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Aliases for TRAPPC5 Gene

Aliases for TRAPPC5 Gene

  • Trafficking Protein Particle Complex 5 2 3
  • Trafficking Protein Particle Complex Subunit 5 3
  • TRS31 3

External Ids for TRAPPC5 Gene

Previous GeneCards Identifiers for TRAPPC5 Gene

  • GC19P007640
  • GC19P007651
  • GC19U900665
  • GC19P007745
  • GC19P007415

Summaries for TRAPPC5 Gene

GeneCards Summary for TRAPPC5 Gene

TRAPPC5 (Trafficking Protein Particle Complex 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TRAPPC5 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC5 Gene

Genomics for TRAPPC5 Gene

Regulatory Elements for TRAPPC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAPPC5 Gene

Start:
7,680,821 bp from pter
End:
7,687,703 bp from pter
Size:
6,883 bases
Orientation:
Plus strand

Genomic View for TRAPPC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC5 Gene

Proteins for TRAPPC5 Gene

  • Protein details for TRAPPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR0-TPPC5_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 5
    Protein Accession:
    Q8IUR0
    Secondary Accessions:
    • A8K7I6

    Protein attributes for TRAPPC5 Gene

    Size:
    188 amino acids
    Molecular mass:
    20783 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

neXtProt entry for TRAPPC5 Gene

Proteomics data for TRAPPC5 Gene at MOPED

Post-translational modifications for TRAPPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC5 Gene

No data available for DME Specific Peptides for TRAPPC5 Gene

Domains for TRAPPC5 Gene

Gene Families for TRAPPC5 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Suggested Antigen Peptide Sequences for TRAPPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUR0

UniProtKB/Swiss-Prot:

TPPC5_HUMAN :
  • Q8IUR0
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC5: view

Function for TRAPPC5 Gene

Molecular function for TRAPPC5 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Ontology (GO) - Molecular Function for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TRAPPC5: view

Phenotypes for TRAPPC5 Gene

GenomeRNAi human phenotypes for TRAPPC5:
genes like me logo Genes that share phenotypes with TRAPPC5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRAPPC5 Gene

Localization for TRAPPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC5 Gene COMPARTMENTS Subcellular localization image for TRAPPC5 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030008 TRAPP complex IEA --
genes like me logo Genes that share ontologies with TRAPPC5: view

Pathways for TRAPPC5 Gene

SuperPathways for TRAPPC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC5: view

No data available for Pathways by source for TRAPPC5 Gene

Compounds for TRAPPC5 Gene

(1) Drugbank Compounds for TRAPPC5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-PALMITOYL-L-CYSTEINE
target
genes like me logo Genes that share compounds with TRAPPC5: view

Transcripts for TRAPPC5 Gene

Unigene Clusters for TRAPPC5 Gene

Trafficking protein particle complex 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRAPPC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3: -
SP4:

Relevant External Links for TRAPPC5 Gene

GeneLoc Exon Structure for
TRAPPC5
ECgene alternative splicing isoforms for
TRAPPC5

Expression for TRAPPC5 Gene

mRNA expression in normal human tissues for TRAPPC5 Gene

mRNA differential expression in normal tissues according to GTEx for TRAPPC5 Gene

This gene is overexpressed in Testis (11.8) and Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC5 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC5 Gene Hs.432413

genes like me logo Genes that share expressions with TRAPPC5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRAPPC5 Gene

Orthologs for TRAPPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC5 35
  • 99.47 (n)
  • 99.47 (a)
TRAPPC5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC5 35
  • 94.15 (n)
  • 98.94 (a)
TRAPPC5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC5 35
  • 93.97 (n)
  • 98.4 (a)
TRAPPC5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc5 35
  • 89.18 (n)
  • 98.94 (a)
Trappc5 16
Trappc5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC5 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc5 35
  • 88.48 (n)
  • 98.94 (a)
chicken
(Gallus gallus)
Aves TRAPPC5 35
  • 79.79 (n)
  • 80.85 (a)
TRAPPC5 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC5 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2195 35
trappc5 35
  • 67.38 (n)
  • 77.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4571 35
zebrafish
(Danio rerio)
Actinopterygii trappc5 35
  • 73.4 (n)
  • 78.72 (a)
trappc5 36
  • 79 (a)
OneToOne
wufc34a11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012083 35
  • 64.76 (n)
  • 57.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10153 35
  • 63 (n)
  • 64.29 (a)
CG10153 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.16 35
  • 53.79 (n)
  • 53.41 (a)
trpp-5 36
  • 51 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR408C 35
  • 53.45 (n)
  • 37.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS31 35
  • 41.83 (n)
  • 34.31 (a)
TRS31 36
  • 20 (a)
OneToOne
TRS31 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03345g 35
  • 38.86 (n)
  • 31.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G58030 35
  • 51.64 (n)
  • 51.45 (a)
rice
(Oryza sativa)
Liliopsida Os01g0708600 35
  • 52.83 (n)
  • 53.8 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08874 35
  • 52.33 (n)
  • 45.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs31 35
  • 44.82 (n)
  • 42.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4272 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for TRAPPC5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC5 Gene

ENSEMBL:
Gene Tree for TRAPPC5 (if available)
TreeFam:
Gene Tree for TRAPPC5 (if available)

Paralogs for TRAPPC5 Gene

No data available for Paralogs for TRAPPC5 Gene

Variants for TRAPPC5 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs6952 - 7,682,407(-) GCGCG(A/C)CTGCA missense, reference
rs1053363 -- 7,682,559(-) TTGTC(A/C/G/T)GCCTC synonymous-codon, reference
rs3826739 -- 7,680,920(-) GGAGC(A/G)GACGA utr-variant-5-prime, intron-variant
rs10405586 -- 7,683,312(+) CACCT(C/T)GGGTT downstream-variant-500B
rs11557470 -- 7,682,425(+) CGCTG(G/T)GCCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC5 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv910970 CNV Loss 21882294
nsv833731 CNV Loss 17160897
nsv833732 CNV Gain 17160897

Relevant External Links for TRAPPC5 Gene

HapMap Linkage Disequilibrium report
TRAPPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Disorders for TRAPPC5 Gene

No disorders were found for TRAPPC5 Gene.

No data available for UniProtKB/Swiss-Prot for TRAPPC5 Gene

Publications for TRAPPC5 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 3

Products for TRAPPC5 Gene

Sources for TRAPPC5 Gene

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