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Aliases for TRAT1 Gene

Aliases for TRAT1 Gene

  • T Cell Receptor Associated Transmembrane Adaptor 1 2 3 5
  • T Cell Receptor Interacting Molecule 2 3
  • Pp29/30 3 4
  • TCRIM 3 4
  • TRIM 3 4
  • T-Cell Receptor-Interacting Molecule 4
  • HSPC062 3

External Ids for TRAT1 Gene

Previous HGNC Symbols for TRAT1 Gene


Previous GeneCards Identifiers for TRAT1 Gene

  • GC03P110026
  • GC03P108541
  • GC03P105915

Summaries for TRAT1 Gene

GeneCards Summary for TRAT1 Gene

TRAT1 (T Cell Receptor Associated Transmembrane Adaptor 1) is a Protein Coding gene. Among its related pathways are CTLA4 Signaling and TCR signaling (REACTOME). GO annotations related to this gene include transmembrane receptor protein tyrosine kinase adaptor activity.

UniProtKB/Swiss-Prot for TRAT1 Gene

  • Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.

Gene Wiki entry for TRAT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAT1 Gene

Genomics for TRAT1 Gene

Regulatory Elements for TRAT1 Gene

Enhancers for TRAT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAT1 Gene

108,822,698 bp from pter
108,855,005 bp from pter
32,308 bases
Plus strand

Genomic View for TRAT1 Gene

Genes around TRAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAT1 Gene

Proteins for TRAT1 Gene

  • Protein details for TRAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell receptor-associated transmembrane adapter 1
    Protein Accession:
    Secondary Accessions:
    • Q9NZX5

    Protein attributes for TRAT1 Gene

    186 amino acids
    Molecular mass:
    21211 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with CD3Z. When phosphorylated, interacts with PIK3R1.
    • Sequence=AAF29034.1; Type=Frameshift; Positions=166; Evidence={ECO:0000305};

neXtProt entry for TRAT1 Gene

Proteomics data for TRAT1 Gene at MOPED

Post-translational modifications for TRAT1 Gene

  • Phosphorylated on tyrosines by LCK or FYN upon TCR activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAT1 Gene

Domains & Families for TRAT1 Gene

Protein Domains for TRAT1 Gene

Suggested Antigen Peptide Sequences for TRAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAT1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TRAT1 Gene

Function for TRAT1 Gene

Molecular function for TRAT1 Gene

UniProtKB/Swiss-Prot Function:
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
genes like me logo Genes that share phenotypes with TRAT1: view

Animal Models for TRAT1 Gene

MGI Knock Outs for TRAT1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAT1 Gene

Localization for TRAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAT1 Gene

Cell membrane; Single-pass type III membrane protein.

Subcellular locations from

Jensen Localization Image for TRAT1 Gene COMPARTMENTS Subcellular localization image for TRAT1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
cytosol 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TRAT1 Gene

Pathways & Interactions for TRAT1 Gene

SuperPathways for TRAT1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 Immune System
4 Downstream signaling events of B Cell Receptor (BCR)
5 Immune response NFAT in immune response
genes like me logo Genes that share pathways with TRAT1: view

Gene Ontology (GO) - Biological Process for TRAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001920 negative regulation of receptor recycling IDA 11390434
GO:0002250 adaptive immune response IEA --
GO:0006968 cellular defense response TAS 9687533
GO:0007165 signal transduction TAS 9687533
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TRAT1: view

No data available for SIGNOR curated interactions for TRAT1 Gene

Drugs & Compounds for TRAT1 Gene

No Compound Related Data Available

Transcripts for TRAT1 Gene

Unigene Clusters for TRAT1 Gene

T cell receptor associated transmembrane adaptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAT1 Gene

No ASD Table

Relevant External Links for TRAT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAT1 Gene

mRNA expression in normal human tissues for TRAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAT1 Gene

This gene is overexpressed in Whole Blood (x20.8), Spleen (x6.3), and Small Intestine - Terminal Ileum (x4.9).

Protein differential expression in normal tissues from HIPED for TRAT1 Gene

This gene is overexpressed in CD8 Tcells (30.3), CD4 Tcells (26.0), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAT1 Gene

SOURCE GeneReport for Unigene cluster for TRAT1 Gene Hs.138701

mRNA Expression by UniProt/SwissProt for TRAT1 Gene

Tissue specificity: Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).
genes like me logo Genes that share expression patterns with TRAT1: view

Protein tissue co-expression partners for TRAT1 Gene

- Elite partner

Primer Products

Orthologs for TRAT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRAT1 35
  • 79.17 (n)
  • 65.76 (a)
TRAT1 36
  • 63 (a)
(Canis familiaris)
Mammalia TRAT1 35
  • 82.34 (n)
  • 70.27 (a)
TRAT1 36
  • 70 (a)
(Mus musculus)
Mammalia Trat1 35
  • 80.54 (n)
  • 70.27 (a)
Trat1 16
Trat1 36
  • 66 (a)
(Pan troglodytes)
Mammalia TRAT1 35
  • 99.28 (n)
  • 99.46 (a)
TRAT1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trat1 35
  • 79.35 (n)
  • 68.48 (a)
(Monodelphis domestica)
Mammalia TRAT1 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia TRAT1 36
  • 49 (a)
(Gallus gallus)
Aves TRAT1 35
  • 58.16 (n)
  • 48.28 (a)
TRAT1 36
  • 45 (a)
Species with no ortholog for TRAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAT1 Gene

Gene Tree for TRAT1 (if available)
Gene Tree for TRAT1 (if available)

Paralogs for TRAT1 Gene

No data available for Paralogs for TRAT1 Gene

Variants for TRAT1 Gene

Sequence variations from dbSNP and Humsavar for TRAT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs57744779 - 108,853,726(+) TGGAG(A/G)TGAGC reference, missense
rs61585973 - 108,853,758(+) GCGTT(C/T)CTAAG reference, missense
rs2290055 -- 108,830,873(-) ATGAC(A/C)TTTCA intron-variant
rs2290056 -- 108,830,427(-) ATAAA(C/T)GACTT intron-variant
rs2399254 -- 108,847,216(+) ATCAA(A/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAT1 Gene

Variant ID Type Subtype PubMed ID
nsv829661 CNV Gain 17160897
nsv522119 CNV Gain 19592680
nsv829662 CNV Gain 17160897
nsv521830 CNV Loss 19592680
nsv508236 CNV Loss 20534489
nsv877326 CNV Gain 21882294

Variation tolerance for TRAT1 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRAT1 Gene

Disorders for TRAT1 Gene

Relevant External Links for TRAT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAT1 Gene

Publications for TRAT1 Gene

  1. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide- linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. (PMID: 9687533) Bruyns E. … Schraven B. (J. Exp. Med. 1998) 2 3 4 67
  2. Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM). (PMID: 10663578) HA1bener C. … Bruyns E. (Immunogenetics 2000) 2 3 23
  3. TRIM proteins in therapeutic membrane repair of muscular dystrophy. (PMID: 23699904) Alloush J. … Weisleder N. (JAMA Neurol 2013) 3
  4. TRIM proteins as trim tabs for the homoeostasis. (PMID: 23969027) Horie-Inoue K. (J. Biochem. 2013) 3
  5. The mitochondrial targeting chaperone 14-3-3I/ regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. (PMID: 22607805) Liu H.M. … Gale M. (Cell Host Microbe 2012) 3

Products for TRAT1 Gene

Sources for TRAT1 Gene