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Aliases for TRAPPC4 Gene

Aliases for TRAPPC4 Gene

  • Trafficking Protein Particle Complex 4 2 3 5
  • Hematopoietic Stem/Progenitor Cell Protein 172 3 4
  • TRS23 Homolog 3 4
  • SYNBINDIN 3 4
  • SBDN 3 4
  • CGI-104 3
  • HSPC172 3
  • PTD009 3
  • TRS23 3

External Ids for TRAPPC4 Gene

Previous GeneCards Identifiers for TRAPPC4 Gene

  • GC11P118923
  • GC11P118426
  • GC11P118394
  • GC11P114828
  • GC11P118889

Summaries for TRAPPC4 Gene

GeneCards Summary for TRAPPC4 Gene

TRAPPC4 (Trafficking Protein Particle Complex 4) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Transport to the Golgi and subsequent modification. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for TRAPPC4 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Wiki entry for TRAPPC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC4 Gene

Genomics for TRAPPC4 Gene

Regulatory Elements for TRAPPC4 Gene

Promoters for TRAPPC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC4 Gene

Chromosome:
11
Start:
119,018,432 bp from pter
End:
119,025,454 bp from pter
Size:
7,023 bases
Orientation:
Plus strand

Genomic View for TRAPPC4 Gene

Genes around TRAPPC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC4 Gene

Proteins for TRAPPC4 Gene

  • Protein details for TRAPPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y296-TPPC4_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 4
    Protein Accession:
    Q9Y296
    Secondary Accessions:
    • A8K3A5
    • B4DME1

    Protein attributes for TRAPPC4 Gene

    Size:
    219 amino acids
    Molecular mass:
    24340 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TRAPPC4 Gene

    Alternative splice isoforms for TRAPPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC4 Gene

Proteomics data for TRAPPC4 Gene at MOPED

Post-translational modifications for TRAPPC4 Gene

  • Ubiquitination at Lys 41
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC4 Gene

Domains & Families for TRAPPC4 Gene

Gene Families for TRAPPC4 Gene

Protein Domains for TRAPPC4 Gene

Suggested Antigen Peptide Sequences for TRAPPC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y296

UniProtKB/Swiss-Prot:

TPPC4_HUMAN :
  • Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
genes like me logo Genes that share domains with TRAPPC4: view

Function for TRAPPC4 Gene

Molecular function for TRAPPC4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
genes like me logo Genes that share phenotypes with TRAPPC4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC4 Gene

Localization for TRAPPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC4 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC4 Gene COMPARTMENTS Subcellular localization image for TRAPPC4 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRAPPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005795 Golgi stack ISS 11018053
GO:0005829 cytosol TAS --
GO:0030425 dendrite ISS 11018053
genes like me logo Genes that share ontologies with TRAPPC4: view

Pathways & Interactions for TRAPPC4 Gene

genes like me logo Genes that share pathways with TRAPPC4: view

Gene Ontology (GO) - Biological Process for TRAPPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TRAPPC4: view

No data available for SIGNOR curated interactions for TRAPPC4 Gene

Drugs & Compounds for TRAPPC4 Gene

(1) Drugs for TRAPPC4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC4: view

Transcripts for TRAPPC4 Gene

Unigene Clusters for TRAPPC4 Gene

Trafficking protein particle complex 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: -
SP6:
SP7:

Relevant External Links for TRAPPC4 Gene

GeneLoc Exon Structure for
TRAPPC4
ECgene alternative splicing isoforms for
TRAPPC4

Expression for TRAPPC4 Gene

mRNA expression in normal human tissues for TRAPPC4 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC4 Gene

This gene is overexpressed in Bone (14.8) and Serum (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC4 Gene



SOURCE GeneReport for Unigene cluster for TRAPPC4 Gene Hs.132760

genes like me logo Genes that share expression patterns with TRAPPC4: view

Protein tissue co-expression partners for TRAPPC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC4 Gene

Orthologs for TRAPPC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC4 36
  • 100 (a)
OneToOne
TRAPPC4 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TRAPPC4 36
  • 99 (a)
OneToOne
TRAPPC4 35
  • 90.41 (n)
  • 98.63 (a)
dog
(Canis familiaris)
Mammalia TRAPPC4 35
  • 90.56 (n)
  • 97.72 (a)
TRAPPC4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc4 36
  • 98 (a)
OneToOne
Trappc4 35
  • 91.17 (n)
  • 98.17 (a)
Trappc4 16
oppossum
(Monodelphis domestica)
Mammalia TRAPPC4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC4 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc4 35
  • 90.72 (n)
  • 97.26 (a)
chicken
(Gallus gallus)
Aves TRAPPC4 35
  • 78.54 (n)
  • 89.95 (a)
TRAPPC4 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC4 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11434 35
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc4 35
  • 76.56 (n)
  • 87.67 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc4 35
  • 75.95 (n)
  • 86.3 (a)
zgc73260 35
trappc4 36
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008106 35
  • 61.37 (n)
  • 60.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trs23 35
  • 61.03 (n)
  • 59.62 (a)
Trs23 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trpp-4 36
  • 47 (a)
OneToOne
F36D4.2 35
  • 53.24 (n)
  • 49.03 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR459W 35
  • 45.57 (n)
  • 36.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS23 35
  • 43.55 (n)
  • 37.1 (a)
TRS23 36
  • 31 (a)
OneToOne
TRS23 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12144g 35
  • 50.15 (n)
  • 50.45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02280 35
  • 58.81 (n)
  • 57.55 (a)
rice
(Oryza sativa)
Liliopsida Os07g0454700 35
  • 56.92 (n)
  • 51.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11085 35
  • 57.2 (n)
  • 49.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs23 35
  • 56.77 (n)
  • 53.47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7090 35
Species with no ortholog for TRAPPC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC4 Gene

ENSEMBL:
Gene Tree for TRAPPC4 (if available)
TreeFam:
Gene Tree for TRAPPC4 (if available)

Paralogs for TRAPPC4 Gene

No data available for Paralogs for TRAPPC4 Gene

Variants for TRAPPC4 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_052397 -
rs11290 -- 119,023,419(-) TTTGG(A/G)GGTCC nc-transcript-variant, utr-variant-3-prime
rs4938621 -- 119,021,567(+) CATAA(C/T)AAAGT intron-variant
rs7127188 -- 119,022,313(+) AAGGA(A/C)AGGCc intron-variant
rs11541990 -- 119,023,504(-) TCCCA(C/G)TTTCA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC4 Gene

Variant ID Type Subtype PubMed ID
nsv826101 CNV Gain 20364138

Variation tolerance for TRAPPC4 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.37; 85.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC4 Gene

HapMap Linkage Disequilibrium report
TRAPPC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC4 Gene

Disorders for TRAPPC4 Gene

Relevant External Links for TRAPPC4

Genetic Association Database (GAD)
TRAPPC4
Human Genome Epidemiology (HuGE) Navigator
TRAPPC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC4

No disorders were found for TRAPPC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC4 Gene

Publications for TRAPPC4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. Crystal structure of human synbindin reveals two conformations of longin domain. (PMID: 18466758) Fan S. … Gong W. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The role of ERK2 in colorectal carcinogenesis is partly regulated by TRAPPC4. (PMID: 23625650) Weng Y.R. … Fang J.Y. (Mol. Carcinog. 2014) 3

Products for TRAPPC4 Gene

Sources for TRAPPC4 Gene

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