Aliases for TRAPPC4 Gene
Aliases for TRAPPC4 Gene
External Ids for TRAPPC4 Gene
- HGNC: 19943
- Entrez Gene: 51399
- Ensembl: ENSG00000196655
- OMIM: 610971
- UniProtKB: Q9Y296
Previous GeneCards Identifiers for TRAPPC4 Gene
- GC11P118923
- GC11P118426
- GC11P118394
- GC11P114828
- GC11P118889
Summaries for TRAPPC4 Gene
GeneCards Summary for TRAPPC4 Gene
TRAPPC4 (Trafficking Protein Particle Complex 4) is a Protein Coding gene. Among its related pathways are Non-integrin membrane-ECM interactions and Transport to the Golgi and subsequent modification. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity.
UniProtKB/Swiss-Prot for TRAPPC4 Gene
-
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC4 Gene
Genomics for TRAPPC4 Gene
Regulatory Elements for TRAPPC4 Gene
Enhancers for TRAPPC4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TRAPPC4 on UCSC Golden Path with GeneCards custom track
Promoters for TRAPPC4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TRAPPC4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TRAPPC4 gene promoter:
Regulatory Element Products
Genomic Location for TRAPPC4 Gene
- Chromosome:
- 11
- Start:
- 119,018,432 bp from pter
- End:
- 119,025,454 bp from pter
- Size:
- 7,023 bases
- Orientation:
- Plus strand
Genomic View for TRAPPC4 Gene
Genes around TRAPPC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by Ensembl
- 11q23.3 by Entrez Gene
- 11q23.3 by HGNC
TRAPPC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRAPPC4 Gene
Proteins for TRAPPC4 Gene
-
Protein details for TRAPPC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y296-TPPC4_HUMAN
- Recommended name:
- Trafficking protein particle complex subunit 4
- Protein Accession:
- Q9Y296
- A8K3A5
- B4DME1
Protein attributes for TRAPPC4 Gene
- Size:
- 219 amino acids
- Molecular mass:
- 24340 Da
- Quaternary structure:
-
- Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 (By similarity).
Three dimensional structures from OCA and Proteopedia for TRAPPC4 Gene
Protein Expression for TRAPPC4 Gene
Post-translational modifications for TRAPPC4 Gene
Other Protein References for TRAPPC4 Gene
Antibody Products
- Novus Biologicals Antibodies for TRAPPC4
- Invitrogen Antibodies for TRAPPC4
- antibodies-online Antibodies for TRAPPC4: See all 47
- Search GeneTex for Antibodies for TRAPPC4
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC4
Protein Products
-
OriGene Purified Proteins for TRAPPC4
- Search Origene for MassSpec and Protein Over-expression Lysates for TRAPPC4
- Origene Custom Protein Services for TRAPPC4
- ProSpec Recombinant Proteins for TRAPPC4
- antibodies-online Proteins for TRAPPC4: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TRAPPC4
Assay Products
No data available for DME Specific Peptides for TRAPPC4 Gene
Domains & Families for TRAPPC4 Gene
Gene Families for TRAPPC4 Gene
Protein Domains for TRAPPC4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRAPPC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y296- Family:
-
- Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
Function for TRAPPC4 Gene
Molecular function for TRAPPC4 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Phenotypes for TRAPPC4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
- Search ViGene Biosciences for TRAPPC4
CRISPR Products
-
OriGene CRISPR knockouts for TRAPPC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC4
- GenScript: Design CRISPR guide RNA sequences for TRAPPC4
miRNA for TRAPPC4 Gene
- miRTarBase miRNAs that target TRAPPC4
miRNA Products
- Search ViGene Biosciences for TRAPPC4
Clone Products
- OriGene clones in human for TRAPPC4
- OriGene ORF clones in human,mouse,rat for TRAPPC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TRAPPC4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC4 Gene
Localization for TRAPPC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC4 Gene
- Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005795 | Golgi stack | ISS | 11018053 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0030425 | dendrite | ISS | 11018053 |
Pathways & Interactions for TRAPPC4 Gene
More details on SuperPathways for TRAPPC4Pathways by source for TRAPPC4 Gene
1 BioSystems pathway for TRAPPC4 Gene
11 Reactome pathways for TRAPPC4 Gene
Interacting Proteins for TRAPPC4 Gene
Selected Interacting proteins:
Q9Y296-TPPC4_HUMAN
ENSP00000436005
for TRAPPC4 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0018279 | protein N-linked glycosylation via asparagine | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0044267 | cellular protein metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for TRAPPC4 Gene
Drugs & Compounds for TRAPPC4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| S-PALMITOYL-L-CYSTEINE | Experimental | Pharma | Target | 0 |
Transcripts for TRAPPC4 Gene
mRNA/cDNA for TRAPPC4 Gene
- (9) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (354) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRAPPC4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRAPPC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC4
- GenScript: Design CRISPR guide RNA sequences for TRAPPC4
miRNA Products
- Search ViGene Biosciences for TRAPPC4
Clone Products
- OriGene clones in human for TRAPPC4
- OriGene ORF clones in human,mouse,rat for TRAPPC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: |
Expression for TRAPPC4 Gene
This gene is overexpressed in Bone (14.8) and Serum (10.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC4 Gene
SOURCE GeneReport for Unigene cluster for TRAPPC4 Gene Hs.132760
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for TRAPPC4
-
OriGene qPCR primer pairs and template standards for TRAPPC4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC4 Gene
Orthologs for TRAPPC4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TRAPPC4 35 |
|
||
| TRAPPC4 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TRAPPC4 35 |
|
||
| TRAPPC4 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Trappc4 35 |
|
||
| Trappc4 16 |
|
||||
| Trappc4 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TRAPPC4 35 |
|
||
| TRAPPC4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Trappc4 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TRAPPC4 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRAPPC4 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TRAPPC4 35 |
|
||
| TRAPPC4 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TRAPPC4 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | trappc4 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11434 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | trappc4 35 |
|
||
| zgc73260 35 |
|
||||
| trappc4 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008106 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Trs23 35 |
|
||
| Trs23 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | F36D4.2 35 |
|
||
| trpp-4 36 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR459W 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D12144g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TRS23 35 |
|
||
| TRS23 36 |
|
OneToOne | |||
| TRS23 38 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G02280 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0454700 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7090 35 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11085 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | trs23 35 |
|
- Species with no ortholog for TRAPPC4:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRAPPC4 Gene
No data available for Paralogs for TRAPPC4 Gene
Variants for TRAPPC4 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_052397 | - | ||||
| rs7127188 | -- | 119,022,313(+) | AAGGA(A/C)AGGCc | intron-variant | |
| rs11541990 | -- | 119,023,504(-) | TCCCA(C/G)TTTCA | nc-transcript-variant, utr-variant-3-prime | |
| rs11541991 | -- | 119,023,378(-) | AAAGT(C/T)CCAGC | nc-transcript-variant, reference, synonymous-codon | |
| rs11541993 | -- | 119,021,787(+) | AGATC(A/C)TAGGC | nc-transcript-variant, reference, missense |
Residual Variation Intolerance Score:
25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.37;
85.44% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRAPPC4 Gene
Disorders for TRAPPC4 Gene
Relevant External Links for TRAPPC4
No disorders were found for TRAPPC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC4 Gene
Publications for TRAPPC4 Gene
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
- Crystal structure of human synbindin reveals two conformations of longin domain. (PMID: 18466758) Fan S. … Gong W. (Biochem. Biophys. Res. Commun. 2009) 3 23
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
Products for TRAPPC4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TRAPPC4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRAPPC4
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- Browse OriGene Inhibitory RNA Products For TRAPPC4
- OriGene qPCR primer pairs for TRAPPC4
- OriGene qPCR primer pairs and template standards for TRAPPC4
- OriGene CRISPR knockouts for TRAPPC4
- OriGene clones in human for TRAPPC4
- OriGene ORF clones in human,mouse,rat for TRAPPC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TRAPPC4
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- GenScript: Design CRISPR guide RNA sequences for TRAPPC4
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- GenScript Custom Peptide Services for TRAPPC4
- Novus Biologicals Antibodies for TRAPPC4
- Novus Biologicals proteins and lysates for TRAPPC4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for TRAPPC4
- antibodies-online Antibodies for TRAPPC4: See all 47
- Search antibodies-online for kits
- antibodies-online Proteins for TRAPPC4: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for TRAPPC4
- Search GeneTex for Proteins for TRAPPC4
- ViGene Biosciences adenoviral particle packaged cDNA for TRAPPC4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC4 gene
- Search ViGene Biosciences for TRAPPC4
- Search ViGene Biosciences for TRAPPC4
- Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC4
- Search Santa Cruz Biotechnology (SCBT) for TRAPPC4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC4
Sources for TRAPPC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon