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Aliases for TRAPPC8 Gene

Aliases for TRAPPC8 Gene

  • Trafficking Protein Particle Complex 8 2 3
  • KIAA1012 2 3 4 6
  • Protein TRS85 Homolog 3 4
  • General Sporulation Gene 1 Homolog (S. Cerevisiae) 2
  • Trafficking Protein Particle Complex Subunit 8 3
  • General Sporulation Gene 1 Homolog 3
  • HsT2706 3
  • TRS85 3
  • GSG1 3

External Ids for TRAPPC8 Gene

Previous HGNC Symbols for TRAPPC8 Gene

  • KIAA1012

Previous GeneCards Identifiers for TRAPPC8 Gene

  • GC00U913618
  • GC18M029409
  • GC18M026266

Summaries for TRAPPC8 Gene

GeneCards Summary for TRAPPC8 Gene

TRAPPC8 (Trafficking Protein Particle Complex 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TRAPPC8 Gene

  • May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Gene Wiki entry for TRAPPC8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC8 Gene

Genomics for TRAPPC8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAPPC8 Gene

Start:
31,829,173 bp from pter
End:
31,953,136 bp from pter
Size:
123,964 bases
Orientation:
Minus strand

Genomic View for TRAPPC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC8 Gene

No data available for Regulatory Elements for TRAPPC8 Gene

Proteins for TRAPPC8 Gene

  • Protein details for TRAPPC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2L5-TPPC8_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 8
    Protein Accession:
    Q9Y2L5
    Secondary Accessions:
    • A0JP15
    • B3KME5
    • Q9H0L2

    Protein attributes for TRAPPC8 Gene

    Size:
    1435 amino acids
    Molecular mass:
    160997 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    SequenceCaution:
    • Sequence=AAI27110.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI27111.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA76856.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG50957.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC8 Gene

Proteomics data for TRAPPC8 Gene at MOPED

Post-translational modifications for TRAPPC8 Gene

  • Ubiquitination at Lys1288
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAPPC8 Gene

No data available for DME Specific Peptides for TRAPPC8 Gene

Domains for TRAPPC8 Gene

Gene Families for TRAPPC8 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Protein Domains for TRAPPC8 Gene

Suggested Antigen Peptide Sequences for TRAPPC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2L5

UniProtKB/Swiss-Prot:

TPPC8_HUMAN :
  • Q9Y2L5
Family:
  • Belongs to the TRS85 family.
genes like me logo Genes that share domains with TRAPPC8: view

Function for TRAPPC8 Gene

Molecular function for TRAPPC8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Gene Ontology (GO) - Molecular Function for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21453443
genes like me logo Genes that share ontologies with TRAPPC8: view

Phenotypes for TRAPPC8 Gene

GenomeRNAi human phenotypes for TRAPPC8:
genes like me logo Genes that share phenotypes with TRAPPC8: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC8 Gene

miRTarBase miRNAs that target TRAPPC8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAPPC8 Gene

Localization for TRAPPC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC8 Gene

Golgi apparatus, cis-Golgi network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC8 Gene COMPARTMENTS Subcellular localization image for TRAPPC8 gene
Compartment Confidence
golgi apparatus 3
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005794 Golgi apparatus --
GO:0031410 cytoplasmic vesicle IBA --
GO:1990072 TRAPPIII protein complex IBA --
genes like me logo Genes that share ontologies with TRAPPC8: view

Pathways for TRAPPC8 Gene

SuperPathways for TRAPPC8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0016192 vesicle-mediated transport --
GO:0030242 peroxisome degradation IBA --
GO:0032258 CVT pathway IBA --
genes like me logo Genes that share ontologies with TRAPPC8: view

No data available for Pathways by source for TRAPPC8 Gene

Transcripts for TRAPPC8 Gene

Unigene Clusters for TRAPPC8 Gene

Trafficking protein particle complex 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c · 32d
SP1: - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TRAPPC8 Gene

GeneLoc Exon Structure for
TRAPPC8
ECgene alternative splicing isoforms for
TRAPPC8

Expression for TRAPPC8 Gene

mRNA expression in normal human tissues for TRAPPC8 Gene

Protein differential expression in normal tissues for TRAPPC8 Gene

This gene is overexpressed in Breast (26.2), Peripheral blood mononuclear cells (11.4), and Lymph node (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC8 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC8 Gene Hs.202001

genes like me logo Genes that share expressions with TRAPPC8: view

Expression partners for TRAPPC8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC8 Gene

Orthologs for TRAPPC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAPPC8 35
  • 91.89 (n)
  • 94.13 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRAPPC8 35
  • 94.35 (n)
  • 96.58 (a)
TRAPPC8 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc8 35
  • 88.63 (n)
  • 91.98 (a)
Trappc8 16
Trappc8 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC8 35
  • 99.7 (n)
  • 99.51 (a)
TRAPPC8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc8 35
  • 87.65 (n)
  • 91.28 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAPPC8 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRAPPC8 35
  • 80.97 (n)
  • 85.65 (a)
TRAPPC8 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC8 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc8 35
  • 73.66 (n)
  • 78.31 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc8 35
  • 63.69 (n)
  • 69.12 (a)
TRAPPC8 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006965 35
  • 41.92 (n)
  • 34.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)76BDm 35
  • 44.64 (n)
  • 35.77 (a)
l(3)76BDm 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trpp-8 36
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16280 35
  • 44.74 (n)
  • 31.64 (a)
rice
(Oryza sativa)
Liliopsida Os03g0786900 35
  • 45.31 (n)
  • 31.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for TRAPPC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC8 Gene

ENSEMBL:
Gene Tree for TRAPPC8 (if available)
TreeFam:
Gene Tree for TRAPPC8 (if available)

Paralogs for TRAPPC8 Gene

Selected SIMAP similar genes for TRAPPC8 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRAPPC8: view

No data available for Paralogs for TRAPPC8 Gene

Variants for TRAPPC8 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC8 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1915 -- 31,883,772(-) TTTTT(A/G)GAACT intron-variant
rs503454 -- 31,839,809(-) atcac(A/C)accac intron-variant
rs503457 -- 31,839,806(-) accac(A/C)acctt intron-variant
rs506446 -- 31,831,759(+) TATAC(A/C)AAAAT intron-variant
rs520531 -- 31,900,242(+) aaaaa(A/C)cagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC8 Gene

Variant ID Type Subtype PubMed ID
nsv2247 CNV Loss 18451855
esv990849 CNV Deletion 20482838
nsv820095 CNV Loss 19587683
nsv131072 CNV Loss 16902084
esv1720728 CNV Insertion 17803354

Relevant External Links for TRAPPC8 Gene

HapMap Linkage Disequilibrium report
TRAPPC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC8 Gene

Disorders for TRAPPC8 Gene

No disorders were found for TRAPPC8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TRAPPC8 Gene

Publications for TRAPPC8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin A.-C. … Superti-Furga G. (Nature 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 3 4

Products for TRAPPC8 Gene

Sources for TRAPPC8 Gene

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