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Aliases for TRAPPC3L Gene

Aliases for TRAPPC3L Gene

  • Trafficking Protein Particle Complex 3 Like 2 3 5
  • TRAPPC3-Like Protein 3 4
  • BET3-Like Protein 3 4
  • BET3L 3 4
  • Trafficking Protein Particle Complex Subunit 3-Like Protein 3
  • Trafficking Protein Particle Complex 3-Like 2
  • BET3 Like (S. Cerevisiae) 2
  • BA259P20.2 3

External Ids for TRAPPC3L Gene

Previous HGNC Symbols for TRAPPC3L Gene

  • BET3L

Previous GeneCards Identifiers for TRAPPC3L Gene

  • GC06M116817

Summaries for TRAPPC3L Gene

GeneCards Summary for TRAPPC3L Gene

TRAPPC3L (Trafficking Protein Particle Complex 3 Like) is a Protein Coding gene. An important paralog of this gene is TRAPPC3.

UniProtKB/Swiss-Prot for TRAPPC3L Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC3L Gene

Genomics for TRAPPC3L Gene

Regulatory Elements for TRAPPC3L Gene

Enhancers for TRAPPC3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F116384 1.6 FANTOM5 Ensembl ENCODE 10.9 +156.3 156254 9.9 PKNOX1 WRNIP1 ZNF2 RAD21 ZNF366 ETV6 FOS CREM ZNF263 YY2 DSE FAM26F FAM26D CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
GH06F116444 1.5 FANTOM5 Ensembl ENCODE 10.9 +99.3 99310 4.6 PKNOX1 ARNT RAD21 ZNF48 GATA2 SCRT2 ZMIZ1 FOS CEBPB REST FAM26F FAM26D ENSG00000234117 TRAPPC3L DSE ZUFSP CBX3P9 PIR34878
GH06F116630 1.3 Ensembl ENCODE 11 -86.2 -86232 2.0 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GATA2 SP5 NFYC ZHX2 RSPH4A TRAPPC3L KPNA5 FAM26D GC06P116597 ZUFSP
GH06F116276 1.1 ENCODE 11.4 +266.2 266184 5.1 HDGF CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 FOS FAM26F TSPYL4 FAM26D TSPYL1 TRAPPC3L KRT18P22 CBX3P9 ENSG00000244158 ENSG00000234117 ZUFSP
GH06F116268 1.2 Ensembl ENCODE 10.4 +277.0 277009 0.8 ELF3 TBP ARID4B THRB ZSCAN9 BRCA1 RAD21 RARA RFX5 SLC30A9 FAM26D TRAPPC3L CBX3P9 FAM26F KRT18P22 ENSG00000244158 ENSG00000234117 ENSG00000237021 GC06P116262 PIR59102
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAPPC3L on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC3L Gene

Chromosome:
6
Start:
116,494,989 bp from pter
End:
116,545,610 bp from pter
Size:
50,622 bases
Orientation:
Minus strand

Genomic View for TRAPPC3L Gene

Genes around TRAPPC3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC3L Gene

Proteins for TRAPPC3L Gene

  • Protein details for TRAPPC3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T215-TPC3L_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 3-like protein
    Protein Accession:
    Q5T215
    Secondary Accessions:
    • Q5T213
    • Q5T214

    Protein attributes for TRAPPC3L Gene

    Size:
    181 amino acids
    Molecular mass:
    20566 Da
    Quaternary structure:
    • Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

    Alternative splice isoforms for TRAPPC3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC3L Gene

Post-translational modifications for TRAPPC3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAPPC3L Gene

Domains & Families for TRAPPC3L Gene

Suggested Antigen Peptide Sequences for TRAPPC3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T215

UniProtKB/Swiss-Prot:

TPC3L_HUMAN :
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC3L: view

No data available for Gene Families for TRAPPC3L Gene

Function for TRAPPC3L Gene

Molecular function for TRAPPC3L Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC3L Gene

Localization for TRAPPC3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC3L Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC3L gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRAPPC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030008 TRAPP complex IEA --
genes like me logo Genes that share ontologies with TRAPPC3L: view

Pathways & Interactions for TRAPPC3L Gene

SuperPathways for TRAPPC3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048193 Golgi vesicle transport IEA --
genes like me logo Genes that share ontologies with TRAPPC3L: view

No data available for Pathways by source and SIGNOR curated interactions for TRAPPC3L Gene

Transcripts for TRAPPC3L Gene

mRNA/cDNA for TRAPPC3L Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC3L Gene

No ASD Table

Relevant External Links for TRAPPC3L Gene

GeneLoc Exon Structure for
TRAPPC3L
ECgene alternative splicing isoforms for
TRAPPC3L

Expression for TRAPPC3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAPPC3L Gene

mRNA differential expression in normal tissues according to GTEx for TRAPPC3L Gene

This gene is overexpressed in Spleen (x11.0).

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC3L Gene:

TRAPPC3L
genes like me logo Genes that share expression patterns with TRAPPC3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAPPC3L Gene

Orthologs for TRAPPC3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BET3L 34
  • 99.63 (n)
TRAPPC3L 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC3L 35
  • 94 (a)
OneToOne
BET3L 34
  • 92.27 (n)
dog
(Canis familiaris)
Mammalia TRAPPC3L 34 35
  • 91.16 (n)
mouse
(Mus musculus)
Mammalia Trappc3l 34 16 35
  • 89.5 (n)
rat
(Rattus norvegicus)
Mammalia Trappc3l 34
  • 88.58 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAPPC3L 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC3L 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAPPC3L 35
  • 77 (a)
OneToOne
BET3L 34
  • 72.04 (n)
lizard
(Anolis carolinensis)
Reptilia TRAPPC3L 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488207 34
  • 64.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bet3 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trpp-3 35
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET3 35
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8333 35
  • 53 (a)
OneToMany
Species where no ortholog for TRAPPC3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TRAPPC3L Gene

ENSEMBL:
Gene Tree for TRAPPC3L (if available)
TreeFam:
Gene Tree for TRAPPC3L (if available)

Paralogs for TRAPPC3L Gene

Paralogs for TRAPPC3L Gene

(1) SIMAP similar genes for TRAPPC3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAPPC3L: view

Variants for TRAPPC3L Gene

Sequence variations from dbSNP and Humsavar for TRAPPC3L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10034483 -- 116,506,485(+) GAAAT(A/G)CCATT intron-variant
rs10457307 -- 116,499,508(+) AGCTT(A/G)TCATA intron-variant
rs10485185 -- 116,497,560(+) GCTTT(C/G)AGAAT intron-variant
rs10485186 -- 116,497,897(+) TACCT(A/G)ACTCA intron-variant
rs10485187 -- 116,498,367(+) GTAGA(C/T)GCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC3L Gene

Variant ID Type Subtype PubMed ID
esv2663254 CNV deletion 23128226
esv3326453 CNV insertion 20981092
esv3340874 CNV insertion 20981092
esv3364800 CNV insertion 20981092
esv3610471 CNV loss 21293372
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for TRAPPC3L Gene

Gene Damage Index Score: 1.81; 34.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAPPC3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC3L Gene

Disorders for TRAPPC3L Gene

Relevant External Links for TRAPPC3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC3L

No disorders were found for TRAPPC3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC3L Gene

Publications for TRAPPC3L Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for TRAPPC3L Gene

Sources for TRAPPC3L Gene

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