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Aliases for TRAPPC4 Gene

Aliases for TRAPPC4 Gene

  • Trafficking Protein Particle Complex 4 2 3
  • Hematopoietic Stem/Progenitor Cell Protein 172 3 4
  • TRS23 Homolog 3 4
  • SYNBINDIN 3 4
  • SBDN 3 4
  • Trafficking Protein Particle Complex Subunit 4 3
  • CGI-104 3
  • HSPC172 3
  • PTD009 3
  • TRS23 3

External Ids for TRAPPC4 Gene

Summaries for TRAPPC4 Gene

GeneCards Summary for TRAPPC4 Gene

TRAPPC4 (Trafficking Protein Particle Complex 4) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Non-integrin membrane-ECM interactions.

UniProtKB/Swiss-Prot for TRAPPC4 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Wiki entry for TRAPPC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC4 Gene

Genomics for TRAPPC4 Gene

Genomic Location for TRAPPC4 Gene

Start:
119,018,432 bp from pter
End:
119,025,454 bp from pter
Size:
7,023 bases
Orientation:
Plus strand

Genomic View for TRAPPC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC4 Gene

Regulatory Elements for TRAPPC4 Gene

Proteins for TRAPPC4 Gene

  • Protein details for TRAPPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y296-TPPC4_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 4
    Protein Accession:
    Q9Y296
    Secondary Accessions:
    • A8K3A5
    • B4DME1

    Protein attributes for TRAPPC4 Gene

    Size:
    219 amino acids
    Molecular mass:
    24340 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TRAPPC4 Gene

    Alternative splice isoforms for TRAPPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC4 Gene

Proteomics data for TRAPPC4 Gene at MOPED

Post-translational modifications for TRAPPC4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys41

Other Protein References for TRAPPC4 Gene

No data available for DME Specific Peptides for TRAPPC4 Gene

Domains for TRAPPC4 Gene

Gene Families for TRAPPC4 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Protein Domains for TRAPPC4 Gene

Suggested Antigen Peptide Sequences for TRAPPC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y296

UniProtKB/Swiss-Prot:

TPPC4_HUMAN
Family:
  • Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.:
    • Q9Y296
genes like me logo Genes that share domains with TRAPPC4: view

Function for TRAPPC4 Gene

Molecular function for TRAPPC4 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Ontology (GO) - Molecular Function for TRAPPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17110339
GO:0017112 Rab guanyl-nucleotide exchange factor activity IBA --
genes like me logo Genes that share ontologies with TRAPPC4: view
genes like me logo Genes that share phenotypes with TRAPPC4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRAPPC4 Gene

Localization for TRAPPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC4 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC4 Gene COMPARTMENTS Subcellular localization image for TRAPPC4 gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 2
mitochondrion 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRAPPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005783 endoplasmic reticulum IEA --
GO:0005795 Golgi stack ISS 11018053
GO:0005801 cis-Golgi network IEA --
GO:0008021 synaptic vesicle ISS 11018053
genes like me logo Genes that share ontologies with TRAPPC4: view

Pathways for TRAPPC4 Gene

genes like me logo Genes that share pathways with TRAPPC4: view

Pathways by source for TRAPPC4 Gene

Gene Ontology (GO) - Biological Process for TRAPPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0016358 dendrite development ISS 11018053
GO:0030198 extracellular matrix organization TAS --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TRAPPC4: view

Compounds for TRAPPC4 Gene

(1) Drugbank Compounds for TRAPPC4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-PALMITOYL-L-CYSTEINE
target
genes like me logo Genes that share compounds with TRAPPC4: view

Transcripts for TRAPPC4 Gene

Unigene Clusters for TRAPPC4 Gene

Trafficking protein particle complex 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: -
SP6:
SP7:

Relevant External Links for TRAPPC4 Gene

GeneLoc Exon Structure for
TRAPPC4
ECgene alternative splicing isoforms for
TRAPPC4

Expression for TRAPPC4 Gene

mRNA expression in normal human tissues for TRAPPC4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC4 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC4 Gene Hs.132760

genes like me logo Genes that share expressions with TRAPPC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC4 Gene

Orthologs for TRAPPC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC4 35
  • 100 (n)
  • 100 (a)
TRAPPC4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC4 35
  • 90.41 (n)
  • 98.63 (a)
TRAPPC4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC4 35
  • 90.56 (n)
  • 97.72 (a)
TRAPPC4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc4 35
  • 91.17 (n)
  • 98.17 (a)
Trappc4 16
Trappc4 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC4 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc4 35
  • 90.72 (n)
  • 97.26 (a)
chicken
(Gallus gallus)
Aves TRAPPC4 35
  • 78.54 (n)
  • 89.95 (a)
TRAPPC4 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC4 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11434 35
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc4 35
  • 76.56 (n)
  • 87.67 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc4 35
  • 75.95 (n)
  • 86.3 (a)
trappc4 36
  • 87 (a)
OneToOne
zgc73260 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008106 35
  • 61.37 (n)
  • 60.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trs23 35
  • 61.03 (n)
  • 59.62 (a)
Trs23 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F36D4.2 35
  • 53.24 (n)
  • 49.03 (a)
trpp-4 36
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR459W 35
  • 45.57 (n)
  • 36.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS23 35
  • 43.55 (n)
  • 37.1 (a)
TRS23 36
  • 31 (a)
OneToOne
TRS23 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12144g 35
  • 50.15 (n)
  • 50.45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02280 35
  • 58.81 (n)
  • 57.55 (a)
rice
(Oryza sativa)
Liliopsida Os07g0454700 35
  • 56.92 (n)
  • 51.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11085 35
  • 57.2 (n)
  • 49.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs23 35
  • 56.77 (n)
  • 53.47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7090 35
Species with no ortholog for TRAPPC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC4 Gene

ENSEMBL:
Gene Tree for TRAPPC4 (if available)
TreeFam:
Gene Tree for TRAPPC4 (if available)

Paralogs for TRAPPC4 Gene

No data available for Paralogs for TRAPPC4 Gene

Variants for TRAPPC4 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs569 -- 119,023,577(+) TATAT(A/G)CCATG utr-variant-3-prime
rs9056 -- 119,023,517(-) AGGGT(C/G)AGCAT utr-variant-3-prime
rs11290 -- 119,023,419(-) TTTGG(A/G)GGTCC utr-variant-3-prime
rs12494 -- 119,021,851(-) TTCTT(A/C/G)AGGGC reference, synonymous-codon
rs4938621 -- 119,021,567(+) CATAA(C/T)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC4 Gene

Variant ID Type Subtype PubMed ID
nsv826101 CNV Gain 20364138

Relevant External Links for TRAPPC4 Gene

HapMap Linkage Disequilibrium report
TRAPPC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC4 Gene

Disorders for TRAPPC4 Gene

Relevant External Links for TRAPPC4

Genetic Association Database (GAD)
TRAPPC4
Human Genome Epidemiology (HuGE) Navigator
TRAPPC4
genes like me logo Genes that share disorders with TRAPPC4: view

No data available for UniProtKB/Swiss-Prot for TRAPPC4 Gene

Publications for TRAPPC4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. Crystal structure of human synbindin reveals two conformations of longin domain. (PMID: 18466758) Fan S. … Gong W. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin A.-C. … Superti-Furga G. (Nature 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRAPPC4 Gene

Sources for TRAPPC4 Gene

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