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Aliases for TRAPPC8 Gene

Aliases for TRAPPC8 Gene

  • Trafficking Protein Particle Complex 8 2 3 5
  • KIAA1012 2 3 4
  • Protein TRS85 Homolog 3 4
  • General Sporulation Gene 1 Homolog (S. Cerevisiae) 2
  • Trafficking Protein Particle Complex Subunit 8 3
  • General Sporulation Gene 1 Homolog 3
  • HsT2706 3
  • TRS85 3
  • GSG1 3

External Ids for TRAPPC8 Gene

Previous HGNC Symbols for TRAPPC8 Gene

  • KIAA1012

Previous GeneCards Identifiers for TRAPPC8 Gene

  • GC00U913618
  • GC18M029409
  • GC18M026266

Summaries for TRAPPC8 Gene

GeneCards Summary for TRAPPC8 Gene

TRAPPC8 (Trafficking Protein Particle Complex 8) is a Protein Coding gene. Diseases associated with TRAPPC8 include Alzheimer Disease 18. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs.

UniProtKB/Swiss-Prot for TRAPPC8 Gene

  • May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Gene Wiki entry for TRAPPC8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC8 Gene

Genomics for TRAPPC8 Gene

Regulatory Elements for TRAPPC8 Gene

Enhancers for TRAPPC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G032084 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -132.8 -132766 3.4 HDGF INSM2 KLF17 FEZF1 ZNF2 ZEB1 ZSCAN5C SCRT2 FOS RELB TRAPPC8 RNF138 RPS15AP35
GH18G032017 1.5 FANTOM5 ENCODE 12.2 -66.0 -66017 3.9 HDGF FOXA2 MLX ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF263 SP3 RNF125 ENSG00000263924 TRAPPC8 RNF138 ENSG00000263917 ENSG00000274275
GH18G031825 0.6 ENCODE 26 +126.6 126621 2.9 PKNOX1 POLR2A GLIS1 MAX POU5F1 WT1 ATF2 TRAPPC8 RNU6-1050P SLC25A52 RNF125 ENSG00000263924
GH18G031977 0.7 ENCODE 12.6 -24.3 -24307 0.2 CTCF ATF1 RAD21 ZNF316 ZNF143 SMC3 MAFK ZNF652 ZNF654 TRIM22 TRAPPC8 RNU6-1050P ENSG00000280380 LOC100287539
GH18G031982 0.7 ENCODE 12 -29.9 -29877 0.9 PKNOX1 MAX RAD21 ZNF7 GABPA YY1 JUND ATF3 HNF4G HNF4A RNF125 TRAPPC8 RNU6-1050P ENSG00000280380
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAPPC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC8 Gene

Chromosome:
18
Start:
31,829,173 bp from pter
End:
31,953,136 bp from pter
Size:
123,964 bases
Orientation:
Minus strand

Genomic View for TRAPPC8 Gene

Genes around TRAPPC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC8 Gene

Proteins for TRAPPC8 Gene

  • Protein details for TRAPPC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2L5-TPPC8_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 8
    Protein Accession:
    Q9Y2L5
    Secondary Accessions:
    • A0JP15
    • B3KME5
    • Q9H0L2

    Protein attributes for TRAPPC8 Gene

    Size:
    1435 amino acids
    Molecular mass:
    160997 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    SequenceCaution:
    • Sequence=AAI27110.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI27111.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA76856.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG50957.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC8 Gene

Post-translational modifications for TRAPPC8 Gene

  • Ubiquitination at posLast=12881288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC8 Gene

Domains & Families for TRAPPC8 Gene

Gene Families for TRAPPC8 Gene

Protein Domains for TRAPPC8 Gene

Suggested Antigen Peptide Sequences for TRAPPC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2L5

UniProtKB/Swiss-Prot:

TPPC8_HUMAN :
  • Belongs to the TRS85 family.
Family:
  • Belongs to the TRS85 family.
genes like me logo Genes that share domains with TRAPPC8: view

Function for TRAPPC8 Gene

Molecular function for TRAPPC8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Gene Ontology (GO) - Molecular Function for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21453443
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with TRAPPC8: view
genes like me logo Genes that share phenotypes with TRAPPC8: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC8 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC8 Gene

Localization for TRAPPC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC8 Gene

Golgi apparatus, cis-Golgi network.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC8 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IBA --
GO:1990072 TRAPPIII protein complex IBA --
genes like me logo Genes that share ontologies with TRAPPC8: view

Pathways & Interactions for TRAPPC8 Gene

genes like me logo Genes that share pathways with TRAPPC8: view

Pathways by source for TRAPPC8 Gene

Gene Ontology (GO) - Biological Process for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0030242 pexophagy IBA --
GO:0032258 NOT CVT pathway IBA --
genes like me logo Genes that share ontologies with TRAPPC8: view

No data available for SIGNOR curated interactions for TRAPPC8 Gene

Drugs & Compounds for TRAPPC8 Gene

No Compound Related Data Available

Transcripts for TRAPPC8 Gene

Unigene Clusters for TRAPPC8 Gene

Trafficking protein particle complex 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c · 32d
SP1: - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TRAPPC8 Gene

GeneLoc Exon Structure for
TRAPPC8
ECgene alternative splicing isoforms for
TRAPPC8

Expression for TRAPPC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC8 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC8 Gene

This gene is overexpressed in Breast (26.2), Peripheral blood mononuclear cells (11.4), and Lymph node (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC8 Gene



Protein tissue co-expression partners for TRAPPC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC8 Gene:

TRAPPC8

SOURCE GeneReport for Unigene cluster for TRAPPC8 Gene:

Hs.202001

Evidence on tissue expression from TISSUES for TRAPPC8 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TRAPPC8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC8 Gene

Orthologs for TRAPPC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC8 34 35
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 95 (a)
OneToMany
TRAPPC8 34
  • 91.89 (n)
-- 35
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRAPPC8 34 35
  • 94.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TRAPPC8 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc8 34 16 35
  • 88.63 (n)
rat
(Rattus norvegicus)
Mammalia Trappc8 34
  • 87.65 (n)
chicken
(Gallus gallus)
Aves TRAPPC8 34 35
  • 80.97 (n)
lizard
(Anolis carolinensis)
Reptilia TRAPPC8 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc8 34
  • 73.66 (n)
zebrafish
(Danio rerio)
Actinopterygii TRAPPC8 35
  • 66 (a)
OneToOne
trappc8 34
  • 63.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(3)76BDm 34 35
  • 44.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006965 34
  • 41.92 (n)
worm
(Caenorhabditis elegans)
Secernentea trpp-8 35
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16280 34
  • 44.74 (n)
rice
(Oryza sativa)
Liliopsida Os03g0786900 34
  • 45.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for TRAPPC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC8 Gene

ENSEMBL:
Gene Tree for TRAPPC8 (if available)
TreeFam:
Gene Tree for TRAPPC8 (if available)

Paralogs for TRAPPC8 Gene

(1) SIMAP similar genes for TRAPPC8 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRAPPC8: view

No data available for Paralogs for TRAPPC8 Gene

Variants for TRAPPC8 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC8 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs754569032 A breast cancer sample 31,890,853(+) CACTT(C/T)GAAGA nc-transcript-variant, reference, missense
rs1000001596 -- 31,834,921(+) CTCTT(C/T)GTGTT intron-variant
rs1000002891 -- 31,910,586(+) TTTTA(C/T)TGATC intron-variant, upstream-variant-2KB
rs1000029841 -- 31,920,504(+) TTCTT(-/ATAAA)AGAGG intron-variant
rs1000039731 -- 31,928,294(+) AGAAG(C/T)TCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC8 Gene

Variant ID Type Subtype PubMed ID
esv1720728 CNV insertion 17803354
esv2855347 CNV duplication 24192839
esv3642135 CNV gain 21293372
esv3642136 CNV gain 21293372
esv3642140 CNV gain 21293372
esv3642141 CNV loss 21293372
esv3893086 CNV gain 25118596
esv990849 CNV deletion 20482838
nsv1057229 CNV gain 25217958
nsv1067252 CNV gain 25217958
nsv1117196 CNV tandem duplication 24896259
nsv1138617 CNV deletion 24896259
nsv131072 CNV deletion 16902084
nsv2247 CNV deletion 18451855
nsv820095 CNV loss 19587683

Variation tolerance for TRAPPC8 Gene

Residual Variation Intolerance Score: 8.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.04; 93.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAPPC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC8 Gene

Disorders for TRAPPC8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAPPC8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 18
  • alzheimer's disease 18
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRAPPC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC8
genes like me logo Genes that share disorders with TRAPPC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC8 Gene

Publications for TRAPPC8 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin A.-C. … Superti-Furga G. (Nature 2002) 3 4 64

Products for TRAPPC8 Gene

Sources for TRAPPC8 Gene

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