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Aliases for TRAV17 Gene

Aliases for TRAV17 Gene

  • T-Cell Receptor Alpha Variable 17 2 5
  • T Cell Receptor Alpha Variable 17 2 3
  • TCRAV17S1 3
  • TCRAV3S1 3

External Ids for TRAV17 Gene

Previous GeneCards Identifiers for TRAV17 Gene

  • GC14U990303
  • GC14P020457
  • GC14P020458
  • GC14P021535
  • GC14P022466
  • GC14P022705
  • GC14P022820

Summaries for TRAV17 Gene

Entrez Gene Summary for TRAV17 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV17 Gene

TRAV17 (T-Cell Receptor Alpha Variable 17) is a Protein Coding gene. An important paralog of this gene is TRAV6.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV17 Gene

Genomics for TRAV17 Gene

Regulatory Elements for TRAV17 Gene

Enhancers for TRAV17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G021992 0.5 FANTOM5 0.7 -4.6 -4643 0.1 CREB1 HMBOX1 OR10G3 OR4E2 TRAV16 TRAV17
GH14G021997 0.4 ENCODE 0.7 0.0 -43 0.2 CTCF RAD21 TRAV17 TRAV16
GH14G021999 0.3 FANTOM5 0.7 +2.0 2045 0.1 OR10G3 OR4E2 OR10G2 TRAV17 TRAV18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV17 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV17 Gene

Chromosome:
14
Start:
21,997,539 bp from pter
End:
21,998,168 bp from pter
Size:
630 bases
Orientation:
Plus strand

Genomic View for TRAV17 Gene

Genes around TRAV17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV17 Gene

Proteins for TRAV17 Gene

  • Protein details for TRAV17 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J275
    Recommended name:
    T-cell receptor alpha variable 17
    Protein Accession:
    A0A0B4J275

    Protein attributes for TRAV17 Gene

    Size:
    112 amino acids
    Molecular mass:
    12500 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV17 Gene

Post-translational modifications for TRAV17 Gene

No Post-translational modifications

Other Protein References for TRAV17 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV17 Gene

Domains & Families for TRAV17 Gene

Gene Families for TRAV17 Gene

Protein Domains for TRAV17 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV17: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV17 Gene

Function for TRAV17 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV17 Gene

Localization for TRAV17 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV17 Gene

Pathways & Interactions for TRAV17 Gene

SuperPathways for TRAV17 Gene

No Data Available

Interacting Proteins for TRAV17 Gene

Gene Ontology (GO) - Biological Process for TRAV17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV17 Gene

Drugs & Compounds for TRAV17 Gene

No Compound Related Data Available

Transcripts for TRAV17 Gene

mRNA/cDNA for TRAV17 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV17 Gene

No ASD Table

Relevant External Links for TRAV17 Gene

GeneLoc Exon Structure for
TRAV17
ECgene alternative splicing isoforms for
TRAV17

Expression for TRAV17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV17 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV17 Gene

This gene is overexpressed in Whole Blood (x27.3) and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of TRAV17 Gene:

TRAV17
genes like me logo Genes that share expression patterns with TRAV17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV17 Gene

Orthologs for TRAV17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV17 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Trav8-1 35
  • 71 (a)
OneToMany
Trav8d-1 35
  • 70 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRAV17 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
ManyToMany
Species where no ortholog for TRAV17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV17 Gene

ENSEMBL:
Gene Tree for TRAV17 (if available)
TreeFam:
Gene Tree for TRAV17 (if available)

Paralogs for TRAV17 Gene

Variants for TRAV17 Gene

Relevant External Links for TRAV17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV17 Gene

Disorders for TRAV17 Gene

Relevant External Links for TRAV17

Human Genome Epidemiology (HuGE) Navigator
TRAV17

No disorders were found for TRAV17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV17 Gene

Publications for TRAV17 Gene

  1. Identifying DNA polymorphisms in human TCRA/D variable genes by direct sequencing of PCR products. (PMID: 8662074) Boysen C. … Nickerson D.A. (Immunogenetics 1996) 2 3 64
  2. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAV17 Gene

Sources for TRAV17 Gene

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