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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAPPC3L Gene

protein-coding   GIFtS: 30
GCID: GC06M116817

Trafficking Protein Particle Complex 3-Like

(Previous name: BET3 like (S. cerevisiae))
(Previous symbol: BET3L)
  Search for TRAPPC3L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Trafficking Protein Particle Complex 3-Like1 2     BET3 Like (S. Cerevisiae)1
BET3L1 2 3     bA259P20.22
BET3-Like Protein2 3     Trafficking Protein Particle Complex Subunit 3-Like Protein2
TRAPPC3-Like Protein2 3     

External Ids:    HGNC: 210901   Entrez Gene: 1001283272   Ensembl: ENSG000001736267   OMIM: 6141375   UniProtKB: Q5T2153   

Export aliases for TRAPPC3L gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRAPPC3L Gene: 
TRAPPC3L (trafficking protein particle complex 3-like) is a protein-coding gene. An important paralog of this gene is TRAPPC3.

UniProtKB/Swiss-Prot: TPC3L_HUMAN, Q5T215
Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRAPPC3L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRAPPC3L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAPPC3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.31

TRAPPC3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAPPC3L gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M116817:  view genomic region     (about GC identifiers)

Start:
116,816,152 bp from pter      End:
116,866,773 bp from pter
Size:
50,622 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPC3L_HUMAN, Q5T215 (See protein sequence)
Recommended Name: Trafficking protein particle complex subunit 3-like protein  
Size: 181 amino acids; 20566 Da
Subunit: Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at
least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12
Subcellular location: Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity)
Secondary accessions: Q5T213 Q5T214
Alternative splicing: 2 isoforms:  Q5T215-1   Q5T215-2   

Explore the universe of human proteins at neXtProt for TRAPPC3L: NX_Q5T215

Explore proteomics data for TRAPPC3L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T215

  • TRAPPC3L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAPPC3L Protein Expression
    REFSEQ proteins: NP_001132916.1  
    ENSEMBL proteins: 
     ENSP00000348445   ENSP00000395769   ENSP00000357591  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--

    TRAPPC3L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR007194 TRAPP_component
     IPR016721 TRAPP_I_complex_Bet3
     IPR024096 NO_sig/Golgi_transp_ligand-bd

    Graphical View of Domain Structure for InterPro Entry Q5T215

    ProtoNet protein and cluster: Q5T215

    1 Blocks protein domain: IPB007194 Transport protein particle (TRAPP) component

    UniProtKB/Swiss-Prot: TPC3L_HUMAN, Q5T215
    Similarity: Belongs to the TRAPP small subunits family. BET3 subfamily


    TRAPPC3L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPC3L_HUMAN, Q5T215
    Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity)

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRAPPC3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for TRAPPC3L (ENSP000003575914) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAPPC1ENSP000003027834STRING: ENSP00000302783
    TRAPPC4ENSP000003518964STRING: ENSP00000351896
    TRAPPC5ENSP000003169904STRING: ENSP00000316990
    TRAPPC2ENSP000003527084STRING: ENSP00000352708
    NSFENSP000003812934STRING: ENSP00000381293
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192vesicle-mediated transport IEA--

    TRAPPC3L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAPPC3L (TPC3L)

    Search CenterWatch for drugs/clinical trials and news about TRAPPC3L / TPC3L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAPPC3L gene: 
    NM_001139444.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356128(uc003pwx.3) ENST00000437098(uc003pww.3) ENST00000368602(uc011ebh.2)

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRAPPC3L
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See TRAPPC3L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAPPC3L
        SABiosciences Custom PCR Arrays for TRAPPC3L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC3L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRAPPC3L gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bet3l1 , 5 BET3 like (S. cerevisiae)1, 5 89.5(n)1
    92.82(a)1
      10 (18.85 cM)5
    6921321  NM_001162937.11  NP_001156409.11 
     340375975 
    chicken
    (Gallus gallus)
    Aves BET3L1 BET3 like (S. cerevisiae) 72.04(n)
    76.67(a)
      421743  XM_419775.3  XP_419775.1 
    lizard
    (Anolis carolinensis)
    Reptilia BET3L6
    BET3 like (S. cerevisiae)
    75(a)
    1 ↔ 1
    1(186193061-186216953)
    zebrafish
    (Danio rerio)
    Actinopterygii trappc36
    trafficking protein particle complex 3
    62(a)
    1 → many
    19(37271262-37281761)
    fruit fly
    (Drosophila melanogaster)
    Insecta Bet36
    --
    47(a)
    1 → many
    3L(9431582-9435367)
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1098.56
    Probable trafficking protein particle complex subu...
    39(a)
    1 → many
    III(9525550-9527080)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BET36
    Hydrophilic protein that acts in conjunction with ...
    42(a)
    1 → many
    XI(570328-570909)


    ENSEMBL Gene Tree for TRAPPC3L (if available)
    TreeFam Gene Tree for TRAPPC3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAPPC3L gene
    TRAPPC32  
    1 SIMAP similar gene for TRAPPC3L using alignment to 1 protein entry:     TPC3L_HUMAN:
    TRAPPC3

    TRAPPC3L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/445 SNPs in TRAPPC3L are shown (see all 445)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756591221,2
    F--116817349(+) AATGAT/CAGTAG 1 -- int11Minor allele frequency- C:0.01NA 120
    rs77450801,2
    C,F,A,H--116817453(+) CAATAT/CTTCAT 1 -- int121Minor allele frequency- C:0.31NS EA NA 2090
    rs1864816841,2
    --116817592(+) GTAGCA/GTCAGA 1 -- int10--------
    rs1510791901,2
    --116817599(+) CAGAAA/GGCTAA 1 -- int10--------
    rs26376671,2
    H--116817613(-) CTTGGC/TTTATA 1 -- int1 ese34Minor allele frequency- T:0.00NS EA 392
    rs1402012451,2
    --116817691(+) TATACA/GGTATC 1 -- ut310--------
    rs1889294221,2
    --116817819(+) ATACGC/TGAATG 1 -- ut310--------
    rs1503356491,2
    --116817880(+) CTGCTA/GTCTTG 1 -- ut310--------
    rs1816815811,2
    --116817935(+) AATGCA/GTGATT 1 -- ut310--------
    rs1409626921,2
    C--116817953(+) AAAGG-/AAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRAPPC3L (116816152 - 116866773 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TRAPPC3L: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAPPC3L
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAPPC3L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRAPPC3L for disorders           About MalaCards
    OMIM gene information: 614137    OMIM disorders: --


    TRAPPC3L for disorders           About GeneDecksing


    Export disorders for TRAPPC3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAPPC3L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TRAPPC3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C4orf41 and TTC-15 are mammalian TRAPP components wit h a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)1, 2, 3 Scrivens P.J....Sacher M. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100128327 HGNC: 21090 Ensembl:ENSG00000173626 euGenes: HUgn100128327 ECgene: TRAPPC3L
    H-InvDB: TRAPPC3L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAPPC3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAPPC3L gene:
    Search GeneIP for patents involving TRAPPC3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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