Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAPPC8 Gene

protein-coding   GIFtS: 48
GCID: GC18M029409

Trafficking Protein Particle Complex 8

(Previous name: KIAA1012)
(Previous symbol: KIAA1012)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Trafficking Protein Particle Complex 81 2     HsT27062
KIAA10121 2 3     TRS852
Protein TRS85 Homolog2 3     General Sporulation Gene 1 Homolog2
General Sporulation Gene 1 Homolog (S. Cerevisiae)1     Trafficking Protein Particle Complex Subunit 82
GSG12     

External Ids:    HGNC: 291691   Entrez Gene: 228782   Ensembl: ENSG000001533397   OMIM: 6141365   UniProtKB: Q9Y2L53   

Export aliases for TRAPPC8 gene to outside databases

Previous GC identifers: GC00U913618 GC18M026266


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRAPPC8 Gene: 
TRAPPC8 (trafficking protein particle complex 8) is a protein-coding gene. Diseases associated with TRAPPC8 include intellectual disability, and microcephaly.

UniProtKB/Swiss-Prot: TPPC8_HUMAN, Q9Y2L5
Function: May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage

Gene Wiki entry for TRAPPC8 (KIAA1012) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRAPPC8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAPPC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAPPC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAPPC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

TRAPPC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAPPC8 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M029409:  view genomic region     (about GC identifiers)

Start:
29,409,136 bp from pter      End:
29,533,099 bp from pter
Size:
123,964 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPPC8_HUMAN, Q9Y2L5 (See protein sequence)
Recommended Name: Trafficking protein particle complex subunit 8  
Size: 1435 amino acids; 160997 Da
Subunit: Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2,
TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12
Subcellular location: Golgi apparatus, cis-Golgi network (By similarity)
Sequence caution: Sequence=AAI27110.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI27111.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA76856.2;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG50957.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: A0JP15 B3KME5 Q9H0L2
Alternative splicing: 2 isoforms:  Q9Y2L5-1   Q9Y2L5-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAPPC8: NX_Q9Y2L5

Explore proteomics data for TRAPPC8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2L5

  • TRAPPC8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAPPC8 Protein Expression
    REFSEQ proteins: NP_055754.2  
    ENSEMBL proteins: 
     ENSP00000283351   ENSP00000462550   ENSP00000463764   ENSP00000463876   ENSP00000463139  
     ENSP00000464591   ENSP00000463973  

    Human Recombinant Protein Products for TRAPPC8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TRAPPC8
    GenScript Custom Purified and Recombinant Proteins Services for TRAPPC8
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRAPPC8 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005801cis-Golgi network NAS--

    TRAPPC8 for ontologies           About GeneDecksing



    TRAPPC8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRAPPC8
    GenScript Custom Superior Antibodies Services for TRAPPC8
    Novus Biologicals TRAPPC8 Antibody
    Abcam antibodies for TRAPPC8
    Cloud-Clone Corp. Antibodies for TRAPPC8 
    Search ThermoFisher Antibodies for TRAPPC8
    Search LSBio for Antibodies for TRAPPC8 

    Assay Products for TRAPPC8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRAPPC8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRAPPC8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRAPPC8 
    Cloud-Clone Corp. CLIAs for TRAPPC8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRAPPC: Trafficking protein particle complex

    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR024420 TRAPP_III_complex_Trs85

    Graphical View of Domain Structure for InterPro Entry Q9Y2L5

    ProtoNet protein and cluster: Q9Y2L5

    UniProtKB/Swiss-Prot: TPPC8_HUMAN, Q9Y2L5
    Similarity: Belongs to the TRS85 family


    TRAPPC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPPC8_HUMAN, Q9Y2L5
    Function: May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage

    Phenotypes:
         1 GenomeRNAi human phenotype for TRAPPC8:

     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAPPC8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAPPC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAPPC8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAPPC8 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAPPC8
    8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAPPC8 (see all 73):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-200a hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRAPPC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAPPC8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRAPPC8
    Sirion Biotech Customized adenovirus for overexpression of TRAPPC8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRAPPC8 (see all 6)
    OriGene ORF clones in mouse, rat for TRAPPC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAPPC8 (NM_014939)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAPPC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC8
    Sirion Biotech Customized lentivirus for stable overexpression of TRAPPC8 
                         Customized lentivirus expression plasmids for stable overexpression of TRAPPC8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRAPPC8
    Search LifeMap BioReagents cell lines for TRAPPC8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRAPPC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for TRAPPC8 (Q9Y2L53 ENSP000002833514) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TECPR1Q7Z6L13, ENSP000004049234I2D: score=3 STRING: ENSP00000404923
    TRAPPC3O436173, ENSP000003622614I2D: score=1 STRING: ENSP00000362261
    TRAPPC13A5PLN93, ENSP000004092314STRING: ENSP00000409231 I2D: score=1 
    TRAPPC2LQ9UL333, ENSP000003010214I2D: score=1 STRING: ENSP00000301021
    EIF3LQ9Y2623I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888ER to Golgi vesicle-mediated transport NAS--

    TRAPPC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAPPC8 (TPPC8)

    Search CenterWatch for drugs/clinical trials and news about TRAPPC8 / TPPC8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAPPC8 gene: 
    NM_014939.3  

    Unigene Cluster for TRAPPC8:

    Trafficking protein particle complex 8
    Hs.202001  [show with all ESTs]
    Unigene Representative Sequence: NM_014939
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283351(uc002kxb.4 uc002kxc.4 uc002kxd.4) ENST00000580104
    ENST00000582509 ENST00000582539 ENST00000581057 ENST00000584604 ENST00000578886
    ENST00000578252 ENST00000577474 ENST00000582513(uc021uio.1 uc002kxe.2)
    ENST00000578658 ENST00000584876 ENST00000577426
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAPPC8
    8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAPPC8 (see all 73):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-200a hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRAPPC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAPPC8
    Clone
    Products:
         
    OriGene clones in human, mouse for TRAPPC8 (see all 6)
    OriGene ORF clones in mouse, rat for TRAPPC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAPPC8 (NM_014939)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAPPC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC8
    Sirion Biotech Customized lentivirus for stable overexpression of TRAPPC8 
                         Customized lentivirus expression plasmids for stable overexpression of TRAPPC8 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAPPC8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAPPC8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAPPC8

    Additional mRNA sequence: 

    AB023229.1 AK001662.1 AK292537.1 BC059380.1 BC127109.1 BC127110.1 

    16 DOTS entries:

    DT.100730208  DT.92429088  DT.100754471  DT.101966440  DT.438190  DT.99998714  DT.121091526  DT.91842883 
    DT.95117194  DT.100754472  DT.121091547  DT.92429087  DT.91875385  DT.92429090  DT.95116066  DT.100019949 

    24/140 AceView cDNA sequences (see all 140):

    AI942382 BM682428 AL043322 AW197187 AA112168 AB023229 CD368790 CD654662 
    AA287708 AW474786 AI220374 AL136749 AI873828 AL041590 NM_014939 BX500037 
    AA553615 BQ008534 AK001662 AU132862 AW137286 BU520994 T35356 AW751570 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC8 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -                                                                 -                 -                             -                           
    SP2:              -                                                                 -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c · 32d
    SP1:              -                                   -           -                                 
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                              -                                 


    ECgene alternative splicing isoforms for TRAPPC8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAPPC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCATAATAC
    TRAPPC8 Expression
    About this image


    See TRAPPC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAPPC8

    SOURCE GeneReport for Unigene cluster: Hs.202001
        SABiosciences Custom PCR Arrays for TRAPPC8
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAPPC8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAPPC8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAPPC8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRAPPC8 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trappc81 , 5 trafficking protein particle complex 81, 5 88.65(n)1
    92.04(a)1
      18 (11.53 cM)5
    759641  NM_177038.31  NP_796012.21 
     208172245 
    chicken
    (Gallus gallus)
    Aves TRAPPC81 trafficking protein particle complex 8 80.97(n)
    85.65(a)
      421095  XM_003640812.1  XP_003640860.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAPPC86
    trafficking protein particle complex 8
    79(a)
    1 ↔ 1
    GL343207.1(3478335-3574256)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060750.12   -- 75.89(n)    BC060750.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trappc81 trafficking protein particle complex 8 64.43(n)
    70.01(a)
      570167  XM_001920683.3  XP_001920718.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)76BDm1 lethal (3) 76BDm 44.35(n)
    35.43(a)
      40140  NM_140878.3  NP_649135.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F46F11.96
    Protein F46F11.9, isoform a
    18(a)
    1 ↔ 1
    I(5610374-5616402)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G162801 hypothetical protein 44.64(n)
    31.2(a)
      831488  NM_121633.4  NP_197132.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07869001 hypothetical protein 44.96(n)
    30.23(a)
      4334355  NM_001058028.1  NP_001051493.1 


    ENSEMBL Gene Tree for TRAPPC8 (if available)
    TreeFam Gene Tree for TRAPPC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAPPC8 gene
    1 SIMAP similar gene for TRAPPC8 using alignment to 7 protein entries:     TPPC8_HUMAN (see all proteins):
    KIAA1012

    TRAPPC8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2665 SNPs in TRAPPC8 are shown (see all 2665)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362704
    A breast cancer sample4--see VAR_0362702 R Q mis40--------
    VAR_0602504
    ----see VAR_0602502 L S mis40--------
    rs1407445971,2
    --29408720(+) ATGCTA/GGTTGA 1 -- ds50010--------
    rs1458487171,2
    --29408849(+) CAGGAA/GTATTT 1 -- ds50010--------
    rs1378872181,2
    --29408876(+) CTACTC/TGTTAC 1 -- ds50010--------
    rs744497211,2
    C,F--29408885(+) ACAGCT/AACAAA 1 -- ds50012Minor allele frequency- A:0.03WA NA 238
    rs1423138451,2
    --29409060(+) GAATGC/TAGGGT 1 -- ds50010--------
    rs96753741,2
    C,F,H--29409169(+) GAGTGC/TTTTAT 1 -- ut3111Minor allele frequency- T:0.02NS EA NA WA 1380
    rs1911540241,2
    --29409215(+) TATAGC/TTTAAT 1 -- ut310--------
    rs177417961,2
    C,F,H--29409319(+) CTTGTC/TTTTCC 1 -- ut3122Minor allele frequency- T:0.28NA NS EA WA 2484

    HapMap Linkage Disequilibrium report for TRAPPC8 (29409136 - 29533099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRAPPC8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv990849CNV Deletion20482838
    esv1720728CNV Insertion17803354
    nsv131072CNV Loss16902084
    nsv2247CNV Loss18451855
    nsv820095CNV Loss19587683

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAPPC8
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAPPC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614136    OMIM disorders: --

    2 diseases for TRAPPC8:    About MalaCards
    intellectual disability    microcephaly


    TRAPPC8 for disorders           About GeneDecksing


    Export disorders for TRAPPC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAPPC8 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TRAPPC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. C4orf41 and TTC-15 are mammalian TRAPP components wit h a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)1, 2 Scrivens P.J....Sacher M. (2011)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PubMed id 11805826)1, 2 Gavin A.-C....Superti-Furga G. (2002)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. The adaptor function of TRAPPC2 in mammalian TRAPPs e xplains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability. (PubMed id 21858081)1 Zong M....Yu S. (2011)
    8. Organization and assembly of the TRAPPII complex. (PubMed id 21453443)1 Choi C....Conibear E. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22878 HGNC: 29169 AceView: KIAA1012 Ensembl:ENSG00000153339 euGenes: HUgn22878
    ECgene: TRAPPC8 H-InvDB: TRAPPC8

    (According to HUGE)
    About This Section
    HUGE: KIAA1012

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAPPC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAPPC8 gene:
    Search GeneIP for patents involving TRAPPC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRAPPC8  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRAPPC8  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRAPPC8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRAPPC8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRAPPC8   OriGene Custom Protein Services for TRAPPC8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRAPPC8
     QIAGEN SeqTarget long-range PCR primers for resequencing TRAPPC8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAPPC8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAPPC8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAPPC8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC8
     GenScript Custom Purified and Recombinant Proteins Services for TRAPPC8 GenScript cDNA clones with any tag delivered in your preferred vector for TRAPPC8
     GenScript Custom Assay Services for TRAPPC8 GenScript Custom Superior Antibodies Services for TRAPPC8
     GenScript Custom overexpressing Cell Line Services for TRAPPC8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for TRAPPC8
     Search Chromatin IP Primers for TRAPPC8
     RT2 qPCR Primer Assay in human, mouse, rat TRAPPC8
     Search GNC Networks for TRAPPC8
     SABiosciences Custom PCR Arrays for TRAPPC8
     Search Tocris compounds for TRAPPC8 (TPPC8)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRAPPC8 antibodies
     Antibodies for TRAPPC8
     See all of Abcam's Antibodies, Kits and Proteins for TRAPPC8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRAPPC8
     Antibodies for TRAPPC8
     ELISAs for TRAPPC8
     CLIAs for TRAPPC8
     Search LifeMap BioReagents cell lines for TRAPPC8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC8
     SwitchGear 3'UTR luciferase reporter plasmids for TRAPPC8
     SwitchGear Promoter luciferase reporter plasmids for TRAPPC8
     Search ThermoFisher Antibodies for TRAPPC8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAPPC8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAPPC8
    Customized:
     lentivirus for stable overexpression of TRAPPC8
     lentivirus expression plasmids for stable overexpression of TRAPPC8
     adenovirus for overexpression of TRAPPC8
     Search LSBio for Antibodies for TRAPPC8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRAPPC8 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4