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Aliases for TRAV16 Gene

Aliases for TRAV16 Gene

  • T Cell Receptor Alpha Variable 16 2 3 5
  • TCRAV16S1 3
  • TCRAV9S1 3

External Ids for TRAV16 Gene

Previous GeneCards Identifiers for TRAV16 Gene

  • GC14U990304
  • GC14P020448
  • GC14P021529
  • GC14P021530
  • GC14P022459
  • GC14P022704
  • GC14P022819

Summaries for TRAV16 Gene

Entrez Gene Summary for TRAV16 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV16 Gene

TRAV16 (T Cell Receptor Alpha Variable 16) is a Protein Coding gene. An important paralog of this gene is TRAV8-4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV16 Gene

Genomics for TRAV16 Gene

Regulatory Elements for TRAV16 Gene

Enhancers for TRAV16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F021988 0.2 ENCODE 0.8 -2.4 -2371 0.1 CTCF MAFG JUND MAFF ZNF316 IRF1 NFE2 MAFK EMSY NFE2L2 TRAV16 TRAV8-6
GH14F021990 0.5 ENCODE 0.8 -0.2 -200 0.2 CTCF PKNOX1 CBX8 PRMT5-AS1 TRAV16 TRAV8-6
GH14F021991 0.5 Ensembl 0.8 +0.4 405 0.2 TRAV16 TRAV17
GH14F021992 0.5 FANTOM5 0.8 +2.4 2401 0.1 HMBOX1 OR10G3 OR4E2 TRAV16 TRAV17
GH14F021997 0.4 ENCODE 0.4 +7.0 7001 0.2 CTCF RAD21 TRAV17 TRAV16
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRAV16 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV16 Gene

Chromosome:
14
Start:
21,990,496 bp from pter
End:
21,990,938 bp from pter
Size:
443 bases
Orientation:
Plus strand

Genomic View for TRAV16 Gene

Genes around TRAV16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV16 Gene

Proteins for TRAV16 Gene

  • Protein details for TRAV16 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYK6
    Recommended name:
    Protein TRAV16
    Protein Accession:
    A0A0A6YYK6

    Protein attributes for TRAV16 Gene

    Size:
    109 amino acids
    Molecular mass:
    12578 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV16 Gene

Post-translational modifications for TRAV16 Gene

No Post-translational modifications

Other Protein References for TRAV16 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV16 Gene

Domains & Families for TRAV16 Gene

Gene Families for TRAV16 Gene

Protein Domains for TRAV16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV16: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV16 Gene

Function for TRAV16 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV16 Gene

Localization for TRAV16 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAV16 Gene

Pathways & Interactions for TRAV16 Gene

SuperPathways for TRAV16 Gene

No Data Available

Interacting Proteins for TRAV16 Gene

Gene Ontology (GO) - Biological Process for TRAV16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAV16 Gene

Transcripts for TRAV16 Gene

mRNA/cDNA for TRAV16 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV16 Gene

No ASD Table

Relevant External Links for TRAV16 Gene

GeneLoc Exon Structure for
TRAV16
ECgene alternative splicing isoforms for
TRAV16

Expression for TRAV16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAV16 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV16 Gene

This gene is overexpressed in Whole Blood (x26.4), Spleen (x4.7), and Small Intestine - Terminal Ileum (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of TRAV16 Gene:

TRAV16
genes like me logo Genes that share expression patterns with TRAV16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAV16 Gene

Orthologs for TRAV16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAV16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAV16 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trav12d-1 35
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
Species where no ortholog for TRAV16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV16 Gene

ENSEMBL:
Gene Tree for TRAV16 (if available)
TreeFam:
Gene Tree for TRAV16 (if available)

Paralogs for TRAV16 Gene

genes like me logo Genes that share paralogs with TRAV16: view

Variants for TRAV16 Gene

Relevant External Links for TRAV16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV16 Gene

Disorders for TRAV16 Gene

No disorders were found for TRAV16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV16 Gene

Publications for TRAV16 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAV16 Gene

Sources for TRAV16 Gene

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