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TRAPPC4 Gene

protein-coding GIFtS: 60
GCID: GC11P118889

Trafficking Protein Particle Complex 4

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Trafficking Protein Particle Complex 4¹ ²		PTD009²
Hematopoietic Stem/Progenitor Cell Protein 172² ³		SYNBINDIN²
SBDN² ³		TRS23²
TRS23 Homolog² ³		Trafficking Protein Particle Complex Subunit 4²
HSPC172²		Synbindin³

External Ids:	HGNC: 19943¹	Entrez Gene: 51399²	Ensembl: ENSG00000196655⁷	OMIM: 610971⁵	UniProtKB: Q9Y296³

Export aliases for TRAPPC4 gene to outside databases

Previous GC identifers: GC11P118923 GC11P118426 GC11P118394 GC11P114828

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRAPPC4 Gene:

TRAPPC4 (trafficking protein particle complex 4) is a protein-coding gene.

UniProtKB/Swiss-Prot: TPPC4_HUMAN, Q9Y296

Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Wiki entry for TRAPPC4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000011.9 NC_018922.2 NT_033899.9

Regulatory elements:

Regulatory transcription factor binding sites in the TRAPPC4 gene promoter:
NF-1 NF-1/L AML1a Tal-1beta HNF-4alpha1 Gfi-1 Ik-2 Nkx6-1 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRAPPC4 promoter sequence

Search Chromatin IP Primers for TRAPPC4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAPPC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

TRAPPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAPPC4 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P118889: view genomic region (about GC identifiers)

Start:	118,889,142 bp from pter	End:	118,896,164 bp from pter
Size:	7,023 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TPPC4_HUMAN, Q9Y296 (See protein sequence)

Recommended Name: Trafficking protein particle complex subunit 4

Size: 219 amino acids; 24340 Da

Subunit: Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least

TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

Interacts with SDC2 (By similarity)

3 PDB 3D structures from and Proteopedia for TRAPPC4:

2J3T (3D)

2JSN (3D)

2ZMV (3D)

Secondary accessions: A8K3A5

Explore the universe of human proteins at neXtProt for TRAPPC4: NX_Q9Y296

Explore proteomics data for TRAPPC4 at MOPED

Post-translational modifications:

Ubiquitination² at Lys41

Modification sites at PhosphoSitePlus

See TRAPPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057230.1

ENSEMBL proteins:

ENSP00000436005 ENSP00000436827 ENSP00000435339 ENSP00000405033 ENSP00000351896

ENSP00000432920 ENSP00000433658 ENSP00000436281

Reactome Protein details: Q9Y296

TRAPPC4 Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for TRAPPC4
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	antibodies-online proteins for TRAPPC4 (6 products)
	antibodies-online peptides for TRAPPC4

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TRAPPC4 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

TRAPPC: Trafficking protein particle complex

2 InterPro protein domains:

IPR007233 Sybindin

IPR011012 Longin-like_dom

Graphical View of Domain Structure for InterPro Entry Q9Y296

ProtoNet protein and cluster: Q9Y296

1 Blocks protein domain: IPB007233 Sybindin-like protein

UniProtKB/Swiss-Prot: TPPC4_HUMAN, Q9Y296

Similarity: Belongs to the TRAPP small subunits family. TRAPPC4 subfamily

Find genes that share domains with TRAPPC4 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TPPC4_HUMAN, Q9Y296

Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17110339

Find genes that share ontologies with TRAPPC4 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for TRAPPC4:

Decreased Salmonella enterica

Increased TP53 protein express

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TRAPPC4

miRNA Products:		Block miRNA regulation of human, mouse, rat TRAPPC4 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate TRAPPC4:
		hsa-let-7g* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: TRAPPC4 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRAPPC4
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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TPPC4_HUMAN, Q9Y296: Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
golgi apparatus	4
endoplasmic reticulum	2
mitochondrion	2
cytoskeleton	1
cytosol	1
nucleus	1

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Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005795	Golgi stack	ISS	11018053
GO:0005801	cis-Golgi network	IEA	--
GO:0008021	synaptic vesicle	ISS	11018053

Find genes that share ontologies with TRAPPC4 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TRAPPC4 About

See pathways by source

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SuperPath

Contained pathways About

Non-integrin membrane-ECM interactions

Non-integrin membrane-ECM interactions

0.35

Syndecan interactions

0.00

Degradation of the extracellular matrix

Extracellular matrix organization

0.34

Syndecan-2-mediated signaling events

Syndecan-2-mediated signaling events

Find genes that share SuperPaths with TRAPPC4 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for TRAPPC4

Syndecan-2-mediated signaling events

1 Reactome Pathway for TRAPPC4

Syndecan interactions

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TRAPPC4
Interactions:

GeneGlobe Interaction Network for TRAPPC4

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

Selected Interacting proteins for TRAPPC4 (Q9Y296^{1, 2, 3} ENSP00000351896⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRSS23	O95084²^,³	MINT-63266 I2D: score=5
TRAPPC1	Q9Y5R8³, ENSP00000302783⁴	I2D: score=1 STRING: ENSP00000302783
TRAPPC5	Q8IUR0³, ENSP00000316990⁴	I2D: score=1 STRING: ENSP00000316990
TRAPPC6A	O75865³, ENSP00000006275⁴	I2D: score=1 STRING: ENSP00000006275
TRAPPC6B	Q86SZ2³, ENSP00000330289⁴	I2D: score=1 STRING: ENSP00000330289

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Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0006888	ER to Golgi vesicle-mediated transport	IEA	--
GO:0016358	dendrite development	ISS	11018053
GO:0030198	extracellular matrix organization	TAS	--

Find genes that share ontologies with TRAPPC4 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TRAPPC4 (TPPC4)

1 DrugBank Compound for TRAPPC4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
S-PALMITOYL-L-CYSTEINE	--	--	target	--	10592235

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TRAPPC4 gene:

NM_016146.4

Unigene Cluster for TRAPPC4:

Trafficking protein particle complex 4

Hs.132760 [show with all ESTs]

Unigene Representative Sequence: AK025623

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000533632(uc010ryo.2 uc010ryp.2 uc010ryq.2) ENST00000527680

ENST00000447216(uc010ryn.2) ENST00000528230 ENST00000525303 ENST00000434101

ENST00000531290 ENST00000359005 ENST00000533058 ENST00000525079 ENST00000533012

ENST00000533149 ENST00000524797 ENST00000526141

miRNA Products:		Block miRNA regulation of human, mouse, rat TRAPPC4 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate TRAPPC4:
		hsa-let-7g* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: TRAPPC4 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat TRAPPC4

Clone Products:		OriGene clones in human, mouse for TRAPPC4 (see all 7) OriGene ORF clones in mouse, rat for TRAPPC4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene qPCR primer pairs and template standards for TRAPPC4 OriGene qSTAR qPCR primer pairs in human, mouse for TRAPPC4
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TRAPPC4
		QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC4
		QuantiFast Probe-based Assays in human, mouse, rat TRAPPC4

Additional mRNA sequence:

AF078862.1 AF105025.1 AF151862.1 AF161520.1 AK025623.1 AK290520.1 AK293914.1 AK293977.1

AK297422.1 BC010866.1

24 DOTS entries:

DT.100037918 DT.92013154 DT.100704827 DT.97818376 DT.95375608 DT.100823294 DT.447749 DT.100849948

DT.97803106 DT.95375614 DT.120718714 DT.120718605 DT.120718576 DT.120718713 DT.120718573 DT.100823290

DT.120718729 DT.87015757 DT.92332931 DT.100823291 DT.101984735 DT.95336243 DT.95375612 DT.95378937

Selected AceView cDNA sequences (see all 354):

BU687278 CR591716 CD673388 BM717207 BM970633 CD673387 BU624012 BM978209

N89815 AA365174 AI193498 BM669250 BQ224089 BM547721 BQ019048 BU726333

CR614639 AI298203 AI927319 BM477442 CA941660 CB123910 BE796919 CR599720

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC4 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c
SP1:															-		-										-
SP2:													-		-		-										-
SP3:					-		-		-						-		-
SP4:															-		-		-								-
SP5:																	-

ECgene alternative splicing isoforms for TRAPPC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRAPPC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTCTTACTTT

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TRAPPC4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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TRAPPC4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.132760

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC4 gene from Selected species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trappc4^{1 , 5}	trafficking protein particle complex 4^{1, 5}	91.17(n)¹ 98.17(a)¹		9 (24.84 cM)⁵ 60409¹ NM_021789.2¹ NP_068561.1¹ 44403761⁵
chicken (Gallus gallus)	Aves	TRAPPC4¹	trafficking protein particle complex 4	78.54(n) 89.95(a)		419788 NM_001006320.1 NP_001006320.1
lizard (Anolis carolinensis)	Reptilia	TRAPPC4⁶	trafficking protein particle complex 4	88(a)	1 ↔ 1	GL344273.1(12645-19003)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11434²	Xenopus laevis transcribed sequence with moderate similarity more	77.54(n)		AW640558.1
zebrafish (Danio rerio)	Actinopterygii	zgc73260²	trafficking protein particle complex 4	76.7(n)		393737 BC059594.1
fruit fly (Drosophila melanogaster)	Insecta	Trs23¹	Trs23	61.03(n) 59.62(a)		34197 NM_135403.2 NP_609247.1
worm (Caenorhabditis elegans)	Secernentea	F36D4.2¹	F36D4.2	53.24(n) 49.03(a)		185357 NM_073034.1 NP_505435.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TRS23(YDR246W)⁴ TRS23¹	One of 10 subunits of the transport protein particle more⁴ TRS23¹	43.55(n)¹ 37.1(a)¹		4(954288-954947)⁴ 851833^{1, 4} NP_010532.3¹ NP_010532.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G02280¹	AT5G02280	58.81(n) 57.55(a)		831680 NM_120306.3 NP_195848.1
rice (Oryza sativa)	Liliopsida	Os07g0454700¹	Os07g0454700	56.92(n) 51.89(a)		4343141 NM_001066092.1 NP_001059557.1

ENSEMBL Gene Tree for TRAPPC4 (if available)
TreeFam Gene Tree for TRAPPC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183936915^1,2		--	118891095(+)	`GACACC/TTTTGG`	1	--	int¹		0	--	--	--	--
rs139812120^1,2	C	--	118891137(+)	`CACAA-/TTCCTTTT`	1	--	int¹		0	--	--	--	--
rs78604692^1,2		--	118891139(+)	`CAATTC/TTTTTT`	1	--	int¹		0	--	--	--	--
rs199734981^1,2	C	--	118891139(+)	`AATTC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs142545556^1,2	F	--	118891141(+)	`CAATTCTT/-TTTTT`	2	--	int¹ cds¹		1		NS	136
rs12785336^1,2	C	--	118891188(+)	`TGCAGT/GGGCAT`	1	--	int¹		13		NA WA CSA EA	377
rs139868474^1,2	C	--	118891238(+)	`CTCCCA/CAATAG`	1	--	int¹		0	--	--	--	--
rs117694374^1,2	F	--	118891314(+)	`CTCCAT/CATTGG`	1	--	int¹		1		NA	120
rs12790025^1,2	C,H	--	118891403(+)	`ACCCGG/ACCCAC`	1	--	int¹		11		NS EA WA NA CSA	433
rs187757149^1,2	C	--	118891490(+)	`GGCTCA/GCTGCA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRAPPC4 (118889142 - 118896164 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for TRAPPC4: About this table

Variant ID	Type	Subtype	PubMed ID
nsv826101	CNV	Gain	20364138

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TRAPPC4

DNA2.0 Custom Variant and Variant Library Synthesis for TRAPPC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610971 OMIM disorders: --

Find genes that share disorders with TRAPPC4 About GenesLikeMe

Genetic Association Database (GAD): TRAPPC4
Human Genome Epidemiology (HuGE) Navigator: TRAPPC4 (1 document)

Export disorders for TRAPPC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRAPPC4 gene, integrated from 10 sources (see all 27):
(articles sorted by number of sources associating them with TRAPPC4)

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Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.-H.... Lin W.-C. (Genome Res. 2000)
C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)^{1, 2} Scrivens P.J.... Sacher M. (Mol. Biol. Cell 2011)
Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. (PubMed id 20035503)^{1, 4} Elstner M....Turnbull D.M. (Ann. Neurol. 2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Functional organization of the yeast proteome by systematic analysis of protein complexes. (PubMed id 11805826)^{1, 2} Gavin A.-C....Superti-Furga G. (Nature 2002)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (Genome Res. 2000)
Crystal structure of human synbindin reveals two conformations of longin domain. (PubMed id 18466758)^{1, 9} Fan S....Gong W. (Biochem. Biophys. Res. Commun. 2009)
Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. (PubMed id 24104608)¹ Kong X....Fang J.Y. (J. Natl. Cancer Inst. 2013)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells. (PubMed id 21826244)¹ Zhao S.L....Fang J.Y. (PLoS ONE 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51399	HGNC: 19943	AceView: TRAPPC4	Ensembl:ENSG00000196655	euGenes: HUgn51399
ECgene: TRAPPC4	H-InvDB: TRAPPC4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRAPPC4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRAPPC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRAPPC4 gene:
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Trafficking Protein Particle Complex 4

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Trafficking Protein Particle Complex 4

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