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Aliases for TRAPPC6A Gene

Aliases for TRAPPC6A Gene

  • Trafficking Protein Particle Complex 6A 2 3
  • TRAPP Complex Subunit 6A 3 4
  • Trafficking Protein Particle Complex Subunit 6A 3
  • TRS33 3

External Ids for TRAPPC6A Gene

Summaries for TRAPPC6A Gene

Entrez Gene Summary for TRAPPC6A Gene

  • This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for TRAPPC6A Gene

TRAPPC6A (Trafficking Protein Particle Complex 6A) is a Protein Coding gene. An important paralog of this gene is TRAPPC6B.

UniProtKB/Swiss-Prot for TRAPPC6A Gene

  • May play a role in vesicular transport during the biogenesis of melanosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC6A Gene

Genomics for TRAPPC6A Gene

Genomic Location for TRAPPC6A Gene

45,162,928 bp from pter
45,178,243 bp from pter
15,316 bases
Minus strand

Genomic View for TRAPPC6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC6A Gene

Regulatory Elements for TRAPPC6A Gene

Proteins for TRAPPC6A Gene

  • Protein details for TRAPPC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 6A
    Protein Accession:
    Secondary Accessions:
    • K7ERB1
    • K7ERQ4
    • Q9BQ45
    • Q9P092

    Protein attributes for TRAPPC6A Gene

    159 amino acids
    Molecular mass:
    17605 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex. Heterodimer with TRAPPC3. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L.
    • Sequence=AAC62259.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF28967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAPPC6A Gene

    Alternative splice isoforms for TRAPPC6A Gene


neXtProt entry for TRAPPC6A Gene

Proteomics data for TRAPPC6A Gene at MOPED

Post-translational modifications for TRAPPC6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC6A Gene

No data available for DME Specific Peptides for TRAPPC6A Gene

Domains for TRAPPC6A Gene

Gene Families for TRAPPC6A Gene

  • TRAPPC :Trafficking protein particle complex

Protein Domains for TRAPPC6A Gene


  • Belongs to the TRAPP small subunits family. BET3 subfamily.:
    • O75865
genes like me logo Genes that share domains with TRAPPC6A: view

Function for TRAPPC6A Gene

Molecular function for TRAPPC6A Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport during the biogenesis of melanosomes.

Gene Ontology (GO) - Molecular Function for TRAPPC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRAPPC6A: view

Phenotypes for TRAPPC6A Gene

genes like me logo Genes that share phenotypes with TRAPPC6A: view

miRNA for TRAPPC6A Gene

miRTarBase miRNAs that target TRAPPC6A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAPPC6A Gene

Localization for TRAPPC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC6A Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for TRAPPC6A Gene COMPARTMENTS Subcellular localization image for TRAPPC6A gene
Compartment Confidence
golgi apparatus 3
cytosol 2
endoplasmic reticulum 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRAPPC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with TRAPPC6A: view

Pathways for TRAPPC6A Gene

SuperPathways for TRAPPC6A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC6A: view

No data available for Pathways by source for TRAPPC6A Gene

Compounds for TRAPPC6A Gene

(1) Drugbank Compounds for TRAPPC6A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
genes like me logo Genes that share compounds with TRAPPC6A: view

Transcripts for TRAPPC6A Gene

Unigene Clusters for TRAPPC6A Gene

Trafficking protein particle complex 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC6A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP3: - -

Relevant External Links for TRAPPC6A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC6A Gene

mRNA expression in normal human tissues for TRAPPC6A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC6A Gene

SOURCE GeneReport for Unigene cluster for TRAPPC6A Gene Hs.466929

genes like me logo Genes that share expressions with TRAPPC6A: view

Orthologs for TRAPPC6A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC6A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC6A 37
  • 71 (a)
(Bos Taurus)
Mammalia TRAPPC6A 36
  • 88.4 (n)
  • 89.24 (a)
  • 89 (a)
(Canis familiaris)
Mammalia TRAPPC6A 36
  • 88.89 (n)
  • 90.57 (a)
  • 75 (a)
(Mus musculus)
Mammalia Trappc6a 36
  • 85.12 (n)
  • 83.02 (a)
Trappc6a 16
Trappc6a 37
  • 83 (a)
(Monodelphis domestica)
Mammalia TRAPPC6A 37
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia TRAPPC6A 37
  • 42 (a)
(Rattus norvegicus)
Mammalia Trappc6a 36
  • 85.74 (n)
  • 85.53 (a)
(Danio rerio)
Actinopterygii trappc6bl 37
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6196 37
  • 41 (a)
(Caenorhabditis elegans)
Secernentea trpp-6 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS33 37
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
Species with no ortholog for TRAPPC6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRAPPC6A Gene

Gene Tree for TRAPPC6A (if available)
Gene Tree for TRAPPC6A (if available)

Paralogs for TRAPPC6A Gene

Paralogs for TRAPPC6A Gene

Selected SIMAP similar genes for TRAPPC6A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRAPPC6A: view

Variants for TRAPPC6A Gene

Sequence variations from dbSNP and Humsavar for TRAPPC6A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1048552 -- 45,162,976(-) GGCAG(A/C/T)GTCAC utr-variant-3-prime
rs2240742 -- 45,170,671(+) ATCCC(A/G)TGCCT intron-variant
rs2377007 -- 45,172,271(+) GCCTG(C/T)GCTAC intron-variant
rs3188512 -- 45,163,169(-) TGAGC(C/T)GCACT utr-variant-3-prime
rs4012975 -- 45,173,463(+) GCCTG(C/T)GCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC6A Gene

Variant ID Type Subtype PubMed ID
nsv912142 CNV Loss 21882294
nsv833842 CNV Loss 17160897
nsv833843 CNV Loss 17160897
nsv912143 CNV Loss 21882294
nsv912144 CNV Loss 21882294
esv2668324 CNV Deletion 23128226
nsv828565 CNV Gain 20364138
esv1005203 CNV Deletion 20482838
esv2422482 CNV Duplication 17116639

Relevant External Links for TRAPPC6A Gene

HapMap Linkage Disequilibrium report

Disorders for TRAPPC6A Gene

Relevant External Links for TRAPPC6A

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TRAPPC6A: view

No data available for UniProtKB/Swiss-Prot for TRAPPC6A Gene

Publications for TRAPPC6A Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p. (PMID: 16262728) Kim M.-S. … Sacher M. (Traffic 2005) 3 4
  4. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 49
  5. Entry and exit mechanisms at the cis-face of the Golgi complex. (PMID: 21482742) Lorente-RodrA-guez A. … Barlowe C. (Cold Spring Harb Perspect Biol 2011) 3

Products for TRAPPC6A Gene

Sources for TRAPPC6A Gene

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