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Aliases for TRAV14DV4 Gene

Aliases for TRAV14DV4 Gene

  • T-Cell Receptor Alpha Variable 14/Delta Variable 4 2 5
  • T Cell Receptor Alpha Variable 14/Delta Variable 4 2 3
  • T Cell Receptor Alpha/Delta Variable 14/DV4 3
  • TCRAV6S1-HDV104S1 3
  • TRAV14/DV4 3
  • HADV14S1 3

External Ids for TRAV14DV4 Gene

Previous GeneCards Identifiers for TRAV14DV4 Gene

  • GC14U990306
  • GC14P020382
  • GC14P021462
  • GC14P022393
  • GC14P022421
  • GC14P022452
  • GC14P022815

Summaries for TRAV14DV4 Gene

Entrez Gene Summary for TRAV14DV4 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV14DV4 Gene

TRAV14DV4 (T-Cell Receptor Alpha Variable 14/Delta Variable 4) is a Protein Coding gene. An important paralog of this gene is TRAV38-1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV14DV4 Gene

Genomics for TRAV14DV4 Gene

Regulatory Elements for TRAV14DV4 Gene

Enhancers for TRAV14DV4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G021922 1.1 Ensembl ENCODE 0.7 +0.5 455 3.3 HDGF PKNOX1 NFIB RAD21 ZNF143 ETV6 FOS CREM IKZF2 ZNF654 TRAV19 TRAV14DV4 TRAV9-2
GH14G021917 1.1 Ensembl ENCODE 0.4 -5.4 -5359 2.8 ELF3 FOXA2 RAD21 RFX5 GATA2 SCRT2 ZNF143 FOS RELB RCOR1 TRAV19 TRAV13-2 TRAV14DV4
GH14G021940 0.6 ENCODE 0.4 +17.0 16988 0.2 ELF3 CTCF NFIB NFIA RAD21 NFIC GABPB1 ZNF143 TRAV9-2 TRAV14DV4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAV14DV4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAV14DV4 Gene

Chromosome:
14
Start:
21,924,063 bp from pter
End:
21,924,651 bp from pter
Size:
589 bases
Orientation:
Plus strand

Genomic View for TRAV14DV4 Gene

Genes around TRAV14DV4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV14DV4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV14DV4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV14DV4 Gene

Proteins for TRAV14DV4 Gene

  • Protein details for TRAV14DV4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYC5
    Recommended name:
    T-cell receptor alpha variable 14/delta variable 4
    Protein Accession:
    A0A0A6YYC5

    Protein attributes for TRAV14DV4 Gene

    Size:
    116 amino acids
    Molecular mass:
    12931 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV14DV4 Gene

Post-translational modifications for TRAV14DV4 Gene

No Post-translational modifications

Other Protein References for TRAV14DV4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV14DV4 Gene

Domains & Families for TRAV14DV4 Gene

Gene Families for TRAV14DV4 Gene

Protein Domains for TRAV14DV4 Gene

Suggested Antigen Peptide Sequences for TRAV14DV4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV14DV4: view

No data available for UniProtKB/Swiss-Prot for TRAV14DV4 Gene

Function for TRAV14DV4 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV14DV4 Gene

Localization for TRAV14DV4 Gene

Gene Ontology (GO) - Cellular Components for TRAV14DV4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with TRAV14DV4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TRAV14DV4 Gene

Pathways & Interactions for TRAV14DV4 Gene

SuperPathways for TRAV14DV4 Gene

No Data Available

Interacting Proteins for TRAV14DV4 Gene

Gene Ontology (GO) - Biological Process for TRAV14DV4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with TRAV14DV4: view

No data available for Pathways by source and SIGNOR curated interactions for TRAV14DV4 Gene

Drugs & Compounds for TRAV14DV4 Gene

No Compound Related Data Available

Transcripts for TRAV14DV4 Gene

mRNA/cDNA for TRAV14DV4 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV14DV4 Gene

No ASD Table

Relevant External Links for TRAV14DV4 Gene

GeneLoc Exon Structure for
TRAV14DV4
ECgene alternative splicing isoforms for
TRAV14DV4

Expression for TRAV14DV4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV14DV4 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV14DV4 Gene

This gene is overexpressed in Whole Blood (x30.1) and Spleen (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of TRAV14DV4 Gene:

TRAV14DV4
genes like me logo Genes that share expression patterns with TRAV14DV4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV14DV4 Gene

Orthologs for TRAV14DV4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV14DV4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAV14DV4 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 33 (a)
ManyToMany
Species where no ortholog for TRAV14DV4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV14DV4 Gene

ENSEMBL:
Gene Tree for TRAV14DV4 (if available)
TreeFam:
Gene Tree for TRAV14DV4 (if available)

Paralogs for TRAV14DV4 Gene

Paralogs for TRAV14DV4 Gene

Pseudogenes.org Pseudogenes for TRAV14DV4 Gene

genes like me logo Genes that share paralogs with TRAV14DV4: view

Variants for TRAV14DV4 Gene

Relevant External Links for TRAV14DV4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV14DV4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV14DV4 Gene

Disorders for TRAV14DV4 Gene

No disorders were found for TRAV14DV4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV14DV4 Gene

Publications for TRAV14DV4 Gene

  1. Use of a variable alpha region to create a functional T-cell receptor delta chain. (PMID: 2456576) Guglielmi P. … Bensussan A. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 64

Products for TRAV14DV4 Gene

Sources for TRAV14DV4 Gene

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