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Aliases for TRAPPC6A Gene

Aliases for TRAPPC6A Gene

  • Trafficking Protein Particle Complex 6A 2 3 5
  • TRAPP Complex Subunit 6A 3 4
  • Trafficking Protein Particle Complex Subunit 6A 3
  • TRS33 3

External Ids for TRAPPC6A Gene

Previous GeneCards Identifiers for TRAPPC6A Gene

  • GC00U913616
  • GC19M050360
  • GC19M045666
  • GC19M042096

Summaries for TRAPPC6A Gene

Entrez Gene Summary for TRAPPC6A Gene

  • This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for TRAPPC6A Gene

TRAPPC6A (Trafficking Protein Particle Complex 6A) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is TRAPPC6B.

UniProtKB/Swiss-Prot for TRAPPC6A Gene

  • May play a role in vesicular transport during the biogenesis of melanosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC6A Gene

Genomics for TRAPPC6A Gene

Regulatory Elements for TRAPPC6A Gene

Enhancers for TRAPPC6A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045038 1.1 ENCODE 5.2 +138.2 138177 3.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 YY1 ZNF302 ZNF180 ZNF234 ZNF284 ZNF224 MRPS15P2 ZNF225 ENSG00000267395 GEMIN7 CCDC61 ZNF223
GH19F045438 1.9 FANTOM5 Ensembl ENCODE 1.6 -267.6 -267636 14.2 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 CD3EAP ERCC1 RTN2 CCDC61 RELB PPM1N FBXO46 ZNF180 IGFL4 LOC105372421
GH19F045477 1.5 FANTOM5 ENCODE 1.3 -300.1 -300057 2.4 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ZNF180 IRF2BP1 CD3EAP FBXO46 CCDC61 ENSG00000269148 PPP1R37 PPM1N ENSG00000268810 VASP
GH19F045163 1.3 Ensembl ENCODE 0.4 +13.7 13743 2.2 HDGF ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 ZNF133 ARID4B SIN3A GLI4 ZNF180 RELB PPP1R37 NKPD1 TRAPPC6A
GH19F045170 1.2 Ensembl ENCODE 0.4 +5.6 5648 4.4 HDGF PKNOX1 MLX ARID4B SP3 SP5 PPARG KAT8 SMARCA4 ETV4 GEMIN7 PPP1R37 NKPD1 EIF5AP3 TRAPPC6A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAPPC6A on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000347346 -657 3001 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for TRAPPC6A Gene

Chromosome:
19
Start:
45,162,928 bp from pter
End:
45,178,243 bp from pter
Size:
15,316 bases
Orientation:
Minus strand

Genomic View for TRAPPC6A Gene

Genes around TRAPPC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC6A Gene

Proteins for TRAPPC6A Gene

  • Protein details for TRAPPC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75865-TPC6A_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 6A
    Protein Accession:
    O75865
    Secondary Accessions:
    • K7ERB1
    • K7ERQ4
    • Q9BQ45
    • Q9P092

    Protein attributes for TRAPPC6A Gene

    Size:
    159 amino acids
    Molecular mass:
    17605 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex. Heterodimer with TRAPPC3. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L.
    SequenceCaution:
    • Sequence=AAC62259.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF28967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAPPC6A Gene

    Alternative splice isoforms for TRAPPC6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC6A Gene

Post-translational modifications for TRAPPC6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC6A Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC6A

No data available for DME Specific Peptides for TRAPPC6A Gene

Domains & Families for TRAPPC6A Gene

Gene Families for TRAPPC6A Gene

Suggested Antigen Peptide Sequences for TRAPPC6A Gene

Graphical View of Domain Structure for InterPro Entry

O75865

UniProtKB/Swiss-Prot:

TPC6A_HUMAN :
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC6A: view

Function for TRAPPC6A Gene

Molecular function for TRAPPC6A Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport during the biogenesis of melanosomes.

Gene Ontology (GO) - Molecular Function for TRAPPC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRAPPC6A: view
genes like me logo Genes that share phenotypes with TRAPPC6A: view

Animal Model Products

miRNA for TRAPPC6A Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC6A Gene

Localization for TRAPPC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC6A Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC6A gene
Compartment Confidence
cytosol 5
golgi apparatus 4
endoplasmic reticulum 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRAPPC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network IBA --
GO:0005802 trans-Golgi network IBA --
genes like me logo Genes that share ontologies with TRAPPC6A: view

Pathways & Interactions for TRAPPC6A Gene

genes like me logo Genes that share pathways with TRAPPC6A: view

Gene Ontology (GO) - Biological Process for TRAPPC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0043473 pigmentation IEA --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC6A: view

No data available for SIGNOR curated interactions for TRAPPC6A Gene

Drugs & Compounds for TRAPPC6A Gene

(1) Drugs for TRAPPC6A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC6A: view

Transcripts for TRAPPC6A Gene

Unigene Clusters for TRAPPC6A Gene

Trafficking protein particle complex 6A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC6A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -

Relevant External Links for TRAPPC6A Gene

GeneLoc Exon Structure for
TRAPPC6A
ECgene alternative splicing isoforms for
TRAPPC6A

Expression for TRAPPC6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAPPC6A Gene

Protein differential expression in normal tissues from HIPED for TRAPPC6A Gene

This gene is overexpressed in Serum (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC6A Gene



NURSA nuclear receptor signaling pathways regulating expression of TRAPPC6A Gene:

TRAPPC6A

SOURCE GeneReport for Unigene cluster for TRAPPC6A Gene:

Hs.466929
genes like me logo Genes that share expression patterns with TRAPPC6A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAPPC6A Gene

Orthologs for TRAPPC6A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC6A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TRAPPC6A 34 35
  • 88.89 (n)
cow
(Bos Taurus)
Mammalia TRAPPC6A 34 35
  • 88.4 (n)
rat
(Rattus norvegicus)
Mammalia Trappc6a 34
  • 85.74 (n)
mouse
(Mus musculus)
Mammalia Trappc6a 34 16 35
  • 85.12 (n)
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC6A 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC6A 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC6A 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trappc6bl 35
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6196 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trpp-6 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS33 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for TRAPPC6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRAPPC6A Gene

ENSEMBL:
Gene Tree for TRAPPC6A (if available)
TreeFam:
Gene Tree for TRAPPC6A (if available)

Paralogs for TRAPPC6A Gene

Paralogs for TRAPPC6A Gene

(1) SIMAP similar genes for TRAPPC6A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TRAPPC6A Gene

genes like me logo Genes that share paralogs with TRAPPC6A: view

Variants for TRAPPC6A Gene

Sequence variations from dbSNP and Humsavar for TRAPPC6A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs281865116 Pathogenic 45,179,744(+) CAGCC(-/C)AGGCG nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs75792246 Likely benign 45,179,618(+) GCTCG(C/G)TCCTG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs148910210 Uncertain significance 45,179,388(+) CTCTG(C/T)GTCCT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs142688123 Benign 45,179,905(+) GCCTA(A/G)CCATG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs182286598 Benign 45,179,440(+) ACGCG(A/C)GGCCG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC6A Gene

Variant ID Type Subtype PubMed ID
nsv953587 CNV deletion 24416366
nsv833843 CNV loss 17160897
nsv833842 CNV loss 17160897
nsv828565 CNV gain 20364138
esv3644500 CNV loss 21293372
esv2668324 CNV deletion 23128226
esv2422482 CNV duplication 17116639
esv1005203 CNV deletion 20482838

Variation tolerance for TRAPPC6A Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAPPC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC6A Gene

Disorders for TRAPPC6A Gene

Relevant External Links for TRAPPC6A

Genetic Association Database (GAD)
TRAPPC6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC6A

No disorders were found for TRAPPC6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC6A Gene

Publications for TRAPPC6A Gene

  1. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 46 64
  2. Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p. (PMID: 16262728) Kim M.-S. … Sacher M. (Traffic 2005) 3 4 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TRAPPC6A Gene

Sources for TRAPPC6A Gene

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