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Aliases for TRAPPC6B Gene

Aliases for TRAPPC6B Gene

  • Trafficking Protein Particle Complex 6B 2 3 5
  • TPC6 3

External Ids for TRAPPC6B Gene

Previous GeneCards Identifiers for TRAPPC6B Gene

  • GC14M037607
  • GC14M038686
  • GC14M039617
  • GC14M019731

Summaries for TRAPPC6B Gene

Entrez Gene Summary for TRAPPC6B Gene

  • TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRAPPC6B Gene

TRAPPC6B (Trafficking Protein Particle Complex 6B) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is TRAPPC6A.

UniProtKB/Swiss-Prot for TRAPPC6B Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC6B Gene

Genomics for TRAPPC6B Gene

Regulatory Elements for TRAPPC6B Gene

Enhancers for TRAPPC6B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAPPC6B on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC6B on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC6B Gene

39,147,811 bp from pter
39,170,532 bp from pter
22,722 bases
Minus strand

Genomic View for TRAPPC6B Gene

Genes around TRAPPC6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC6B Gene

Proteins for TRAPPC6B Gene

  • Protein details for TRAPPC6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 6B
    Protein Accession:
    Secondary Accessions:
    • B3KPS2
    • Q5JPD6
    • Q86U35
    • Q86X35

    Protein attributes for TRAPPC6B Gene

    158 amino acids
    Molecular mass:
    17983 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex. Homodimer. Heterodimer with TRAPPC3.
    • Sequence=CAD62341.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAPPC6B Gene

    Alternative splice isoforms for TRAPPC6B Gene


neXtProt entry for TRAPPC6B Gene

Proteomics data for TRAPPC6B Gene at MOPED

Post-translational modifications for TRAPPC6B Gene

  • Ubiquitination at Lys 109
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAPPC6B Gene

No data available for DME Specific Peptides for TRAPPC6B Gene

Domains & Families for TRAPPC6B Gene

Gene Families for TRAPPC6B Gene

Protein Domains for TRAPPC6B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPP small subunits family. BET3 subfamily.
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC6B: view

Function for TRAPPC6B Gene

Molecular function for TRAPPC6B Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
genes like me logo Genes that share phenotypes with TRAPPC6B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC6B Gene

Localization for TRAPPC6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC6B Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for TRAPPC6B Gene COMPARTMENTS Subcellular localization image for TRAPPC6B gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endoplasmic reticulum 3
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TRAPPC6B Gene

Pathways & Interactions for TRAPPC6B Gene

genes like me logo Genes that share pathways with TRAPPC6B: view

Gene Ontology (GO) - Biological Process for TRAPPC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC6B: view

No data available for SIGNOR curated interactions for TRAPPC6B Gene

Drugs & Compounds for TRAPPC6B Gene

(1) Drugs for TRAPPC6B Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC6B: view

Transcripts for TRAPPC6B Gene

Unigene Clusters for TRAPPC6B Gene

Trafficking protein particle complex 6B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC6B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - -

Relevant External Links for TRAPPC6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC6B Gene

mRNA expression in normal human tissues for TRAPPC6B Gene

Protein differential expression in normal tissues from HIPED for TRAPPC6B Gene

This gene is overexpressed in Cardia (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC6B Gene

SOURCE GeneReport for Unigene cluster for TRAPPC6B Gene Hs.13303

genes like me logo Genes that share expression patterns with TRAPPC6B: view

Protein tissue co-expression partners for TRAPPC6B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC6B Gene

Orthologs for TRAPPC6B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC6B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRAPPC6B 35
  • 96.41 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia TRAPPC6B 35
  • 97.26 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Trappc6b 35
  • 92.19 (n)
  • 97.47 (a)
Trappc6b 16
Trappc6b 36
  • 97 (a)
(Pan troglodytes)
Mammalia TRAPPC6B 35
  • 99.37 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Trappc6b 35
  • 94.09 (n)
  • 98.73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
-- 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia TRAPPC6B 36
  • 98 (a)
(Gallus gallus)
Aves TRAPPC6B 35
  • 83.97 (n)
  • 94.3 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia TRAPPC6B 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc6b 35
  • 79.96 (n)
  • 91.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52668 35
(Danio rerio)
Actinopterygii trappc6b 35
  • 72.61 (n)
  • 84.08 (a)
zgc66304 35
trappc6b 36
  • 83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13840 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002385 35
  • 60.35 (n)
  • 60.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6196 35
  • 55.19 (n)
  • 55.63 (a)
CG6196 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea CELE_K08H10.9 35
  • 52.28 (n)
  • 48.2 (a)
trpp-6 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS33 36
  • 20 (a)
TRS33 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05000 35
  • 59.02 (n)
  • 54.92 (a)
(Hordeum vulgare)
Liliopsida Hv.2066 35
(Oryza sativa)
Liliopsida Os07g0291100 35
  • 57.92 (n)
  • 54.92 (a)
(Triticum aestivum)
Liliopsida Ta.7375 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06212 35
  • 53.85 (n)
  • 53.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs33 35
  • 48.48 (n)
  • 36.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
Species with no ortholog for TRAPPC6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TRAPPC6B Gene

Gene Tree for TRAPPC6B (if available)
Gene Tree for TRAPPC6B (if available)

Paralogs for TRAPPC6B Gene

Paralogs for TRAPPC6B Gene

(1) SIMAP similar genes for TRAPPC6B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAPPC6B: view

Variants for TRAPPC6B Gene

Sequence variations from dbSNP and Humsavar for TRAPPC6B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs53416 -- 39,169,342(-) TACTT(A/C)TAATA intron-variant
rs175341 -- 39,170,326(-) ACTTT(A/C)GTTCG utr-variant-5-prime
rs175342 -- 39,165,555(-) agcct(A/C)ctacg intron-variant
rs175343 -- 39,164,633(-) cctcg(A/T)actcc intron-variant
rs175344 -- 39,164,480(-) agttt(C/T)actgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC6B Gene

Variant ID Type Subtype PubMed ID
esv27326 CNV Loss 19812545
esv2670683 CNV Deletion 23128226
nsv85488 CNV Loss 16902084

Variation tolerance for TRAPPC6B Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRAPPC6B Gene

Disorders for TRAPPC6B Gene

Relevant External Links for TRAPPC6B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRAPPC6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC6B Gene

Publications for TRAPPC6B Gene

  1. The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex. (PMID: 16025134) Kuemmel D. … Heinemann U. (EMBO Rep. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 3
  5. Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells. (PMID: 18930054) KA1mmel D. … Heinemann U. (FEBS Lett. 2008) 3

Products for TRAPPC6B Gene

Sources for TRAPPC6B Gene