Aliases for TRAV16 Gene
Aliases for TRAV16 Gene
External Ids for TRAV16 Gene
- HGNC: 12112
- Entrez Gene: 28667
- Ensembl: ENSG00000211796
Previous GeneCards Identifiers for TRAV16 Gene
- GC14U990304
- GC14P020448
- GC14P021529
- GC14P021530
- GC14P022459
- GC14P022704
- GC14P022819
Summaries for TRAV16 Gene
-
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
GeneCards Summary for TRAV16 Gene
TRAV16 (T Cell Receptor Alpha Variable 16) is a Protein Coding gene. An important paralog of this gene is TRAV8-4.
Additional gene information for TRAV16 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV16 Gene
Genomics for TRAV16 Gene
GeneHancer (GH) Regulatory Elements for TRAV16 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14I021990 | Enhancer | 0.3 | ENCODE | 550.8 | -0.2 | -199 | 0.2 | CTCF | TRAV16 TRAV8-6 TRA | |
GH14I021988 | Enhancer | 0.6 | ENCODE | 0.8 | -2.4 | -2370 | 0.1 | CTCF MAFG BACH1 ETS1 MAFF ZNF316 ZNF143 NFE2 EMSY MAFK | TRAV16 TRAV8-6 TRA | |
GH14I021992 | Enhancer | 0.4 | FANTOM5 | 0.8 | +2.4 | 2401 | 0.1 | CREB1 | OR10G3 OR4E2 TRAV16 TRAV17 TRA | |
GH14I021997 | Enhancer | 0.3 | ENCODE | 0.4 | +7.0 | 7001 | 0.2 | CTCF | TRAV17 TRAV16 TRA | |
GH14I021978 | Enhancer | 0.3 | Ensembl | 0.4 | -11.8 | -11795 | 0.2 | CTCF | TRAV8-6 TRAV19 TRAV16 TRA |
Regulatory Element Products
Genomic Locations for TRAV16 Gene
- chr14:21,990,496-21,990,938
- (GRCh38/hg38)
- Size:
- 443 bases
- Orientation:
- Plus strand
- chr14:22,458,735-22,459,177
- (GRCh37/hg19)
Genomic View for TRAV16 Gene
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC


RefSeq DNA sequence for TRAV16 Gene
Proteins for TRAV16 Gene
-
Protein details for TRAV16 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0A6YYK6
- Recommended name:
- T-cell receptor alpha variable 16
- Protein Accession:
- A0A0A6YYK6
Protein attributes for TRAV16 Gene
- Size:
- 109 amino acids
- Molecular mass:
- 12578 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TRAV16 Gene
Other Protein References for TRAV16 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for TRAV16
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TRAV16
- Origene Custom Protein Services for TRAV16
- Search GeneTex for Proteins for TRAV16
No data available for DME Specific Peptides for TRAV16 Gene
Domains & Families for TRAV16 Gene
Gene Families for TRAV16 Gene
Protein Domains for TRAV16 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV16 Gene
Function for TRAV16 Gene
Animal Model Products
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-
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CRISPR Products
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- Applied Biological Materials CRISPR for TRAV16
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for TRAV16
Inhibitory RNA Products
- Search ViGene Biosciences for TRAV16
Clone Products
- GenScript: Custom all cDNA clones Services for TRAV16
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRAV16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV16 Gene
Localization for TRAV16 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAV16 Gene
Transcripts for TRAV16 Gene
mRNA/cDNA for TRAV16 Gene
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for TRAV16
- Applied Biological Materials CRISPR for TRAV16
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for TRAV16
Inhibitory RNA Products
- Search ViGene Biosciences for TRAV16
Clone Products
- GenScript: Custom all cDNA clones Services for TRAV16
- VectorBuilder custom plasmid, inducible vectors for TRAV16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAV16
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRAV16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TRAV16 Gene
mRNA differential expression in normal tissues according to GTEx for TRAV16 Gene
NURSA nuclear receptor signaling pathways regulating expression of TRAV16 Gene:
TRAV16Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV16 Gene
Orthologs for TRAV16 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
cow (Bos Taurus) |
Mammalia | TRAV16 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
mouse (Mus musculus) |
Mammalia | Trav12d-1 34 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany |
- Species where no ortholog for TRAV16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TRAV16 Gene
Variants for TRAV16 Gene
Additional Variant Information for TRAV16 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRAV16
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV16 Gene
Disorders for TRAV16 Gene
No disorders were found for TRAV16 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV16 Gene
Publications for TRAV16 Gene
- The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58
Products for TRAV16 Gene
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRAV16
- VectorBuilder custom plasmid, inducible vectors for TRAV16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAV16
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for TRAV16
- Search GeneTex for Proteins for TRAV16
Sources for TRAV16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew