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Aliases for TRAPPC5 Gene

Aliases for TRAPPC5 Gene

  • Trafficking Protein Particle Complex 5 2 3 5
  • Trafficking Protein Particle Complex Subunit 5 3
  • TRS31 3

External Ids for TRAPPC5 Gene

Previous GeneCards Identifiers for TRAPPC5 Gene

  • GC19P007640
  • GC19P007651
  • GC19U900665
  • GC19P007745
  • GC19P007415

Summaries for TRAPPC5 Gene

GeneCards Summary for TRAPPC5 Gene

TRAPPC5 (Trafficking Protein Particle Complex 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for TRAPPC5 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC5 Gene

Genomics for TRAPPC5 Gene

Regulatory Elements for TRAPPC5 Gene

Enhancers for TRAPPC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F007807 1.2 Ensembl ENCODE 11.8 +127.3 127274 1.4 PKNOX1 ARID4B ZNF48 GLIS2 CBX5 KLF7 FOS SP3 JUNB TBX21 TRAPPC5 MCEMP1 RPL21P129 CD209 CLEC4G C19orf45 PEX11G EXOSC3P2 CLEC4GP1
GH19F007799 1.1 Ensembl ENCODE 12.3 +119.0 118981 1.6 KLF17 NFXL1 RAD21 RFX5 MIXL1 SMARCA5 ZNF654 ZHX2 CEBPB ZEB2 TRAPPC5 MCEMP1 CLEC4G RPL21P129 CD209 PET100 XAB2 LRRC8E PRR36 CLEC4GP1
GH19F007713 0.8 Ensembl ENCODE 13.1 +33.8 33802 1.6 MBD2 CTBP1 GATA3 PKNOX1 DPF2 MNT CD209 TRAPPC5 MCEMP1 RPL21P129 CAMSAP3 CLEC4G FCER2 XAB2 LOC105372262
GH19F007779 0.7 ENCODE 12 +99.1 99058 1.2 PKNOX1 NR2F1 MNT THRB MBD2 GATA3 HNF1A NR2F6 ZNF652 TCF7L2 CLEC4GP1 RPL21P129 CD209 CLEC4G FCER2 TRAPPC5 MCEMP1 GC19P007785 LOC105372263
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000342878 379 1601 ATF1 CREB3L1 WRNIP1 SIN3A ARID4B GLI4 ZNF48 YY1 ZNF121 GLIS2

Genomic Location for TRAPPC5 Gene

7,680,821 bp from pter
7,687,703 bp from pter
6,883 bases
Plus strand

Genomic View for TRAPPC5 Gene

Genes around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC5 Gene

Proteins for TRAPPC5 Gene

  • Protein details for TRAPPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 5
    Protein Accession:
    Secondary Accessions:
    • A8K7I6

    Protein attributes for TRAPPC5 Gene

    188 amino acids
    Molecular mass:
    20783 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

neXtProt entry for TRAPPC5 Gene

Post-translational modifications for TRAPPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC5 Gene

No data available for DME Specific Peptides for TRAPPC5 Gene

Domains & Families for TRAPPC5 Gene

Gene Families for TRAPPC5 Gene

Suggested Antigen Peptide Sequences for TRAPPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPP small subunits family. BET3 subfamily.
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC5: view

Function for TRAPPC5 Gene

Molecular function for TRAPPC5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Ontology (GO) - Molecular Function for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TRAPPC5: view
genes like me logo Genes that share phenotypes with TRAPPC5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAPPC5 Gene

Localization for TRAPPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC5 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 3
mitochondrion 2
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030008 TRAPP complex IEA --
genes like me logo Genes that share ontologies with TRAPPC5: view

Pathways & Interactions for TRAPPC5 Gene

genes like me logo Genes that share pathways with TRAPPC5: view

Gene Ontology (GO) - Biological Process for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048193 Golgi vesicle transport IEA --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC5: view

No data available for SIGNOR curated interactions for TRAPPC5 Gene

Drugs & Compounds for TRAPPC5 Gene

(1) Drugs for TRAPPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC5: view

Transcripts for TRAPPC5 Gene

Unigene Clusters for TRAPPC5 Gene

Trafficking protein particle complex 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP3: -

Relevant External Links for TRAPPC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAPPC5 Gene

mRNA differential expression in normal tissues according to GTEx for TRAPPC5 Gene

This gene is overexpressed in Testis (x11.8) and Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TRAPPC5 Gene

This gene is overexpressed in Nasal epithelium (35.9) and Bone (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC5 Gene

Protein tissue co-expression partners for TRAPPC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC5 Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC5 Gene:

genes like me logo Genes that share expression patterns with TRAPPC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRAPPC5 Gene

Orthologs for TRAPPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC5 34 35
  • 99.47 (n)
(Bos Taurus)
Mammalia TRAPPC5 34 35
  • 94.15 (n)
(Canis familiaris)
Mammalia TRAPPC5 34 35
  • 93.97 (n)
(Mus musculus)
Mammalia Trappc5 34 16 35
  • 89.18 (n)
(Rattus norvegicus)
Mammalia Trappc5 34
  • 88.48 (n)
(Monodelphis domestica)
Mammalia TRAPPC5 35
  • 88 (a)
(Gallus gallus)
Aves TRAPPC5 34 35
  • 79.79 (n)
(Anolis carolinensis)
Reptilia TRAPPC5 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc5 34
  • 67.38 (n)
Str.2195 34
(Danio rerio)
Actinopterygii trappc5 34 35
  • 73.4 (n)
wufc34a11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4571 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012083 34
  • 64.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10153 34 35
  • 63 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.16 34
  • 53.79 (n)
trpp-5 35
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR408C 34
  • 53.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS31 34 35 37
  • 41.83 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03345g 34
  • 38.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G58030 34
  • 51.64 (n)
(Oryza sativa)
Liliopsida Os01g0708600 34
  • 52.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 62 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08874 34
  • 52.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs31 34
  • 44.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4272 34
Species where no ortholog for TRAPPC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC5 Gene

Gene Tree for TRAPPC5 (if available)
Gene Tree for TRAPPC5 (if available)

Paralogs for TRAPPC5 Gene

No data available for Paralogs for TRAPPC5 Gene

Variants for TRAPPC5 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs398122420 Uncertain significance 7,682,801(+) AGACC(C/G)GGCCC reference, missense
rs10405586 -- 7,683,312(+) CACCT(C/T)GGGTT downstream-variant-500B
rs10409343 -- 7,678,959(+) AAATC(C/T)TGGAG upstream-variant-2KB, reference, synonymous-codon
rs10411016 -- 7,680,157(+) CCTAA(G/T)GTACT downstream-variant-500B, upstream-variant-2KB
rs1053363 -- 7,682,559(-) TTGTC(C/T)GCCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC5 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for TRAPPC5 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Disorders for TRAPPC5 Gene

Relevant External Links for TRAPPC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRAPPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC5 Gene

Publications for TRAPPC5 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TRAPPC5 Gene

Sources for TRAPPC5 Gene

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