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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRAT1 Gene

protein-coding GIFtS: 52
GCID: GC03P108541

T cell receptor associated transmembrane adaptor 1

(Previous name: T cell receptor interacting molecule )
(Previous symbol: TCRIM)

Explore 3 diseases affiliated with
TRAT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T Cell Receptor Associated Transmembrane Adaptor 1¹ ²		T-Cell Receptor-Interacting Molecule² ³
TRIM¹ ² ³ ⁵		HSPC062¹
TCRIM¹ ² ³		T-Cell Receptor Interacting Molecule²
T Cell Receptor Interacting Molecule¹ ²		T-Cell Receptor-Associated Transmembrane Adapter 1²
Pp29/30¹

External Ids:	HGNC: 30698¹	Entrez Gene: 50852²	Ensembl: ENSG00000163519⁷	OMIM: 604962⁵	UniProtKB: Q6PIZ9³

Export aliases for TRAT1 gene to outside databases

Previous GC identifers: GC03P110026 GC03P105915

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TRAT1_HUMAN, Q6PIZ9

Function: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells

Gene Wiki entry for TRAT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRAT1 gene promoter:
TBP Sox5 AML1a MyoD AREB6 Max TFIID STAT3 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRAT1 promoter sequence

Search SABiosciences Chromatin IP Primers for TRAT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13 Ensembl cytogenetic band: 3q13.13 HGNC cytogenetic band: 3q13

TRAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAT1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P108541: view genomic region (about GC identifiers)

Start:	108,541,545 bp from pter	End:	108,573,852 bp from pter
Size:	32,308 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRAT1_HUMAN, Q6PIZ9 (See protein sequence)

Recommended Name: T-cell receptor-associated transmembrane adapter 1

Size: 186 amino acids; 21211 Da

Subunit: Homodimer; disulfide-linked. Interacts with CD3Z. When phosphorylated, interacts with PIK3R1

Subcellular location: Cell membrane; Single-pass type III membrane protein

Developmental stage: Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and

fetal liver

Sequence caution: Sequence=AAF29034.1; Type=Frameshift; Positions=166;

Secondary accessions: Q9NZX5

Explore the universe of human proteins at neXtProt for TRAT1: NX_Q6PIZ9

Post-translational modifications:

Phosphorylated on tyrosines by LCK or FYN upon TCR activation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6PIZ9

TRAT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057472.2

ENSEMBL proteins:

ENSP00000295756 ENSP00000410097

Reactome Protein details: Q6PIZ9
Human Recombinant Protein Products for TRAT1:

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	Uscn Proteins for TRAT1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9687533
GO:0042101	T cell receptor complex	IDA	11390434

TRAT1 for ontologies About GeneDecksing

TRAT1 Antibody Products:

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	Uscn Antibodies for TRAT1
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Assay Products for TRAT1:

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	GenScript Custom Assay Services for TRAT1
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	Uscn ELISAs and CLIAs for TRAT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRAT1 for domains About GeneDecksing

1 InterPro domain/family:

IPR020399 T-cell_rcpt-assoc_TM_adapter-1

Graphical View of Domain Structure for InterPro Entry Q6PIZ9

ProtoNet protein and cluster: Q6PIZ9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRAT1_HUMAN, Q6PIZ9

Function: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	TAS	9687533

TRAT1 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trat1):

growth/size

hematopoietic system

immune system

TRAT1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Trat1^tm1Lsmn for TRAT1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRAT1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAT1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAT1:
		hsa-miR-3119 hsa-miR-331-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TRAT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAT1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PIP3 activates AKT signaling	1.00	PI3K/AKT activation	0.97
PI3K/AKT Signaling in Cancer	1.00	GAB1 signalosome	0.96
PI3K events in ERBB2 signaling	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB4 signaling	1.00	Signaling by SCF-KIT	0.72

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Immune response_NFAT in immune response

Immune response_NFAT in immune response

1.00

Immune response NFAT in immune response

0.91

Immune response_ICOS pathway in T-helper cell

Immune response_ICOS pathway in T-helper cell

1.00

Immune response ICOS pathway in T-helper cell

0.91

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for TRAT1

	Immune response NFAT in immune response
	Immune response ICOS pathway in T-helper cell
	Immune response T cell receptor signaling pathway

3 GeneGo (Thomson Reuters) Pathways for TRAT1

	Immune response ICOS pathway in T-helper cell
	Immune response T cell receptor signaling pathway
	Immune response NFAT in immune response

5/31 Reactome Pathways for TRAT1 (see all 31)

	Signaling by EGFR in Cancer
	Disease
	Signaling by ERBB2
	GAB1 signalosome
	PI3K/AKT activation

TRAT1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRAT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/26 Interacting proteins for TRAT1 (Q6PIZ9³ ENSP00000295756⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD247	P20963³, ENSP00000354782⁴	I2D: score=2 STRING: ENSP00000354782
FYN	P06241³, ENSP00000357656⁴	I2D: score=2 STRING: ENSP00000357656
LCK	P06239³, ENSP00000337825⁴	I2D: score=2 STRING: ENSP00000337825
CD3E	P07766³, ENSP00000354566⁴	I2D: score=1 STRING: ENSP00000354566
LCP2	Q13094³, ENSP00000046794⁴	I2D: score=1 STRING: ENSP00000046794

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001920	negative regulation of receptor recycling	IDA	11390434
GO:0006968	cellular defense response	TAS	9687533
GO:0007165	signal transduction	TAS	9687533
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	9687533
GO:0050850	positive regulation of calcium-mediated signaling	IDA	11390434

TRAT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRAT1
Search CenterWatch for drugs/clinical trials and news about TRAT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRAT1 gene:

NM_016388.2

Unigene Cluster for TRAT1:

T cell receptor associated transmembrane adaptor 1

Hs.138701 [show with all ESTs]

Unigene Representative Sequence: AF161547

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295756(uc003dxi.1) ENST00000484927 ENST00000426646(uc010hpx.1)

ENST00000493604 ENST00000478830

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAT1
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		hsa-miR-3119 hsa-miR-331-5p
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TRAT1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAT1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAT1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRAT1 (NM_016388)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAT1

Additional cDNA sequence:

AF161547.1 AJ224878.1 AJ240085.1 AK291991.1 BC025713.1

3 DOTS entries:

DT.75168759 DT.120879513 DT.120879521

24/27 AceView cDNA sequences (see all 27):

CR623824 CR593848 BX415345 BI833851 BC025713 AI453185 BX329167 BI767372

NM_016388 BX414764 CD522032 AL558415 AV761152 BX506779 AF161547 BP368118

D31303 BI909324 CD696498 CD702669 BI490901 CD639080 CD687867 AI445595

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRAT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTATGTATG

About this image

TRAT1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Early limb mesenchymal cells (ELM cells) (Primary Cell)

Bone, Cartilage, Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRAT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAT1

SOURCE GeneReport for Unigene cluster: Hs.138701

UniProtKB/Swiss-Prot: TRAT1_HUMAN, Q6PIZ9

Tissue specificity: Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood

lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level)

SABiosciences Custom PCR Arrays for TRAT1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRAT1 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trat1^{1 , 5}	T cell receptor associated transmembrane adaptor 1^{1, 5}	80.54(n)¹ 70.27(a)¹		16 (30.75 cM)⁵ 77647¹ NM_198297.3¹ NP_938039.2¹ 48734690⁵
chicken (Gallus gallus)	Aves	TRAT1¹	T cell receptor associated transmembrane adaptor 1	59.01(n) 49.07(a)		418412 XM_416627.2 XP_416627.2

ENSEMBL Gene Tree for TRAT1 (if available)
TreeFam Gene Tree for TRAT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1449353^1,2	C,F	--	108539651(-)	`CCAACA/GGGAAG`	1	--	us2k¹ trp³		3		WA NA EA	358
rs75536509^1,2		--	108539783(+)	`GAATTG/ACACTT`	1	--	us2k¹		3		CSA WA	121
rs191888095^1,2		--	108540008(+)	`ACTTCC/TACTTT`	1	--	us2k¹		0	--	--	--	--
rs183936468^1,2		--	108540014(+)	`ACTTTC/TCTTAC`	1	--	us2k¹		0	--	--	--	--
rs147557146^1,2		--	108540103(+)	`GTGCCC/TGAATC`	1	--	us2k¹		0	--	--	--	--
rs142308102^1,2		--	108540147(+)	`TCTTCC/TTCCCT`	1	--	us2k¹		0	--	--	--	--
rs146086408^1,2		--	108540292(+)	`GCTAAC/TGGTTA`	1	--	us2k¹		0	--	--	--	--
rs9853709^1,2	C,F,H	--	108540316(+)	`GAGTCC/TTCtgg`	1	--	us2k¹ tfbs³		5		NS EA WA	536
rs77786092^1,2	C	--	108540359(+)	`ATTATT/CTGGGT`	1	--	us2k¹		2		NA	122
rs138601824^1,2		--	108540374(+)	`TTTTCA/GCAGGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRAT1 (108541545 - 108573852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRAT1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAT1

DNA2.0 Custom Variant and Variant Library Synthesis for TRAT1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRAT1 for disorders           About GeneDecksing

OMIM gene information: 604962    OMIM disorders: --

3 diseases for TRAT1:    About MalaCards

dermatitis herpetiformis dermatitis lung cancer

2 Novoseek disease relationships for TRAT1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer lung	25.8	1	10459492 (1)
cancer	0	3	10459492 (2), 12797908 (1)

Export disorders for TRAT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRAT1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TRAT1)

Utopia: connect your pdf to the dynamic
world of online information

T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. (PubMed id 9687533)^{1, 2, 3} Bruyns E....Schraven B. (1998)
Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM). (PubMed id 10663578)^{1, 3, 9} Hubener C....Bruyns E. (2000)
Transmembrane adaptor molecules: a new category of lymphoid-cell markers. (PubMed id 16160011)^{1, 2} Tedoldi S....Horejsi V. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. (PubMed id 11390434)^{1, 2} Kirchgessner H.... Schraven B. (2001)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
The mitochondrial targeting chaperone 14-3-3e regulate s a RIG-I translocon that mediates membrane association and innate antiviral imm unity. (PubMed id 22607805)¹ Liu H.M....Gale M. (2012)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells. (PubMed id 18817831)¹ Jarvis L.B....Gaston J.S. (2008)
The role of PI3K in immune cells. (PubMed id 12660731)¹ Koyasu S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 50852	HGNC: 30698	AceView: TRIM	Ensembl:ENSG00000163519	euGenes: HUgn50852
ECgene: TRAT1	H-InvDB: TRAT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRAT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRAT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRAT1 gene:
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TRAT1 Gene

T cell receptor associated transmembrane adaptor 1

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TRAT1 Gene

T cell receptor associated transmembrane adaptor 1

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