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TRAPPC4 Gene

protein-coding   GIFtS: 60
GCID: GC11P118889

Trafficking Protein Particle Complex 4

  Search for TRAPPC4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trafficking Protein Particle Complex 41 2     PTD0092
Hematopoietic Stem/Progenitor Cell Protein 1722 3     SYNBINDIN2
SBDN2 3     TRS232
TRS23 Homolog2 3     Trafficking Protein Particle Complex Subunit 42
HSPC1722     Synbindin3

External Ids:    HGNC: 199431   Entrez Gene: 513992   Ensembl: ENSG000001966557   OMIM: 6109715   UniProtKB: Q9Y2963   

Export aliases for TRAPPC4 gene to outside databases

Previous GC identifers: GC11P118923 GC11P118426 GC11P118394 GC11P114828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRAPPC4 Gene:
TRAPPC4 (trafficking protein particle complex 4) is a protein-coding gene.

UniProtKB/Swiss-Prot: TPPC4_HUMAN, Q9Y296
Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Wiki entry for TRAPPC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAPPC4 gene promoter:
         NF-1   NF-1/L   AML1a   Tal-1beta   HNF-4alpha1   Gfi-1   Ik-2   Nkx6-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAPPC4 promoter sequence
   Search Chromatin IP Primers for TRAPPC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAPPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

TRAPPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAPPC4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118889:  view genomic region     (about GC identifiers)

Start:
118,889,142 bp from pter      End:
118,896,164 bp from pter
Size:
7,023 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPPC4_HUMAN, Q9Y296 (See protein sequence)
Recommended Name: Trafficking protein particle complex subunit 4  
Size: 219 amino acids; 24340 Da
Subunit: Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least
TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
Interacts with SDC2 (By similarity)
3 PDB 3D structures from and Proteopedia for TRAPPC4:
2J3T (3D)        2JSN (3D)        2ZMV (3D)    
Secondary accessions: A8K3A5

Explore the universe of human proteins at neXtProt for TRAPPC4: NX_Q9Y296

Explore proteomics data for TRAPPC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys41
  • Modification sites at PhosphoSitePlus

  • See TRAPPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057230.1  
    ENSEMBL proteins: 
     ENSP00000436005   ENSP00000436827   ENSP00000435339   ENSP00000405033   ENSP00000351896  
     ENSP00000432920   ENSP00000433658   ENSP00000436281  
    Reactome Protein details: Q9Y296

    TRAPPC4 Human Recombinant Protein Products:

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    Novus Biologicals TRAPPC4 Proteins
    Novus Biologicals TRAPPC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TRAPPC4
    Cloud-Clone Corp. Proteins for TRAPPC4

     
    Search eBioscience for Proteins for TRAPPC4 

    TRAPPC4 Antibody Products:

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    Cloud-Clone Corp. ELISAs for TRAPPC4
    Cloud-Clone Corp. CLIAs for TRAPPC4
    Search eBioscience for ELISAs for TRAPPC4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRAPPC: Trafficking protein particle complex

    2 InterPro protein domains:
     IPR007233 Sybindin
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y296

    ProtoNet protein and cluster: Q9Y296

    1 Blocks protein domain: IPB007233 Sybindin-like protein

    UniProtKB/Swiss-Prot: TPPC4_HUMAN, Q9Y296
    Similarity: Belongs to the TRAPP small subunits family. TRAPPC4 subfamily


    Find genes that share domains with TRAPPC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPPC4_HUMAN, Q9Y296
    Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17110339
         
    Find genes that share ontologies with TRAPPC4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRAPPC4:
     Decreased Salmonella enterica   Increased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAPPC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAPPC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAPPC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAPPC4

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TRAPPC4:
    hsa-let-7g* hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRAPPC4
    Predesigned siRNA for gene silencing in human, mouse, rat TRAPPC4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TRAPPC4

    Clone
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    GenScript: all cDNA clones in your preferred vector: TRAPPC4 (NM_016146)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAPPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRAPPC4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPPC4_HUMAN, Q9Y296: Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    endoplasmic reticulum2
    mitochondrion2
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005795Golgi stack ISS11018053
    GO:0005801cis-Golgi network IEA--
    GO:0008021synaptic vesicle ISS11018053

    Find genes that share ontologies with TRAPPC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRAPPC4 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35
    Syndecan interactions0.00
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    3Syndecan-2-mediated signaling events
    Syndecan-2-mediated signaling events


    Find genes that share SuperPaths with TRAPPC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TRAPPC4
        Syndecan-2-mediated signaling events

    1 Reactome Pathway for TRAPPC4
        Syndecan interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRAPPC4
    Interactions:

        GeneGlobe Interaction Network for TRAPPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for TRAPPC4 (Q9Y2961, 2, 3 ENSP000003518964) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS23O950842, 3MINT-63266 I2D: score=5 
    TRAPPC1Q9Y5R83, ENSP000003027834I2D: score=1 STRING: ENSP00000302783
    TRAPPC5Q8IUR03, ENSP000003169904I2D: score=1 STRING: ENSP00000316990
    TRAPPC6AO758653, ENSP000000062754I2D: score=1 STRING: ENSP00000006275
    TRAPPC6BQ86SZ23, ENSP000003302894I2D: score=1 STRING: ENSP00000330289
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006888ER to Golgi vesicle-mediated transport IEA--
    GO:0016358dendrite development ISS11018053
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with TRAPPC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAPPC4 (TPPC4)

    1 DrugBank Compound for TRAPPC4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-PALMITOYL-L-CYSTEINE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRAPPC4 gene: 
    NM_016146.4  

    Unigene Cluster for TRAPPC4:

    Trafficking protein particle complex 4
    Hs.132760  [show with all ESTs]
    Unigene Representative Sequence: AK025623
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533632(uc010ryo.2 uc010ryp.2 uc010ryq.2) ENST00000527680
    ENST00000447216(uc010ryn.2) ENST00000528230 ENST00000525303 ENST00000434101
    ENST00000531290 ENST00000359005 ENST00000533058 ENST00000525079 ENST00000533012
    ENST00000533149 ENST00000524797 ENST00000526141
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRAPPC4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TRAPPC4:
    hsa-let-7g* hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRAPPC4
    Predesigned siRNA for gene silencing in human, mouse, rat TRAPPC4
    Clone
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    GenScript: all cDNA clones in your preferred vector: TRAPPC4 (NM_016146)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAPPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC4
    Primer
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    OriGene qPCR primer pairs and template standards for TRAPPC4
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAPPC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAPPC4
      QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC4
      QuantiFast Probe-based Assays in human, mouse, rat TRAPPC4

    Additional mRNA sequence: 

    AF078862.1 AF105025.1 AF151862.1 AF161520.1 AK025623.1 AK290520.1 AK293914.1 AK293977.1 
    AK297422.1 BC010866.1 

    24 DOTS entries:

    DT.100037918  DT.92013154  DT.100704827  DT.97818376  DT.95375608  DT.100823294  DT.447749  DT.100849948 
    DT.97803106  DT.95375614  DT.120718714  DT.120718605  DT.120718576  DT.120718713  DT.120718573  DT.100823290 
    DT.120718729  DT.87015757  DT.92332931  DT.100823291  DT.101984735  DT.95336243  DT.95375612  DT.95378937 

    Selected AceView cDNA sequences (see all 354):

    BU687278 CR591716 CD673388 BM717207 BM970633 CD673387 BU624012 BM978209 
    N89815 AA365174 AI193498 BM669250 BQ224089 BM547721 BQ019048 BU726333 
    CR614639 AI298203 AI927319 BM477442 CA941660 CB123910 BE796919 CR599720 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                                            -     -                             -                     
    SP2:                                      -     -     -                             -                     
    SP3:              -     -     -                 -     -                                                   
    SP4:                                            -     -     -                       -                     
    SP5:                                                  -                                                   


    ECgene alternative splicing isoforms for TRAPPC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAPPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTACTTT
    TRAPPC4 Expression
    About this image

    TRAPPC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAPPC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132760
        Custom PCR Arrays for TRAPPC4
    Primer
    Products:
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    QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC4
    QuantiFast Probe-based Assays in human, mouse, rat TRAPPC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRAPPC4 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trappc41 , 5 trafficking protein particle complex 41, 5 91.17(n)1
    98.17(a)1
      9 (24.84 cM)5
    604091  NM_021789.21  NP_068561.11 
     444037615 
    chicken
    (Gallus gallus)
    Aves TRAPPC41 trafficking protein particle complex 4 78.54(n)
    89.95(a)
      419788  NM_001006320.1  NP_001006320.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAPPC46
    trafficking protein particle complex 4
    88(a)
    1 ↔ 1
    GL344273.1(12645-19003)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114342 Xenopus laevis transcribed sequence with moderate similarity more 77.54(n)    AW640558.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732602 trafficking protein particle complex 4 76.7(n)   393737  BC059594.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trs231 Trs23 61.03(n)
    59.62(a)
      34197  NM_135403.2  NP_609247.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F36D4.21 F36D4.2 53.24(n)
    49.03(a)
      185357  NM_073034.1  NP_505435.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRS23(YDR246W)4
    TRS231
    One of 10 subunits of the transport protein particle more4
    TRS231
    43.55(n)1
    37.1(a)1
      4(954288-954947)4
    8518331, 4  NP_010532.31  NP_010532.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G022801 AT5G02280 58.81(n)
    57.55(a)
      831680  NM_120306.3  NP_195848.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04547001 Os07g0454700 56.92(n)
    51.89(a)
      4343141  NM_001066092.1  NP_001059557.1 


    ENSEMBL Gene Tree for TRAPPC4 (if available)
    TreeFam Gene Tree for TRAPPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAPPC4 (see all 117)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839369151,2
    --118891095(+) GACACC/TTTTGG 1 -- int10--------
    rs1398121201,2
    C--118891137(+) CACAA-/TTCCTTTT 1 -- int10--------
    rs786046921,2
    --118891139(+) CAATTC/TTTTTT 1 -- int10--------
    rs1997349811,2
    C--118891139(+) AATTC-/TTTTTT 1 -- int10--------
    rs1425455561,2
    F--118891141(+) CAATTCTT/-TTTTT 2 -- int1 cds11Minor allele frequency- -:0.02NS 136
    rs127853361,2
    C--118891188(+) TGCAGT/GGGCAT 1 -- int113Minor allele frequency- G:0.00NA WA CSA EA 377
    rs1398684741,2
    C--118891238(+) CTCCCA/CAATAG 1 -- int10--------
    rs1176943741,2
    F--118891314(+) CTCCAT/CATTGG 1 -- int11Minor allele frequency- C:0.02NA 120
    rs127900251,2
    C,H--118891403(+) ACCCGG/ACCCAC 1 -- int111Minor allele frequency- A:0.00NS EA WA NA CSA 433
    rs1877571491,2
    C--118891490(+) GGCTCA/GCTGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRAPPC4 (118889142 - 118896164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRAPPC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv826101CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAPPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAPPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610971    OMIM disorders: --


    Find genes that share disorders with TRAPPC4           About GenesLikeMe

    Genetic Association Database (GAD): TRAPPC4
    Human Genome Epidemiology (HuGE) Navigator: TRAPPC4 (1 document)

    Export disorders for TRAPPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAPPC4 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TRAPPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)1, 2 Scrivens P.J.... Sacher M. (Mol. Biol. Cell 2011)
    3. Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. (PubMed id 20035503)1, 4 Elstner M....Turnbull D.M. (Ann. Neurol. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PubMed id 11805826)1, 2 Gavin A.-C....Superti-Furga G. (Nature 2002)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. Crystal structure of human synbindin reveals two conformations of longin domain. (PubMed id 18466758)1, 9 Fan S....Gong W. (Biochem. Biophys. Res. Commun. 2009)
    8. Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. (PubMed id 24104608)1 Kong X....Fang J.Y. (J. Natl. Cancer Inst. 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells. (PubMed id 21826244)1 Zhao S.L....Fang J.Y. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51399 HGNC: 19943 AceView: TRAPPC4 Ensembl:ENSG00000196655 euGenes: HUgn51399
    ECgene: TRAPPC4 H-InvDB: TRAPPC4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRAPPC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRAPPC4 gene:
    Search GeneIP for patents involving TRAPPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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