Aliases for TRAPPC4 Gene
Aliases for TRAPPC4 Gene
External Ids for TRAPPC4 Gene
- HGNC: 19943
- Entrez Gene: 51399
- Ensembl: ENSG00000196655
- OMIM: 610971
- UniProtKB: Q9Y296
Previous GeneCards Identifiers for TRAPPC4 Gene
- GC11P118923
- GC11P118426
- GC11P118394
- GC11P114828
- GC11P118889
Summaries for TRAPPC4 Gene
GeneCards Summary for TRAPPC4 Gene
TRAPPC4 (Trafficking Protein Particle Complex 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity.
UniProtKB/Swiss-Prot for TRAPPC4 Gene
-
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Additional gene information for TRAPPC4 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC4 Gene
Genomics for TRAPPC4 Gene
GeneHancer (GH) Regulatory Elements for TRAPPC4 Gene
Regulatory Element Products
Genomic Locations for TRAPPC4 Gene
- chr11:119,018,432-119,025,454
- (GRCh38/hg38)
- Size:
- 7,023 bases
- Orientation:
- Plus strand
- chr11:118,889,142-118,896,164
- (GRCh37/hg19)
Genomic View for TRAPPC4 Gene
- Cytogenetic band:
-
- 11q23.3 by Ensembl
- 11q23.3 by Entrez Gene
- 11q23.3 by HGNC


RefSeq DNA sequence for TRAPPC4 Gene
Proteins for TRAPPC4 Gene
-
Protein details for TRAPPC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y296-TPPC4_HUMAN
- Recommended name:
- Trafficking protein particle complex subunit 4
- Protein Accession:
- Q9Y296
- A8K3A5
- B4DME1
Protein attributes for TRAPPC4 Gene
- Size:
- 219 amino acids
- Molecular mass:
- 24340 Da
- Quaternary structure:
-
- Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 (By similarity).
Three dimensional structures from OCA and Proteopedia for TRAPPC4 Gene
Protein Expression for TRAPPC4 Gene
Post-translational modifications for TRAPPC4 Gene
- Ubiquitination at isoforms=241
Other Protein References for TRAPPC4 Gene
Antibody Products
- Novus Biologicals Antibodies for TRAPPC4
-
Abcam antibodies for TRAPPC4
- Invitrogen Antibodies for TRAPPC4
- Search GeneTex for Antibodies for TRAPPC4
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC4
Protein Products
-
OriGene Purified Proteins for TRAPPC4
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-
Abcam proteins for TRAPPC4
Assay Products
No data available for DME Specific Peptides for TRAPPC4 Gene
Domains & Families for TRAPPC4 Gene
Gene Families for TRAPPC4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TRAPPC4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRAPPC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y296- Family:
-
- Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
Function for TRAPPC4 Gene
Molecular function for TRAPPC4 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Phenotypes From GWAS Catalog for TRAPPC4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17110339 |
GO:0017112 | Rab guanyl-nucleotide exchange factor activity | IBA,TAS | -- |
Phenotypes for TRAPPC4 Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for TRAPPC4
- genomics-online: gRNA clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
- Applied Biological Materials CRISPR for TRAPPC4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC4
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miRNA for TRAPPC4 Gene
- miRTarBase miRNAs that target TRAPPC4
miRNA Products
- Search ViGene Biosciences for TRAPPC4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRAPPC4
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- genomics-online: shRNA clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
Clone Products
- Sino Biological Human cDNA Clone for TRAPPC4
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRAPPC4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TRAPPC4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC4 Gene
Localization for TRAPPC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC4 Gene
- Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
- Cytosol (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005795 | Golgi stack | ISS | 11018053 |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for TRAPPC4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Vesicle-mediated transport | ||
3 | Metabolism of proteins | ||
4 | Non-integrin membrane-ECM interactions | ||
5 | Degradation of the extracellular matrix |
Pathways by source for TRAPPC4 Gene
1 BioSystems pathway for TRAPPC4 Gene
12 Reactome pathways for TRAPPC4 Gene
Interacting Proteins for TRAPPC4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0006888 | ER to Golgi vesicle-mediated transport | IBA | -- |
GO:0016192 | vesicle-mediated transport | IEA | -- |
GO:0016358 | dendrite development | ISS | 11018053 |
GO:0048208 | COPII vesicle coating | TAS | -- |
No data available for SIGNOR curated interactions for TRAPPC4 Gene
Drugs & Compounds for TRAPPC4 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
S-PALMITOYL-L-CYSTEINE | Experimental | Pharma | Target | 0 |
Transcripts for TRAPPC4 Gene
mRNA/cDNA for TRAPPC4 Gene
- (7) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (354) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRAPPC4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRAPPC4
- genomics-online: gRNA clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
- Applied Biological Materials CRISPR for TRAPPC4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC4
- GenScript: Design CRISPR guide RNA sequences for TRAPPC4
miRNA Products
- Search ViGene Biosciences for TRAPPC4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRAPPC4
- Browse OriGene Inhibitory RNA Products For TRAPPC4
- genomics-online: shRNA clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
Clone Products
- Sino Biological Human cDNA Clone for TRAPPC4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRAPPC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAPPC4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRAPPC4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||
SP7: |
Expression for TRAPPC4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC4 Gene
NURSA nuclear receptor signaling pathways regulating expression of TRAPPC4 Gene:
TRAPPC4SOURCE GeneReport for Unigene cluster for TRAPPC4 Gene:
Hs.132760Evidence on tissue expression from TISSUES for TRAPPC4 Gene
- Nervous system(4.8)
- Lung(4.4)
- Blood(4.2)
Primer Products
-
OriGene qPCR primer pairs for TRAPPC4
-
OriGene qPCR primer pairs and template standards for TRAPPC4
- genomics-online: primer clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC4 Gene
Orthologs for TRAPPC4 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TRAPPC4 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TRAPPC4 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TRAPPC4 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Trappc4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Trappc4 33 |
|
||
dog (Canis familiaris) |
Mammalia | TRAPPC4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | TRAPPC4 33 34 |
|
||
chicken (Gallus gallus) |
Aves | TRAPPC4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TRAPPC4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | trappc4 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.11434 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | trappc4 33 34 |
|
||
zgc73260 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008106 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Trs23 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | F36D4.2 33 |
|
||
trpp-4 34 |
|
OneToOne | |||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D12144g 33 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR459W 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TRS23 33 34 36 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G02280 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os07g0454700 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU11085 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | trs23 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7090 33 |
|
- Species where no ortholog for TRAPPC4 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRAPPC4 Gene
No data available for Paralogs for TRAPPC4 Gene
Variants for TRAPPC4 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000178354 | -- | 119,021,545(+) | C/T | intron_variant | |
rs1000250463 | -- | 119,021,935(+) | C/T | intron_variant | |
rs1000708180 | -- | 119,019,907(+) | A/G | intron_variant | |
rs1000730956 | -- | 119,017,219(+) | G/A | upstream_transcript_variant | |
rs1000893817 | -- | 119,024,149(+) | A/C/G | downstream_transcript_variant |
Additional Variant Information for TRAPPC4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRAPPC4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC4 Gene
Disorders for TRAPPC4 Gene
Additional Disease Information for TRAPPC4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TRAPPC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC4 Gene
Publications for TRAPPC4 Gene
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
- C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 3 4 58
- Crystal structure of human synbindin reveals two conformations of longin domain. (PMID: 18466758) Fan S … Gong W (Biochemical and biophysical research communications 2009) 3 22 58
- Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. (PMID: 20035503) Elstner M … Turnbull DM (Annals of neurology 2009) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for TRAPPC4 Gene
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- Invitrogen Antibodies for TRAPPC4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRAPPC4
- VectorBuilder custom plasmid, inducible vectors for TRAPPC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAPPC4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 53 available TRAPPC4 Antibodies ranked by validation data
- Compare Top TRAPPC4 Antibodies
- antibodies-online: Search results for available TRAPPC4 related products ranked by validation data
- antibodies-online: Search results for 8 available TRAPPC4 Proteins ranked by validation data
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- Quality Products:
- Search GeneTex for Antibodies for TRAPPC4
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- ViGene Biosciences adenoviral particle packaged cDNA for TRAPPC4 gene
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- Search ViGene Biosciences for TRAPPC4
- Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC4
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- Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC4
- genomics-online: cdna clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
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- Overview of 115 available TRAPPC4 gene related products
- genomics-online: primer clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
- genomics-online: shRNA clones - Search results for 115 available TRAPPC4 gene related products
- Overview of 115 available TRAPPC4 gene related products
Sources for TRAPPC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
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