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Aliases for TRAPPC6A Gene

Aliases for TRAPPC6A Gene

  • Trafficking Protein Particle Complex 6A 2 3 5
  • TRAPP Complex Subunit 6A 3 4
  • TRS33 3

External Ids for TRAPPC6A Gene

Previous GeneCards Identifiers for TRAPPC6A Gene

  • GC00U913616
  • GC19M050360
  • GC19M045666
  • GC19M042096

Summaries for TRAPPC6A Gene

Entrez Gene Summary for TRAPPC6A Gene

  • This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for TRAPPC6A Gene

TRAPPC6A (Trafficking Protein Particle Complex 6A) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is TRAPPC6B.

UniProtKB/Swiss-Prot for TRAPPC6A Gene

  • May play a role in vesicular transport during the biogenesis of melanosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC6A Gene

Genomics for TRAPPC6A Gene

Regulatory Elements for TRAPPC6A Gene

Enhancers for TRAPPC6A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAPPC6A on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC6A on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC6A Gene

Chromosome:
19
Start:
45,162,928 bp from pter
End:
45,178,243 bp from pter
Size:
15,316 bases
Orientation:
Minus strand

Genomic View for TRAPPC6A Gene

Genes around TRAPPC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC6A Gene

Proteins for TRAPPC6A Gene

  • Protein details for TRAPPC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75865-TPC6A_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 6A
    Protein Accession:
    O75865
    Secondary Accessions:
    • K7ERB1
    • K7ERQ4
    • Q9BQ45
    • Q9P092

    Protein attributes for TRAPPC6A Gene

    Size:
    159 amino acids
    Molecular mass:
    17605 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex. Heterodimer with TRAPPC3. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L.
    SequenceCaution:
    • Sequence=AAC62259.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF28967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAPPC6A Gene

    Alternative splice isoforms for TRAPPC6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC6A Gene

Proteomics data for TRAPPC6A Gene at MOPED

Post-translational modifications for TRAPPC6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC6A Gene

Antibody Products

No data available for DME Specific Peptides for TRAPPC6A Gene

Domains & Families for TRAPPC6A Gene

Gene Families for TRAPPC6A Gene

Protein Domains for TRAPPC6A Gene

Suggested Antigen Peptide Sequences for TRAPPC6A Gene

Graphical View of Domain Structure for InterPro Entry

O75865

UniProtKB/Swiss-Prot:

TPC6A_HUMAN :
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC6A: view

Function for TRAPPC6A Gene

Molecular function for TRAPPC6A Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport during the biogenesis of melanosomes.
genes like me logo Genes that share phenotypes with TRAPPC6A: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC6A Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC6A Gene

Localization for TRAPPC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC6A Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC6A Gene COMPARTMENTS Subcellular localization image for TRAPPC6A gene
Compartment Confidence
cytosol 5
golgi apparatus 4
endoplasmic reticulum 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TRAPPC6A Gene

Pathways & Interactions for TRAPPC6A Gene

genes like me logo Genes that share pathways with TRAPPC6A: view

Gene Ontology (GO) - Biological Process for TRAPPC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0048208 COPII vesicle coating TAS --
GO:0061024 membrane organization TAS --
GO:1903232 melanosome assembly IEA --
genes like me logo Genes that share ontologies with TRAPPC6A: view

No data available for SIGNOR curated interactions for TRAPPC6A Gene

Drugs & Compounds for TRAPPC6A Gene

(1) Drugs for TRAPPC6A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC6A: view

Transcripts for TRAPPC6A Gene

Unigene Clusters for TRAPPC6A Gene

Trafficking protein particle complex 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC6A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -

Relevant External Links for TRAPPC6A Gene

GeneLoc Exon Structure for
TRAPPC6A
ECgene alternative splicing isoforms for
TRAPPC6A

Expression for TRAPPC6A Gene

mRNA expression in normal human tissues for TRAPPC6A Gene

Protein differential expression in normal tissues from HIPED for TRAPPC6A Gene

This gene is overexpressed in Serum (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC6A Gene



SOURCE GeneReport for Unigene cluster for TRAPPC6A Gene Hs.466929

genes like me logo Genes that share expression patterns with TRAPPC6A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRAPPC6A Gene

Orthologs for TRAPPC6A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC6A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAPPC6A 35
  • 88.4 (n)
  • 89.24 (a)
TRAPPC6A 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC6A 35
  • 88.89 (n)
  • 90.57 (a)
TRAPPC6A 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc6a 35
  • 85.12 (n)
  • 83.02 (a)
Trappc6a 16
Trappc6a 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc6a 35
  • 85.74 (n)
  • 85.53 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAPPC6A 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC6A 36
  • 42 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC6A 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trappc6bl 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6196 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trpp-6 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS33 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for TRAPPC6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRAPPC6A Gene

ENSEMBL:
Gene Tree for TRAPPC6A (if available)
TreeFam:
Gene Tree for TRAPPC6A (if available)

Paralogs for TRAPPC6A Gene

Paralogs for TRAPPC6A Gene

(1) SIMAP similar genes for TRAPPC6A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRAPPC6A: view

Variants for TRAPPC6A Gene

Sequence variations from dbSNP and Humsavar for TRAPPC6A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7260565 -- 45,176,309(+) aaaaa(A/C)caaaa intron-variant
rs12977014 -- 45,167,734(+) cacct(C/T)ggcct intron-variant
rs28367893 -- 45,170,443(+) GAGTG(A/G)GCTGT intron-variant
rs71338749 -- 45,168,300(+) CCCGG(-/C)CCCTG intron-variant
rs28555639 -- 45,173,106(+) GACAA(A/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC6A Gene

Variant ID Type Subtype PubMed ID
nsv912142 CNV Loss 21882294
nsv833842 CNV Loss 17160897
nsv833843 CNV Loss 17160897
nsv912143 CNV Loss 21882294
nsv912144 CNV Loss 21882294
esv2668324 CNV Deletion 23128226
nsv828565 CNV Gain 20364138
esv1005203 CNV Deletion 20482838
esv2422482 CNV Duplication 17116639

Variation tolerance for TRAPPC6A Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC6A Gene

HapMap Linkage Disequilibrium report
TRAPPC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC6A Gene

Disorders for TRAPPC6A Gene

Relevant External Links for TRAPPC6A

Genetic Association Database (GAD)
TRAPPC6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC6A

No disorders were found for TRAPPC6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC6A Gene

Publications for TRAPPC6A Gene

  1. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Protein interactions of the transcription factor Hoxa1. (PMID: 23088713) Lambert B. … Rezsohazy R. (BMC Dev. Biol. 2012) 3

Products for TRAPPC6A Gene

Sources for TRAPPC6A Gene

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