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Aliases for TRAPPC6B Gene

Aliases for TRAPPC6B Gene

  • Trafficking Protein Particle Complex 6B 2 3
  • TPC6 3 6
  • Trafficking Protein Particle Complex Subunit 6B 3

External Ids for TRAPPC6B Gene

Summaries for TRAPPC6B Gene

Entrez Gene Summary for TRAPPC6B Gene

  • TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRAPPC6B Gene

TRAPPC6B (Trafficking Protein Particle Complex 6B) is a Protein Coding gene. An important paralog of this gene is TRAPPC6A.

UniProtKB/Swiss-Prot for TRAPPC6B Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC6B Gene

Genomics for TRAPPC6B Gene

Genomic Location for TRAPPC6B Gene

Start:
39,147,811 bp from pter
End:
39,170,532 bp from pter
Size:
22,722 bases
Orientation:
Minus strand

Genomic View for TRAPPC6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC6B Gene

Regulatory Elements for TRAPPC6B Gene

Proteins for TRAPPC6B Gene

  • Protein details for TRAPPC6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SZ2-TPC6B_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 6B
    Protein Accession:
    Q86SZ2
    Secondary Accessions:
    • B3KPS2
    • Q5JPD6
    • Q86U35
    • Q86X35

    Protein attributes for TRAPPC6B Gene

    Size:
    158 amino acids
    Molecular mass:
    17983 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex. Homodimer. Heterodimer with TRAPPC3.
    SequenceCaution:
    • Sequence=CAD62341.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAPPC6B Gene

    Alternative splice isoforms for TRAPPC6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC6B Gene

Proteomics data for TRAPPC6B Gene at MOPED

Post-translational modifications for TRAPPC6B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys109

Other Protein References for TRAPPC6B Gene

No data available for DME Specific Peptides for TRAPPC6B Gene

Domains for TRAPPC6B Gene

Gene Families for TRAPPC6B Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Protein Domains for TRAPPC6B Gene

UniProtKB/Swiss-Prot:

TPC6B_HUMAN
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.:
    • Q86SZ2
genes like me logo Genes that share domains with TRAPPC6B: view

Function for TRAPPC6B Gene

Molecular function for TRAPPC6B Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Ontology (GO) - Molecular Function for TRAPPC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18930054
genes like me logo Genes that share ontologies with TRAPPC6B: view

Phenotypes for TRAPPC6B Gene

GenomeRNAi human phenotypes for TRAPPC6B:
genes like me logo Genes that share phenotypes with TRAPPC6B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRAPPC6B Gene

Localization for TRAPPC6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC6B Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC6B Gene COMPARTMENTS Subcellular localization image for TRAPPC6B gene
Compartment Confidence
golgi apparatus 3
cytosol 2
endoplasmic reticulum 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRAPPC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with TRAPPC6B: view

Pathways for TRAPPC6B Gene

SuperPathways for TRAPPC6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC6B: view

No data available for Pathways by source for TRAPPC6B Gene

Compounds for TRAPPC6B Gene

(1) Drugbank Compounds for TRAPPC6B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-PALMITOYL-L-CYSTEINE
target
genes like me logo Genes that share compounds with TRAPPC6B: view

Transcripts for TRAPPC6B Gene

Unigene Clusters for TRAPPC6B Gene

Trafficking protein particle complex 6B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC6B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for TRAPPC6B Gene

GeneLoc Exon Structure for
TRAPPC6B
ECgene alternative splicing isoforms for
TRAPPC6B

Expression for TRAPPC6B Gene

mRNA expression in normal human tissues for TRAPPC6B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC6B Gene

SOURCE GeneReport for Unigene cluster for TRAPPC6B Gene Hs.13303

genes like me logo Genes that share expressions with TRAPPC6B: view

Orthologs for TRAPPC6B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC6B 36
  • 99.37 (n)
  • 100 (a)
TRAPPC6B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC6B 36
  • 96.41 (n)
  • 100 (a)
TRAPPC6B 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC6B 36
  • 97.26 (n)
  • 100 (a)
TRAPPC6B 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc6b 36
  • 92.19 (n)
  • 97.47 (a)
Trappc6b 16
Trappc6b 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 91 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC6B 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc6b 36
  • 94.09 (n)
  • 98.73 (a)
chicken
(Gallus gallus)
Aves TRAPPC6B 36
  • 83.97 (n)
  • 94.3 (a)
TRAPPC6B 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC6B 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52668 36
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc6b 36
  • 79.96 (n)
  • 91.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13840 36
zebrafish
(Danio rerio)
Actinopterygii trappc6b 36
  • 72.61 (n)
  • 84.08 (a)
trappc6b 37
  • 83 (a)
OneToOne
zgc66304 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002385 36
  • 60.35 (n)
  • 60.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6196 36
  • 55.19 (n)
  • 55.63 (a)
CG6196 37
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_K08H10.9 36
  • 52.28 (n)
  • 48.2 (a)
trpp-6 37
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS33 37
  • 20 (a)
OneToMany
TRS33 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05000 36
  • 59.02 (n)
  • 54.92 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2066 36
rice
(Oryza sativa)
Liliopsida Os07g0291100 36
  • 57.92 (n)
  • 54.92 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7375 36
bread mold
(Neurospora crassa)
Ascomycetes NCU06212 36
  • 53.85 (n)
  • 53.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs33 36
  • 48.48 (n)
  • 36.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 74 (a)
OneToMany
Species with no ortholog for TRAPPC6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TRAPPC6B Gene

ENSEMBL:
Gene Tree for TRAPPC6B (if available)
TreeFam:
Gene Tree for TRAPPC6B (if available)

Paralogs for TRAPPC6B Gene

Paralogs for TRAPPC6B Gene

Selected SIMAP similar genes for TRAPPC6B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAPPC6B: view

Variants for TRAPPC6B Gene

Sequence variations from dbSNP and Humsavar for TRAPPC6B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2869 -- 39,147,899(+) TTCAA(C/T)TGTCC utr-variant-3-prime
rs53416 -- 39,169,342(-) TACTT(A/C)TAATA intron-variant
rs175341 -- 39,170,326(-) ACTTT(A/C)GTTCG utr-variant-5-prime
rs175342 -- 39,165,555(-) agcct(A/C)ctacg intron-variant
rs175343 -- 39,164,633(-) cctcg(A/T)actcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC6B Gene

Variant ID Type Subtype PubMed ID
esv27326 CNV Loss 19812545
esv2670683 CNV Deletion 23128226
nsv85488 CNV Loss 16902084

Relevant External Links for TRAPPC6B Gene

HapMap Linkage Disequilibrium report
TRAPPC6B

Disorders for TRAPPC6B Gene

Relevant External Links for TRAPPC6B

Genetic Association Database (GAD)
TRAPPC6B
genes like me logo Genes that share disorders with TRAPPC6B: view

No data available for UniProtKB/Swiss-Prot for TRAPPC6B Gene

Publications for TRAPPC6B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex. (PMID: 16025134) Kuemmel D. … Heinemann U. (EMBO Rep. 2005) 3 4
  4. A mouse TRAPP-related protein is involved in pigmentation. (PMID: 16697553) Gwynn B. … Peters L.L. (Genomics 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TRAPPC6B Gene

Sources for TRAPPC6B Gene

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