TRAPPC4 Gene

Aliases
for TRAPPC4 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC11P118923 GC11P118426 GC11P118394 GC11P114828

Summaries
for TRAPPC4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for TRAPPC4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000011.9  NC_018922.2  NT_033899.9  

SwitchGear Promoter luciferase reporter plasmid: TRAPPC4 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAPPC4

TRAPPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118889:  view genomic region     (about GC identifiers)

Proteins
for TRAPPC4 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

3 PDB 3D structures from and Proteopedia for TRAPPC4:

2J3T (3D)        2JSN (3D)        2ZMV (3D)    

Explore the universe of human proteins at neXtProt for TRAPPC4: NX_Q9Y296

Explore proteomics data for TRAPPC4 at MOPED

Post-translational modifications: 

TRAPPC4 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for TRAPPC4 OriGene Protein Over-expression Lysate for TRAPPC4 OriGene MassSpec for TRAPPC4 OriGene Custom Protein Services for TRAPPC4
	GenScript Custom Purified and Recombinant Proteins Services for TRAPPC4
	Novus Biologicals TRAPPC4 Proteins Novus Biologicals TRAPPC4 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for TRAPPC4
	Cloud-Clone Corp. Proteins for TRAPPC4
	Search eBioscience for Proteins for TRAPPC4
	Search GeneTex for Proteins for TRAPPC4
	antibodies-online proteins for TRAPPC4 (6 products)
	antibodies-online peptides for TRAPPC4

TRAPPC4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for TRAPPC4 OriGene Custom Antibody Services for TRAPPC4
	Novus Biologicals TRAPPC4 Antibodies
	Abcam antibodies for TRAPPC4
	Cloud-Clone Corp. Antibodies for TRAPPC4
	ThermoFisher Antibodies for TRAPPC4
	antibodies-online antibodies for TRAPPC4 (27 products)

TRAPPC4 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TRAPPC4
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRAPPC4
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TRAPPC4 Cloud-Clone Corp. CLIAs for TRAPPC4
	Search eBioscience for ELISAs for TRAPPC4
	antibodies-online kits for TRAPPC4 (8 products)

Domains /
Families
for TRAPPC4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q9Y296

Find genes that share domains with TRAPPC4           About GenesLikeMe

Function
for TRAPPC4 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for TRAPPC4

miRNA Products:		Block miRNA regulation of human, mouse, rat TRAPPC4 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate TRAPPC4:
		hsa-let-7g* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: TRAPPC4 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRAPPC4
		Predesigned siRNA for gene silencing in human, mouse, rat TRAPPC4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TRAPPC4

Clone Products:		OriGene clones in human, mouse for TRAPPC4 (see all 7) OriGene ORF clones in mouse, rat for TRAPPC4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRAPPC4 (NM_016146)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAPPC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRAPPC4
		Browse ESI BIO Cell Lines and PureStem Progenitors for TRAPPC4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC4

Localization
for TRAPPC4 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	4
endoplasmic reticulum	2
mitochondrion	2
cytoskeleton	1
cytosol	1
nucleus	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

Pathways & Interactions
for TRAPPC4 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for TRAPPC4 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	Non-integrin membrane-ECM interactions	Non-integrin membrane-ECM interactions 0.35 Syndecan interactions 0.00
2	Degradation of the extracellular matrix	Extracellular matrix organization 0.34
3	Syndecan-2-mediated signaling events	Syndecan-2-mediated signaling events

1 BioSystems Pathway for TRAPPC4

Syndecan-2-mediated signaling events

1 Reactome Pathway for TRAPPC4

Syndecan interactions

Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for TRAPPC4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for TRAPPC4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for TRAPPC4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRAPPC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTCTTACTTT

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for TRAPPC4 OriGene qSTAR qPCR primer pairs in human, mouse for TRAPPC4
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAPPC4
		QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC4
		QuantiFast Probe-based Assays in human, mouse, rat TRAPPC4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC4

Orthologs
for TRAPPC4 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for TRAPPC4 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Genomic Variants
for TRAPPC4 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for TRAPPC4 (see all 117)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1839369151,2		--	118891095(+)	GACACC/TTTTGG	1	--	int1		0	--	--	--	--
rs1398121201,2	C	--	118891137(+)	CACAA-/TTCCTTTT	1	--	int1		0	--	--	--	--
rs786046921,2		--	118891139(+)	CAATTC/TTTTTT	1	--	int1		0	--	--	--	--
rs1997349811,2	C	--	118891139(+)	AATTC-/TTTTTT	1	--	int1		0	--	--	--	--
rs1425455561,2	F	--	118891141(+)	CAATTCTT/-TTTTT	2	--	int1 cds1		1		NS	136
rs127853361,2	C	--	118891188(+)	TGCAGT/GGGCAT	1	--	int1		13		NA WA CSA EA	377
rs1398684741,2	C	--	118891238(+)	CTCCCA/CAATAG	1	--	int1		0	--	--	--	--
rs1176943741,2	F	--	118891314(+)	CTCCAT/CATTGG	1	--	int1		1		NA	120
rs127900251,2	C,H	--	118891403(+)	ACCCGG/ACCCAC	1	--	int1		11		NS EA WA NA CSA	433
rs1877571491,2	C	--	118891490(+)	GGCTCA/GCTGCA	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRAPPC4 (118889142 - 118896164 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TRAPPC4:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv826101	CNV	Gain	20364138

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TRAPPC4

DNA2.0 Custom Variant and Variant Library Synthesis for TRAPPC4

Disorders / Diseases
for TRAPPC4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for TRAPPC4 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.-H.... Lin W.-C. (Genome Res. 2000)
2. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)^{1, 2} Scrivens P.J.... Sacher M. (Mol. Biol. Cell 2011)
3. Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. (PubMed id 20035503)^{1, 4} Elstner M....Turnbull D.M. (Ann. Neurol. 2009)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PubMed id 11805826)^{1, 2} Gavin A.-C....Superti-Furga G. (Nature 2002)
6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (Genome Res. 2000)
7. Crystal structure of human synbindin reveals two conformations of longin domain. (PubMed id 18466758)^{1, 9} Fan S....Gong W. (Biochem. Biophys. Res. Commun. 2009)
8. Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. (PubMed id 24104608)¹ Kong X....Fang J.Y. (J. Natl. Cancer Inst. 2013)
9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
10. TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells. (PubMed id 21826244)¹ Zhao S.L....Fang J.Y. (PLoS ONE 2011)

External Searches for TRAPPC4 gene

Genome Databases showing TRAPPC4 gene

Other Databases showing TRAPPC4 gene

Specialized Databases showing TRAPPC4 gene

Products
for TRAPPC4 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section