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Aliases for TRAV18 Gene

Aliases for TRAV18 Gene

  • T Cell Receptor Alpha Variable 18 2 3 5
  • TCRAV18S1 3

External Ids for TRAV18 Gene

Previous GeneCards Identifiers for TRAV18 Gene

  • GC14U990302
  • GC14P020461
  • GC14P021528
  • GC14P021541
  • GC14P022472
  • GC14P022477
  • GC14P022587
  • GC14P022708
  • GC14P022821

Summaries for TRAV18 Gene

Entrez Gene Summary for TRAV18 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV18 Gene

TRAV18 (T Cell Receptor Alpha Variable 18) is a Protein Coding gene. An important paralog of this gene is TRAV9-2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV18 Gene

Genomics for TRAV18 Gene

Regulatory Elements for TRAV18 Gene

Enhancers for TRAV18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022002 1.1 Ensembl ENCODE 12.6 +0.3 278 1.8 HDGF BMI1 ZBTB40 RAD21 ELK1 EGR2 ZNF654 REST ZNF518A ZFP69B TRAV18 TRAV19
GH14F022471 1.8 FANTOM5 Ensembl ENCODE 5.2 +485.0 484957 32.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 PRMT5-AS1 BCL2L2 ABHD4 HOMEZ MRPL52 SLC7A7 MMP14 OR6J1 TRAV18 TRAV8-5
GH14F022504 1.9 FANTOM5 Ensembl ENCODE 4.7 +535.1 535082 66.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 MMP14 ABHD4 OXA1L LOC105370399 EFS HOMEZ C14orf119 DAD1 ENSG00000258457 TRAV37
GH14F021999 0.3 FANTOM5 0.8 -3.5 -3523 0.1 OR10G3 OR4E2 OR10G2 TRAV17 TRAV18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV18 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV18 Gene

Chromosome:
14
Start:
22,003,106 bp from pter
End:
22,003,673 bp from pter
Size:
568 bases
Orientation:
Plus strand

Genomic View for TRAV18 Gene

Genes around TRAV18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV18 Gene

Proteins for TRAV18 Gene

  • Protein details for TRAV18 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A075B6X5
    Recommended name:
    Protein TRAV18
    Protein Accession:
    A0A075B6X5

    Protein attributes for TRAV18 Gene

    Size:
    111 amino acids
    Molecular mass:
    12414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV18 Gene

Post-translational modifications for TRAV18 Gene

No Post-translational modifications

Other Protein References for TRAV18 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV18 Gene

Domains & Families for TRAV18 Gene

Gene Families for TRAV18 Gene

Protein Domains for TRAV18 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV18: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV18 Gene

Function for TRAV18 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV18 Gene

Localization for TRAV18 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV18 Gene

Pathways & Interactions for TRAV18 Gene

SuperPathways for TRAV18 Gene

No Data Available

Interacting Proteins for TRAV18 Gene

Gene Ontology (GO) - Biological Process for TRAV18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV18 Gene

Transcripts for TRAV18 Gene

mRNA/cDNA for TRAV18 Gene

(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV18 Gene

No ASD Table

Relevant External Links for TRAV18 Gene

GeneLoc Exon Structure for
TRAV18
ECgene alternative splicing isoforms for
TRAV18

Expression for TRAV18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAV18 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV18 Gene

This gene is overexpressed in Whole Blood (x9.2), Esophagus - Gastroesophageal Junction (x6.0), and Small Intestine - Terminal Ileum (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of TRAV18 Gene:

TRAV18
genes like me logo Genes that share expression patterns with TRAV18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV18 Gene

Orthologs for TRAV18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAV18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAV18 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trav12-2 35
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 41 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
Species where no ortholog for TRAV18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV18 Gene

ENSEMBL:
Gene Tree for TRAV18 (if available)
TreeFam:
Gene Tree for TRAV18 (if available)

Paralogs for TRAV18 Gene

genes like me logo Genes that share paralogs with TRAV18: view

Variants for TRAV18 Gene

Relevant External Links for TRAV18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV18 Gene

Disorders for TRAV18 Gene

No disorders were found for TRAV18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV18 Gene

Publications for TRAV18 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAV18 Gene

Sources for TRAV18 Gene

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