TRAPPC5 Gene
protein-coding GIFtS : 46
GCID: GC19 P007745
trafficking protein particle complex 5
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Aliasesfor TRAPPC5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Trafficking Protein Particle Complex 5 1 2 TRS311 2 MGC524241 Trafficking Protein Particle Complex Subunit 52
Export aliases for TRAPPC5 gene to outside databases Previous GC identifers: GC19P007640 GC19P007651 GC19U900665 GC19P007415
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Summariesfor TRAPPC5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TPPC5_HUMAN, Q8IUR0 Function : May play a role in vesicular transport from endoplasmic reticulum to Golgi
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Genomic Viewsfor TRAPPC5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_077812.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRAPPC5 gene promoter: p300 ATF-2 c-Jun AP-2alpha Other transcription factors Search SABiosciences Chromatin IP Primers for TRAPPC5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRAPPC5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3 TRAPPC5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P007745: view genomic region
(about GC identifiers )
Start:
7,745,707 bp from pter
End:
7,747,748 bp from pter
Size:
2,042 bases
Orientation:
plus strand
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Proteinsfor TRAPPC5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TPPC5_HUMAN, Q8IUR0 (See
protein sequence )Recommended Name: Trafficking protein particle complex subunit 5 Size : 188 amino acids; 20783 Da
Subunit : Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2,TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12
Subcellular location : Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity)
Secondary accessions : A8K7I6Explore the universe of human proteins at neXtProt for TRAPPC5: NX_Q8IUR0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IUR0 TRAPPC5 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts):
NP_001035926.1 NP_001035927.1 NP_777554.1 ENSEMBL proteins: ENSP00000316990 ENSP00000399025 Human Recombinant Protein Products for TRAPPC5: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005783 endoplasmic reticulum
IEA -- GO:0030008 TRAPP complex
IEA --
TRAPPC5 for ontologies About GeneDecksing TRAPPC5 Antibody Products: Assay Products for TRAPPC5:
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Protein
Domains / Familiesfor TRAPPC5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TRAPPC5 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IUR0 ProtoNet protein and cluster: Q8IUR0
1 Blocks protein family : IPB007194 Transport protein particle (TRAPP) component UniProtKB/Swiss-Prot: TPPC5_HUMAN, Q8IUR0 Similarity : Belongs to the TRAPP small subunits family. BET3 subfamily
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Functionfor TRAPPC5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TPPC5_HUMAN, Q8IUR0 Function : May play a role in vesicular transport from endoplasmic reticulum to Golgi
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
-- --
TRAPPC5 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for TRAPPC5 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRAPPC5 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRAPPC5 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): TRAPPC5 (NM_174894 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAPPC5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRAPPC5
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Pathways & Interactionsfor TRAPPC5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRAPPC5 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/12 Interacting proteins for TRAPPC5 (Q8IUR0 3 ENSP00000316990 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 12 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016192 vesicle-mediated transport
IEA --
TRAPPC5 for ontologies About GeneDecksing
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Drugs & Compoundsfor TRAPPC5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TRAPPC5 1 DrugBank Compound for TRAPPC5 About this table Search CenterWatch for drugs/clinical trials and news about TRAPPC5 / TPPC5
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Transcriptsfor TRAPPC5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TRAPPC5 gene (3 alternative transcripts): NM_001042461.2 NM_001042462.1 NM_174894.2 Unigene Cluster for TRAPPC5:
Trafficking protein particle complex 5 Hs.432413 [show with all ESTs ] Unigene Representative Sequence: BU856835 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000317378 (uc002mhi.1 uc002mhj.1 ) ENST00000426877 (uc002mhk.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRAPPC5 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRAPPC5 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): TRAPPC5 (NM_174894 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAPPC5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRAPPC5
Additional cDNA sequence: AK292001.1 BC022836.1 BC042161.1
8 DOTS entries : DT.216673 DT.99982856
DT.91743797 DT.95090061 DT.100820643 DT.100027622 DT.97843586 DT.91743790 24/310 AceView cDNA sequences (see all 310 ):
CR620460 AW135805 BF446463 BU952043 BM504529 AW207248 AI239739 BF002349 AI671423 AW005290 AI869955 AI141521 AI564047 AI343440 BU627000 CR622194 BU850193 AI075441 BM129686 BU689568 AI693817 BU634406 AI037887 AW025316 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC5 About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c SP1 :   -   -           SP2 :               SP3 :     -           SP4 :              
ECgene alternative splicing isoforms for TRAPPC5
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Expression for TRAPPC5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TRAPPC5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATCAAGTTCGAbout this image TRAPPC5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Adipose Visceral White Adipose Adipose Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TRAPPC5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRAPPC5 SOURCE GeneReport for Unigene cluster: Hs.432413 SABiosciences Custom PCR Arrays for TRAPPC5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRAPPC5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TRAPPC5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRAPPC5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRAPPC5
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Orthologsfor TRAPPC5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRAPPC5 gene from 10/33 species (see all 33 ) About this table
ENSEMBL Gene Tree for TRAPPC5 (if available)TreeFam Gene Tree for TRAPPC5 (if available)
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Paralogsfor TRAPPC5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TRAPPC5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TRAPPC5 (7745707 - 7747748 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TRAPPC5 1 CNV : 8863
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRAPPC5
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Disorders
/ Diseasesfor TRAPPC5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TRAPPC5 for disorders About GeneDecksing 1 disease for TRAPPC5 : About MalaCards malaria Export disorders for TRAPPC5 gene to outside databases
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Publicationsfor TRAPPC5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRAPPC5 gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with TRAPPC5) Utopia : connect your pdf to the dynamic world of online information
C4orf41 and TTC-15 are mammalian TRAPP components wit h a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244) 1 , 2 Scrivens P.J....Sacher M. (2011) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940) 1 Soler-Lopez M....Aloy P. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 1 Oh J.H....Kim N.S. (2005)
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External Searches for TRAPPC5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TRAPPC5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TRAPPC5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TRAPPC5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TRAPPC5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TRAPPC5 gene: Search GeneIP for patents involving TRAPPC5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRAPPC5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TRAPPC5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TRAPPC5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRAPPC5 OriGene Protein Over-expression Lysate for TRAPPC5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TRAPPC5 OriGene 3'-UTR Clone for TRAPPC5 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRAPPC5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRAPPC5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRAPPC5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRAPPC5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRAPPC5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TRAPPC5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRAPPC5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRAPPC5
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TRAPPC5 Proteins, Antibodies, CLIAs, and ELISAs
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRAPPC5
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