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Aliases for TRAPPC5 Gene

Aliases for TRAPPC5 Gene

  • Trafficking Protein Particle Complex 5 2 3 5
  • TRS31 3

External Ids for TRAPPC5 Gene

Previous GeneCards Identifiers for TRAPPC5 Gene

  • GC19P007640
  • GC19P007651
  • GC19U900665
  • GC19P007745
  • GC19P007415

Summaries for TRAPPC5 Gene

GeneCards Summary for TRAPPC5 Gene

TRAPPC5 (Trafficking Protein Particle Complex 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for TRAPPC5 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC5 Gene

Genomics for TRAPPC5 Gene

Regulatory Elements for TRAPPC5 Gene

Promoters for TRAPPC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC5 Gene

Chromosome:
19
Start:
7,680,821 bp from pter
End:
7,687,703 bp from pter
Size:
6,883 bases
Orientation:
Plus strand

Genomic View for TRAPPC5 Gene

Genes around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC5 Gene

Proteins for TRAPPC5 Gene

  • Protein details for TRAPPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR0-TPPC5_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 5
    Protein Accession:
    Q8IUR0
    Secondary Accessions:
    • A8K7I6

    Protein attributes for TRAPPC5 Gene

    Size:
    188 amino acids
    Molecular mass:
    20783 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

neXtProt entry for TRAPPC5 Gene

Proteomics data for TRAPPC5 Gene at MOPED

Post-translational modifications for TRAPPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC5 Gene

Antibody Products

No data available for DME Specific Peptides for TRAPPC5 Gene

Domains & Families for TRAPPC5 Gene

Gene Families for TRAPPC5 Gene

Suggested Antigen Peptide Sequences for TRAPPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUR0

UniProtKB/Swiss-Prot:

TPPC5_HUMAN :
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC5: view

Function for TRAPPC5 Gene

Molecular function for TRAPPC5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
genes like me logo Genes that share phenotypes with TRAPPC5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAPPC5 Gene

Localization for TRAPPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC5 Gene COMPARTMENTS Subcellular localization image for TRAPPC5 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
endoplasmic reticulum 3
mitochondrion 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TRAPPC5 Gene

Pathways & Interactions for TRAPPC5 Gene

genes like me logo Genes that share pathways with TRAPPC5: view

Gene Ontology (GO) - Biological Process for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC5: view

No data available for SIGNOR curated interactions for TRAPPC5 Gene

Drugs & Compounds for TRAPPC5 Gene

(1) Drugs for TRAPPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC5: view

Transcripts for TRAPPC5 Gene

Unigene Clusters for TRAPPC5 Gene

Trafficking protein particle complex 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3: -
SP4:

Relevant External Links for TRAPPC5 Gene

GeneLoc Exon Structure for
TRAPPC5
ECgene alternative splicing isoforms for
TRAPPC5

Expression for TRAPPC5 Gene

mRNA expression in normal human tissues for TRAPPC5 Gene

mRNA differential expression in normal tissues according to GTEx for TRAPPC5 Gene

This gene is overexpressed in Testis (x11.8) and Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TRAPPC5 Gene

This gene is overexpressed in Nasal epithelium (35.9) and Bone (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC5 Gene



SOURCE GeneReport for Unigene cluster for TRAPPC5 Gene Hs.432413

genes like me logo Genes that share expression patterns with TRAPPC5: view

Protein tissue co-expression partners for TRAPPC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRAPPC5 Gene

Orthologs for TRAPPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC5 36
  • 99 (a)
OneToOne
TRAPPC5 35
  • 99.47 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia TRAPPC5 36
  • 99 (a)
OneToOne
TRAPPC5 35
  • 94.15 (n)
  • 98.94 (a)
dog
(Canis familiaris)
Mammalia TRAPPC5 35
  • 93.97 (n)
  • 98.4 (a)
TRAPPC5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc5 16
Trappc5 35
  • 89.18 (n)
  • 98.94 (a)
Trappc5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC5 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc5 35
  • 88.48 (n)
  • 98.94 (a)
chicken
(Gallus gallus)
Aves TRAPPC5 35
  • 79.79 (n)
  • 80.85 (a)
TRAPPC5 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC5 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2195 35
trappc5 35
  • 67.38 (n)
  • 77.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4571 35
zebrafish
(Danio rerio)
Actinopterygii trappc5 35
  • 73.4 (n)
  • 78.72 (a)
wufc34a11 35
trappc5 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012083 35
  • 64.76 (n)
  • 57.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10153 35
  • 63 (n)
  • 64.29 (a)
CG10153 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trpp-5 36
  • 51 (a)
OneToOne
CELE_Y57A10A.16 35
  • 53.79 (n)
  • 53.41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR408C 35
  • 53.45 (n)
  • 37.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS31 35
  • 41.83 (n)
  • 34.31 (a)
TRS31 36
  • 20 (a)
OneToOne
TRS31 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03345g 35
  • 38.86 (n)
  • 31.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G58030 35
  • 51.64 (n)
  • 51.45 (a)
rice
(Oryza sativa)
Liliopsida Os01g0708600 35
  • 52.83 (n)
  • 53.8 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08874 35
  • 52.33 (n)
  • 45.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs31 35
  • 44.82 (n)
  • 42.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4272 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for TRAPPC5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC5 Gene

ENSEMBL:
Gene Tree for TRAPPC5 (if available)
TreeFam:
Gene Tree for TRAPPC5 (if available)

Paralogs for TRAPPC5 Gene

No data available for Paralogs for TRAPPC5 Gene

Variants for TRAPPC5 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs6952 - 7,682,407(-) GCGCG(A/C)CTGCA reference, missense
rs3826739 -- 7,680,920(-) GGAGC(A/G)GACGA intron-variant, utr-variant-5-prime
rs10405586 -- 7,683,312(+) CACCT(C/T)GGGTT downstream-variant-500B
rs72996477 -- 7,681,744(+) TTCCC(A/G)AGGGT intron-variant
rs80109157 -- 7,682,243(+) GCAGG(C/G)TGGCG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC5 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv910970 CNV Loss 21882294
nsv833731 CNV Loss 17160897
nsv833732 CNV Gain 17160897

Variation tolerance for TRAPPC5 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC5 Gene

HapMap Linkage Disequilibrium report
TRAPPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Disorders for TRAPPC5 Gene

Relevant External Links for TRAPPC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC5

No disorders were found for TRAPPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC5 Gene

Publications for TRAPPC5 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TRAPPC5 Gene

Sources for TRAPPC5 Gene

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