
genes like me logo Genes that share expression patterns with TRAV20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV20 Gene

Orthologs for TRAV20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV20 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
OneToMany
Species where no ortholog for TRAV20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV20 Gene

ENSEMBL:
Gene Tree for TRAV20 (if available)
TreeFam:
Gene Tree for TRAV20 (if available)

Paralogs for TRAV20 Gene

Variants for TRAV20 Gene

Relevant External Links for TRAV20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV20 Gene

Disorders for TRAV20 Gene

Relevant External Links for TRAV20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAV20

No disorders were found for TRAV20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV20 Gene

Publications for TRAV20 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64
  2. A genome-wide association study of recipient genotype and medium-term kidney allograft function. (PMID: 23432519) O'Brien R.P. … Conlon P.J. (Clin Transplant 2013) 3 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TRAV20 Gene

Sources for TRAV20 Gene

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